Matches 151 - 200 out of 289 < 1 2 3 4 5 6 >
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6165468 Antigenic carbohydrate linked to an immunogenic carrier  
A general method of producing an immunogenic product consisting of antigenically active carbohydrate moieties (ACM) which each are covalently coupled via identical divalent bridge groups to...
6156302 Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes  
The present invention relates to methods and compositions for enhancing immunological responses and for the prevention and treatment of infectious diseases or primary and metastatic neoplastic...
6150341 Vitamin B.sub.12 derivatives and methods for their preparation  
This invention relates to methods for preparing vitamin B 12 (VB 12 ) derivatives suitable for linking to a polymer, nanoparticle or therapeutic agent, protein or peptide. The methods involve...
6149921 Vaccine compositions for eliciting an immune response against N-acetylated gangliosides and their use for cancer treatment  
The invention provides novel uses for n-glycolylated gangliosides and N-acetylated gangliosides, or derivatives and/or oligosaccharides thereof The invention further provides methods of obtaining...
6139843 Peptide compositions for the treatment of HIV  
The present invention provides for peptide conjugate compositions, methods of using the peptide conjugate compositions, and pharmaceutical compositions comprising the peptide conjugate...
6132720 Immunogens against gonadotropin releasing hormone  
Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal...
6132723 Immunogenic oligosaccharide compositions  
The invention provides immunogenic oligosaccharide compositions and methods of making and using them. In particular, the compositions comprise oligosaccharides covalently coupled to carrier...
6117427 Vaccines and methods for preventing and treating fescue toxicosis in herbivores  
The present invention provides an immunogenic compound the formula: ##STR1## wherein X is selected from the group consisting of methyl and hydrogen; wherein R 1 is a suitable functional group of...
6113906 Water-soluble non-antigenic polymer linkable to biologically active material  
Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating...
6096318 Antigenically modified HCG polypeptides  
Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the...
6090388 Peptide composition for prevention and treatment of HIV infection and immune disorders  
The invention provides peptides comprising a sequence homologous to a portion of the CDR-2 like domain of CD4, covalently linked to a helper T cell epitope, and optionally to other...
6086881 Spatially aligned conjugated composition having a thioether bond linkage  
The present invention is a spatially aligned conjugated composition which comprises at least one chemically modified substance which is immunologically representative of a prechosen infectious...
6080409 Immunostimulatory method  
Disclosed are therapeutic compositions and methods for inducing cytotoxic T cell responses in vitro and in vivo. The therapeutic compositions consist of antigen presenting cells activated by...
6072040 Stabilized conjugates of uncomplexed subunits of multimeric proteins  
The present invention provides methods for preparing, and compositions comprising, stabilized protein-polymer conjugates. More particularly, the present invention relates to the stabilization of...
6054127 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same  
Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed....
6048529 PVA or PEG conjugates of peptides for epitope-specific immunosuppression  
The invention relates to a procedure for synthesis of well-defined conjugates of peptides to the tolerogenic polymer monomethoxypolyethylene glycol (mPEG) or polyvinyl alcohol (PVA). This method...
6048531 Immunogenic composites capable of stimulating production of anti-peptide antibodies, pharmaceutical compositions employing these composites and methods of selectively inducing production of anti-peptide antibodies  
An essentially pure immunogenic composite capable of selectively inducing antibody production in an animal to a peptide that if administered by itself to the animal without being conjugated to or...
6045805 Oligosaccharide derived from an antigenic polysaccharide obtained from a pathogenic agent  
An oligosaccharide derived from an antigen polysaccharide obtained from a pathogenic agent, a method for its preparation, and its use particularly as a vaccinal agent. The oligosaccharide is...
6034053 EGF-isoflavone conjugates for the prevention of restenosis  
A protein conjugate containing EGF coupled to a tyrosine kinase inhibitor such as Genistein, for inhibiting or preventing restenosis following vascular injury.
6025325 Pegylated obese (ob) protein compositions  
Polyethylene and polypropylene protein conjugates which modulate body weight of animals and humans for the treatment, prevention and control of obesity and associated diseases or conditions, and...
6025324 Pegylated obese (ob) protein compositions  
Polyethylene and polypropylene protein conjugates which modulate body weight of ani is and humans for the treatment, prevention and control obesity and associated diseases or conditions, and the...
6022544 Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry  
The invention features a method for reducing an undesired antibody response in a mammal by administering to the mammal a non-immunogenic construct which is free of high molecular weight...
6019974 SPE-4 peptides  
This application discloses SPE-4 related peptides, peptide-carrier protein conjugates and fusion proteins, immunogenic compositions, antibodies and methods for characterizing the SPE-4 related...
6017541 Immunogens for the production of cocaine-hydrolyzing catalytic antibodies  
Methods are described for the rapid synthesis in satisfactory yield of methyl ecgonine phenylphosphonates as analogues of transition states for the hydrolysis of the benzoyl ester of an ecgonine...
5997861 Antiviral supramolecules containing target-binding molecules and therapeutic molecules bound to spectrin  
Complexes are prepared containing two or more different effector molecules joined to each other by a joining component. One effector molecule is a binding molecule such as an antibody or Fc...
5976538 Adjuvant composition containing synthetic hydrophobic lipopolysaccharide  
According to the present invention the adjuvants comprise an emulsion containing at least one synthetic hydrophobic lipopolysaccharide, which can either or not be provided with anionic groups,...
5977313 Platelet substitutes and conjugation methods suitable for their preparation  
Platelet substitutes, comprising fibrinogen, or analogous products useful in therapy, which further comprise an insoluble carrier to which is bound an essentially non-degraded active protein...
5976546 Immunostimulatory compositions  
Disclosed are therapeutic compositions and methods for inducing cytotoxic T cell responses in vitro and in vivo. The therapeutic compositions consist of antigen presenting cells activated by...
5972349 Synthesis of polyribosylribitol phosphate oligosaccharides  
Polyribosylribitol phosphate oligosaccharides are produced in a multistep process. The compound of the formula: ##STR1## wherein R 1 is a first protecting group and R 2 is a second protecting...
5968522 Immunogenic compositions and antibodies directed against human papillomavirus type 49 (HPV 49), type 50 (HPV 50), type 54 (HPV 54), and type 55 (HPV 55).  
The invention relates to papillomavirus probes derived from new DNA-HPVs deposited with the CNCM on the May 6, 1988 under the following filing numbers: PGEM 4 HPV49: I-754 PSP 65 HPV50: I-755...
5965713 Dye labeled protein conjugate its preparing method and sensor using the same  
It is intended to present a sensor capable of labeling with more dyes, applying the labeled protein in immunochromatography making use of antigen-antibody reaction, and having an excellent...
5965714 Method for the covalent attachment of polysaccharides to protein molecules  
Disclosed and claimed are a method for the covalent attachment of poly- and oligosaccharides to protein molecules via hydrogen peroxide depolymerization of the polysaccharide units, followed by...
5955080 Self-adjuvanting peptide vaccine delivery system and production thereof  
The present invention provides self-adjuvanting vaccines for use in raising antibodies to peptides without the use of oil or alum adjuvants. Further, the present invention provides methods of...
5955090 Immunogenic hybrid protein OprF-OprI derived from Pseudomonas aeruginosa membrane proteins  
The present invention relates to a hybrid protein comprising the Pseudomonas aeruginosa outer membrane protein I (OprI) which is fused with its amino terminal end to the carboxy-terminal end of a...
5914114 Method of raising antibodies against E. coli of the family CS4-CFA/I  
A consensus poptide of 36 amino acids has been designed which acts as an immunogen raising antibodies against the proteins of all members of the E. coli family CS4-CFA/1. While the N-terminus of...
5911996 43 Kd protein vaccine and method for the production thereof  
A protein derivable from Actinobacillus pleuropneumoniae (APP) having a molecular size ranging between 43 Kd on SDS PAGE is described. The protein is soluble on sodium lauryl sarcosinate (SLS) and...
5882645 Peptide compounds  
Synthetic peptides are widely used to generate antibodies. To induce high antibody response, it is known to conjugate the peptide to a carrier protein (e.g. KLH, BSA) or to incorporate it into...
5882649 Oral vaccine comprising antigen surface-associated with red blood cells  
Red blood cells or derivatives thereof such as ghost preparations, whole cell membrane preparations or fragments thereof, can act as a potent carrier for orally administered antigens. Mucosal...
5874085 Vaccine for enhanced production of IgA antibodies  
The invention describes compositions and methods for optimizing IgA class switching in B cells. The compositions comprise a multivalent antigen receptor crosslinker, CD40 ligand or...
5871749 Therapeutic treatment of H. pylori associated gastroduodenal disease  
The application discloses a method for the treatment of Heliobacter infection in a mammalian host, which comprises administration to said infected host of an immunologically effective amount of one...
5869058 Peptides used as carriers in immunogenic constructs suitable for development of synthetic vaccines  
The invention relates to conjugates of poorly immunogenic antigens, e.g., peptides, proteins and polysaccharides, with a synthetic peptide carrier constituting a T cell epitope derived from the...
5858367 Methods for screening for antimicrobials utilizing AarC and compositions thereof  
The present invention provides an oligonucleotide (aarC) which encodes a novel bacterial polypeptide (AarC) that is essential for the viability of bacteria. The invention provides recombinant...
5849301 Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents  
The invention relates to a process for producing an immunogenic construct comprising activating at least one first carbohydrate-containing moiety with CDAP, CTEA or pNPC, and covalently joining the...
5846545 Targeted delivery of cyclopropylbenzindole-containing cytotoxic drugs  
Gytotoxic agents containing a cell binding agent chemically linked to one or more analogue or derivative of CC-1065 are described. The therapeutic use of the cytotoxic agents is also described....
5837250 Adjuvant compositions  
Adjuvant compositions for modulating an immune response to an antigen administered to a host comprise a mineral salt adjuvant and at least one other adjuvant. The compositions provide an...
5837825 Campylobacter jejuni flagellin/Escherichia coli LT-B fusion protein  
A fusion protein which comprises the B subunit of the labile toxin (LT-B) of E. coli and part of the flagellin (flaA) protein of C. jejuni is antigenic and is useful for decreasing colonization in...
5824310 Lipopplysaccharide conjugate vaccines  
The present invention relates to lipopolysaccharides from Brucella abortus and their use as carriers in vaccines for humans and animals. In particular, the present invention relates to conjugate...
5811100 Compounds for the prevention and treatment of helmith infections  
A compound for protecting a vertebrate against infection by helminths comprising hyaluronidase covalently coupled to an immunostimulating carrier, in preferred form, the immunostimulating carrier...
5811102 Modified meningococcal polysaccharide conjugate vaccines  
The invention relates to chemically-modified group B polysaccharides of Neisseria meningitidis. The invention also provides vaccines in which the respective modified polysaccharides are conjugated...
5807553 Immonogenic oligosaccharide compositions  
The invention provides immunogenic oligosaccharide compositions and methods of making and using them. In particular, the compositions comprise oligosaccharides covalently coupled to carrier...
Matches 151 - 200 out of 289 < 1 2 3 4 5 6 >