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7390872 |
NF-κB peptides designed to disrupt NEMO oligomerization
The present invention relates to polypeptides that inhibit the NF-κB signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of...
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7381805 |
Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF
A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino...
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7371385 |
Method of treating immune pathologies with low dose estrogen
The invention provides a method of ameliorating a Th1-mediated immune pathology in a mammal. The method is practiced by administering a low dose of estrogen to the mammal. Optionally, an...
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7368115 |
Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (PACAP)
The present invention relates to a method of increasing the number and/or differentiation of neural stem cells and/or neural stem cell progeny using pituitary adenylate cyclase-activating...
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7365172 |
Loop peptide and TGFα for stimulating stem cell proliferation and migration
There is disclosed a novel genus of small peptides, much smaller than human TGFα, was discovered as having TGFα biological activity and therefore are useful as pharmacologic agents for the same...
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7365170 |
Adiponectin and uses thereof
The invention provides methods and reagents for regulation of metabolic events, such as those mediated by adiponectin and adiponectin agonists. The invention also provides screening assays for...
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7354722 |
Modulators of Smurf and BMP/TGFβ signaling pathways
This invention provides unique members of the Hect family of ubiquitin ligases that specifically target BMP and TGFβ/activin pathway-specific Smads. The novel ligases have been named Smurf1 and...
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7354608 |
Bio-identical hormones and method of use
The embodied composition is an evening dose of bio-identical hormones in a solvent with a vasodilator, a hormone modulator, and a carrier for balancing and maintaining Cortisol level in a human....
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7351414 |
Method of reducing the risk of bone fracture
The invention relates to a method for increasing the toughness and/or stiffness of bone and/or reducing the likelihood and/or severity of bone fracture by administering a parathyroid hormone. The...
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7344717 |
Use of erythropoietin in the treatment of rheumatoid arthritis
A novel use of the known protein Erythropoietin (EPO) and/or a derivative and/or a fragment thereof is disclosed. EPO is used as a pharmaceutical for the treatment of chronic inflammations. A...
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7335640 |
Administration of hypocretin-1 for treatment of narcolepsy
The invention provides compositions and methods for treatment of sleep disorders. Such methods entail administering to the patient a therapeutically effective dosage regime of an agonist of a...
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7335636 |
SPRR1A and axonal regeneration
The present invention provides polynucleotides, polypeptides, pharmaceutical compositions, and methods for modulation of nerve growth and regeneration.
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7335362 |
Methods of treating pre-eclampsia or eclampsia
Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels...
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7332575 |
Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species
Purified GDF-8 polypeptides of aquatic organisms.
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7320793 |
Molecular antigen array
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7317095 |
Mutant glycoproteins
The inventors have designed novel FSH mutants with increased glycosylation and longer half-lives for use in inducing folliculogenesis in human patients. The use of a FSH mutant preparation of the...
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7317002 |
Site-specific preparation of polyethylene glycol-GRF conjugates
A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys 12 and/or Lys 21 and/or N α ,...
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7309492 |
Soluble lymphotoxin-β receptors as therapeutic agents for the treatment of systemic lupus erythematosus
Compositions and methods comprising “lymphotoxin-β receptor blocking agents” which block lymphotoxin-β receptor signaling and are useful for altering immunological diseases, and particularly...
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7309486 |
HER cancer protocols
The present invention discloses protocols for HER cancers that are also endocrine dependent in a manner that provides dual action by using both HER antibodies and endocrine blockers/downregulators...
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7291341 |
Stresscopins and their uses
The invention provides novel nucleic acids and polypeptides, referred to herein as stresscopin 1 and stresscopin 2, which preferentially activate the CRH-R2 receptor over the R1 receptor....
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7291339 |
Homogeneity and secretion of a recombinant follicle stimulating hormone (FSH) in mammalian systems
A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-β and...
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7288257 |
Diagnosis and treatment of human dormancy syndrome
New methods for diagnosis of human dormancy syndrome are provided. Human dormancy syndrome is characterized by elevated serum ratio of rT3/fT3 compared to a population of normal subjects from which...
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7282201 |
Methods of promoting the growth or differentiation of hematopoietic stem or progenitor cells by non-muscle type cofilin
This invention has as its object providing promoters of the growth and/or differentiation of hematopoietic stem cells and/or hematopoietic progenitors which are useful as therapeutics of diseases...
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7276473 |
Methods and compositions for the treatment of pancreatitis
Methods and compositions for the treatment of acute pancreatitis in a mammal. Particular compositions comprise a binding element, a translocation element, and a therapeutic element able to prevent...
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7265091 |
Methods and compositions for treating male erectile dysfunction
The invention provides a method for preventing or treating male erectile dysfunction or female sexual arousal disorder by administering an effective amount of one or more factors from a group of...
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7261881 |
Modulation of angiogenesis and wound healing
Methods of regulating angiogenesis, ischemic injury and/or wound healing by modulating the activity of leptin, particularly as mediated by the leptin receptor, and/or the interaction between leptin...
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7258861 |
TNF-derived peptides for use in treating oedema
The present invention is based on the finding that peptides derived from a specific domain of tumor necrosis factor-alpha (TNF-α) can efficiently be used to treat oedema. More specifically, the...
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7250169 |
Anti-tumor activity of Ea-4-peptide of pro-IGF-1
Compositions of pro-IFG-I E-peptides for the treatment and amelioration of tumor-producing diseases, and methods for their utilization.
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7250161 |
Equine GM-CSF
Disclosed and/or claimed is subject matter including: equine GM-CSF, its amino acid sequence, nucleic acid molecules encoding equine GM-CSF, use of equine GM-CSF as an adjuvant or non-specific...
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7238790 |
PRO1313 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7235240 |
Antagonists of interleukin-15
Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are...
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7208472 |
Pharmaceutical compositions including variants of vascular endothelial cell growth factor having altered pharmacological properties
Described herein are pharmaceutical compositions including vascular endothelial cell growth factor (VEGF) variants having modifications in the C-terminal heparin binding domain. The variants...
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7196058 |
Method of treatment of conditions by administration of streptolysin O
Method for administering streptolysin O for treatment of various conditions including connective tissue disorders, reproductive fibroses and conditions mediated by the CD44 receptor. The invention...
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7196055 |
Inhibition of apoptosis in keratinocytes by a ligand of p75 nerve growth factor receptor
Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is...
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7193033 |
Peptide having appetite stimulating activity
The present invention provides a ligand to GPR8, in particular polypeptides capable of binding to GPR8 or its amides or esters, or salts thereof, as well as DNA, encoding for such polypeptides. The...
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7186407 |
Methods and compositions for the treatment of peripheral artery disease
Compositions and methods for treating peripheral artery disease in a patient are provided. Compositions comprise recombinant fibroblast growth factor-2. Fibroblast growth factor, such as FGF-2, is...
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7183254 |
Use of leptin for treating human lipoatrophy and method of determining predisposition to said treatment
Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipoatrophy. Leptin is effective against conditions of lipoatrophy for both genetic and acquired forms of the disease....
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7166699 |
Mosquito arrestin 1 polypeptides
The invention discloses polynucleotides and polypeptides of arrestin and odorant receptors. Also disclosed are methods for producing such polypeptides and methods of making antibodies. This...
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7163684 |
Method of increasing bone toughness and stiffness and reducing fractures
The invention relates to a method for increasing the toughness and/or stiffness of bone and/or reducing the likelihood and/or severity of bone fracture by administering a parathyroid hormone. The...
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7160726 |
Compositions comprising conditioned cell culture media and uses thereof
The invention relates to compositions comprising cell culture medium conditioned by cells grown in three-dimensional culture. The cells used to condition the medium may be genetically modified to...
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7148193 |
Compounds that bind to growth hormone receptor
The present invention provides peptides that bind to the active site of the growth hormone receptor. The present invention also provides methods of using these peptides to identify small organic...
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7144577 |
Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
Pathological regional adipose tissue accumulation associated with HIV-associated dysmorphic/dysmetabolic syndrome (HADDS) which may occur with or without subcutaneous adipose tissue lipodystrophy...
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7141649 |
Mosquito arrestin 2 polypeptides
The invention discloses a polynucleotide and polypeptide of arrestin 2. Also disclosed are methods for producing such polypeptide. This invention also discloses a method of identifying compounds...
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7141548 |
Prevention of hyperinsulinemia in subjects undergoing growth hormone (GH) treatment
The present invention provides methods and compositions for preventing hyperinsulinemia that can result from therapeutic administration of growth hormone. The methods are carried out by imposing a...
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7141428 |
Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof
The present invention provides methods for making, delivering and using formulations that combine a therapeutically active agent(s) (such as for example a Rho antagonist(s)) and a flowable carrier...
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7138123 |
Methods for diagnosing and treating dysautonomia and other dysautonomic conditions
Methods for aiding in the diagnosis of dysautonomic disorders and dysautonomic conditions and methods for treating individuals diagnosed as having a dysautonomic disorder or a dysautonomic...
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7132104 |
Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression,...
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7122349 |
Human zven proteins
The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular...
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7118752 |
Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
A method is described for using an a-type or b-type E domain of the human or trout IGF peptide for the inhibition of proliferation and invasiveness of a broad spectrum of malignant cells and for...
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7118746 |
Conditioned cell culture medium compositions and methods of use
Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known...
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