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6911206 |
Fusion proteins comprising carriers that can induce a dual immune response
The subject invention provides a fusion protein for producing a dual immune response in a vertebrate, which fusion protein comprises: (a) a first proteinaceous portion analogous to all or part of a...
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6903188 |
Neurogenic compositions and methods
The present invention has found that the Mts1 protein is expressed in white matter astrocytes in the spinal cord. Such expression is significantly increased following sciatic nerve injury or dorsal...
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6899882 |
Endothelial cell growth factor methods of isolation and expression
A novel growth factor specific for vascular endothelial cells has been identified in conditioned medium of bovine pituitary derived folliculo stellate cells. This factor, named folliculo stellate...
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6897060 |
Composition comprising multipotent neural stem cells for generation of hematopoietic cells
Multipotent neural stem cell (MNSC) progeny are induced to generate cells of the hematopoietic system by placing the MNSC progeny in a hematopoietic-inducing environment. The hematopoietic-inducing...
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6890897 |
Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair
A melanoma inhibiting activity factor (MIA), preferably in combination with an osteoinductive protein, is a useful pharmaceutical agent for promoting bone healing and/or cartilage repair.
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6887477 |
Method of treating ischemic disease by intramuscular administration of Hepatocyte growth factor
Preparations to be administered for treating or preventing ischemic diseases or arterial diseases which contain Hepatocyte growth factor (HGF) as an active ingredient. The preparations provide such...
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6884410 |
Methods for modulating antigen-specific immune responses
Interleukin-10 for producing a population of cells which are capable of inhibiting or suppressing reactions to alloantigens, for example in graft-versus-host disease or tissue rejection, is...
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6884419 |
hG-CSF fusion polypeptide having c-mpl activity, DNA coding for same and methods of treating anemia using same
The present invention relates to a fusion polypeptide which comprises a polypeptide having G-CSF activity and a polypeptide having TPO activity and DNA which codes for the fusion polypeptide, to a...
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6884785 |
Compositions and methods for the treatment or prevention of autoimmune diabetes
The present invention provides compostions and methods for the prevention or treatment of autoimmune disorders. In particular, the invention methods utilize genetic material encoding at least a...
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6881401 |
Methods of treatment of immune system related disorders using Neutrokine-alpha
The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In...
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6869609 |
Method for treatment of renal failure and occlusive lesion of blood vessels by administration of hepatocyte growth factor
The invention presents a preparation for continuous intravenous administration containing hepatocyte growth factor (HGF) as an active ingredient. The preparation for continuous administration of...
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6869932 |
Site-specific preparation of polyethlene glycol-GRF conjugates
A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys 12 and/or Lys 21 and/or N α ,...
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6867191 |
Preparation and use of oligopeptide lyophilisate for gonad protection
A lyophilizate, method of preparation, and use of the lyophilizate for gonad protection is described. The lyophilizate comprises cetrorelix dissolved in 30% (v/v) acetic acid, transferred to water,...
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6852313 |
Method of stimulating growth of melanocyte cells by administering stem cell factor
Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also...
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6846906 |
Modified proteins of the TGF-β superfamily, including morphogenic proteins
The invention provides modified proteins and DNAs of the TGF-β superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical...
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6844427 |
Method for removing the transforming growth factor-β by adsorption
An adsorbent suitable for adsorption of a transforming growth factor-β (TGF-β) comprising a compound which has a log P value of at least 2.50 wherein P is a partition coefficient in an...
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6843998 |
Methods and compositions for the treatment of pancreatitis
Methods and compositions for the treatment of acute pancreatitis in a mammal. Particular compositions comprise a binding element, a translocation element, and a therapeutic element able to prevent...
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6841147 |
Stem cell factor compositions
Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also...
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6841160 |
Meningococcal vaccines formulated with interleukin-12
This invention pertains to vaccine compositions comprising a mixture of antigen, such as pneumococcal or meningococcal antigen, and interleukin IL-12, which may be adsorbed onto a mineral in...
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6828113 |
IgM antibodies to the 70 kDa heat shock protein as a marker for cytomegalovirus infection
The present invention provides a method for detecting the presence of cytomegalovirus (CMV) in a fetal sample by determining the presence of anti-hsp70 antibodies present in the fetal sample. The...
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6827938 |
Compositions and methods for improving kidney function
Materials and methods for improving kidney function or enhancing proliferation or survival of kidney tubule epithelial cells or epithelial cell precursors in a mammal are disclosed. The methods...
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6818220 |
Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof
Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such...
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6818217 |
Immunoreactive peptides
The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with antibodies or T-cells in subjects having pre-clinical or...
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6812327 |
Neutrokine-alpha polypeptides
The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In...
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6805865 |
Compositions and methods for treating cancer and hyperproliferative disorders
Compositions and methods effective for eliciting an immune response for inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related...
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6800604 |
Polypeptides that inhibit human serum-induced cleavage of hepatocyte growth factor
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or...
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6797271 |
Methods for enhancing immune responses by fibroblast growth factor receptor 5 polypeptides
Isolated polynucleotides and polypeptides derived from mammalian fsn -/-lymph node stromal cells are provided, together with expression vectors and host cells comprising such isolated...
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6790824 |
Cytokines having neurotrophic activity
The present invention relates to a pharmaceutical composition having neurotrophic activity, comprising a biologically active amount of at least two cytokines, wherein at least one of said cytokines...
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6790825 |
Method of using secretin and compositions made therefrom for the treatment of autism and other neurological, behavioral and immunological disorders
Secretin and secretin compositions are used for the treatment of autism and other neurological, behavioral and immunological disorders. The method includes administering an effective amount of...
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6790942 |
Biologically active conjugates having a detectable reporter moiety and method of identification of the derivative
Biologically active drug polymer derivatives, namely peptides or protein derivatives, are useful medicaments and are represented by the generic formula: RO—(CH 2 —CH 2 O) n...
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6790838 |
Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
Combinations and methods for inducing a semi-synchronous wave of liver cell proliferation in vivo and combinations and methods for inducing a semi-synchronous wave of liver cell proliferation and...
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6780969 |
Synthetic peptide composition as immunogens for prevention of urinary tract infection
The invention provides a peptide immunogen comprising a FAFSD target peptide or an anlogue thereof, covalently linked to a helper T cell epitope and optionally to an invasin immunostimulatory...
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6776984 |
Induced regeneration and repair of damaged neurons and nerve axon myelin
A method of treatment of and composition for human degenerative neurologic diseases discloses the administration of therapeutically amounts of an enhancement agent, such as thrombopoietin, to...
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6770460 |
Fusion protein and its use in an immunoassay for the simultaneous detection of autoantibodies related to insulin-dependent diabetes mellitus
The invention relates to a fusion protein having epitopes of at least two of the autoantigens glutamic acid decarboxylase (GAD65), islet cell antigen (IA2) and preproinsulin (PPINS) wherenin said...
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6753419 |
DNA molecules encoding hormone-dependent forms of the adeno-associated virus rep proteins
The subject matters of this invention are the hormone-dependent forms of Rep 78 and Rep 68 proteins of the Adeno-associated virus (AAV), obtained by the fusion of their specific mutants with the...
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6749846 |
Interferon-beta use in the treatment of ewing's family of tumors
The invention relates to the use of interferon-beta for the treatment of Ewing's family of tumors in mammals. A method for treating Ewing's family of tumors in a mammal comprising administering to...
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6746670 |
Regulatory T cells; methods
Methods for increasing yields of Tr1 cells, useful, e.g., in transplantation contexts. Use of interferon and IL-15 are described.
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6743429 |
Use of calcitonin gene-related peptide in the prevention and alleviation of asthma and related bronchospastic pulmonary diseases
The present invention relates to the use of calcitonin gene-related peptide (CGRP) in the prevention and alleviation of asthmatic symptoms. In contrast to other therapeutic agents now in use, CGRP...
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6740739 |
Substitutional variants of APO-2 ligand
A novel cytokine, designated Apo-2 ligand, which induces mammalian cancer cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including...
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6740794 |
Methods of isolating the androgenic sex hormone from crustacean prawn and marine shrimp and methods of use
This work constitutes a novel approach and methodology, e.g., the in vitro secretion method to isolate the androgenic polypeptide hormone (AH) from the androgenic gland of shrimp or prawns....
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6730303 |
Fused G-CSF and IL-3 proteins and uses thereof
Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional...
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6723702 |
Use of relaxin treat diseases related to vasoconstriction
The invention related to methods of treating disease related to vasoconstriction that is a major factor in hypertensive vascular diseases and vasodilation, generally comprising administering to an...
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6719977 |
Methods to potentiate cancer therapies
Disclosed are methods for potentiating the anti-cancer properties of an anti-cancer therapy in a mammal by administering with the therapy a compound (such as relaxin or γ-IFN) that has a tissue...
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6716428 |
Antigenic modification of polypeptides
Endogenous protein hormones, fragments thereof including epitopes, and synthetic peptides mimicking epitope regions of hormones such as human chorionic gonadotropin can be conjugated to a foreign...
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6713065 |
Methods of using hedgehog proteins to modulate hematopoiesis and vascular growth
This application pertains to methods and compositions that modulate proliferation and/or differentiation of undifferentiated mesodermally-derived cells so as to have an effect on at least one of...
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6709658 |
Pneumococcal vaccines formulated with interleukin-12
This invention pertains to vaccine compositions comprising a mixture of antigen, such as a pneumococcal or meningococcal antigen, and interleukin IL-12, which may be adsorbed onto a mineral in...
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6706683 |
Method for controlling the release of granules
A method of controlling granule secretion comprising performing a treatment to increase or decrease an active form of calgranulin on a cell line having capability of secreting granules, thereby...
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6699656 |
Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
The present invention relates to β-hCG, particularly β-hCG proteins having a sequence of amino acids 41-54, 45-54, 47-53, 45-57 and 45-58 and analogs and derivatives thereof. The invention...
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6696063 |
Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
Pathological regional adipose tissue accumulation associated with HIV-associated dysmorphic/dysmetabolic syndrome (HADDS) which may occur with or without subcutaneous adipose tissue lipodystrophy...
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6693082 |
Method of inhibiting metastatic dissemination using desmopressin
The present invention relates to the use of 1-deamino-8-D-arginine vasopressin (desmopressin), or a pharmaceutically acceptable salt thereof or a pharmaceutical composition containing any of them,...
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