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5993821 |
Modified papilloma virus L2 protein and VLPs formed therefrom
The invention, in one aspect, is directed to a modified papilloma virus L2 protein which does not bind DNA or which has a substantially impaired ability to bind DNA compared to wild-type papilloma...
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5989561 |
Recombinant poxvirus-calicivirus rabbit hemorrhagic disease virus (RHDV) compositions and uses
Attenuated recombinant viruses containing DNA encoding a calicivirus antigen such as a RHDV antigen, e.g., a capsid gene, as well as methods and compositions employing the viruses, expression...
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5989562 |
Recombinant raccoon pox viruses and their use as an effective vaccine against feline immunodeficiency virus infection
The present invention provides recombinant raccoon poxviruses (RRPVs) useful in vaccines for the prophylaxis of disease caused by feline immunodeficiency virus (FIV). RRPVs according to the...
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5985283 |
Adenovirus E1A-Associated protein BS69, inhibitor of E1A-transactivation
The present invention relates to a transcription inhibiting factor, designated BS69. The factor can bind to both the 243R and 289R E1A adenovirus proteins, inhibiting the transactivating activity...
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5981173 |
Genital human papillomavirus type 68a (HPV-68a), related to the potentially oncogenic HPV-39
The genomes of two novel human papillomavirus (HPV) types, HPV68 and HPV70, were cloned from a low grade cervical intraepithelial neoplasia and a vulvar papilloma, respectively, and sequenced. Both...
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5976552 |
Virus vaccines
Improved mammalian virus vaccines are combinations that contain an immunogenic amount of inactivated virus, such as influenza virus, Herpes varicella virus, measles virus, Epstein Barr virus,...
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5972347 |
Pharmaceutical composition containing a neutralized virus and use thereof
The invention relates to a pharmaceutical composition for prophylactic and/or therapeutic treatment of patients for immunization against a virus infection and is characterized in that this is...
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5965139 |
Chicken infectious anemia virus vaccine
Novel sequences in the genome of a wild type isolate of chicken infectious anemia virus are described, The amino acid sequence of a polypeptide, VP1, encoded by a novel sequence is also disclosed....
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5965134 |
Immunogenic composition against Classical Swine Fever Virus (CSFV)
This application is concerned with immunogenic polypeptides of pestiviruses, specifically Classical Swine Fever Virus (CVFV), specifically the nonstructural protein p10, more specifically T-cell...
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5965124 |
Replication-competent recombinant viral vaccines and method of producing same
Replication-competent recombinant viruses, particularly replication-competent recombinant polioviruses, which include (1) exogenous nucleic acid sequences which encode an exogenous polypeptide and...
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5962217 |
MSRV1 virus and MSRV2 pathogen and/or infective agent associated with multiple sclerosis, and biopolymer constituents thereof
Composition including two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and...
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5961982 |
Recombinant herpesvirus of turkeys and uses thereof
The present invention provides a recombinant herpesvirus of turkeys designated S-HVT-050 (ATCC Accession No. VR 2400). A vaccine is provided which comprises an effective immunizing amount of...
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5955342 |
Non-infectious, replication-defective, self-assembling HIV-1 viral particles containing antigenic markers in the gag coding region
The present invention is concerned with the ability to differentiate between infection by HIV and immunization with an immunogenic preparation. Accordingly, the present invention provides a...
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5942235 |
Recombinant poxvirus compositions and methods of inducing immune responses
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The...
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5922315 |
Adenoviruses having altered hexon proteins
An adenovirus wherein at least one portion of at least one loop region of the hexon is changed. In one embodiment, the adenovirus, prior to modification, is of a first serotype, and at least a...
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5922328 |
Methods and compositions for treatment of HSV-2 infections and conditions
A live, attenuated HSV-2 virus and methods of making and using the virus are provided. The live, attenuated HSV-2 virus is constructed using recombinant techniques and can be used in a...
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5912338 |
Nucleic acids encoding self-assembled, non-infectious, non-replicating, immunogenic retrovirus-like particles comprising modified HIV genomes and chimeric envelope glycoproteins
This invention is directed toward nucleic acids encoding self-assembled, non-infectious, non-replicating, immunogenic retrovirus-like particles comprising modified HIV-1 genomes devoid of long...
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5895756 |
Non-antibiotic system for selection of recombinant mycobacteria
The present invention provides a Mycobacterium-E. coli shuttle vector containing sequences coding for a tribrid fusion containing the M. leprae 18kDa antigen sequence, a phoA protein antigen...
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5891442 |
Infectious bursal disease virus recombination poxvirus vaccine
What is described is a recombinant poxvirus, such as fowlpox virus, containing foreign DNA from infectious bursal disease virus. What is also described is a vaccine containing the recombinant...
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5888513 |
Recombinant PRRSV proteins, diagnostic kits and vaccines containing such recombinant PRRSV proteins
Recombinant proteins of the causative virus of porcine reproductive and respiratory syndrome (PRRS), corresponding to ORFs 2 to 7 of the PRRSV Spanish isolate (PRRS-Olot), have been produced in...
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5882652 |
Empty canine parvovirus capsids having CPV recombinant VP2 and vaccines having such capsids
The present invention is a method for the production of a subunit vaccine against canine parvovirus (CPV). The method includes the step wherein a recombinant protein VP2 of CPV is obtained by using...
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5879925 |
Genetically engineered human immunodeficiency virus-like particles with modified chimeric envelope glycoproteins containing influenza virus transmembrane spanning domains
Non-infectious, retrovirus-like particles comprise an assembly of an env gene product, a pol gene product and a gag gene product contain an antigenic marker which is non-retroviral or non-HIV...
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5874280 |
Vector vaccines of bovine herpesvirus I
The present invention is concerned with a Bovine Herpesvirus I (BHV-I) mutant comprising a heterologous gene introduced into a section of the BHV-I genome. The invention also relates to a vector...
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5874089 |
Protecting against canine oral papillomavirus (copy)
Recombinantly produced L1 major capsid proteins which mimic conformational naturalizing epitopes on human and animal papilloma virions including canine and equine papilloma virions are provided....
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5871742 |
Recombinant Avipox virus encoding polypeptide of mycoplasma gallisepticum, and utilized a live vaccine
A polypeptide exhibiting the antigenicity of Mycoplasma gallisepticum, a fused polypeptide comprising the above polypeptide and, connected to the N-terminus thereof, a signal membrane anchor of a...
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5866136 |
Recombinant vaccine
A recombinant vaccine comprises a vaccine vector which incorporates a first nucleotide sequence capable of being expressed as all or a part of an antigenic polypeptide, together with a second...
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5866401 |
Porcine reproductive and respiratory syndrome vaccine
The invention discloses a vaccine and methods for the treatment of porcine reproductive and respiratory syndrome. The vaccine is derived from the viral agent NEB-l-P94, deposited at the American...
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5866137 |
Self-assembled, non-infectious, non-replicating; immunogenic retrovirus-like particles comprising modified HIV genomes devoid of long terminal repeats and chimeric envelope glycoproteins
This invention is directed toward self-assembled, non-infectious, non-replicating, immunogenic retrovirus-like particles comprising modified HIV-1 genomes devoid of long terminal repeats and...
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5866320 |
Nucleic acids encoding for non-infectious, replication-defective, self-assembling HIV-1 viral particles containing antigenic markers in the gag coding region
Non-infectious, retrovirus-like particles comprise an assembly of an env gene product, a pol gene product and a gag gene product contain an antigenic marker which is non-retroviral or non-HIV...
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5863542 |
Recombinant attenuated ALVAC canaryopox virus containing heterologous HIV or SIV inserts
Attenuated recombinant viruses containing DNA encoding an immunodeficiency virus and/or CTL antigen, as well as methods and compositions employing the viruses, expression products therefrom, and...
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5858373 |
Recombinant poxvirus-feline infectious peritionitis virus, compositions thereof and methods for making and using them
Attenuated recombinant viruses containing DNA encoding FIPV antigen(s) compositions thereof, as well as methods for making and using the compositions, expression products therefrom, and antibodies...
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5858729 |
Expression of porcine reproductive respiratory syndrome virus polypeptides in the same cell
The present invention provides a process for the recombinant DNA production of a mature form of the PRRSV ORF 3 or ORF 4 protein. This is achieved by the co-expression of the PRRSV ORF 2, ORF 3 and...
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5858726 |
Self-assembling replication defective hybrid virus particles
The invention pertains to self-assembled replication defective hybrid virus-like particles having capsid and membrane glycoproteins from at least two different virus types and method of making...
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5858368 |
Vaccine comprising a baculovirus produced influenza hemagglutinin protein fused to a second protein
A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of...
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5853734 |
Glycoprotein L and clycoprotein M from kaposi's sarcoma associated herpesvirus, DNA encoding same and uses thereof
This invention provides an isolated nucleic acid molecule which encodes KSHV glycoprotein L (gL). This invention provides an isolated nucleic acid molecule which encodes KSHV glycoprotein M (gM)....
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5851813 |
Primate lentivirus antigenic compositions
Molecular clones of primate lentiviruses that harbor an engineered non-revertible null mutation in the nef gene and which may further include a non-revertible null mutation in one or more...
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5849475 |
Immunoassay diagnostic kit containing antigens derived from self-assembled, non-infectious, non-replicating, immunogenic retrovirus-like particles comprising modified HIV genomes and chimeric envelope glycoproteins
This invention is directed toward diagnostic kits and antigens useful for the detection of viral antigens in a test sample. The kit contains antigens obtained from self-assembled, non-infectious,...
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5849303 |
Recombinant feline Immunodeficiency virus subunit vaccines employing baculoviral-expressed envelope glycoproteins derived from isolate NCSU-1 and their use against feline immunodeficiency virus infection
The present invention pertains to the prevention or lessening of disease in cats caused by Feline Immunodeficiency Virus (FIV). Prevention or lessening of disease is understood to mean the...
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5843456 |
Alvac poxvirus-rabies compositions and combination compositions and uses
Attenuated recombinant viruses containing DNA encoding a rabies virus antigen in a "cocktail" or combination or multivalent compositions well as methods for making and using the compositions,...
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5840520 |
Recombinant negative strand RNA virus expression systems
Recombinant negative strand virus RNA templates which may be used to express heterologous gene products and/or to construct chimeric viruses are described. Influenza viral polymerase, which was...
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5837262 |
Pharmaceutical compositions against several herpes virus infections and/or atherosclerotic plaque
A pharmaceutical composition is disclosed for the treatment against several herpes virus infections or atherosclerotic plaques in a mammalian subject suspectible thereto which comprises: (a) 10 to...
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5833993 |
Feline immunodeficiency virus vaccine
Disclosed are vaccines containing both a DNA sequence encoding FIV gag protein and a DNA sequence encoding FIV env protein. The gag and env proteins are preferably expressed by baculovirus...
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5827518 |
Viral and insect genes that inhibit the immune system and methods of use thereof
Viral, endoparasitoid and/or host genes that specifically inhibit the immune response of insect pests, useful for broadening the host range of insect viruses. Symbiont viruses of insect pests are...
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5824466 |
Purified polypeptide of human papillomavirus type 49 (HPV49) type 50 (HVP50), and type 55 (HPV55)
The invention relates to papillomavirus probes derived from new DNA-HPVs deposited with the CNCM on the 6 May 1988 under the following filing numbers: PGEM 4 HPV49: I-754 PSP 65 HPV50: I-755 ...
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5811104 |
Recombinant structural and non-structural proteins of FIPV and method of immunizing
The present invention relates to the development of an efficacious vaccine against Feline Infectious Peritonitis Virus (FIPV). The invention provides the tools for the synthesis and manipulation of...
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5804439 |
Plasmid encoding hybrid RNA virus
A recombinant RNA virus is provided allowing encapsidation of genetically engineered viral sequences in heterologous, preferably rod-shaped coat, protein capsids. Since icosahedral viruses are...
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5789388 |
Vaccine against viruses associated with antibody-dependent-enhancement of viral infectivity
The present invention relates to a vaccine against a virus associated with antibody-dependent-enhancement of viral infectivity. Such a vaccine comprises a herpesvirus vector which is able to spread...
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5789390 |
Method for preparing recombinant adeno-associated viruses (AAV), and uses thereof
A novel method for preparing vectors derived from adeno-associated viruses (AAV), cells used therefor, and the use of the resulting vectors, particularly in gene and/or cell therapy, are disclosed.
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5783192 |
Recombinant feline herpesvirus vaccine
The present invention is concerned with a Feline herpesvirus (FHV) mutant comprising a heterologous gene introduced into an insertion-region of the FHV genome. The invention also relates to a...
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5770428 |
Chimeric retrovial expression vectors and particles containing a simple retroviral long terminal repeat, BLV or HIV coding regions and cis-acting regulatory sequences, and an RNA translational enhancer with internal ribsome entry site
This invention is directed toward novel replication competent retroviral expression vectors and particles containing a single chimeric viral genome composed of a simple retroviral (e.g., spleen...
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