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7384639 |
Methods of treating or preventing an infectious disease using an immunogenic conjugate of a gram-negative bacterial autoinducer molecule
The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria The immunogenic conjugate, when combined with a...
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7364740 |
Molecular differences between species of the M. tuberculosis complex
Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared...
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7329409 |
Compositions and methods for treatment of microbial infections
The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an...
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7323175 |
Immunogenicity of glucan binding protein
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7279169 |
Mucosal DTPa vaccines
Mucosal DTPa vaccines, especially intranasal vaccines, comprising (a) a diphtheria antigen, a tetanus antigen and an acellular pertussis antigen, and (b) a detoxified mutant of cholera toxin (CT)...
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7258863 |
Heterologous protection induced by immunization with invaplex vaccine
In this application is described a composition, Invaplex, derived from a gram negative bacteria for use in generating an immune response in a subject against one or more heterologous species or...
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7255867 |
Vaccine
Effective stimulation of immune responses is achieved through the use of a group A streptococcal antigen combined with proteosome adjuvant. The compositions are provided in particular for...
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7235243 |
Immunological combination compositions and methods
Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself...
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7235242 |
IgA1 protease fragment as carrier peptides
The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO:1,...
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7229622 |
Synthetic chimeric fimbrin peptides
The present invention provides synthetic chimeric fimbrin peptides which induce an immunogenic response in animals to non-typable Haemophilus influenzae and that do not require tedious...
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7226603 |
HBV core antigen particles with multiple immunogenic components attached via peptide ligands
This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core...
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7226601 |
Conjugate between a modified superantigen and a target-seeking compound and the use of the conjugate
A method for the treatment of a disease in a mammal by administering a therapeutically effective amount of a conjugate comprising a biospecific affinity counterpart and a peptide, wherein the...
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7220415 |
Vaccine composition
A polypeptide is described herein which comprises (a) the sequence of SEQ ID No. 2, (b) a variant of (a) which is capable of generating a protective immune response to S. pyogenes , or (c) a...
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7217791 |
Compositions and methods for treating or preventing pneumococcal infection
The invention provides polypeptides, polysaccharide-polypeptide conjugates, and expression vectors for treating or preventing pneumococcal infection. The compositions induce an anti-pneumococcal...
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7186411 |
Vaccines absorbable by the transmucosal way
The main object of the present invention is to provide polysaccharide-coated antigens derivatised with lectins for pharmaceutical use. In the vaccines, polysaccharides are preferably selected from...
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7176178 |
Nuclear targeting by means of bacterial proteins
A nuclear delivery construct comprises (i) protein H or a fragment or derivative thereof that is capable of being targeted to the nucleus of a eukaryotic cell; and associated therewith (ii) one or...
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7169392 |
Neisseria meningitidis serogroup B glycoconjugates and methods of producing the same
The present invention pertains generally to novel Neisseria meningitidis serogroup B glycoconjugates. More particularly, the invention pertains to glycoconjugates formed from a Neisseria...
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7163682 |
Glucan binding protein and glucosyltransferase immunogens
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7122191 |
Microfluidized oil-in-water emulsions and vaccine compositions
This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions...
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7118757 |
Meningococcal class 1 outer-membrane protein vaccine
Outer-membrane vesicles, Class 1 outer membrane proteins of Neisseria meningitidis , fragments or oligopeptides containing epitopes of the Class I OMP can be used to immunize against meningococcal...
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7112332 |
Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides
An immunogenic complex, essentially consisting of neisserial outer membrane protein proteosomes hydrophobically complexed to native purified bacterial lipopolysaccaride and formulated in accordance...
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7105162 |
Pharmaceutical composition for immunomodulation based on peptides and adjuvants
Pharmaceutical composition containing at least one peptide or protein (fragment) with an immunomodulatory activity together with an adjuvant. The peptide is derived from a pathogenic agent or a...
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7101562 |
Conjugate vaccines for the prevention of dental caries
The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and...
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7101555 |
Mycobacterial proteins, microorganisms producing them and their use for vaccines and the detection of tuberculosis
Mycobacterium tuberculosis protein having a molecular weight of 28 779 Da, and hybrid proteins containing at least portions of its sequence. These proteins may in particular be used in vaccines...
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7098303 |
Conserved motif of hepatitis C virus E2/NS1 region
Immunogenic polypeptides comprising hepatitis C virus (HCV) immunogens are described. The HCV immunogen comprises the amino acid sequence...
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7097965 |
Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein
The present invention provides a vaccine for inducing an immune response in mammal to a specific antigen, where the vaccine comprises a unit dose of a binary toxin protective antigen and the...
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7074407 |
Method for increasing HDL cholesterol level
The present invention provides a method for increasing HDL cholesterol in a mammal by stimulating an immune response that inhibits the function of CETP. Such an immune response can be induced by...
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7063852 |
Hybrid LT-A/CT-B holotoxin for use as an adjuvant
The present invention provides a novel composition which is a hybrid heat labile enterotoxin comprising the A-subunit of the heat labile toxin of Escherichia coli (LT-A) and the B-subunit of the...
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7056517 |
Glucosyltransferase immunogens
Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a...
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7056510 |
Streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines
The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneunoniae. The invention further relates to isolated nucleic acid molecules...
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7018637 |
Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
Multivalent immunogenic molecules comprise a carrier molecule containing at least one functional T-cell epitope and multiple different carbohydrate fragments each linker to the carrier molecule and...
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7014857 |
Anti-sepsis conjugate vaccine
The present invention provides an immunogenic conjugate comprising biologically deacylated gram-negative bacterial moieties linked to D. discoideum proteinase 1, as well as novel subunits...
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7005129 |
Non-toxic mutants of pathogenic gram-negative bacteria
A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen...
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6962694 |
Cytolysis of target cells by superantigen conjugates inducing T-cell activation
A method for inactivating target cells in the presence of T cells by bringing the two types of cells in contact with a superantigen (SAG) in the presence of an immune modulator, characterized in...
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6936707 |
Modified DNA molecule, recombinant containing the same, and uses thereof
There is provided a DNA molecule derived from a prokaryotic cell in which at least one of the DNA regions encoding NXB (N is asparagine, X is any amino acid other than proline, and B is serine or...
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6936263 |
Th1 inducing natural adjuvant for heterologous antigens
The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates...
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6936258 |
Staphylococcus antigen and vaccine
A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of ...
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6921538 |
Therapeutic treatments for neuropsychiatric disorders
Methods for treating psychiatric disorders include intracranial administration of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A, to a human patient.
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6919079 |
FcεPE chimeric protein for targeted treatment of allergy responses, a method for its production and pharmaceutical compositions containing the same
The present invention generally relates to a new approach for the therapy of allergic responses, based on targeted elimination of cells expressing the FcεRI receptor by a chimeric cytotoxin Fc...
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6916478 |
Vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same
The invention relates to novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, methods for preparing same, and their use in the prevention and treatment of...
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6843998 |
Methods and compositions for the treatment of pancreatitis
Methods and compositions for the treatment of acute pancreatitis in a mammal. Particular compositions comprise a binding element, a translocation element, and a therapeutic element able to prevent...
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6827937 |
HBV capsid-binding peptide immunogens
This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core...
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6827936 |
Synthetic peptide vaccines for dental caries
Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a...
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6822075 |
Protein L and hybrid proteins thereof
The invention relates to sequences of protein L which bind to light chains of immunoglobulins. The invention also relates to hybrid proteins thereof which are able to bind to both light and heavy...
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6814971 |
Adjuvants for use in vaccines
The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local...
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6803042 |
Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides
An immunogenic complex, essentially consisting of neisserial outer membrane protein proteosomes hydrophobically complexed to native purified bacterial lipopolysaccharide and formulated in...
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6794368 |
Composition and method for inducing apoptosis in prostate cancer cells
The present invention relates to a composition and method useful for regulating cell proliferation and cell death in a multicellular organism. The present invention particularly relates to a...
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6793928 |
Vaccines with an LTB adjuvant
The present invention relates to a vaccine containing at least one particulate immunogen and an adjuvanting amount of B subunits of heat-labile enterotoxin characteristic of E. Coli . More in...
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6783764 |
Actinobacillus pleuropneumoniae subunit vaccine
The present invention relates to live attenuated bacteria of the genus Actinobacillus pleuropneumoniae that have a mutation in an apxIV gene such that no functional ApxIV toxin can be produced....
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6773707 |
Heat shock protein-based vaccines and immunotherapies
The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to...
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