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7384643 |
Recombinant poxvirus
Use for novel chemokine-binding protein designated A41L, and chemokine-binding fragments thereof, for the treatment of conditions such as inflammation. The A41L protein binds to chemokines in the...
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7378099 |
Human papillomavirus polypeptides and immunogenic compositions
The present invention provides immunogenic and pharmaceutical compositions for the treatment and prevention of human papillomavirus (HPV)-associated cancers and in particular, cervical cancer. In...
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7374768 |
Viral vaccines
A mutant virus for use as a vaccine for prophylaxis or therapy, wherein the genome of the virus is defective in respect of a gene essential for the production of infectious virus. In one aspect the...
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7371572 |
Mouse titers after two immunizations with VLPs alone
The invention described herein relates to compositions and methods for stimulating immune responses in vivo against a tolerogen. Novel biotechnological tools, pharmaceuticals, therapeutics and...
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7368116 |
Method of enhancing a targeted immune response against tumors
The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus...
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7364729 |
Method of inducing a CTL response
Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system....
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7361354 |
Methods for treating malignancies expressing ICAM-1 using coxsackie a group viruses
There is disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognizing at least one of a cell adhesion molecule and a complement...
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7344872 |
Method for rapid screening of bacterial transformants and novel simian adenovirus proteins
Chimpanzee serotype C68 proteins, peptides, and polypeptide are provided. Also provided are novel adenoviruses derived from these proteins, as well as compositions containing these proteins and...
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7338662 |
Recombinant poxvirus expressing homologous genes inserted into the foxviral genome
The sent invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have...
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7335364 |
Modified Vaccinia Ankara virus variant
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell...
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7335363 |
Membrane virus host range mutations and their uses as vaccine substrates
The present invention is directed to genetically engineered, membrane-enveloped viruses with deletion mutations in the protein transmembrane domains. Also provided are viral vaccines based on the...
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7332170 |
Classical swine fever virus virulence determinant and a novel classical swine fever vaccine
Transposon linker insertion mutagenesis of a full-length infectious clone of the highly pathogenic classical swine fever virus (CSFV) isolate Brescia (pBIC) was used to identify genetic...
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7329407 |
Recombinant herpesvirus and polyvalent vaccine
A polyvalent vaccine for chicken coccidium-herpesvirus infections comprising as an active ingredient a recombinant herpesvirus comprising a gene encoding SEQ ID NO: 5 which is a microneme protein...
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7323177 |
Recombinant porcine adenovirus vector
This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The...
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7318928 |
Molecular vaccine linking intercellular spreading protein to an antigen
Superior molecular vaccines comprise nucleic acids, including naked DNA and replicon RNA, that encode a fusion polypeptide that includes an antigenic peptide or polypeptide against which an immune...
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7314631 |
Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV)
Chimeric parainfluenza viruses (PIVs) are provided that incorporate a PIV vector genome or antigenome and one or more antigenic determinant(s) of a heterologous PIV or non-PIV pathogen. These...
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7294338 |
Polynucleotide vaccine formula against canine pathologies, in particular respiratory and digestive pathologies
Disclosed is an immunological or vaccine composition that includes at least one plasmid that contains and expresses in vivo in host canine cells a nucleic acid molecule that encodes an antigen of a...
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7279168 |
Recombinant virus expressing foreign DNA encoding feline CD86 and uses thereof
The present invention involves a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign...
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7279166 |
Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning...
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7276243 |
Optimized expression of HPV31 L1 in yeast
Synthetic DNA molecules encoding the HPV31 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV31 L1 protein, wherein said polynucleotides are free...
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7276242 |
Vipox vector coding an HIV antigen and a cytokine
The invention relates to a fowl pox virus encoding an HIV antigen (gag and/or pol) and a cytokine (γ-interferon).
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7273616 |
Genetically engineered cell lines and systems for propagating Varicella zoster virus and methods of use thereof
The present invention provides genetically engineered cell lines, recombinant vectors, and vaccines. The present invention also provides methods for generating an in vitro system for Varicella...
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7273605 |
Vaccine
The present invention relates to a fowlpox virus genome which has modifications in one or more wild-type FPV genes. The present invention also relates to a viral particle comprising such a genome...
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7264815 |
Process for producing a recombinant protein in a mycobacterium host plasmid pJAM2
This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic...
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7264814 |
Composition and method for treating cancer using herpes virus
The present invention provides a herpes virus in which a non-essential gene for replication is inactivated More particularly, the present invention provides a herpes virus in which a non-essential...
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7256281 |
Recombinant P. falciparum merozoite protein-142 vaccine
In this application is described the expression and purification of a recombinant Plasmodium falciparum (FVO) MSP-1 42 . The method of the present invention produces a highly purified protein...
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7256037 |
Modified vaccinia Ankara expressing p53 in cancer immunotherapy
Mutations to the tumor suppressor protein p53 have been observed in 40-60% of all human cancers. These mutations are often associated with high nuclear and cytoplasmic concentrations of p53. Since...
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7255862 |
ALVAC/FIV constructs
Recombinants containing and expressing lentivirus, retrovirus or immunodeficiency virus DNA and methods for making and using the same are disclosed and claimed. In an exemplified embodiment,...
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7241447 |
Adeno-associated virus vectors and uses thereof
The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated...
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7235235 |
Alphavirus RNA replicon systems
The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper...
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7223584 |
Recombinant rabies vaccine and methods of preparation and use
Live rabies virus vaccines comprising a recombinant rabies virus genome which overexpresses the rabies virus G protein increase apoptotic activity in infected cells, and enhance the generation of...
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7223411 |
Herpesvirus replication defective mutants
A herpesvirus vaccine comprising a mutated herpesvirus suspended in a pharmaceutically acceptable carrier. The mutated herpesvirus is capable of infecting cells of the mammal to be vaccinated, but...
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7211659 |
Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof
The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and...
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7208161 |
Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences
Isolated polynucleotide molecules provide recombinant PIV genomes and antigenomes for production of recombinant PIV vaccines. The recombinant genome or antigenome can be expressed with a...
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7201907 |
Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines
Chimeric human-bovine parainfluenza viruses (PIVs) are infectious and attenuated in humans and other mammals and useful individually or in combination in vaccine formulations for eliciting an...
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7198934 |
Recombinant MVA virus, and the use thereof
The present invention relates to recombinant vaccinia viruses derived from the modified vaccinia virus Ankara (MVA) and containing and capable of expressing foreign genes which are inserted at the...
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7198792 |
Genetic immunization against cervical carcinoma
An alphavirus vector system comprising nucleic acid of a human papilloma virus origin is disclosed. A method of treating or preventing cervical cancer is also disclosed. The method includes...
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7192593 |
Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens
Chimeric parainfluenza viruses (PIVs) incorporate a PIV vector genome or antigenome and one or more antigenic determinant(s) of a heterologous PIV or non-PIV pathogen. These chimeric viruses are...
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7189401 |
Live attenuated viruses for use as vectors or vaccines
The present invention provides modified viral genomes for use as vaccines or vectors, which are improved in their ability to retain attenuating mutations. The genomes are from viruses that...
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7163818 |
Bacteriophage having multiple host range
The present invention discloses compositions and methods for the prophylaxis and treatment of bacterial infections by the use of polyvalent bacteriophage having multiple host range.
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7163685 |
Human cytomegalovirus antigens expressed in MVA and methods of use
DNA and protein constructs useful in producing vaccines against human cytomegalovirus contain optionally N-end modified and N-terminal ubiquitinated human cytomegalovirus antigenic proteins,...
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7153511 |
Avian herpesvirus-based recombinant Infectious Bursal Disease vaccine
The present invention provides an avian recombinant herpesvirus modified by the presence of the cDNA encoding, the VP2 of the Delaware Variant E strain of IBDV, a subtype of IBDV serotype 1...
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7153510 |
Recombinant vesiculoviruses and their uses
The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable...
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7150874 |
Vector for integration of heterologous sequences into poxviral genomes
A new DNA vector is disclosed comprising a nucleic acid sequence useful for inserting heterologous sequences into the genome of poxviruses by homologous recombination. Also disclosed are...
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7148341 |
AAV DNA comprising helper virus sequences
The present invention relates to an AAV DNA having helper virus sequences which are necessary for developing AAV viral particles, a system containing such a DNA and the use of both.
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7144579 |
Paramyxoviruses comprising modified transcription start sequence
The present invention provides virus vectors of the family Paramyxoviridae in which the transcription start (S) sequence has been modified so as to modify the expression of genes located downstream...
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7144578 |
Poxvirus-rabies recombinants and compositions and methods employing the recombinants
Recombinant viruses containing DNA coding for a rabies virus antigen, such as rabies virus G are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The...
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7135185 |
Conserved motif of hepatitis C virus E2/NS1 region
Immunogenic compositions comprising an immunogenic polypeptide and a pharmaceutically acceptable vehicle are described. The immunogenic polypeptide comprises the amino acid sequence...
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7128916 |
Bacteriophage-mediated immunisation
The present invention relates to vaccines comprising a bacteriophage which has been engineered to express an immunogenic protein/peptide and wherein the surface of the bacteriophage has not been...
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7128915 |
Membrane virus host range mutations and their uses as vaccine substrates
The present invention is directed to genetically engineered, membrane-enveloped viruses with deletion mutations in the protein transmembrane domains. Also provided are viral vaccines based on the...
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