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7348453 |
Labile linkage for compound delivery to a cell
Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The...
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7335733 |
Tissue cement proteins from Rhipicephalus appendiculatus
The present invention relates to tissue cement proteins produced by certain species of blood-feeding ectoparasites. These proteins and compositions comprising these proteins are particularly useful...
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7329500 |
Moraxella (Branhamella) catarrhalis polypeptides and corresponding DNA fragments
The present invention relates to polypeptides of Moraxella ( Branhamela ) catarrhalis which may be used for prophy-laxis, diagnostic and/or therapy purposes.
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7320793 |
Molecular antigen array
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7311892 |
Multidrug multiligand conjugates for targeted drug delivery
Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite...
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7306782 |
Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases
The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide...
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7279165 |
Amyloid β1-6 antigen arrays
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7226603 |
HBV core antigen particles with multiple immunogenic components attached via peptide ligands
This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core...
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7211445 |
Conjugation of biomolecules using diels-alder cycloaddition
A method is provided for covalently linking carbohydrates, proteins, nucleic acids, and other biomolecules under neutral conditions, using a Diels-Alder cycloaddition reaction. In an example,...
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7208157 |
Proteolysis targeting chimeric pharmaceutical
The present invention is based on the discovery of a composition that provides targeted ubiquitination. Specifically the composition contains a ubiquitin pathway protein binding moiety which...
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7198791 |
Compositions and methods for the generation of protective immune responses against malaria
The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory...
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7193031 |
Polyalkylene glycol acid additives
A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small...
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7169392 |
Neisseria meningitidis serogroup B glycoconjugates and methods of producing the same
The present invention pertains generally to novel Neisseria meningitidis serogroup B glycoconjugates. More particularly, the invention pertains to glycoconjugates formed from a Neisseria...
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7166708 |
Process for preparing conjugate vaccines and the conjugate vaccines
This invention relates to a process for preparing a hapten-protein-polysaccharide conjugate and a hapten-protein conjugate by reacting a protein with a hapten to produce a hapten-protein conjugate,...
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7160856 |
α-O-linked glycoconjugates, methods of preparation and uses thereof
The present invention provides novel α-O-linked glycoconjugates such as α-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified...
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7147917 |
Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
Water-dispersible nanoparticles are prepared by applying a coating of a multiply amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic...
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7129330 |
Multivalent antibody constructs
The present invention relates to multivalent F v antibody construct having at least four variable domains which are linked with each over via the peptide linkers 1, 2 and 3. The invention also...
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7128913 |
Erythropoietin conjugates
The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having an N-terminal α-amino group and having the in vivo...
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7128911 |
Antigen arrays for treatment of bone disease
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7122189 |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
Activated polymeric bicine derivatives such as
as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
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7118757 |
Meningococcal class 1 outer-membrane protein vaccine
Outer-membrane vesicles, Class 1 outer membrane proteins of Neisseria meningitidis , fragments or oligopeptides containing epitopes of the Class I OMP can be used to immunize against meningococcal...
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7115266 |
Angiotensin peptide-carrier conjugates and uses thereof
The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling...
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7112566 |
Systemic administration of Hypocretin-1
The invention provides compositions and methods for treatment of sleep disorders. Such methods entail administering to the patient a therapeutically effective dosage regime of an agonist of a...
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7101562 |
Conjugate vaccines for the prevention of dental caries
The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and...
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7101556 |
Preparation and usage of plasmodium fusion antigen
The invention provides a fusion protein comprising the Plasmodium merozoite surface protein-1 (MSP1) and the Plasmodium apical membrane antigen 1 (AMA-1), the encoding DNA sequence, the vector...
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7094409 |
Antigen arrays for treatment of allergic eosinophilic diseases
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7090851 |
Long lasting fusion peptide inhibitors of viral infection
Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107...
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7087229 |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
Activated polymeric bicine derivatives such as,
as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
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7078191 |
Composition and method for the detection of diseases associated with amyloid-like fibril or protein aggregate formation
The present invention relates to novel compositions useful for elucidating the onset or progress of diseases such as Huntington's disease, that are associated with the formation of fibrils or...
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7067133 |
Methods and compositions for diseases associated with amyloidosis
The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of...
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7063848 |
Lipoglycan compositions and methods of treating parasitic infections
A composition for and a method of eliciting in a vertebrate a protective immune response against an eukaryotic parasite are disclosed. The method includes administering to the vertebrate a...
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7056519 |
Methods for inducing HIV-neutralizing antibodies
The present invention relates to a method for inducing antibodies neutralizing HIV primary isolates in a mammal, comprising administration of a pharmaceutical composition comprising a polypeptide...
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7052704 |
Methods and compositions for lipidization of hydrophilic molecules
Fatty acid derivatives of sulfhydryl-containing compounds (for example, sulfhydryl-containing peptides or proteins) comprising fatty acid-conjugated products with a disulfide linkage are employed...
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7052702 |
Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics
A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby...
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7048930 |
Expression of core-glycosylated HCV envelope proteins in yeast
The present invention relates to the general field of recombinant protein expression, purification of recombinant proteins, diagnosis of HCV infection, prophylactic treatment against HCV infection...
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7041298 |
Proteolysis targeting chimeric pharmaceutical
The present invention is based on the discovery of a composition that provides targeted ubiquitination. Specifically the composition contains an ubiquitin pathway protein binding moiety which...
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7033594 |
Method of treatment using ligand-immunogen conjugates
A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic...
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7033593 |
Immunogen comprising an HIV envelope protein, a ligand and H2 peptide
The invention relates to an immunogen comprising an HIV envelope protein bound to a ligand, which ligand upregulates at least one of the CD4 binding site and the CCR5 binding site on the protein,...
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7018637 |
Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
Multivalent immunogenic molecules comprise a carrier molecule containing at least one functional T-cell epitope and multiple different carbohydrate fragments each linker to the carrier molecule and...
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7014857 |
Anti-sepsis conjugate vaccine
The present invention provides an immunogenic conjugate comprising biologically deacylated gram-negative bacterial moieties linked to D. discoideum proteinase 1, as well as novel subunits...
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7014856 |
Ganglioside-KLH conjugate vaccines plus OS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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7001601 |
Ganglioside-KLH conjugate vaccine plus QS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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6995237 |
Preparation and composition of peptides useful for treatment of autoimmune and transplant related graft versus host conditions
Peptide constructs including a first peptide segment which includes an amino acid sequence associated with autoimmune disease, asthma, allergy or xeno- or allograft transplantation rejections...
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6989436 |
Stabilization of cardiac troponin I subunits and complexes
The present invention provides methods for preparing, and compositions comprising, stabilized protein-polymer conjugates. More particularly, the present invention relates to the stabilization of...
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6967022 |
Ganglioside-KLH conjugate vaccines plus QS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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6964769 |
Molecular antigen array
The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the...
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RE38827 |
Adhesive sealant composition
This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first...
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6936263 |
Th1 inducing natural adjuvant for heterologous antigens
The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates...
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6916476 |
Ganglioslide-KLH conjugate vaccine plus QS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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6896887 |
Bacterial ghosts provided with antigens
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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