Matches 101 - 150 out of 186 < 1 2 3 4 >
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6168793 Heat shock protein 70 preparations in vaccination against cancer and infectious disease  
The present invention relates to compositions comprising a population of non-covalent heat shock protein 70-peptide complexes purified from mammalian tumor tissues or mammalian cells infected with...
6149911 Method for enhancing the immunogenicity of an immunogenic compound or hapten, and use thereof for preparing vaccines  
The present invention relates to a process for improving the immunogenicity of an immunogen, an antigen or a hapten, when it is administered to a host, independently of the mode of administration,...
6139843 Peptide compositions for the treatment of HIV  
The present invention provides for peptide conjugate compositions, methods of using the peptide conjugate compositions, and pharmaceutical compositions comprising the peptide conjugate...
6136319 Method of treating viral diseases in animals  
A method of producing active immunity against a viral disease in an animal subject comprises administering to the subject a vaccine conjugate consisting essentially of a live virus and a...
6132723 Immunogenic oligosaccharide compositions  
The invention provides immunogenic oligosaccharide compositions and methods of making and using them. In particular, the compositions comprise oligosaccharides covalently coupled to carrier...
6129921 Viral ribonucleocapsid as an immunological enhancer  
Methods of enhancing an antigen-induced immune response through use of a ribonucleocapsid complex are provided. Composition containing a ribonucleocapsid complex and an antigen which are capable of...
6106836 Container with freeze-dried vaccine components  
The present invention relates to a vaccine container that contains one or more freeze-dried vaccine components. The vaccine component or components are present in two or more freeze-dried bodies,...
6096321 ClpG subunit of CS31A protein capsule containing heterologous peptides  
6090390 Diagnostic test for equine arteritis virus mediated disease  
This invention relates to recombinant DNA and polypeptides encoded thereby which have use in the provision of vaccines, diagnostic test kits and methods of diagnosis and treatment or prophylaxis...
6090406 Potentiation of immune responses with liposomal adjuvants  
A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with said liposome, adapted for parenteral administration to an animal,...
6086881 Spatially aligned conjugated composition having a thioether bond linkage  
The present invention is a spatially aligned conjugated composition which comprises at least one chemically modified substance which is immunologically representative of a prechosen infectious...
6086880 Rotavirus peptide compositions and methods of use  
A number of subunits of various rotaviral proteins have been shown to be useful in diagnosis, therapy, and prevention of rotaviral infection. Specifically, the subunits represented by positions...
6083505 1H-imidazo[4,5-C]quinolin-4-amines as vaccine adjuvants  
An immunogen/vaccine adjuvant composition containing an immunogen in an amount effective to stimulate an immune response and as a vaccine adjuvant a 1H-imidazo[4,5-c]quinolin-4-amine in an amount...
6063380 Enhanced immunogenic vaccine  
Vaccines, composed of antigens absorbed on alum or formulated in an alum-containing composition, have enhanced immunogenicity over existing vaccines. The vaccines of the invention are characterized...
6033668 Chimeric protein which confers protection against parainfluenza virus and respiratory syncytial virus  
Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for...
6017537 Formyl methionyl peptide vaccine adjuvant  
The present invention relates to immunological adjuvants comprised of the N-formyl methionyl peptide fMLP. FMLP, when used as an adjuvant in accordance with the present invention, provides for an...
5997873 Method of preparation of heat shock protein 70-peptide complexes  
The present invention relates to methods of preparing a purified non-covalent heat shock protein 70-peptide complex capable of eliciting an immune response in a mammal comprising purifying heat...
5993852 Biphasic lipid vesicle composition for transdermal administration of an immunogen  
A composition for transdermal administration of an immunogen is described. The immunogen is entrapped in lipid vesicles having a oil-in-water emulsion in the central core compartment. The vesicles...
5976538 Adjuvant composition containing synthetic hydrophobic lipopolysaccharide  
According to the present invention the adjuvants comprise an emulsion containing at least one synthetic hydrophobic lipopolysaccharide, which can either or not be provided with anionic groups,...
5965139 Chicken infectious anemia virus vaccine  
Novel sequences in the genome of a wild type isolate of chicken infectious anemia virus are described, The amino acid sequence of a polypeptide, VP1, encoded by a novel sequence is also disclosed....
5965714 Method for the covalent attachment of polysaccharides to protein molecules  
Disclosed and claimed are a method for the covalent attachment of poly- and oligosaccharides to protein molecules via hydrogen peroxide depolymerization of the polysaccharide units, followed by...
5928647 Inducing cytotoxic T lymphocyte responses  
The invention provides compositions and methods for inducing MHC class I-restricted cytotoxic T lymphocyte responses in a mammalian host by immunization with non-replicating protein antigens. The...
5882649 Oral vaccine comprising antigen surface-associated with red blood cells  
Red blood cells or derivatives thereof such as ghost preparations, whole cell membrane preparations or fragments thereof, can act as a potent carrier for orally administered antigens. Mucosal...
5858368 Vaccine comprising a baculovirus produced influenza hemagglutinin protein fused to a second protein  
A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of...
5849301 Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents  
The invention relates to a process for producing an immunogenic construct comprising activating at least one first carbohydrate-containing moiety with CDAP, CTEA or pNPC, and covalently joining the...
5843454 HIV immunogenic complexes  
A vaccine and a method of raising neutralizing antibodies against HIV infection. The vaccine comprises a complex of gp120 covalently bonded to CD4 or to succinyl concanvalin A. Also disclosed are...
5840305 Treatment of HIV-Infection by interfering with host cell cyclophilin receptor activity  
The present invention relates to therapeutic modalities and pharmaceutical compositions for the treatment of HIV-infection using cyclophilin A and its corresponding human cellular binding partner...
5837249 Method for generating an immunogenic T cell response protective against a virus  
A novel method of presenting an immunogenic peptide to an antigen presenting cell (APC) of a mammalian host, in order to generate a T cell response protective against a virus, such as herpes or...
5824310 Lipopplysaccharide conjugate vaccines  
The present invention relates to lipopolysaccharides from Brucella abortus and their use as carriers in vaccines for humans and animals. In particular, the present invention relates to conjugate...
5817315 Recombinant vaccine  
A method for an induction of immune response against polypeptide employing antigenic presentation of said polypeptide in the form of either fusion protein with MHC product amino acid sequence or...
5807553 Immonogenic oligosaccharide compositions  
The invention provides immunogenic oligosaccharide compositions and methods of making and using them. In particular, the compositions comprise oligosaccharides covalently coupled to carrier...
5785973 Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines  
The present invention relates to novel T-cell epitopes of bacterial products. The epitopes of the invention may be employed in the preparation of conjugates between the epitopes and medically...
5756104 Liposome-containing intranasal vaccine formulation  
The present invention relates to a vaccine formulation for intranasal or inhalation administration, and to the preparation thereof, which formulation contains antigenic material freely mixed with...
5695757 Methods for treating post-exposure rabies and anti-rabies compositions  
Pharmaceutical compositions that comprise a pharmaceutically acceptable carrier or diluent and a antibodies that each comprise at least a portion of the variable region from MAb 1112-1 are...
5695762 Immunodominant sites of HTLV-I envelope protein  
The invention resides in various peptides derived from the envelope glycoprotein of HTLV-1 and conjugates of the peptides. Compositions including the peptides are also included in the invention....
5693325 Peptide vaccines and methods relating thereto  
There are disclosed peptide vaccines and methods related thereto for generating a protective immune response in warm-blooded animals. The peptide vaccines comprise a conformationally constrained...
5679774 DNA sequences of the EBV genome, recombinant DNA molecules, processes for preparing EBV-related antigens, diagnostic compositions and pharmaceutical compositions containing said antigens  
DNA sequences of the EBV genome coding for EBV-related antigens as well as the EBV-related antigens, fusion proteins containing the EBV-related antigens, recombinant DNA molecules containing the...
5612037 Influenza virus subunit conjugates  
Conjugates of HA protein of influenza virus suitable for formulation as a vaccine for obtaining a strong immune response to the HA protein are formed by separating whole HA protein from the...
5580563 Multiple antigen peptide system having adjuvant properties, vaccines prepared therefrom and methods of use thereof  
A multiple antigenic peptide system is disclosed that comprises a dendritic core and peptide and a lipophilic anchoring moiety. This particular combination has as an advantage that it eliminates...
5503833 VP6 encapsulated drug delivery  
Compositions and methods for preparing and delivering encapsulated biologically active agents to specific cell types are disclosed. Substances can be encapsulated in the VP6 inner capsid protein of...
5480966 Peptides derived from the envelope glycoprotein of HIV viruses, their applications to the detection of infection caused by these viruses and to the vaccination against AIDS  
Peptides are derived from the envelope glycoprotein of HIV virus and having one of the following formulae ##STR1## in which X represents an NH 2 group which is free or converted into an amide by...
5409703 Dried hydrogel from hydrophilic-hygroscopic polymer  
A therapeutic medical device is described that is comprised of a dried hydrogel of a hydrophilic-hygroscopic polymer, such as an unmodified or modified polymeric carbohydrate, in the form of a...
5254339 Process for preparing immune complexes  
A process is provided for preparing an immunogenic complex containing antigenic proteins and peptides with hydrophobic domains, whereby proteins or peptides from viruses, mycoplasmas, bacteria,...
5229490 Multiple antigen peptide system  
Multiple antigen peptide systems are described in which a large number of antigens are bound to the functional groups of a dendritic core molecule providing a high concentration of antigen in a low...
5219577 Biologically active composition having a nanocrystalline core  
A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically...
5198536 Peptides comprising an immunogenic site of poliovirus and DNAs containing nucleotide sequences coding for these peptides  
The invention relates to a DNA fragment containing at the most 315 pairs of nucleotides coding for a peptide which can be recognized by antibodies acting both against the "C" and "D" particles of...
5153311 Immunogenic glycoproteins of human cytomegalovirus gCII  
Substantially-pure immunogenic glycoprotein complexes of the gCII family, and constituent glycoproteins which can be derived from the membrane envelope of human cytomegalovirus are provided.
5149529 Compositions and treatment for herpes simplex  
A method for preventing or ameliorating HSV infection in a bird or mammal comprises administering a composition comprising an effective amount of an HSV surface glycoprotein and an effective amount...
5143726 T cell epitopes of the hepatitis B virus nucleocapsid protein  
Polypeptides corresponding in amino acid residue sequence to T cell stimulating regions of the HBV nucleocapsid protein are disclosed. A method of enhancing the immunogenicity of a polypeptide...
5110794 Method of immunization with partially cationized substances and said partially cationized substances  
A partially cationized protein-containing substance that exhibits enhanced immunogenicity as compared to the native protein-containing substance and is useful in mammalian immunization by oral or...
Matches 101 - 150 out of 186 < 1 2 3 4 >