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6146633 |
Method for treatment of antigenically modified polypeptides
Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the...
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6143305 |
Antigenically modified polypeptides composition
Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the...
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6113900 |
Use of IL-2 receptor-targeted therapeutics to inhibit allograft rejection and treat autoimmune disorders
Methods of inhibiting allograft rejection and of inhibiting B lymphocyte-mediated autoimmune diseases are provided. The methods involve the use of agents specific for the IL-2 receptor, such as...
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6106832 |
Treatment of individuals exhibiting defective CD40L
There is disclosed a method of detecting a mutation in a CD40 ligand gene, comprising isolating nucleic acid from an individual, selectively amplifying nucleic acid derived from the CD40 ligand...
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6103243 |
Oral vaccines
The present invention relates to the specific stimulation of serum and secretory antibodies through mucosal presentation of antigens.
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6099846 |
Enhancement of B cell lymphoma and tumor resistance using idiotype/cytokine conjugates
B cell lymphoma tumor-associated antigen or a fragment thereof containing an epitope are linked to an immune-enhancing cytokine, such as GM-CSF, IL-2, or IL-4 to form an immuno-complex. This...
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6096320 |
Vaccines with chimeric protein comprising gamma-interferon and leukotoxin derived from pasteurella haemolytica
New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are...
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6096318 |
Antigenically modified HCG polypeptides
Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the...
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6080390 |
Moisturizing cosmetic stick compositions
A pigmented cosmetic stick composition comprising, by weight of the total composition: 1-40% of a volatile nonaqueous solvent having a viscosity of 0.5 to 5 centipoise at 25° C., 20-80% of a...
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6080409 |
Immunostimulatory method
Disclosed are therapeutic compositions and methods for inducing cytotoxic T cell responses in vitro and in vivo. The therapeutic compositions consist of antigen presenting cells activated by...
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6034053 |
EGF-isoflavone conjugates for the prevention of restenosis
A protein conjugate containing EGF coupled to a tyrosine kinase inhibitor such as Genistein, for inhibiting or preventing restenosis following vascular injury.
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6025325 |
Pegylated obese (ob) protein compositions
Polyethylene and polypropylene protein conjugates which modulate body weight of animals and humans for the treatment, prevention and control of obesity and associated diseases or conditions, and...
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6025324 |
Pegylated obese (ob) protein compositions
Polyethylene and polypropylene protein conjugates which modulate body weight of ani is and humans for the treatment, prevention and control obesity and associated diseases or conditions, and the...
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6019983 |
Carrier system against GnRH
The present invention is concerned with vaccination of mammals against GnRH. The vaccine comprises a GnRH peptide conjugate to E. coli fimbrial-filaments and elicits an immune response against GnRH.
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6017544 |
Composition comprising immunogenic stress protein-peptide complexes against cancer and a cytokine
Disclosed is a method for inhibiting the proliferation of a tumor in a mammal. The method involves the steps of (a) isolating a stress protein-peptide complex from tumor cells previously removed...
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5997873 |
Method of preparation of heat shock protein 70-peptide complexes
The present invention relates to methods of preparing a purified non-covalent heat shock protein 70-peptide complex capable of eliciting an immune response in a mammal comprising purifying heat...
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5993820 |
Chimeric LTB vaccines
A chimeric protein formed of a small peptide antigen inserted into an exposed surface region of the B subunit of heat-labile enterotoxin of E. coli useful as an immunogenic vaccine composition.
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5976546 |
Immunostimulatory compositions
Disclosed are therapeutic compositions and methods for inducing cytotoxic T cell responses in vitro and in vivo. The therapeutic compositions consist of antigen presenting cells activated by...
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5972387 |
Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
Modified hydrolyzed vegetable protein microspheres and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described.
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5942229 |
Method for prolonged suppression of humoral immune response to a thymus-dependent antigen therapeutic agent
Methods of suppressing a humoral immune response to a thymus-dependent (TD) antigen are disclosed. The methods involve administering to a subject a TD antigen with an antagonist of a molecule which...
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5928644 |
T-cell epitopes
T-cell epitopes of or derived from the TraT protein of E. coli have been identified and used in the preparation of complexes with immunogens to enhance or provide immune responses to the...
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5919459 |
Compositions and methods for treating cancer and hyperproliferative disorders
The present invention encompasses methods for reducing or inhibiting growth factor in cancer cells and tissues. More particularly immunogenic growth factor-containing compositions are administered...
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5916559 |
Use of interleukin-2 (IL-2) receptor-specific agents to treat allograft rejection
A method of lysing unwanted, non-malignant cells in a mammal, the cells having on their surfaces a receptor for a growth factor, and the method including administering to the mammal a cell-lysing...
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5911995 |
EGF-genistein conjugates for the treatment of cancer
A conjugate formed of epidermal growth factor covalently linked to a tyrosine kinase inhibitor, such as genistein, and a method for killing cancer cells, in vivo and in vitro, by administering a...
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5906820 |
Epidermal growth factor receptor targeted molecules for treatment of inflammatory arthritis
The invention features a method for treating a patient having inflammatory arthritis, the method includes administering to the patient a molecule which is capable of specifically binding to an...
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5897863 |
LHRH hormones
An analogue of lutenising hormone-releasing hormone (LHRH) having the amino acid sequence: pGlg-His-Trp-Ser-Tyr-X-Len-Arg-Pro-Gly-Y-Z wherein X represents Gly or a D-amino acid, Y represents one...
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5894018 |
Vaccine composition comprising autologous epidermal growth factor or a fragment or a derivative thereof having anti-tumor activity and use thereof in the therapy of malignant diseases
The invention provides novel uses of EGF and vaccine compositions comprising EGF. In particular, autologous EGF, or a fragment or a derivative thereof, is used as an active immunization against the...
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5879683 |
Antibacterial agent containing tea extract or active fraction thereof and β-lactam antibiotic
The invention provides a method of inhibiting production of bacteria which constitutively express PBP2' or bacteria which inducibly express PBP2' in the presence of a β-lactam antibiotic, by...
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5874402 |
Use of cell membrane permeants in the treatment of cellular proliferative diseases
Methods are provided for the treatment of a host suffering from a cellular proliferative disease through administration of a chemotherapeutic agent in conjunction with a cell membrane permeant....
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5874085 |
Vaccine for enhanced production of IgA antibodies
The invention describes compositions and methods for optimizing IgA class switching in B cells. The compositions comprise a multivalent antigen receptor crosslinker, CD40 ligand or...
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5866134 |
Method for enhancing the antibody response to specific antigens with Interleukin-10
A method for enhancing the immune response of a mammal to a vaccine comprising administering to such a mammal an effective amount of IL-10 in conjunction with the vaccine. A pharmaceutical...
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5846545 |
Targeted delivery of cyclopropylbenzindole-containing cytotoxic drugs
Gytotoxic agents containing a cell binding agent chemically linked to one or more analogue or derivative of CC-1065 are described. The therapeutic use of the cytotoxic agents is also described....
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5843446 |
Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
This invention relates to immunogenic luteinizing hormone releasing hormone (LHRH) peptides that lead to suppression of LHRH activity in males or females. These peptides are useful for inducing...
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5843453 |
Growth hormone potentiating molecules
Antigenic molecules cause antibodies to be raised against at least some of the 91 to 102 region of a natural growth hormone when parenterally administered in vivo. The molecules can include...
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5833985 |
Bispecific molecules for use in inducing antibody dependent effector cell-mediated cytotoxicity
Bispecific molecules comprising a non-immunoglobulin tumor cell specific ligand and an antibody which binds the Fc receptor of an effector cell at a site that is not inhibited by endogenous...
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5824315 |
Binding affinity of antigenic peptides for MHC molecules
This invention provides methods of improving the binding affinity of a peptide epitope for MHC Class II molecules by attaching to the N-terminus of the peptide epitope a hydrophobic amino acid or a...
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5817631 |
Therapeutic uses of melanin
The invention is directed to the treatment of degenerative diseases of tissues which have lost melanin and which share a common embryological basis as tissues of the nervous system by the...
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5814459 |
Phosphospecific transcription factor antibodies
Phospho-specific antibodies which recognize the phosphorylated forms of cAMP-responsive transcription factors are provided.
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5773006 |
Lipsome containing IL-2
The present invention provides a liposome comprising an effective immunoadjuvant amount of a lymphokine such as IL-2. Also provided is an effective antineoplastic amount of IL-2 liposomes in...
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5770704 |
Receptor activation with inactive hepatocyte growth factor ligands
The invention concerns a method for activating receptors selected from receptor tyrosine kinases, cytokine receptors and members of the nerve growth factor receptor superfamily. A conjugate...
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5763584 |
Receptor activation with hepatocyte growth factor agonists
The invention concerns a method for activating receptors selected from receptor tyrosine kinases, cytokine receptors and members of the nerve growth factor receptor superfamily. A conjugate...
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5738855 |
Synthesis of typhoid fever vaccine from a plant or fruit polysaccharide
The present invention is a modified plant, fruit or synthetic oligo- or polysaccharide which has been structurally altered so as to render the modified saccharide antigenically similar to the Vi of...
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5738849 |
Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF),...
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5728383 |
Treatment of tumors of the central nervous system with immunotoxins
Potent and specific immunotoxins are prepared by conjugation of moieties binding to receptors on the surface of tumor cells to a mutant diphtheria toxin having A-chain translocation activity, but...
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5725858 |
Methods of enhancing production performance of birds comprising administration of heterologous protein comprising avian alpha-subunit inhibin protein
The present invention relates, in general, to a method of enhancing the production performance of avians, by administering to a bird a heterologous protein comprised of inhibin protein, or a...
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5711942 |
Storage stable hair care emulsion containing only natural substances, their mixtures and/or their reaction products
The hair care emulsion of the invention contains from 0.5 to 5 percent by weight of a monoglyceride of a saturated or unsaturated C 6 - to C 22 -fatty acid, a polyglycerylmonofattyacid ester of a...
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5705606 |
Peptides derived from GPIIIa
The present invention provides oligopeptides corresponding to regions of the GPIIIa protein, which are capable of specifically binding aggregation mediators, such as fibrinogen. The oligopeptides...
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5674494 |
Treating non-malignant disease states with IL-2 receptor-specific substances
Methods of treating a non-malignant, disease state-producing immune response in a mammal are provided. The methods involve administering to the mammal an IL-2 receptor-specific substance during a...
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5650152 |
Liposome immunoadjuvants containing IL-2
The present invention provides a liposome comprising an effective immunoadjuvant amount of a lymphokine such as IL-2. Also provided is an effective antineoplastic amount of IL-2 liposomes in...
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5643575 |
Non-antigenic branched polymer conjugates
Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating...
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