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6726907 |
Purified adenoviral compositions
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of...
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6723558 |
Preparation and use of viral vectors for mixed envelope protein vaccines against human immunodeficiency viruses
Polyenv vaccines are provided that comprise mixtures of at least 4 to about 10,000 different recombinant viruses that each express a different HIV env variant or a portion thereof containing both...
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6723316 |
Herpes simplex virus-1 Glycoprotein C mutants for treating unwanted hyperproliferative cell growth
The present invention relates to pharmaceutical compositions, kits, and methods of use thereof, comprising, a mutant human herpes simplex virus, which is cytopathic to susceptible target cells,...
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6719982 |
Mutant herpes simplex viruses and uses thereof
The present invention provides a herpes simplex virus strain having a functional ICP27 gene and lacking at lease a functional ICP4 gene and a functional ICP34.5 gene. It also provides the use of a...
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6713067 |
Herpes viruses for immune modulation
An attenuated herpes virus which lacks a functional vhs gene or a functional equivalent thereof, but which has a functional UL43 gene or functional equivalent thereof, stimulates an immune response...
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6712612 |
Safe and stable retroviral helper cell line and related compositions and methods
A safe gene transfer system is provided based on simian immunodeficiency virus (SIV). A packaging construct is provided in which the SIV packaging sequence is removed, and, in one instance, the...
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6699475 |
Recombinant pox virus for immunization against tumor-associated antigens
Recombinant pox viruses capable of expressing cell-encoded, tumor-associated antigens are disclosed. The recombinant viruses are useful for evoking an immune response against the antigen.
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6699476 |
Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules
Recombinant respiratory syncytial virus (RSV) are provided which express one or more immune modulatory molecules. The recombinant virus is modified by addition or substitution of a polynucleotide...
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6692750 |
Alphavirus expression vector
The present invention is directed to alphavirus expression vectors comprising at least part of an alphavirus genome and heterologous RNA inserted downstream of an alphavirus base sequence having...
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6689605 |
Controlling immune response to specific antigens
One major problem with adenovirus gene therapy has been the T-cell mediated immune response elicited by inoculation of adenovirus, which leads to rapid clearance of the virus and loss of transgene...
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6682909 |
Immunogenic composition of hepatitis C and methods of use thereof
The present invention provides truncated HCV E2 polypepides. The invention HCV E2 polypeptides lack the HVR1 region that provides immune protection against HCV. The present invention also provides...
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6682743 |
Altered strain of the modified vaccinia virus ankara (MVA)
The invention provides new strains of the Modified Vaccinia Virus Ankara (MVA) that have a strongly reduced virulence for most mammals, especially humans, but nevertheless grows in cells of a...
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6682907 |
Use of triplex structure DNA in transferring nucleotide sequences
A recombinant vector comprising a polynucleotide containing a cis-acting central initiation region (cPPT) and a cis-acting termination region (CTS) is disclosed. These regions are of retroviral or...
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6676958 |
Adjuvant composition for mucosal and injection delivered vaccines
An adjuvant for vaccines comprising lecithin and a polymer, whereby the polymer is preferably polyacrylic acid.
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6673602 |
Herpes simplex virus amplicon vector targeting system and method of using same
The present invention relates to herpes simplex virus (HSV) amplicon vectors, and in particular, HSV-1 amplicon vectors, which have been genetically modified and used alone or with consequent...
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6673572 |
Methods for rescue of RNA viruses
This invention relates to improved methods for producing nonsegmented, negative-sense, single-stranded RNA viruses of the Order designated Mononegavirales virus, including embodiments relating to...
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6669939 |
(Poly)peptides which represent the epitopes of the human herpes virus type 8
The present invention relates to (poly)peptides, which are recognized by anti-HHV8 antibodies of HHV-8 infected patients, whereby these (poly)peptides are not naturally occurring HHV-8 proteins....
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6669942 |
Defective adenoviruses including a therapeutic gene and an immunoprotectove gene
Novel adenovirus-derived viral vectors, the preparation thereof, and the use of such vectors in gene therapy, are disclosed. In particular, defective adenoviruses having a genome that includes a...
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6669943 |
Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals
The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated...
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6664066 |
Modified Morbillivirus V proteins
Modified Morbilliviruses having at least one mutation in the region corresponding to amino acids 112-134 of the measles virus V protein are described, wherein one or both of amino acids 113 or 114...
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6663871 |
Methods and reagents for vaccination which generate a CD8 T cell immune response
New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes...
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6663872 |
Hemorrhagic enteritis virus DNA sequences, proteins encoded thereby and various uses thereof
The present invention relates to a DNA sequence comprising a nucleotide sequence encoding Hemorrhagic Enteritis virus. It is well known to the man of the art that determining the complete sequence...
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6660273 |
Chimeric vaccine against tick-borne encephalitis virus
A live, attenuated chimeric virus vaccine against tick-borne encephalitis virus comprising the preM and E structural genes of the tick-borne encephalitis Langat virus and the non-structural genes...
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6653465 |
Spliced gene of KSHV / HHV8, its promoter and monoclonal antibodies specific for LANA2
This invention provides an isolated nucleic acid which encodes a Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 2 polypeptide (LANA2) or a fragment thereof and also...
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6641817 |
Herpes virus vectors for dendritic cells
An attenuated herpes virus capable of efficiently infecting a dendritic cell without preventing antigen processing occurring within the infected cell. The attenuated herpes virus and dentrictic...
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6635472 |
Retrovirus and viral vectors
This invention relates to the fields of genetic engineering, virus replication and gene transfer. More specifically, this invention relates to polynucleotide construct, recombinant virus,...
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6635476 |
Targeted vectors
This invention provides therapeutic and diagnostic agent delivery vehicles, including viral vectors, that are complexed to a targeting moiety by coordinate covalent linkages mediated by a...
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6632664 |
Avian infectious herpesvirus recombinants and recombinant vaccines prepared with the use of the same
An avian infectious recombinant herpesvirus is prepared by inserting a foreign gene, in particular a heterologous antigen gene, into an insertion site in an untranslated genetic region in the...
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6632438 |
Recombinant poxvirus cytomegalovirus, compositions, and uses
Attenuated recombinant viruses containing DNA encoding an HCMV antigen, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the...
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6616929 |
Swine vesicular disease virus expression vectors
The invention relates to nucleic acids containing a nucleotide sequence encoding a polypeptide, the polypeptide having (1) the P2 and P3 regions of a swine vesicular disease virus polyprotein, and...
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6613892 |
HSV viral vector
A recombinant herpes simplex virus (HSV) viral vector genome which has substantially lost its transducing properties as a result of a DNA sequence change in the gene coding for Vmw65 protein and...
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6610473 |
Peptides for inhibiting HPV E6-proteins
The present invention relates to peptides suited for inhibiting HPV-E6 proteins, DNAs encoding them and the use of both, particularly for eliminating HPV tumor cells.
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6605286 |
Delivery of biologically active polypeptides
Biologically active polypeptides and/or antigens are delivered by administering to a subject a non-invasive or non-pathogenic bacterium which expresses one or more antigens or polypeptides. The...
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6605283 |
Nucleotide sequence for the Avian Metapneumovirus (Colorado) attachment glycoprotein gene
The nucleic acid and the corresponding amino acid sequence for the attachment glycoprotein of Avian Metapneumovirus (Colorado) Type C strain is provided. The nucleotide sequence is 1,321 base pairs...
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6605281 |
Human papillomavirus vectors for the episomal transduction of host cells and method of making same
A replicon for delivery of a transgene for episomal gene expression in a mammalian host cell includes a transgene having an open reading frame or other nucleic acid sequence for transcription into...
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6602505 |
Viral chimeras comprised of CAEV and HIV-1 genetic elements
The invention provides a polynucleotide comprising portions of the genomes of caprine arthritis-encephalitis virus and HIV-1, resulting in a chimeric retrovirus referred to as a “CHIV. ” The...
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6596270 |
Methods of administering adenoviral vectors
The present invention provides methods for administering an adenoviral gene transfer vector comprising an exogenous gene to an animal. One method involves utilizing systemic neutralizing antibodies...
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6596279 |
Immunodeficiency recombinant poxvirus
Attenuated recombinant viruses containing DNA encoding an immunodeficiency virus and/or CTL antigen, as well as methods and compositions employing the viruses, expression products therefrom, and...
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6596269 |
Methods of treating chronic pain
This invention pertains to the surprising discovery of novel compositions and methods which selectively treat chronic pain while not significantly affecting basal nociceptive, acute pain,...
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6596280 |
Method for generating birnavirus from synthetic RNA transcripts
A system for the generation of live Bimavirus such as infectious bursal disease virus (IBDV), a segmented double-stranded (ds) RNA virus of the Bimaviridae family, using synthetic transcripts...
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6589531 |
Recombinant yellow fever virus and method of use thereof
The present invention provides recombinant yellow fever viruses (YFV), particularly live attenuated recombinant YFV, which comprise exogenous (i.e., non-YFV) nucleotide sequences which encode...
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6589532 |
Papilloma viruses, means for the detection thereof and therapy for diseases caused thereby
The invention relates to DNA coding for a peptide of a papilloma virus major capsid protein or a papilloma virus genome. The invention also relates to proteins coded by the papilloma virus genome...
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6582693 |
Recombinant MVA virus expressing the E2 gene of Bovine papillomavirus and its use in the therapy of tumors generated by papillomaviruses
A recombinant vaccinia virus derived from the vaccinia virus Ankara (MVA) encoding and capable of expressing the E2 gene of Bovine papillomavirus. Also, the use of the virus in the treatment of...
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6579526 |
Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes
Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID...
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6576243 |
Polynucleotide vaccine formula against porcine reproductive and respiratory pathologies
Disclosed and claimed is: an immunogenic or vaccine composition for inducing in an avian host an immunological response against avian pathologies containing at least one plasmid that contains and...
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6573091 |
Chimeric viral packaging signal without gag gene sequences
A chimeric viral packaging signal is described for the transmission of genetic materials via retrovirus. The packaging signal contains an essential packaging nucleic acid sequence and a...
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6573090 |
Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors
The present invention relates to an enhanced and simplified herpes virus amplicon packaging system. The packaging system comprises a herpes virus amplicon vector and a packaging vector. In one...
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6566093 |
Alphavirus cDNA vectors
The present invention is related to polynucleotide molecules and to their use for production of desired products after introduction into human or animal cells. In addition, the present invention is...
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6562376 |
DNA vaccines against poxviruses
In this application is described a poxvirus naked DNA vaccine which protects animals against poxvirus challenge comprising IMV and EEV nucleic acids from poxvirus. Methods of use of the vaccine and...
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6558674 |
Polynucleotide vaccine formulation against pathologies of the horse
Disclosed and claimed is: an immunogenic or vaccine composition for inducing in an equine host an immunological response against equine pathologies containing at least one plasmid that contains and...
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