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7250171 |
Construction and use of recombinant parainfluenza viruses expressing a chimeric glycoprotein
Chimeric parainfluenza viruses (PIVs) are provided that incorporate a PIV vector genome or antigenome modified to encode a chimeric glycoprotein incorporating one or more heterologous antigenic...
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7208163 |
Method for producing temperature-sensitive morbillivirus
It was found that a mutation of an amino acid at a specific position in the P protein of a morbillivirus gives a temperature-sensitivity character to a virus. By introducing this mutation, a virus...
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7101553 |
Immune response enhancement methods
A prebiotic for enhancement of an immune response, a nutritional composition for enhancement of an immune response; use of a prebiotic in the manufacture of a medicament or nutritional composition...
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7090853 |
Noscapine derivatives as adjuvant compositions and methods of use thereof
An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines.
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7008790 |
Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae
A method of immunization, and compositions therefor, are provided for substantially preventing or reducing the symptoms of at least one infectious disease and at least one chronic immune mediated...
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6899884 |
Vaccine against mumps containing a jeryl-lynn virus strain
A new mumps vaccine is presented, comprising a homogeneous pure isolate derived from the Jeryl-Lynn strain of mumps virus. In a preferred embodiment of the invention the vaccine produces higher...
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6896881 |
Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family
The invention relates to compositions and methods for treating a patient having a tumor in order to reduce tumor size, comprising administering to the patient a replication-competent...
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6887484 |
Vaccine composition containing a promoter peptide
A vaccine having a good vaccination effect, which comprises an antigen; a peptide selected from the group consisting of a peptide having the amino acid sequence of SEQ ID NO: 1, a peptide having...
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6875436 |
Method for producing cell-fushion type morbillivirus mutants
It was found that a mutation of an amino acid at a specific position in the F protein of a morbillivirus induces a reduction in the cell-fusion ability. By introducing this mutation, a virus...
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6664099 |
Method for the preservation of viruses and mycoplasma
A biologically-active material comprising a live virus or mycoplasma is preserved by a method of desiccation, without lyophilisation, in a matrix of glassy trehalose having a residual moisture...
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6605284 |
Gene coding for the measles virus mutant antigen
Disclosed is a measles virus mutant gene coding for a measles virus mutant H protein antigen, wherein said gene coding for a measles virus mutant H protein antigen is at least one member selected...
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6562350 |
Combined vaccine against both HAV and measles virus and method of producing it
A combined hepatitis A-measles live vaccine, its lyophilized formulations with enhanced storage stability and methods of preparing the same by mixing the viral stocks of hepatitis A virus and...
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6410023 |
Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene
Recombinant parainfluenza virus (PIV) are provided in which expression of the C, D and/or V translational open reading frame(s) (ORFs) is reduced or ablated to yield novel PIV vaccine candidates....
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6383741 |
Method for treatment of canine distemper
The present invention relates to a treatment for animals having canine distemper by administering a composition comprising an attenuated canine distemper virus a sub-vaccine virus level effective...
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6350451 |
Immunotherapy of epithelial tumors using intralesional injection of antigens that induce a delayed type hypersensitivity reaction
The present immunotherapy relates to a method of treating epithelial tumors and the pharmaceutical compositions and kits useful in treating such tumors. The immunotherapy comprises injecting an...
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6309647 |
Poxvirus--canine dispemper virus (CDV) or measles virus recombinants and compositions and methods employing the recombinants
Attenuated recombinant viruses containing DNA coding for a canine distemper virus antigen or measles M or N antigen, as well as methods and compositions employing the viruses, are disclosed and...
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6290967 |
Stabilizers for lyophilized vaccines
Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric...
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6277380 |
Measles virus mutant antigen
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6231860 |
Stabilizers for live vaccines
Stabilizers for live vaccines and attenuated mono- or multivalent live vaccines, stabilized vaccines containig such stabilizers, and methods for preparing such vaccines, are disclosed. Said...
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6210683 |
Stabilizers containing recombinant human serum albumin for live virus vaccines
Compositions are provided for improving the stability of live virus vaccines containing, e.g., live varicella zoster, measles, mumps, and rubella viruses. Such improved stabilizers are aqueous...
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6149911 |
Method for enhancing the immunogenicity of an immunogenic compound or hapten, and use thereof for preparing vaccines
The present invention relates to a process for improving the immunogenicity of an immunogen, an antigen or a hapten, when it is administered to a host, independently of the mode of administration,...
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6086876 |
Methods and compositions for the inhibition of interleukin-12 production
The invention includes compositions and methods for selective suppression of IL-12 production in a cell. Methods of treating a human having a disease associated with dysregulated IL-12 production...
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6051238 |
Stabilizers for lyophilized mumps vaccines
Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric...
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6039958 |
Stabilized live vaccine
A stabilized live vaccine containing a varicella virus and a stabilizer, wherein the vaccine is substantially free of Ca 2 + ions and Mg 2 + ions is described. This stabilized live vaccine is...
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6033886 |
Recombinant infectious non-segmented negative strand RNA virus
The present invention provides the generation of infectious replicating non-segmented negative-stranded RNA virus, entirely from cloned cDNA. This process offers the possibility to introduce...
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6013263 |
Measles virus peptides with antifusogenic and antiviral activities
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5942491 |
Method and compositions for treating arthritis
The present invention provides a process for the treatment of arthritis including the step of administering to an animal or human patient in need of such treatment a plurality of peptides each of...
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5900401 |
Remedy for respiratory-tract viral disease
The present invention is a therapeutic or prophylactic agent for viral diseases whose active ingredient is antileukoprotease (ALP). Formulations containing ALP as an active ingredient have...
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5843451 |
Intranasal immunization against viral infection using viral glycoprotein subunit vaccine
Method for immunizing against viral infection by administering intranasally an immunogenically effective amount of a viral envelope subunit vaccine comprising a glycoprotein complexed with a lipid.
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5837269 |
Vaccine compositions and method for enhancing an immune response
The invention relates to a vaccine which comprises an antigen and an immune response augmenting agent. The immune response augmenting agent is capable of enhancing T cell lymphokine production....
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5824313 |
Vaccine compositions and method for induction of mucosal immune response via systemic vaccination
The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include, but are not limited to, 1,25-dihydroxy Vitamin...
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5807757 |
Preparation of ionically cross-linked polyphosphazene microspheresy by coacervation
A method is provided for preparing polyphosphazene microspheres wherein the polyphosphazene microspheres are produced by coacervation. A solution containing a polyphosphazene is admixed with a...
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5759841 |
Immunological composition of measles virus utilizing recombinant poxvirus
What is described is a recombinant poxvirus, such as vaccinia virus or canarypox virus, containing foreign DNA from Morbillivirus. In one embodiment, the foreign DNA is expressed in a host by the...
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5756104 |
Liposome-containing intranasal vaccine formulation
The present invention relates to a vaccine formulation for intranasal or inhalation administration, and to the preparation thereof, which formulation contains antigenic material freely mixed with...
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5585365 |
Antiviral polysaccharide
An antiviral polysaccharide purified from an extract prepared by extracting Spirulina cells with hot water, having the following properties: (1) it comprises rhamnose, glucose, fructose, ribose,...
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5529777 |
Hydrogel microencapsulated vaccines
Water soluble polymers or polymeric hydrogels are used to encapsulate antigen to form vaccines. The antigen is mixed with a polymer solution, microparticles are formed of the polymer and antigen,...
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5503834 |
Measles virus recombinant poxvirus vaccine
What is described is a recombinant poxvirus, such as vaccinia virus or canarypox virus, containing foreign DNA from Morbillivirus. In one embodiment, the foreign DNA is expressed in a host by the...
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5182109 |
Vaccine preparation comprising a bacterial toxin adjuvant
A vaccine preparation comprising in combination a vaccine and a toxin or subunit thereof as an effective component. The toxin is preferably a bacterial toxin, e.g. cholera toxin, staphylococcal...
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5006335 |
Live vaccine against mumps and process for obtaining thereof
The invention relates to a live vaccine against mumps, which contains live mumps viruses which are capable of multiplication and have been attenuated principally by passages in diploid human tissue...
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4985244 |
Stabilized live attenuated vaccine and its production
A stabilized live attenuated vaccine with improved thermal stability, which comprises a live attenuated plain vaccine consisting of measles, mumps or rubella virus grown in a medium-199 for cell...
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4965069 |
Oxidized viruses or viral antigens and utilization for diagnostic prophylactic and/or therapeutic applications
Novel and improved methods for diagnosis, prognosis, prophylaxis and therapy of viral infections are described. The novel methods employ a virus, viral antigen or fragment thereof in which...
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4744983 |
Immunogenic protein or peptide complex, method of producing said complex and the use thereof as an immune stimulant and as a vaccine
The invention relates to an immunogenic complex containing antigenic membrane proteins or peptides from viruses mycoplasmas, bacteria, parasites or animal cells or prepared synthetically or with...
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4705685 |
Methods and materials for treatment of disease states involving immunological factors
In animals including humans, the symptoms of non-anaphylactic disease states wherein the disease victim's humoral and/or cell-mediated immunological response is involved in disease pathology are...
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4704273 |
Methods and materials for treatment of rheumatoid arthritis
Disclosed are methods and compositions useful for alleviating the symptoms of rheumatoid arthritis. In preferred embodiments, the compositions are administered in essentially minute "neutralizing"...
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4659569 |
Process for the production of virus vaccine
The present invention relates to a process for the production of virus vaccine, comprising covalently attaching virus to saccharide to form a virus-saccharide conjugate, and harvesting the...
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4657761 |
Polyvalent non-specific immuno-stimulating vaccine and method
A non-specific therapeutic polyvalent vaccine for subcutaneous injection containing a minimum combination of a PPD (tuberculin vaccine), a rabies vaccine, and snake venom vaccine and preferably...
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4555401 |
Live mumps vaccine and method of stabilizing the same
A live mumps vaccine can be stabilized to a great extent by adding in an amount, effective for stabilizing said vaccine, at least one stabilizer selected from the group consisting of albumin and...
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4338335 |
Vaccine stabilizer containing L-glutamic acid and L-arginine
An improved stabilized liquid live viral vaccine contains a live virus, partially hydrolyzed gelatin, a monosaccharide or disaccharide, a cell culture medium, L-glutamic acid, L-arginine and...
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4337242 |
Vaccine stabilizer containing L-glutamic acid and L-arginine
An improved stabilized liquid live viral vaccine contains a live virus, partially hydrolyzed gelatin, a monosaccharide or disaccharide, a cell culture medium, L-glutamic acid, L-arginine and...
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4329424 |
Macroscopic method for determining cytopathic effects in viral assay
Semi-automated assays for viral infectivity and an assay for serum neutralizing antibody content are based on staining the cells and macroscopic reading of the cytopathic effect.
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