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5989537 |
Methods for stimulating granulocyte/macrophage lineage using thrombopoietin
Methods for stimulating granulocyte/macrophage lineage cells using thrombopoiet in are provided. The methods provided may be used to stimulate granulocyte/macrophage progenitors and neutrophils in...
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5985262 |
Method of treatment with epithelium derived T-cell factor
Nucleic acid sequences which encode biologically active EMF, expression vectors which direct the expression of ETF, ETE polypeptides, antibodies which specffically bind ETF and processes for...
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5976522 |
Lymphocyte chemoattractant factor and uses thereof
Disclosed is a substantially pure antibody which specifically binds a LCF polypeptide and methods of using such antibodies.
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5972387 |
Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
Modified hydrolyzed vegetable protein microspheres and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described.
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5972880 |
Method of treatment of osteoarthritis with interleuken-1 receptor antagonist
A method and a composition for the preventative treatment of osteoarthritis comprising the periodic administration to a mammal suffering of this disease of a composition comprising an amount of...
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5968513 |
Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin
The present invention relates to methods of treating or preventing diseases or disorders associated with hematopoietic deficiency by administration of human chorionic gonadotropin, β-human...
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5945096 |
Method for recombinant production of biologically active polypeptides
Polypeptides, polynucleotides, fragments thereof, and monoclonal antibodies thereto are provided for antigen-specific and antigen-non-specific glycosylation inhibiting factor and a method for...
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5919459 |
Compositions and methods for treating cancer and hyperproliferative disorders
The present invention encompasses methods for reducing or inhibiting growth factor in cancer cells and tissues. More particularly immunogenic growth factor-containing compositions are administered...
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5916569 |
Human erectile dysfunction and methods of treatment
This invention is a method for treating human erectile dysfunction using therapeutic amounts of human growth hormone (GH) administered systemically. Severing the parasympathetic nerves that...
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5912224 |
Methods and compositions for enhancing cellular response to TGF-β ligands
The present invention concerns the TGF-β receptor-mediated signaling pathway. The invention is based on the unexpected finding that TGF-β receptor-mediated signaling is inhibited by the...
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5910309 |
UV-induced factor for immunosuppression
The present invention comprises the method of selectively suppressing an immune response of a mammal to a particular alloantigen. The method includes several steps. One step is administering to a...
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5906820 |
Epidermal growth factor receptor targeted molecules for treatment of inflammatory arthritis
The invention features a method for treating a patient having inflammatory arthritis, the method includes administering to the patient a molecule which is capable of specifically binding to an...
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5900238 |
Vaccine delivery system
Compositions comprising an immunogenic amount of an antigen encapsulated in a stabilized hydrogel microbead are disclosed. The compositions provide a delivery system for antigens such as vaccines....
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5897863 |
LHRH hormones
An analogue of lutenising hormone-releasing hormone (LHRH) having the amino acid sequence: pGlg-His-Trp-Ser-Tyr-X-Len-Arg-Pro-Gly-Y-Z wherein X represents Gly or a D-amino acid, Y represents one...
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5894018 |
Vaccine composition comprising autologous epidermal growth factor or a fragment or a derivative thereof having anti-tumor activity and use thereof in the therapy of malignant diseases
The invention provides novel uses of EGF and vaccine compositions comprising EGF. In particular, autologous EGF, or a fragment or a derivative thereof, is used as an active immunization against the...
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5891439 |
Lymphocyte stimulating factor
Novel polypeptides having lymphocyte stimulating factor activity are disclosed, as well as the use thereof for treating African sleeping sickness. Also, the corresponding nucleic acid sequences are...
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5891435 |
Methods and compositions for delaying or preventing the onset of autoimmune disease
The subject invention concerns compositions and methods useful for the prevention or amelioration of autoimmune diseases. Specifically exemplified are compositions and methods useful in immunizing...
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5888963 |
Treatment of bone disorders with adrenomedullin
A method for promoting bone growth in a patient (e.g., a mammal such as a human) said method including the step of administering a therapeutically effective amount of adrenomedullin or an...
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5888513 |
Recombinant PRRSV proteins, diagnostic kits and vaccines containing such recombinant PRRSV proteins
Recombinant proteins of the causative virus of porcine reproductive and respiratory syndrome (PRRS), corresponding to ORFs 2 to 7 of the PRRSV Spanish isolate (PRRS-Olot), have been produced in...
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5885584 |
Regeneration of oligodendrocytes
The invention concerns a process for improving the regeneration of oligodendrocytes, in particular of human oligodendrocytes, in which oligodendrocytes are treated in cell culture with nerve growth...
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5876721 |
Vaccines
Vesicles comprising at least one non-ionic surfactant and at least one molecule having the ability to transport or facilitate the transport of fats, fatty acids and lipids across mucosal membranes....
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5876730 |
Heparin-binding growth factor (HBGF) polypeptides
Substantially pure heparin-binding growth factor polypeptides (HBGFs), nucleic acids encoding the HBGFs and antibodies which bind to the HBGFs of the invention are provided. The HBGF polypeptides...
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5874086 |
Synthesis and use for the treatment of osteoporosis
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which...
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5854028 |
Compositions comprising IL-11 and methods of making and using IL-11
A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune...
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5849696 |
Composition and method of treating hepatitis C
Compositions and methods of use for treating hepatitis C virus-infected mammals are disclosed. The compositions include one or more thymosins alone or in combination with one or more interferons....
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5846545 |
Targeted delivery of cyclopropylbenzindole-containing cytotoxic drugs
Gytotoxic agents containing a cell binding agent chemically linked to one or more analogue or derivative of CC-1065 are described. The therapeutic use of the cytotoxic agents is also described....
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5844085 |
Cloning and expression of simian transforming growth factor β1
Recombinant transforming growth factor-β1 (TGF-β1) is expressed to high levels in Chinese hamster ovary (CHO) cells using dihydrofolate reductase (dhfr) gene amplification. The expression plasmid...
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5843461 |
Group B streptococcus type II polysaccharide-tetanus toxoid conjugate vaccines
This invention relates to antigenic conjugate molecules comprising the capsular polysaccharide of Group B streptococcus type II which are covalently linked to protein. This invention also relates...
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5840311 |
Agent accelerating collagen decomposition
The present invention relates to an agent accelerating collagen decomposition and a therapeutic agent for fibrosis disorder containing HGFs (Hepatocyte Growth Factors) as an active ingredient. The...
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5837232 |
Use of an interleukin-10 antagonist to treat a B cell mediated autoimmune disorder
A method is provided for toting a B cell mediated autoimmune disorder comprising administering an effective amount of an interleukin-10 antagonist.
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5837247 |
Chemotactic agents for t-cells
Chemotactic activity of defensins and CAP37 is disclosed. Methods of treatment associated with such activity and compositions for such treatment are also provided.
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5837258 |
Induction of tissue, bone or cartilage formation using connective tissue growth factor
The present invention relates to novel methods and compositions related to the administration of connective tissue growth factor, alone or in combination with other growth factors, compositions or...
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5833985 |
Bispecific molecules for use in inducing antibody dependent effector cell-mediated cytotoxicity
Bispecific molecules comprising a non-immunoglobulin tumor cell specific ligand and an antibody which binds the Fc receptor of an effector cell at a site that is not inhibited by endogenous...
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5833994 |
Use of the AH receptor and AH receptor ligands to treat or prevent cytopathicity of viral infection
The present invention includes the method of treating a viral infection, specifically one occurring as a result of infection by a human immunodeficiency virus (HIV-1). The method of treatment...
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5807550 |
Antibodies specifically recognizing somatotropin binding proteins
The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding...
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5807556 |
Methods of preventing degeneration of myoplasties
Methods of reducing the degeneration of a tissue resulting from mobilization with or without chronic, continuous electrical stimulation by administering basic fibroblast growth factor or heparin to...
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5800820 |
Methods and compositions for treatment of angiogenic diseases
The subject invention pertains to compositions and methods of treatment of angiogenesis using PF4 and peptide fragments thereof.
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5798102 |
Treatment of cardiomyopathy
The invention presents methods for the treatment of symptoms associated with cardiomyopathy comprising treatment with an effective amount of a composition comprising beta-amyloid, streptolysin O,...
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5795568 |
Method of treating infectious disease with GM-CSF
A method for purifying CSF protein is described. The method comprises: precipitating the protein with ammonium sulfate at 80% saturation to form a pellet containing the CSF protein; resuspending...
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5792460 |
Modified glycoprotein hormones having a CTP at the amino terminus
"Partial" and "complete" CTP units are used to modify biologically active proteins and peptides to alter their clearance patterns. "Complete" CTP units have the amino acid sequence found at...
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5788964 |
Method for sensitization of cancer cells for killer cell mediated lysis
The invention relates to a method of sensitizing cancer cells for a killer cell mediated lysis which involves administering to a patient an effective amount of antiestrogen and killer cells either...
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5776464 |
Agent for relieving side effects caused by immunosuppressants
The present invention relates to an agent for relieving side effects caused by immunosuppressants, which comprises HGF (Hepatocyte growth factor) as an active component, a method for relieving side...
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5770577 |
BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
Derivatives of the neurotrophic factors BDNF and NT-3 have been prepared by attachment of these polypeptides to a water soluble polymer, for instance, polyethylene glycol.
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5770209 |
Acceleration of wound healing using connective tissue growth factor
The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with...
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5767251 |
Recombinant heterodimeric human fertility hormones, and methods, cells, and vectors and DNA for the production thereof
Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector...
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5766593 |
Anti-inflammatory CD14 peptides
The invention relates to anti-inflammatory peptides that are based on peptide regions 7-10, 11-14, and 57-64 of CD14.
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5762931 |
Anti-cancer utility of HCG vaccines
This invention relates to a method of combatting cancer which cancer releases chorionic gonadotropin or a subunit thereof present in a mammal which method comprises administering to said animal an...
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5762921 |
Composition and methods for the treatment of tumors
The invention concerns a method for inducing a selective collapse of the vasculature of a solid tumor by administering to a patient a therapeutically effective dose of a combination of a compound...
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5759533 |
Neutrophil-activating peptide-2
Peptides having the amino acid sequence ##STR1## wherein X is H, Asp-Leu-Tyr-, Ser-Asp-Leu-Tyr- or Asp-Ser-Asp-Leu-Tyr-. The peptide wherein X is H is human neutrophil-activating peptide-2 (hNAP-2)...
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5744354 |
Calcineurin inhibitory compounds and anchoring protein to induce IL-2 gene expression
The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are...
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