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9034343 Attenuated human parainfluenza virus, methods and uses thereof  
The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the...
9023364 Vaccine antigen capable of inducing cross-reacting and neutralizing antibody against high-risk-type human papillomavirus  
Disclosed is a vaccine antigen capable of inducing a cross-reacting and neutralizing antibody directed against a high-risk-type human papillomavirus. Specifically disclosed are: a chimeric protein...
9017935 HIV-1 latency model for high throughput screening  
Isolated, latently infected T cell lines are provided that can be utilized in high throughput screening to discover compounds capable of activating HIV-I. The T cell lines harbor a latent HIV-I...
9012618 Nucleic acids encoding modified Ebola virus glycoproteins with diminished cytotoxicity while retaining native antigenic structures  
The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively...
9011872 PCV2 immunogenic compositions and methods of producing such compositions  
An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant...
9011868 Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs  
The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases)....
9005665 Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome  
Disclosed herein are methods and compositions for treating or preventing Porcine reproductive and respiratory syndrome (PRRS) infection in a subject.
8999351 Lipids and compositions for the delivery of therapeutics  
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having...
8999336 Monoclonal antibodies against Orthopoxviruses  
The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding...
8999637 Vector comprising multiple homologous nucleotide sequences  
The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting bases in the homologous nucleotide...
8993624 Method of preventing and treating inflammatory diseases and disorders with abscisic acid  
The present invention relates to the use of a therapeutically effective amount of abscisic acid (ABA) or its analogs to treat or prevent inflammation induced by exposure to lipopolysaccharide...
8986703 Peptide sequences and compositions  
Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells...
8986705 Methods of producing influenza vaccine compositions  
Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
8980634 Reverse genetics of negative-strand RNA viruses in yeast  
The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA...
8980288 Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase  
Emulsion vaccine formulations containing an antigen and an adjuvant in the aqueous phase are used for the vaccination of animals wherein the adjuvant is an acrylic polymer and/or dimethyl...
8968744 Aqueous composition comprising a biological antigen and an acrylic acid polymer  
The current invention pertains to an aqueous composition containing a biological antigen and an acrylic acid polymer, wherein the composition comprises an electrolyte to provide an osmolarity...
8961997 Method for purifying the rabies virus  
The subject of the invention is a method for purifying the rabies virus, comprising a single ion-exchange chromatography step, said step being cation exchange chromatography according to which: a)...
8961995 Methods and compositions for alphavirus replicons  
The present invention provides alphavirus replicons and methods of their use in producing heterologous protein.
8961977 Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies  
The present invention relates to an anti-idiotypic polypeptide scaffold that includes two or more peptide sequences that mimic a discontinuous epitope of a pathogen that is recognized by or...
8961983 Mucosal vaccine using cationic nanogel  
A mucosal vaccine for the prevention or treatment of microbial infections is described that is capable of inducing vaccine antigen-specific immune responses in an organism without the addition of...
8952144 Vectors with modified initiation codon for the translation of AAV-REP78 useful for production of AAV  
The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs...
8951536 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase  
The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions thereof and methods of use thereof...
8945582 Vaccine  
The standard dose of polio vaccines contains 40 D-antigen units of inactivated poliovirus type 1 (Mahoney), 8 D-antigen units of inactivated poliovirus type 2 (MEF-1), and 32 D-antigens units of...
8940307 Lectin compositions and methods for modulating an immune response to an antigen  
The present invention also relates to a method of reducing metastases in a subject comprising administering to the subject a composition comprising a multifunctional molecule comprising a first...
8932603 Modified antibody  
Recombinant antibody-based molecules that trigger both T-cell and B-cell immune responses are disclosed. The recombinant molecules are comprised by at least one targeting unit and at least one...
8932604 Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and newcastle disease virus antigens  
Recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus and Newcastle Disease virus protein antigens, and methods of...
8932607 Batches of recombinant adenovirus with altered terminal ends  
Described is a composition comprising a plurality of recombinant adenovirus particles, being a recombinant human adenovirus of serotype 5, 26, 34, 35, 48, 49 or 50, or a recombinant simian...
8926961 HPV E6 protein T cell epitopes and uses thereof  
The present invention is directed to the examination of the pattern of immunodominant T cell epitopes in the E6 protein of Human Papilloma virus and its further characterization in terms of its...
8920813 Adenoviral vector-based dengue fever vaccine  
The invention relates to a replication-deficient adenoviral vector comprising two or more nucleic acid sequences encoding Dengue virus antigens and a chimeric hexon protein. The chimeric hexon...
8916174 HIV DNA vaccine regulated by a caev-derived promoter  
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of...
8906385 Interferon-inducing porcine reproductive and respiratory syndrome virus isolate  
Provided are polynucleotides and proteins encoded by them which are useful for stimulating an immune response against Porcine reproductive and respiratory syndrome virus (PRRSV) in swine. The...
8906384 Antiviral activity of bovine type III interferon against foot-and-mouth disease virus  
A member of the bovine type III IFN family, boIFN-λ3, was identified and characterized. We expressed boIFN-λ3 using a recombinant replication defective human adenovirus type 5 (Ad5) and...
8900623 Sticky soft gel for treating poultry  
The present invention is directed to a composition, kit and method for delivering a soft flowable gel to a flock of poultry in barns, but can also be used in hatcheries or free range farms, for...
8900595 Filovirus vectors and noninfectious filovirus-based particles  
Cloned filovirus genomic cDNA and methods of using the cDNA are provided. Further provided are noninfectious lipid encapsulated filovirus-based particles.
8895015 Norovirus capsid and rotavirus VP6 protein for use as combined vaccine  
The present invention relates to a combined norovirus and rotavirus vaccine for prevention of norovirus and rotavirus infection and/or viral-induced diarrheal and vomiting diseases in man. More...
8889144 PCSK9 vaccine  
The present invention relates to the provision of immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated...
8889148 Flavivirus host-range mutations and uses thereof  
Methods and compositions concerning mutant flaviviruses with host-range phenotypes are provided. Nucleotide sequences that encode mutant flavivirus proteins are also provided. In certain aspects,...
8883123 Use of vaccines for the treatment/prevention of the transmission of pathogens  
The present invention relates to a method of reducing the transmission of a pathogen from an animal of a first species to an animal of a second species. Specifically, reduction of transmission is...
8883170 Adjuvant  
Methods and immunogenic compositions for generating an immune response against Marburg virus are provided. The immunogenic composition includes antigens obtained from a Marburg viral strain in...
8883165 Modified peptide vaccine derived from influenza M2  
A modified peptide derived from matrix protein 2 (hereinafter also referred to as “M2”), one of surface layer proteins of influenza virus, and a method for utilization of the modified peptide are...
8883745 C—glycolipids with enhanced Th-1 profile  
The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI-type immune response characterized by enhanced IL-12 secretion and increased activation of dendritic cells....
8877209 Recombinant influenza vectors with tandem transcription units  
The invention provides a composition useful to prepare influenza viruses, e.g., in the absence of helper virus, using vectors which include tandem transcription cassettes containing PolI and/or...
8877211 Bovine herpes virus vaccine with multiple mutations  
A BHV-1 mutant virus has been made that incorporates into a single virus two or more deletions in one or more of three genes—glycoprotein N, glycoprotein E and Us9. Specifically, a BHV-1...
8865183 Treatment of pigs with PCV2 antigent  
The present invention relates to a method for the treatment or prophylaxis of a PCV2 infection or for reduction of clinical symptoms caused by or associated with a PCV2 infection in animals a)...
8865184 Vaccine for chikungunya virus infection  
The present invention relates to vaccine formulation capable of eliciting protective immune response against Chikungunya virus infection in humans and other mammalian hosts. The immunogenic...
8859231 Assembly of wild-type and chimeric influenza virus-like particles (VLPs)  
Influenza virus-like particles (VLPs) comprising the structural proteins HA, NA, M1 and M2 are described. VLPs are also generated containing M1 alone, as are VLPs with M1 and any one or two of HA,...
8846055 Virulence determinant within the E2 structural glycoprotein of classical swine fever virus  
Classical Swine Fever Virus (CSFV) E2 glycoprotein is a major inducer of neutralizing antibodies and protective immunity in swine. E2 mediates virus adsorption to the target cell, and harbors...
8846051 Modulation of replicative fitness by deoptimization of synonymous codons  
Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one...
8840899 Use of mTOR inhibitors to enhance T cell immune responses  
It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T...
8834892 Method of preparing live viral vaccines by genetic engineering of viral genome  
Disclosed is an attenuation method of an influenza virus, that is, a reassortant virus and a preparation method thereof. The disclosed reassortant virus has, in a ratio of 6:2, genes encoding a...