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7311918 |
Rotavirus subunit vaccine
The present invention is directed to the generation and use of recombinant rotavirus fusion proteins as immunogens to produce a protective immune response from immunized individuals. In one...
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7309493 |
Inactivated bovine scours vaccines, process and method of preventing bovine scours
Inactivated scours vaccines for immunization and protection of bovine animals from disease caused by infection with bovine rotavirus and bovine coronavirus, which comprise and effective amount of...
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7285280 |
Vaccine
The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major...
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7264798 |
Sensitization of chemotherapeutic agent resistant neoplastic cells with a virus
The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus...
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7223388 |
Modified reoviral therapy
The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the...
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7198783 |
Sensitization of neoplastic cells to radiation therapy with reovirus
The present invention relates to methods of sensitizing neoplastic cells to irradiation by using oncolytic viruses, particularly reoviruses. Also provided are methods of treating or ameliorating a...
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7186542 |
Method of extracting virus from cell culture
The present invention is directed to a method of extracting virus, particularly reovirus, from a culture of cells. Infectious virus can be extracted from the culture with a detergent at a...
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7163678 |
Reovirus for the treatment of ral-mediated cellular proliferative disorders
Methods for treating proliferative disorders, by administering reovirus to a ral-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts...
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7150984 |
Attenuated human rotavirus vaccine
The present invention provides vaccine compositions of attenuated human rotavirus. More particularly, the attenuated human rotavirus is produced by cold passage and thus contains attenuating...
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7128909 |
Immunstimulating lipid formulation
A pharmaceutical formulation for parenteral or mucosal administration of antigens and/or vaccines to humans and animals, comprising monoglyceride preparations having at least 80% monoglyceride...
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7014847 |
Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders,...
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6974577 |
Inactivated bovine scours vaccines, processes and method of preventing bovine scours
Inactivated scours vaccines for immunization and protection of bovine animals from disease caused by infection with bovine rotavirus and bovine coronavirus, which comprise and effective amount of...
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6951650 |
Antigenic class of avian reoviruses
The present invention provides a new antigenic class of avian reoviruses which are involved in enteric disease conditions in poultry. Moreover, the invention provides a vaccine for use in the...
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6867353 |
Production method of recombinant rotavirus structural proteins and vaccine composition
The present invention relates to a method for producing recombinant rotavirus structural proteins by culturing a transformed plant cell, and to a vaccine composition comprising the same as an...
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6805867 |
Bovine rotavirus genes
The present invention provides the genes encoding the following BRV proteins: for group A, the VP4 and VP7 proteins of the Indiana (IND) strain, and the VP7 protein of the 2292B strain; for group...
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6716431 |
Differential cytotoxicity of alternative forms of rotavirus nonstructural protein 4
The nonstructural protein 4 (NSP4) in the SA11 ATCC rotavirus strain has a histidine at amino acid position 47. This substituted form is more cytotoxic than the NSP4 of the Australia rotavirus...
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6673355 |
Rotavirus enterotoxin NSP4 and methods of using same
The rotavirus nonstructural glycoprotein, NSP4, performs multiple functions in the virus replication cycle, especially during viral morphogenesis. Specifically, NSP4 is an intracellular receptor...
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6616931 |
Rotavirus vaccine formulations
The present invention provides liquid and lyophilized formulations of vaccines against rotavirus infection and methods of their preparation. The formulations include buffering agents appropriate...
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6534067 |
Rotavirus enterotoxin adjuvant
This invention relates to a method of potentiating an immune response by administering a viral enterotoxin or derivative as an adjuvant. More particularly it relates to administering a viral...
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6406702 |
Multivalent in ovo avian vaccine
A multivalent poultry vaccine is provided having two or more live biological agents or microbial components. Each live biological agent or microbial component is effective in preventing or treating...
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6372884 |
Biologically active compounds and methods of constructing and using the same
A method of constructing biologically active compounds which mimic the biological activity of the biologically active protein block the activity of the biologically active protein is disclosed. A...
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6368603 |
Lyme combination compositions and uses
Disclosed and claimed are compositions containing a Borrelia burgdorferi antigen, and methods for making and using them. The antigen can be OspA. The compositions can contain at least one...
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6316243 |
Genetically engineered attenuated double-stranded RNA viruses
The present invention relates to engineering attenuated viruses by altering a non-coding region or the coding sequence of a viral gene. Alterations of the non-coding regions which regulate...
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6299874 |
Method of treatment
A method of producing active immunity against a viral disease in an animal subject comprises administering to the subject a vaccine conjugate consisting essentially of a live virus and a...
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6290968 |
Rotavirus reassortant vaccine
The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene...
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6187319 |
Cross-protective rotavirus vaccine
A method of producing an effective immune response in an animal against a first rotavirus, by (1) identifying an animal susceptible to or having a first rotavirus infection; and (2) administering...
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6159472 |
Intradermal Avian immunization with inactivated vaccines
The present invention relates to methods for immunizing birds using small volumes of vaccine. According to the invention, effective immunization can be accomplished with small, relatively...
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6110724 |
Rotavirus antigen, vaccine and diagnostic agent for rotavirus infections, and a method for producing the antigen
The present invention provides a method for producing a rotavirus antigen which the mass culture is difficult, comprising cloning a cell highly permitting the proliferation of rotavirus from a cell...
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6086880 |
Rotavirus peptide compositions and methods of use
A number of subunits of various rotaviral proteins have been shown to be useful in diagnosis, therapy, and prevention of rotaviral infection. Specifically, the subunits represented by positions...
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6001348 |
Non-virulent Mycoplasma synoviae and vaccine thereof
The present invention provides NAD-independent Mycoplasma synoviae of strain MS1. The invention also refers to microbiological cultures comprising Mycoplasma synoviae of this strain. Next to this,...
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5911998 |
Method of producing a virus vaccine from an African green monkey kidney cell line
A method for producing novel African Green Monkey Kidney (AGMK) cell lines is taught. These cell lines which are free of viable adventitious microbial agents are useful as substrates for viruses...
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5871996 |
Retrovirus agents MSRV1 and MSRV2 associated with multiple sclerosis
Composition including two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and...
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5871742 |
Recombinant Avipox virus encoding polypeptide of mycoplasma gallisepticum, and utilized a live vaccine
A polypeptide exhibiting the antigenicity of Mycoplasma gallisepticum, a fused polypeptide comprising the above polypeptide and, connected to the N-terminus thereof, a signal membrane anchor of a...
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5833995 |
Use of bluetongue virus proteins as vaccine components
A protective effect against bluetongue infection in susceptible mammals which is obtained by innoculating said mammals with a polypeptide comprising at least an antigenic portion of bluetongue...
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5807757 |
Preparation of ionically cross-linked polyphosphazene microspheresy by coacervation
A method is provided for preparing polyphosphazene microspheres wherein the polyphosphazene microspheres are produced by coacervation. A solution containing a polyphosphazene is admixed with a...
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5773009 |
Rotavirus strain G9P11
Provided is an isolated rotavirus of the strain G9P11, an isolated nucleic acid encoding the rotavirus of strain G9P11 and a purified antigen specific for the rotavirus. An isolated nucleic acid...
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5695767 |
Human rotaviruses, vaccines and methods
A Novel isolated human rotavirus is disclosed. The novel human rotavirus of the present invention has derived its genomic segments from parental strains of different genogroups and/or serotypes,...
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5690938 |
Oral immunization with multiple particulate antigen delivery system
Method of inducing a mucosal and or/systemic immune response in a host, comprising the step of administering to the host an effective amount of a Bluetongue antigen in the form of virus like and/or...
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5667797 |
Anti-viral composition and kit and use for treating rotavirus infection and diarrhea
An anti-diarrheic product comprises a foodstuff and an anti-rotaviral agent such as human defatted fat globule membranes, the human milk macromolecular fraction, skim milk, curd, whey, the milk...
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5667782 |
Multiple particulate antigen delivery system
Antigens in particulate form are provided wherein chimeric antigens having foreign epitopes are presented on or within virus-like particles (VLPs) or virus core-like particles (CLPs). The VLPs and...
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5610049 |
Human rotavirus HCR3A and method of growing said rotavirus
The present invention refers generally to a novel human cytopathic rotavirus of serotype 3 (HCR3A) and to its use as a vehicle for the expression of human rotavirus genes. The invention also...
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5602023 |
Pharmaceutical product containing live, stabilized virus for the therapy of viral and malignant diseases and process for preparing the same
A process for preparing a purified virus vaccine comprises the steps of purifying a fluid containing a virus by centrifugation, ultracentrifuging to pellet the supernatant, purifying the virus by...
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5529777 |
Hydrogel microencapsulated vaccines
Water soluble polymers or polymeric hydrogels are used to encapsulate antigen to form vaccines. The antigen is mixed with a polymer solution, microparticles are formed of the polymer and antigen,...
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5525342 |
Reovirus strain 2177 and vaccine containing same
Disclosed herein is the isolation of a relatively non-pathogenic reovirus, designated strain 2177, and vaccines comprising this strain.
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5503833 |
VP6 encapsulated drug delivery
Compositions and methods for preparing and delivering encapsulated biologically active agents to specific cell types are disclosed. Substances can be encapsulated in the VP6 inner capsid protein of...
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5474773 |
Human rotaviruses, vaccines and method
Novel isolated human rotaviruses are disclosed. The novel human rotaviruses in accordance with the instant invention have derived their genomic segments from parental strains of different...
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5397569 |
Method of treating Infectious Bursal Disease Virus infections
A method of producing active immunity against a viral disease in an animal subject comprises administering to the subject a vaccine complex consisting essentially of a live virus and a neutralizing...
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5298244 |
Assembled viral particles and their use in a vaccine to rotaviral disease
Assembled viral particles derived from rotavirus proteins are disclosed. The assembled particles include the inner capsid protein, VP6, in combination with either or both of the outer capsid...
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5283172 |
Type-C rotavirus cultures and uses therefor
Type-C rotavirus are propagated in swine testicular cells with reduced concentrations of proteolytic enzyme for subsequent production of antigen and antiserum for use in diagnostic kits and for...
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5182109 |
Vaccine preparation comprising a bacterial toxin adjuvant
A vaccine preparation comprising in combination a vaccine and a toxin or subunit thereof as an effective component. The toxin is preferably a bacterial toxin, e.g. cholera toxin, staphylococcal...
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