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7314627 |
Cationic lipid-mediated enhancement of nucleic acid immunization of cats
The present invention relates to a method to introduce a nucleic acid molecule into a felid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of...
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7279168 |
Recombinant virus expressing foreign DNA encoding feline CD86 and uses thereof
The present invention involves a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign...
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7238672 |
Chimeric lyssavirus nucleic acids and polypeptides
The present invention provides chimeric nucleic acids, preferably contained on an expression vector, that encode chimeric immunogenic polypeptides. The nucleic acids encode at least site III of a ...
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7223584 |
Recombinant rabies vaccine and methods of preparation and use
Live rabies virus vaccines comprising a recombinant rabies virus genome which overexpresses the rabies virus G protein increase apoptotic activity in infected cells, and enhance the generation of...
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7208164 |
Ovo immunization against infectious bronchitis
The present invention is directed to processes and compositions for protecting host animals (e.g., chickens) from exposure to virulent infectious bronchitis virus. In ovo administration of live,...
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7192580 |
Purging of cells using viruses
The subject invention relates to viruses that are able to purge (reduce or eliminate) undesirable cells in a mixture of cells. Undesirable cells can include neoplastic cells, cells mediating...
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7153510 |
Recombinant vesiculoviruses and their uses
The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable...
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7144578 |
Poxvirus-rabies recombinants and compositions and methods employing the recombinants
Recombinant viruses containing DNA coding for a rabies virus antigen, such as rabies virus G are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The...
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7090853 |
Noscapine derivatives as adjuvant compositions and methods of use thereof
An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines.
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7081243 |
Rhabdoviruses with reengineered coats
Replication-competent recombinant rhabdoviruses that lack a functional glycoprotein gene and express at least one foreign polypeptide such as a celluar receptor for another virus in their viral...
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7074413 |
Genetically engineered rabies recombinant vaccine for immunization of stray dogs and wildlife
Live, attenuated recombinant rabies virus vaccines are generated using reverse genetics to combine the antigenic determinants that render the rabies virus non-pathogenic with the determinants that...
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6887484 |
Vaccine composition containing a promoter peptide
A vaccine having a good vaccination effect, which comprises an antigen; a peptide selected from the group consisting of a peptide having the amino acid sequence of SEQ ID NO: 1, a peptide having...
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6887479 |
Attenuated recombinant rabies virus mutants and live vaccines thereof
The present invention describes recombinant RV mutants comprising a combine mutation in two different parts of the viral genome, involving the P and the G genes. The mutations in the P gene...
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6719981 |
Stable, attenuated rabies virus mutants and live vaccines thereof
The present invention relates to recombinant rabies virus mutants comprising a mutation in the viral genome, whereby said mutation comprises at least a substitution of the Arg 333 codon in the...
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6602697 |
Process for purifying human papillomavirus virus-like particles
A process for purifying papillomavirus virus-like particles (VLPs) includes the step of passing a partially purified VLP-containing solution through a hydroxyapatite chromatography column. The VLPs...
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6589533 |
Genetically-engineered alphaviruses, flaviviruses, and bunyaviruses with modified envelope transmembrane glycoproteins and altered host-range phenotype
The present invention is directed toward genetically-engineered, membrane-enveloped Alphaviruses, Flaviviruses, and Bunyaviruses containing modified viral transmembrane envelope glycoproteins...
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6448070 |
Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid
A fusion capsid protein comprising a plant virus capsid protein fused to an antigenic polypeptide is used as a molecule for presentation of that polypeptide to the immune system of an animal such...
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6171591 |
Recombinant nodavirus compositions and methods
Recombinant nodavirus related compositions are disclosed. These compositions include chimeric proteins in which a nodavirus capsid protein is present together with a heterologous peptide segment....
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6168943 |
Methods for making modified recombinant vesiculoviruses
The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable...
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6168787 |
Pluripotent vaccine against enveloped viruses
The present invention is directed to compositions and methods for the induction of immune responses in mammals against enveloped animal viruses. More particularly, the invention provides vaccine...
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6136585 |
Attenuation of negative stranded RNA viruses by rearrangement of genes and uses thereof
Provided is a method of attenuating a virus of the order Mononegavirales, comprising the step of: rearranging said virus' gene order by moving a gene essential for RNA replication away from its...
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6129921 |
Viral ribonucleocapsid as an immunological enhancer
Methods of enhancing an antigen-induced immune response through use of a ribonucleocapsid complex are provided. Composition containing a ribonucleocapsid complex and an antigen which are capable of...
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6106841 |
Delivery method for recombinant raccoon poxvirus
The present invention relates to a novel method to immunize an animal against a heterologous antigen. The method includes the step of administering to the animal, by an intranasal route, a...
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6060068 |
Human IL-2 as a vaccine adjuvant
Methods for enhancing the immune response to vaccination in animals, including humans, comprise administering interleukin-2 (IL-2) as part of the vaccination regimen, preferably for 5 to 14 days...
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6033886 |
Recombinant infectious non-segmented negative strand RNA virus
The present invention provides the generation of infectious replicating non-segmented negative-stranded RNA virus, entirely from cloned cDNA. This process offers the possibility to introduce...
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6008036 |
Method for purifying viruses by chromatography
A method for purifying viruses from a cell line culture by chromatography, comprising an anion exchange chromatography step followed by a cation exchange chromatography step and optionally a...
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5935570 |
Synthesis of immunologic, therapeutic and prophylactic compounds by transformed clavibacter
A process for the synthesis and delivery of bioactive compounds, compounds that have a therapeutic, biochemical, or immunologic, effect on an animal, such as human. In the process, clavibacter is...
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5853735 |
Avirulent anti-rabies vaccine
The invention relates to an avirulent anti-rabies vaccine which consists of an avirulent mutant of an SAD strain of the rabies virus, the glycoprotein of which possesses in position 333 a naturally...
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5843456 |
Alvac poxvirus-rabies compositions and combination compositions and uses
Attenuated recombinant viruses containing DNA encoding a rabies virus antigen in a "cocktail" or combination or multivalent compositions well as methods for making and using the compositions,...
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5837249 |
Method for generating an immunogenic T cell response protective against a virus
A novel method of presenting an immunogenic peptide to an antigen presenting cell (APC) of a mammalian host, in order to generate a T cell response protective against a virus, such as herpes or...
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5830638 |
Cell line and processes for the replicating rabies viruses and detecting them quantitatively
A permanent cell line PH2, and a process for replication of rabies viruses which have a cytopathic effect (CPE) is claimed. The process comprises: infecting the PH2 cell line with the virus to be...
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5616326 |
Recombinant canine adenovirus 2 (CAV-2)
A non-essential region in strains of live non-pathogenic immunogenic canine adenovirus is described. The insertion of genes from pathogenic carnivora viruses into this region, with suitable...
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5494807 |
NYVAC vaccinia virus recombinants comprising heterologous inserts
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential...
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5354555 |
Vaccine to control the viral infection of fish
Subunit vaccines and their use for immunizing fish against infection by viruses are disclosed. In particular, plasmid pG8 is constructed by joining, with the plasmid pUC8, DNA which encodes the...
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5348741 |
Vector for recombinant poxvirus expressing rabies virus glycoprotein
A plasmid vector has been constructed for producing unique vaccinia virus recombinant expressing the gene for rabiesvirus glycoprotein in cells. The recombinant induces production of glycoprotein...
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5266313 |
Raccoon poxvirus as a gene expression and vaccine vector for genes of rabies virus and other organisms
Raccoon poxvirus, an organism that may be indigenous in nature, is established as a suitable substrate for insertion and expression of nucleotide coding sequence of heterolgous organisms. Two...
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5174993 |
Recombinant avipox virus and immunological use thereof
The present invention provides a method for inducing an immunological response in a vertebrate to a pathogen by inoculating the vertebrate with a synthetic recombinant avipox virus modified by the...
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5106619 |
Preparation of inactivated viral vaccines
Vaccines employing inactivated viruses having improved retention of antigenic characteristics are prepared by psoralen-inactivation of the live virus in a non-oxidizing atmosphere. By excluding...
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5066593 |
Synthetic peptide-based anti-rabies compositions and methods
A sequence in the coat glycoprotein of rabies virus is identified as the molecular basis for an essential step in the pathogenesis of the virus, the binding of virus to acetylcholine receptor at...
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4752474 |
Live rabies vaccine
A process for the preparation of a live rabies vaccine for the oral vaccination of Canidae is described. Special variants of the SAD rabies virus strain, called variant strain VA 1 , VA 12 , VA 17 ...
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4744983 |
Immunogenic protein or peptide complex, method of producing said complex and the use thereof as an immune stimulant and as a vaccine
The invention relates to an immunogenic complex containing antigenic membrane proteins or peptides from viruses mycoplasmas, bacteria, parasites or animal cells or prepared synthetically or with...
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4738846 |
Vaccine for vesicular stomatitis virus
Synthetic vaccines for both the Indiana and New Jersey serotypes of vesicular stomatitis virus are provided. Recombinant vaccinia viruses are created with DNA sequences which encode antigenically...
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4731237 |
Immune response to virus induced by anti-idiotype antibodies
A method of inducing an immunological response in a host to a virus is provided employing anti-idiotype antibodies that present an internal image of a viral antigen to the host. Anti-idiotype...
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4726946 |
Inactivated rabies vaccine for veterinary use
The preparation of a vaccine for immunization of canine and feline animals from inactivated HCP-SAD strain of rabies virus is disclosed.
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4725547 |
Method for purfication of rabic virus
Disclosed is a method for the purification of rabic virus, which comprises subjecting a solution containing the rabic virus to column chromatography using, as a gel for chromatography, a sulfuric...
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4664912 |
Process for the large scale production of rabies vaccine
In the large-scale production of rabies vaccine a cell stock comprising a VERO cell strain and a liquid nutritive medium containing serum and microcarriers suspended therein is successively passed...
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4657761 |
Polyvalent non-specific immuno-stimulating vaccine and method
A non-specific therapeutic polyvalent vaccine for subcutaneous injection containing a minimum combination of a PPD (tuberculin vaccine), a rabies vaccine, and snake venom vaccine and preferably...
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4650673 |
Oral immunization of mammals
A composition and method for immunizing carnivores and other mammals, especially foxes, against rabies and other pathogenic diseases, by setting out and orally administering a dose of a vaccine,...
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4649049 |
Rabies vaccine
A rabies vaccine composition is disclosed which comprises a sterilized suspension of proteineous suckling mice or rat brain particles of injectable particle size laden with an amount of inactivated...
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4593002 |
Viruses with recombinant surface proteins
Foreign protein segments having specific medically or commercially useful biological functions are incorporated in surface proteins of viruses. The viruses with the incorporated protein segments...
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