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6180614 |
DNA based vaccination of fish
The present invention relates to methods of immunization of aquaculture species by introducing DNA expression systems into the aquaculture species. Such DNA expression systems preferably include...
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6180108 |
Vectors having terminal repeat sequence of Epstein-Barr virus
The use of a unique terminal repeat sequence derived from Epstein-Barr virus to improve the integration frequency of heterologous expression vectors in transfected cells is described. The vectors...
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6180398 |
Two-step immunization procedure against the pyramyxoviridae family of viruses using recombinant virus and subunit protein preparation
An immunization strategy to provide protection against disease caused by infection with a paramyxoviridae virus, specifically respiratory syncytial virus (RSV) and parainfluenza virus, is...
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6171596 |
Oligomeric HIV-1 envelope glycoproteins
Immunogenic compositions and methods of stimulating an immune response against the envelope protein of HIV-1. Immunogenic compositions include a purified oligomeric structure that comprises a...
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6171591 |
Recombinant nodavirus compositions and methods
Recombinant nodavirus related compositions are disclosed. These compositions include chimeric proteins in which a nodavirus capsid protein is present together with a heterologous peptide segment....
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6168943 |
Methods for making modified recombinant vesiculoviruses
The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable...
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6165471 |
Homogeneous human papillomavirus capsomere containing compositions, methods for manufacture, and use thereof as diagnostic, prophylactic or therapeutic agents
The present invention relates to stable HPV capsomeres which express at least one virus-neutralizing conformational epitope of a native HPV L1 protein which are substantially incapable of assembly...
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6159477 |
Canine herpesvirus based recombinant live vaccine, in particular against canine distemper, rabies or the parainfluenza 2 virus
Disclosed and claimed is a recombinant canine herepes virus (CHV). The recombinant CHV includes and expresses at least one heterologous nucleotide sequence encoding an antigen. The antigen can be...
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6156567 |
Truncated transcriptionally active cytomegalovirus promoters
Recombinant adenoviruses, methods of making them, uses for them, including in immunological, immunogenic, vaccine or therapeutic compositions, or, as a vector for cloning, replicating or expressing...
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6153199 |
Avian recombinant live vaccine using, as vector, the avian infectious laryngotracheitis virus
The living recombinant avian vaccine comprises, as a vector, an ILTV virus comprising and expressing at least one heterologous nucleotide sequence, this nucleotide sequence being inserted in the...
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6146642 |
Recombinant new castle disease virus RNA expression systems and vaccines
This invention relates to genetically engineered Newcastle disease viruses and viral vectors which express heterologous genes or mutated Newcastle disease viral genes or a combination of viral...
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6146641 |
Avian leukosis virus subgroup J envelope gene product for diagnosis and immunogenic composition
The envelope (env) gene from avian leukosis virus subgroup J (ALV-J) strain Hc1 has been isolated, sequenced and cloned into an expression vector. The ALV-J Hc1 env gene and expressed protein are...
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6143520 |
Expression vectors and methods of use
The present invention is related to vectors and methods for increasing the expression of a desired gene product. Preferably this invention is used with genes expressing proteins that are not well...
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6139833 |
Targeted gene discovery
The present invention describes a comprehensive system for gene discovery using retrovirus that have been engineered to exhibit increased accessibility to genomic DNA, or to mutate and identify the...
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6136318 |
Recombinant fowlpox viruses and uses thereof
This invention provides a recombinant fowlpox virus comprising a foreign DNA sequence inserted into the fowlpox virus genomic DNA, wherein the foreign DNA sequence is inserted within a 3.5 kB EcoRI...
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6136538 |
Silent inducible virus replicons and uses thereof
A recombinant cell stably transformed with a cDNA of a silent, inducible replicon encoding a recombinant protein is disclosed. Transcription of the replicon cDNA is under the control of a silent...
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6132731 |
Murine leukemia virus vectors
A proteinaceous particle comprises a capsid enveloped by ecotropic Murine Leukemia virus envelope proteins characterized in that a heterologous peptide which binds to a non-murine cell is inserted...
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6126938 |
Methods for inducing a mucosal immune response
The invention relates to a pharmaceutical composition intended for inducing in a host mammal a protective immune response against an antigen, at a mucosal effector site, which comprises at least...
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6127175 |
Cells for the production of recombinant adenoviruses
The invention relates to cells usable for the production of defective adenoviruses comprising, inserted into their genome, a portion of the region E4 of an adenovirus genome carrying the reading...
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6123949 |
Recombinant fowlpox virus S-FPV-043 and uses thereof
The present invention provides a recombinant fowlpox virus designated S-FPV-043 (ATCC Accession No. VR 2395). A vaccine useful for immunizing an animal against fowlpox virus and Newcastle disease...
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6113913 |
Recombinant adenovirus
The present invention provides a recombinant adenovirus having a genome with a deficiency in the E1 region and a mutation in the MLP. The invention also provides stocks of such viruses and...
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6106841 |
Delivery method for recombinant raccoon poxvirus
The present invention relates to a novel method to immunize an animal against a heterologous antigen. The method includes the step of administering to the animal, by an intranasal route, a...
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6103244 |
Methods for generating immune responses employing modified vaccinia of fowlpox viruses
A method is disclosed for producing a modified eukaryotic cytoplasmic DNA virus by direct molecular cloning of a modified DNA molecule comprising a modified cytoplasmic DNA virus genome. The...
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6099847 |
Chimeric Gag pseudovirions
The present invention provides, inter alia, recombinant chimeric nucleic acids encoding a Gag-fs-fusion partner fusion protein; a pseudovirion comprising a retroviral Gag protein and a fusion...
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6096869 |
Treatment of papillomavirus-associated lesions
Interleukin-12 (IL-12) or a functional analogue thereof, or a polynucleotide encoding IL-12 or encoding a functional analogue thereof, is used as a therapeutic material or adjuvant in treating...
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6086890 |
Bovine adenovirus expression vector system
The present invention relates novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted...
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6074649 |
Recombinant composition containing feline herpes virus type 1, particularly for treating feline infectious peritonitis
The recombinant live vaccine comprises, as vector, a feline herpesvirus comprising and expressing at least one nucleotide sequence encoding a polypeptide, this sequence being inserted into the ORF5...
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6066324 |
Carboxyl terminal of papilloma virus L1 region is not required for formation of virus-like particles
Recombinant papilloma virus-like particles result from the expression of viral structural protein L1 and/or L2 in which one or several sections of the L1 and/or L2 protein are deleted. The ability...
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6063385 |
DNA vaccine for parvovirus
Disclosed herein are methods for vaccinating mammals against parvovirus. In one form, a recombinant, replication incompetent vector containing DNA coding for canine parvoviral capsid protein is...
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6063384 |
Encapsidated recombinant viral nucleic acid and methods of making and using same
The present invention pertains to a method of encapsidating a recombinant poliovirus nucleic acid to obtain a yield of encapsidated viruses which substantially comprises encapsidated recombinant...
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6060064 |
Chimeric virus-like particle antigen presentation and delivery system
Chimeric virus-like particles produced by a non-natural particle-forming protein. The non-natural particle forming protein comprises a self-assembling particle-forming first amino acid sequence...
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6051428 |
Rapid production of autologous tumor vaccines
An autologous vaccine to tumor cells is produced by transducing the tumor cells with a herpes simplex virus amplicon containing the gene for an immunomodulatory protein to provide transient...
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6051238 |
Stabilizers for lyophilized mumps vaccines
Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric...
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6045798 |
Membrane-associated immunogens of mycobacteria
Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive...
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6045803 |
Live recombinant avian vaccine using an avian herpesvirus as vector
The live recombinant avian vaccine comprises, as vector, an avian herpesvirus comprising at least one nucleotide sequence coding for and expressing an antigenic polypeptide of an avian pathogenic...
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6039959 |
Treatment and diagnosis of infections due to helicobacter pylori
The present invention provides agents for the detection of urease from H. pylori, and agents and epitopes for use in the treatment or diagnosis of infection due to H. pylori, as well as diagnostic...
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6033670 |
Recombinant live avian vaccine, using as vector the avian infectious laryngotracheitis virus
The recombinant live avian vaccine comprises as vector an ILTV virus comprising and expressing at least one heterologous nucleotide sequence, this nucleotide sequence being inserted into the...
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6033668 |
Chimeric protein which confers protection against parainfluenza virus and respiratory syncytial virus
Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for...
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6025125 |
Methods for the detection of HIV-specific immune responses employing non-infectious, non-replicating, IIV retrovirus-like particles containing heterologous antigenic markers
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6025181 |
Equine herpesvirus-4TK mutant
An Equine herpesvirus-4 (EHV-4) mutant which does not produce a functional thymidine kinase due to a deletion and/or insertion in the gene encoding thymidine kinase, the deletion and/or insertion...
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6017542 |
Nucleotide and amino acid sequences of canine herpesvirus GD and uses therefor
Disclosed and claimed are nucleotides for genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues. These genes encode polypeptides of 879, 459 and 345 amino acids, respectively, which...
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6015694 |
Method for stimulating an immune response utilizing recombinant alphavirus particles
The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector...
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6013258 |
Immunogenic peptides from the HPV E7 protein
The invention provides immunogenic peptides from the HPV type 16 E7 protein that comprise overlapping class I restricted T cell epitopes. Also disclosed are methods of administering DNA molecules...
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6013266 |
Live attenuated bacteria of the species Actinobacillus pleuropneumoniae
The present invention relates to live attenuated bacteria of the genus Actinobacillus pleuropneumoniae that have a mutation in an apxIV gene such that no functional ApxIV toxin can be produced. The...
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6013506 |
Feline leukemia virus vaccines
Disclosed are recombinant baculovirus expressing the gag, gp70, and gp85 genes of feline leukemia virus. Also disclosed are vaccines based on protein expressed from these recombinants. Also...
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6013261 |
Recombinant Marek's disease virus (MDV) and vaccine
A recombinant herpes virus is provided which efficiently expresses an exogenous protein of interest in an inoculated animal host to thereby endow the host with excellent immunization. A recombinant...
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6010703 |
Recombinant poxvirus vaccine against feline rhinotracheitis
A recombinant poxvirus vaccine against feline herpesvirus (FHV-1) is described. The recombinant poxviruses include synthetic genes encoding either a gB or gD precursor polypeptide or mixtures of...
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6004557 |
Variants of human papillomavirus antigens
Variants of human papilloma virus (HPV) E6 and E7 able to elicit a humoral or cellular immune response against HPV in a host animal but not being cell-transforming in the host animal are disclosed,...
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6001591 |
Recombinant bovine adenoviruses
The present invention provides recombinant bovine adenovirus (BAV) vectors and expression systems for introduction and expression of non-BAV sequences in mammalian cells. Methods for the...
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5998601 |
VR-2332 viral nucleotide sequence and methods of use
A nucleotide sequence is provided for the VR-2332 virus, which is capable of causing Porcine Reproductive and Respiratory Syndrome. The nucleotide sequence includes protein coding regions that are...
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