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7390624 |
Metal chelate-labelled peptides
The invention concerns a process for the production of metal chelate-labelled peptide antigens, peptides obtainable by this process and their use in an immunological method of detection.
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7384641 |
Immuno-modulating effects of chemokines in DNA vaccination
The present invention relates to a composition and method for enhancing the efficacy of a vaccine in a subject treated with the vaccine by administering to the subject an antigen in conjunction...
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7384637 |
Drug for AIDS treatment
Raising the T-cell count in an HIV positive patient having a low T-cell count by orally administering an effective amount of a composition containing a material obtained by treating whole human...
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7378515 |
Synthetic gagpol genes and their uses
The present invention relates to synthetic gag and gagpol genes optimized for high level expression via codon optimization and the uses thereof for the efficient generation of vector particles. The...
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7371846 |
CD4-independent HIV envelope proteins as vaccines and therapeutics
The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
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7364744 |
Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV
The present invention relates to peptides, referred to as CBD-1, CBD-2, CBM-1/TH-1, CBM-1/TH-2, CBM-2/TH-1, CBM-2/TH-2 and C-20 peptides, which are antigenic and elicit a protective immune response...
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7351412 |
Cloned DNA sequences related to the genomic RNA of lymphadenopathy-associated-virus (LAV) and proteins encoded by said LAV genomic RNA
This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus (HIV). This invention relates to a diagnostic means and method to detect the presence...
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7348423 |
Nucleic acids encoding fusion peptides
A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under...
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7348177 |
Expression of HIV polypeptides and production of virus-like particles
The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression...
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7341731 |
HIV-2 antigen compositions
The invention relates to a composition comprising at least one antigen, wherein the antigen is a protein or glycoprotein of a HIV-2 virus, wherein the HIV-2 virus has infectious properties with...
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7335468 |
TSG101-GAG interaction and use thereof
Isolated protein complexes are provided comprising Tsg101 and HIV GAG or GAGp6. The protein complexes are useful in screening assays for selecting compounds effective in modulating the Tsg101-HIV...
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7335365 |
HIV-encoded chemoattractant
The combination of HIV proteins Tat and Nef is chemotactic for CD4+ cells. Utilizing the capacity of Tat and Nef to modulate CD4+ cell trafficking and infiltration, the invention provides various...
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7335364 |
Modified Vaccinia Ankara virus variant
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell...
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7329807 |
High-efficiency fusogenic vesicles, methods of producing them, and pharmaceutical compositions containing them
The present invention relates to novel fusogenic vesicles as highly efficient and versatile encapsulation systems for delivering a substance of choice, such as nucleic acids, proteins, peptides,...
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7323174 |
Modulation of immune response and methods based thereon
The present invention relates to methods for the prevention and/or treatment of cardiovascular and allergic diseases and disorders, methods for inhibiting the growth of, or reducing the volume of,...
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7318927 |
Recombinant poxvirus for chimeric proteins of the human immunodeficiency virus
The invention relates to HIV chimeric gene formed by the union of fragments of different genes of said virus, wherein said fragments contains epitopes for cytotoxic T cells (CTL) or HIV-1 auxiliary...
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7306901 |
Methods and means for assessing HIV envelope inhibitor therapy
The present invention relates to methods and products for the evaluation of HIV treatment. In particular, molecular events at the HIV envelope protein and their effect on therapeutic efficacy of...
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7297476 |
Method of monitoring HIV assembly and maturation
The present invention provides methods to characterize the structure, stability, and intersubunit interfaces between the matrix, capsid, and nucleocapsid domains of the Gag polyprotein during HIV...
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7285271 |
Antigenic composition comprising an HIV gag or env polypeptide
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7276333 |
Viral infection inhibitor targeting integrase N-terminal domain
The object of the present invention is to provide a screening method of a new integrase inhibitor being able to inhibit an HIV infection before the reverse transcription step and having a...
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7276242 |
Vipox vector coding an HIV antigen and a cytokine
The invention relates to a fowl pox virus encoding an HIV antigen (gag and/or pol) and a cytokine (γ-interferon).
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7273695 |
HIV immunoassays using synthetic envelope polypeptides
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7273614 |
Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of...
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7267824 |
Multi-subtype FIV vaccines
The subject invention pertains to novel methods and compositions for protecting cats from infection by a broad range of FIV strains using a multi-subtype FIV vaccine. Multi-subtype FIV vaccines...
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7255862 |
ALVAC/FIV constructs
Recombinants containing and expressing lentivirus, retrovirus or immunodeficiency virus DNA and methods for making and using the same are disclosed and claimed. In an exemplified embodiment,...
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7253270 |
Polynucleotide encoding a mutated HIV gp41 polypeptide
The invention provides a method of searching for and obtaining a vaccine against the pathogenic effects related to the infection of an animal or human host by a retrovirus that penetrates into a...
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7250251 |
Virion-based fusion assay
The present invention features methods and compositions relating to a virion-based fusion assay for detection of infection of a target cell by an enveloped retroviral virion such as HIV. The assay...
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7244814 |
Variant Tat proteins and methods for use thereof
Variants of the HIV-1 Tat protein exhibiting higher transcriptional activation and stronger P-TEFb binding than wild-type Tat are provided. In addition variants that can inhibit transcription...
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7232685 |
Cell lines with latent immunodeficiency virus and methods of use thereof
The present invention provides isolated cells that comprise, integrated into the genome of the cell, a transcription-competent immunodeficiency virus or a transcription-competent immunodeficiency...
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7229625 |
Retrovirus-like particles made non-infectious by a plurality of mutations
Non-infectious, retrovirus-like particles contain mutations to reduce gag-dependent RNA-packaging of the gag gene product, eliminate reverse transcriptase activity of the pol gene product,...
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7211659 |
Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof
The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and...
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7208157 |
Proteolysis targeting chimeric pharmaceutical
The present invention is based on the discovery of a composition that provides targeted ubiquitination. Specifically the composition contains a ubiquitin pathway protein binding moiety which...
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7195768 |
Polyvalent immunogen
The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for...
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7189402 |
Live vaccine for human immunodeficiency virus
The present invention discloses development of a model live vaccine for HIV, using an attenuated strain of Salmonella engineered to surface express specific HIV proteins and testing of this...
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7179468 |
Antigen for developing neutralizing antibodies to human immunodeficiency virus
The present invention provides polypeptides comprising a stabilized trimer of the carboxyl-terminal core region of the ectodomain of an enveloped virus, such as HIV. A subject polypeptide comprises...
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7160721 |
Composition and method for increasing cell density in cell cultures infected with lentivirus
A composition and method for enhancing cell growth and increasing the density of cell cultures containing lentivirus-infected host cells comprises adding a suitable quantity of an antibiotic to the...
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7157083 |
Compositions and methods for treating retroviral infections
The present invention relates to hyaluronidase enzyme methods, vaccines and compositions for treating or preventing pathogenic infections, such as HIV, in a patient. The invention also relates to...
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7153509 |
Immunogenic peptides comprising a T-helper epitope and a B-cell neutralizing antibody epitope
The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for...
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7148325 |
Chimeric retroviral gag genes and screening assays
The subject invention provides novel and advantageous methods for identifying amino acid sequences in random peptide libraries that can bind to Gag polypeptides. The subject invention also...
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7147862 |
Vaccine composition containing adjuvants
The present invention provides vaccine compositions comprising 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccines compositions are potent inducers of CTL and γ IFN responses.
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7122190 |
Fusion proteins comprising DP-178 and other viral fusion inhibitor peptides useful for treating aids
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of...
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7118751 |
DNA vaccines encoding antigen linked to a domain that binds CD40
Vaccines that target one or more antigens to a cell surface receptor improve the antigen-specific humoral and cellular immune response. Antigen(s) linked to a domain that binds to a cell surface...
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7115363 |
Retrovirus capable of causing AIDS, means and methods for detecting it in vitro
The invention relates to a new class of retroviruses, designated by HIV-2, of which samples have been deposited to the ECACC under numbers 87.01.1001 and 87.01.1002 and to the NCIB under numbers...
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7105655 |
Stabilization of envelope glycoprotein trimers by disulfide bonds introduced into a gp41 glycoprotein ectodomain
The present application is directed to stabilized envelope glycoprotein trimers. The trimers are stabilized by introducing disulfide bonds at certain sites in the gp41 ectodomain. DNA molecules...
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7105164 |
HIV-specific cytotoxic T-cell responses
A method of generating an HIV-specific cytotoxic T-cell response in a host involves an initial administration of a T-helper molecule to the host to prime T-helper cells of the immune system of the...
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7101676 |
Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA
The present invention relates to methods of identifying a molecule from a library of molecules that inhibits binding of human immunodeficiency virus nucleocapsid 7 polypeptide (NCp7) to an...
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7101552 |
Immunogen comprising an HIV envelope protein, a ligand and H2 peptide
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also...
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7097971 |
HIV-1 peptide, antigen, immunogenic composition, diagnostic method and immunoassay kit
The present invention comprises novel and modified peptides capable of inducing a HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
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7094408 |
Immunogenicity using a combination of DNA and vaccinia virus vector vaccines
This invention relates to improved methods of inducing an immune response for the prevention or treatment of HIV-1 infection by using a nucleic acid vaccine in conjunction with a recombinant viral...
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7094405 |
Peptides which elicit a high neutralizing antibody titer, cytotoxic T lymphocyte response and T helper cell response in a broad range of MHC type recipients
Peptide constructs comprised of multideterminant T helper peptides from the envelope glycoprotein of HIV previously identified to induce proliferative responses in four different haplotypes of mice...
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