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7381524 |
Method to detect antibodies specific for type-2 turkey astrovirus
A serological method to detect exposure to turkey astrovirus-2 (TAsV-2) is provided.
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7320793 |
Molecular antigen array
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7318926 |
Glycosylated specificity exchangers
The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and...
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7314627 |
Cationic lipid-mediated enhancement of nucleic acid immunization of cats
The present invention relates to a method to introduce a nucleic acid molecule into a felid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of...
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7311916 |
Methods of eliciting broadly neutralizing antibodies targeting HIV-1 gp41
The present invention is directed to the induction and characterization of a humoral immune response targeting “entry-relevant” gp41 structures. In its broadest aspect, the present invention is...
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7311915 |
Method of producing an HIV-1 immune response
The present invention comprises novel and modified peptides capable of inducing an HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
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7229624 |
Ordered molecular presentation of antigens, method of preparation and use
The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the...
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7226603 |
HBV core antigen particles with multiple immunogenic components attached via peptide ligands
This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core...
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7189403 |
Attenuated flavivirus strains containing a mutated M-ectodomain and their applications
The present invention relates to nine residue peptides (ApoptoM) from flavivirus M ectodomain able to modulate specifically the apoptotic activity of diverse flavivirus, to pharmaceutical...
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7151163 |
Antiviral agents for the treatment, control and prevention of infections by coronaviruses
The invention provides compositions and methods that are useful for preventing and treating a coronavirus infection in a subject. More specifically, the invention provides peptides and conjugates...
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7135185 |
Conserved motif of hepatitis C virus E2/NS1 region
Immunogenic compositions comprising an immunogenic polypeptide and a pharmaceutically acceptable vehicle are described. The immunogenic polypeptide comprises the amino acid sequence...
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7122191 |
Microfluidized oil-in-water emulsions and vaccine compositions
This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions...
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7105162 |
Pharmaceutical composition for immunomodulation based on peptides and adjuvants
Pharmaceutical composition containing at least one peptide or protein (fragment) with an immunomodulatory activity together with an adjuvant. The peptide is derived from a pathogenic agent or a...
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7101552 |
Immunogen comprising an HIV envelope protein, a ligand and H2 peptide
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also...
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7098303 |
Conserved motif of hepatitis C virus E2/NS1 region
Immunogenic polypeptides comprising hepatitis C virus (HCV) immunogens are described. The HCV immunogen comprises the amino acid sequence...
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7097971 |
HIV-1 peptide, antigen, immunogenic composition, diagnostic method and immunoassay kit
The present invention comprises novel and modified peptides capable of inducing a HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
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7094409 |
Antigen arrays for treatment of allergic eosinophilic diseases
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7094401 |
HCV core protein binding agents for treatment of hepatitis C virus infection
The present invention provides a method of treating or preventing hepatitis C virus infection in a subject which comprises administering an effective amount of an agent to the subject, wherein the...
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7070787 |
Method of inducing the production of antibodies to HIV
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also...
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7060283 |
Immunoreactive peptides from Epstein-Barr virus
Epstein-Barr virus (EBV) specific polypeptides consisting of a series of one to 1000 peptide units selected from the group consisting of peptide units Φ, Γ, Δ and Ω, wherein Φ is 25 amino...
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7056519 |
Methods for inducing HIV-neutralizing antibodies
The present invention relates to a method for inducing antibodies neutralizing HIV primary isolates in a mammal, comprising administration of a pharmaceutical composition comprising a polypeptide...
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7052696 |
Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
Antigenic epitopes of hepatitis C virus (HCV) and mosaic HCV polypeptides useful as reagents in assays for the diagnosis or monitoring of HCV in a biological sample. The antigenic epitopes and...
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7048930 |
Expression of core-glycosylated HCV envelope proteins in yeast
The present invention relates to the general field of recombinant protein expression, purification of recombinant proteins, diagnosis of HCV infection, prophylactic treatment against HCV infection...
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7029682 |
Inactivated vaccine against feline calicivirosis
Immunogenic preparations and vaccines, in particular which are inactivated, effective against feline calicivirosis, based on an FCV virus strain 431 as deposited at the CNCM under the accession...
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7029680 |
Delivery of immunogenic molecules vis HBsAg particles
Compositions of HBsAg particles having biologically active molecules contained in the particles, and methods of their use, e.g. in stimulating enhanced immune responses, are described. Antigenic...
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6974574 |
Methods of inducing an HIV specific response using a Vpr-specific epitope
The invention features an immunogenic composition containing a frequently-recognized epitope of an HIV-1 accessory protein such as Vpr and methods of inducing an immune response using such an...
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6964769 |
Molecular antigen array
The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the...
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6951647 |
T cell binding ligand peptides and method of inducing a cellular immune response
The present invention is based, in part, on the discovery that a modified version of Peptide G (Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile—SEQ ID NO:2) obtained by replacing Asn...
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6942865 |
Methods and reagents to detect and characterize norwalk and related viruses
Double-stranded cDNA was synthesized from nucleic acid extracted from Norwalk virus purified from stool specimens of volunteers. One clone was isolated from a cDNA library constructed in a pUC-13...
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6936707 |
Modified DNA molecule, recombinant containing the same, and uses thereof
There is provided a DNA molecule derived from a prokaryotic cell in which at least one of the DNA regions encoding NXB (N is asparagine, X is any amino acid other than proline, and B is serine or...
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6827937 |
HBV capsid-binding peptide immunogens
This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core...
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6780420 |
Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine
The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40...
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6773707 |
Heat shock protein-based vaccines and immunotherapies
The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to...
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6756040 |
Vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminum phosphate
The invention relates to a vaccine formulation for the prevention of Haemophilus Influenzae Type B (Hib) infections and where the antigen is adsorbed onto aluminum phosphate. The invention also...
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6713070 |
Viral particles which are released after the infection with the human cytomegalovirus, and the use of said particles as a vaccine
The invention relates to viral particles which are released by mammal cells after the infection with human cytomegalovirus (HCMV). The invention also relates to particles whose antigenicity has...
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6676946 |
Multiple antigen glycopeptide carbohydrate vaccine comprising the same and use thereof
A carbohydrate peptide conjugate containing: (i) a carrier containing a dendrimeric poly-lysine enabling multiple epitopes to be covalently attached thereto, (ii) at least one peptide containing...
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6645501 |
Anti-pathogen system and methods of use thereof
The present invention provides an anti-pathogen system comprising one or more fusion proteins that includes a transduction domain and a cytotoxic domain. The cytotoxic domain is specifically...
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6596278 |
Immunological response potentiation process
An immunological response potentiation process is disclosed for synthetic or genetically engineered antigens having low immunogenicity. The antigen is embedded into biodegradable microparticles,...
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6585981 |
Temperature-sensitive live vaccine for Mycoplasma hyopneumoniae
The present invention provides a live temperature-sensitive vaccine for Mycoplasma hyopneumoniae . The present invention also provides methods of vaccinating a swine against colonization or...
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6585973 |
Method for preparing solid phase conjugated vaccine
A method of preparing conjugate vaccines by adsorbing a protein to a solid phase adjuvant, and covalently linking a carbohydrate to the adsorbed protein. Alternatively, the carbohydrate is first...
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6572860 |
Immunogenic conjugated polypeptide for treatment of herpes simplex virus
Peptide constructs chemically synthesized to contain a Herpes Simplex Virus specific antigenic peptide, such as, the 322-332 peptide (H1) from the ICP27 protein of Herpes Simplex Virus (HSV-1) and...
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6558673 |
Complexes of immunogens derived from RSV surface glycoprotein G covalently coupled to a support molecule
A complex of an immunogen and a support molecule, characterized in that the immunogen is coupled covalently to a support molecule, wherein the support molecule is a polypeptide fragment which is...
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6524586 |
Enhancement of oligomeric viral immunogenicity
A method and structure for forming a viral-physiological structure. A naked virus having a capsid is provided. A linker molecule having a covalently attached polymer is covalently bonded to the...
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6461615 |
Therapeutic and prophylactic methods using heat shock proteins
The present invention relates to immunogenic complexes of heat shock proteins (hsp) noncovalently bound to exogenous antigenic molecules which when administered to an individual elicit specific...
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6455050 |
Production of virus and purfication of viral envelope proteins for vaccine use
Immunogenic envelope glycoproteins are produced from enveloped virus, such as of the paramyxoviridae family, particularly PIV-3 and RSV, by culturing the virus in the substantial absence of...
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6451320 |
Combined hepatitis and herpesvirus antigen compositions
Novel combined vaccine compositions preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in...
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6448070 |
Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid
A fusion capsid protein comprising a plant virus capsid protein fused to an antigenic polypeptide is used as a molecule for presentation of that polypeptide to the immune system of an animal such...
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6403092 |
Immune response modulator alpha-2 macroglobulin complex
Activation of α 2 -macroglobulin (α 2 M) with a nucleophilic compound followed by incubation of the activated α 2 M at elevated temperature with a biomolecule results in covalent incorporation...
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6399070 |
Methods and compositions for eliciting an immune response with hsp90-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6399069 |
Prevention of infectious diseases with hsp70-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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