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6689745 |
Agent for ameliorating pancreatic function disorder
Agents for protecting or ameliorating pancreatic cells and tissues which contains as the active ingredient a neurotrophic factor such as BDNF. By using these drugs, degenerative dropout of...
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6689365 |
Single-chain fertility hormones with fsh and LH activity
Glycosylated or nonglycosylated proteins of the formula FSHβ-(linker 1 ) n 1 -LHβ(1-X)-(linker 2 ) n 2 -α wherein FSHβ is a vertebrate follicle stimulating hormone β subunit or a variant...
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6680057 |
Methods of treating autoimmune disease by administering interleukin-17 receptor
Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
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6677428 |
Mammaglobin, a secreted mammary-specific breast cancer protein
A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the...
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6677300 |
Treatment of microvascular angiopathies
The invention concerns the prevention and treatment of endothelial injury and the injury of tissues containing injured blood vessels by administration of angiogenic factors, such as vascular...
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6676947 |
Use of erythropoietin for the treatment of haemochromatoses
The combination of erythropoietin and calcium, with or without phosphates, is useful for treating haemochromatoses. A method for treating primary haemochromatoses in a patient involves...
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6677302 |
Compositions and methods for the treatment of viral disorders
This invention relates to compositions and methods for the treatment of virus infections and other viral-associated disorders. Compositions comprise an inducing agent and an anti-viral agent. The...
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6673352 |
Use of Mullerian inhibiting substance for treating excess androgen states
The present invention provides a method of treating a condition or disease characterized by an excess of one or more androgens, the method comprising administering an effective amount of MIS...
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6673609 |
Recombinant human erythropoietin with advantageous glycosylation profile
A method for the production of a polypeptide, the method comprising culturing, under conditions which allow for the expression of DNA encoding SEQ ID NO:2 in an eukaryotic host cell, wherein the...
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6663867 |
Hybrid heterodimeric protein hormone comprising a TNF binding protein and a glycoprotein hormone subunit and method of using same
A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-β and...
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6664228 |
Photoselective marking of biological targets
A drug delivery system and methods are provided wherein a therapeutic/diagnostic agent or a component of the immune system is directed to particular cells in a selected organ or a specific site....
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6663870 |
Methods for promoting growth of bone using zvegf3
Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective...
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6660258 |
Oromucosal cytokine compositions and uses thereof
Pharmaceutical compositions for oromucosal; contact to stimulate host defense mechanisms in a mammal, having an effective amount of Th1 or Th2 stimulating cytokine, and methods of treatment with...
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6660499 |
DCR5, a BMP-binding protein, and applications thereof
DCR5, a protein related to DAN (Differential-screening-selected gene Aberrative in Neuroblastoma) and related nucleic acids are provided. Included are natural DCR5 homologs from several species and...
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6660257 |
Circular permuteins of flt3 ligand
Disclosed are novel flt-3 receptor agonist proteins, DNAs which encode the flt-3 receptor agonist proteins, methods of making the flt-3 receptor agonist proteins and methods of using the flt-3...
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6660831 |
Method for diagnosing and treating dysautonomia and other dysautonomic conditions
Methods for aiding in the diagnosis of dysautonomic disorders and dysautonomic conditions and methods for treating individuals diagnosed as having a dysautonomic disorder or a dysautonomic...
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6656474 |
Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders
The present invention relates to methods for enhancing gastrointestinal motility. In particular, the invention relates to the use of neurotrophin-3 and its analogues for enhancing gastrointestinal...
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6656907 |
Method of treating gastric ulcer by administration of epidermal growth factor
New utilities for epidermal growth factor (EGF) are described. In particular, EGF is useful in preventing gastrointestinal colonization by pathogens.
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6656475 |
Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In...
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6649164 |
Method for enhancing the functional capacity of dendritic cells
Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to enhance the functional capacity of dendritic cells.
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6649168 |
Pharmaceutical compositions comprising TGF-beta
This invention provides pharmaceutical compositions comprising TGF-β.
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6645500 |
Method for down-regulating osteoprotegerin ligand activity
The invention provides a novel method for down-regulating the biological activity of osteoprotegerin ligand (OPGL, TRANCE) thereby rendering possible the treatment/amelioration of diseases...
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6645504 |
Bystander suppression of type I diabetes by oral administration of glucagon
Described are methods for treating or preventing type I diabetes and insulitis by oral administration of the bystander antigen glucagon. The methods involve oral administration of glucagon in an...
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6639051 |
Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
The invention provides methods and compositions for modulating hair growth.
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6635256 |
Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
Forms of differentially acting glycoprotein hormones are disclosed. These compositions are of the formula β 1 -(linker 1 ) m -α-(linker 2 ) n -β 2 (1); β 1 -(linker 1 ) m -β 2 -(linker 2 )...
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6630444 |
Intestinal function using leptin
A method for treating a patient that has inadequate intestinal function is described. Administering leptin to a subject increases the intestinal function beyond that for a normal intestine and...
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6610302 |
Anti-tumor activity of Ea-2 and Ea-4-peptide of pro-IGF-I
Compositions of pro-IFG-I E-peptides for the treatment and amelioration of tumor-producing diseases, and methods for their utilization.
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6610285 |
Cytokine-like proteins that promote cell proliferation
A full-length cDNA corresponding to an EST (AA418955), which does not show any homology to other proteins in the database but has a weak homology to G-CSF, has been successfully isolated by...
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6605286 |
Delivery of biologically active polypeptides
Biologically active polypeptides and/or antigens are delivered by administering to a subject a non-invasive or non-pathogenic bacterium which expresses one or more antigens or polypeptides. The...
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6593096 |
Immunotherapeutic agent for cancer containing nucleoidal component of bacterium as active ingredient
An agent for cancer immunotherapy with independent use, containing bacterial components as an active ingredient, which induces cancer patients to exhibit immune responsiveness, as indicated by the...
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6583109 |
Therapeutic polypeptides from β-hCG and derivatives
The present invention relates to peptides of one or more portions of the human chorionic gonadotropin β-chain peptides containing a sequence of one or more portions of the β-chain of human...
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6583334 |
Ovariectomized mouse model for human menopause
A method for determining a response to a biologically active agent in ovariectomized lower test mammals is described. The mammals are divided into those which have an early time post ovariectomy...
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6579525 |
Pharmaceutical compositions comprising erythropoietin for treatment of cancer
Pharmaceutical compositions comprising erythropoietin are provided for treatment of cancer, particularly for treatment of multiple myeloma. Erythropoietin was found to be effective for inhibition...
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6572851 |
Method for suppressing or treating drug-induced nephropathy
The present invention provides a novel drug for relieving drug-induced nephropathy and acute hepatopahy containing a midkine (MK) family protein such as pleiotrophin (PTN). The MK family proteins...
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6572866 |
Nerve growth factor as a vaccine adjuvant
A vaccination method utilizes a pharmaceutical combination for enhancing vaccine effectiveness. The method utilizes an immune response-triggering vaccine capable of stimulating production in an...
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6569434 |
Vascular endothelial cell growth factor C subunit
Vascular endothelial cell growth factor C subunit DNA is prepared by polymerase chain reaction techniques. The DNA encodes a protein that may exist as either a heterodimer or homodimer. The protein...
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6548065 |
Interleukin-15 receptors
There are disclosed Interleukin-15 Receptor (IL-15R) proteins, DNAs and expression vectors encoding IL-15R, and processes for producing IL-15R as products of recombinant cell cultures.
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6548066 |
Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a peptide from the CCK-B/gastrin-receptor conjugated to...
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6548059 |
Promotion of proliferation of adult corneal endothelial cells
Disclosed is a method of stimulating adult corneal endothelial cell proliferation, which includes incubation of corneal endothelium to a mitogen-containing medium and then to an agent that...
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6544523 |
Mutant forms of Fas ligand and uses thereof
The invention provides for DNA encoding Fas ligand muteins and chimeras and the proteins encoded thereby. The invention further includes the use of DNA and vectors to produce transformed cells...
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6541008 |
Vascular endothelial growth factor-like protein from orf viruses binds and activates mammalian VEGF receptor-2, and uses thereof
The invention is based on the discovery that a viral VEGF-like protein from the orf virus strain NZ2 and from the orf virus strain NZ10 is capable of binding to the extracellular domain of the VEGF...
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6537965 |
Amino-terminal modified parathyroid hormone (PTH) analogs
Disclosed are novel parathyroid hormone (PTH) peptide derivatives. In particular, the invention relates to PTH derivatives having amino acid substitutions that confer PTH-1/PTH-2 receptor agonist...
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6537554 |
Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis
Novel angiogenesis/anti-angiogenesis secreted proteins and the nucleic acid sequences which encode them are disclosed by the present invention.
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6534634 |
Diagnostic agent and method to determine pregnancy in ruminants
The present invention relates to diagnosis aids and processes for detecting pregnancy in ruminants based on the relaxin-like factor detectable in ruminants. Antibodies against the relaxin-like...
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6531134 |
Mammalian milk growth factor
A mammalian milk growth factor (MMGF) having the following amino acid sequence or substantially homologous sequence:...
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6528050 |
Growth factor homolog zvegf3
Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that...
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6521234 |
NL3 TIE ligand homologue
The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL2, NL3 and FLS139, the proteins encoded by such nucleic acid molecules, as well as methods and means...
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6518246 |
Pharmaceutical composition and method for the treatment of neoplastic cells
A pharmaceutical composition and method, for treating human or non-human neoplastic disorders, e.g. colorectal disorders, comprising the administration of pharmaceutically effective amounts of...
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6509165 |
Detection methods for type I diabetes
Proinsulin peptide compounds that modulate an immunological response by T cells of Type I diabetic subjects are disclosed. The proinsulin peptide compounds of the invention are preferably derived...
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6509313 |
Stimulation of immune response with low doses of cytokines
A method of activating the immune system of a subject comprises the chronic administration of low doses of an agent having cytokine activity, including natural and recombinant cytokines, fragments,...
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