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7052702 |
Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics
A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby...
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7052704 |
Methods and compositions for lipidization of hydrophilic molecules
Fatty acid derivatives of sulfhydryl-containing compounds (for example, sulfhydryl-containing peptides or proteins) comprising fatty acid-conjugated products with a disulfide linkage are employed...
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7048930 |
Expression of core-glycosylated HCV envelope proteins in yeast
The present invention relates to the general field of recombinant protein expression, purification of recombinant proteins, diagnosis of HCV infection, prophylactic treatment against HCV infection...
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7041298 |
Proteolysis targeting chimeric pharmaceutical
The present invention is based on the discovery of a composition that provides targeted ubiquitination. Specifically the composition contains an ubiquitin pathway protein binding moiety which...
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7033593 |
Immunogen comprising an HIV envelope protein, a ligand and H2 peptide
The invention relates to an immunogen comprising an HIV envelope protein bound to a ligand, which ligand upregulates at least one of the CD4 binding site and the CCR5 binding site on the protein,...
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7033594 |
Method of treatment using ligand-immunogen conjugates
A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic...
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7018637 |
Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
Multivalent immunogenic molecules comprise a carrier molecule containing at least one functional T-cell epitope and multiple different carbohydrate fragments each linker to the carrier molecule and...
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7014857 |
Anti-sepsis conjugate vaccine
The present invention provides an immunogenic conjugate comprising biologically deacylated gram-negative bacterial moieties linked to D. discoideum proteinase 1, as well as novel subunits...
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7014856 |
Ganglioside-KLH conjugate vaccines plus OS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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7001601 |
Ganglioside-KLH conjugate vaccine plus QS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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6995237 |
Preparation and composition of peptides useful for treatment of autoimmune and transplant related graft versus host conditions
Peptide constructs including a first peptide segment which includes an amino acid sequence associated with autoimmune disease, asthma, allergy or xeno- or allograft transplantation rejections...
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6989436 |
Stabilization of cardiac troponin I subunits and complexes
The present invention provides methods for preparing, and compositions comprising, stabilized protein-polymer conjugates. More particularly, the present invention relates to the stabilization of...
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6967022 |
Ganglioside-KLH conjugate vaccines plus QS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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6964769 |
Molecular antigen array
The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the...
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RE38827 |
Adhesive sealant composition
This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first...
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6936263 |
Th1 inducing natural adjuvant for heterologous antigens
The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates...
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6916476 |
Ganglioslide-KLH conjugate vaccine plus QS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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6896887 |
Bacterial ghosts provided with antigens
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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6858210 |
Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
The present invention provides domain 1 β 2 GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 β 2 GPI polypeptides and...
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6824997 |
Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies
A process is disclosed for obtaining a C-polysaccharide cell wall antigen containing not more than about 10% protein from Streptococcus pneumoniae bacteria. The antigen thus obtained is...
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6814964 |
Supramolecules containing binding and therapeutic molecules bound to hybridized nucleic acids
A supramolecule has a first supramolecular component including a first effector molecule covalently joined to a first nucleic acid, and a second supramolecular component including a second effector...
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6811785 |
Multivalent MHC class II—peptide chimeras
The present invention provides a multimeric complex of at least two chimeric molecules, wherein the chimeric molecules comprise an immunoglobulin constant region element and two MHC elements...
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6805865 |
Compositions and methods for treating cancer and hyperproliferative disorders
Compositions and methods effective for eliciting an immune response for inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related...
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6803040 |
Derivatives of tricyclic antidepressants and protein and polypeptide tricyclic antidepressant derivative conjugates and labels
The present invention is directed to novel tricyclic antidepressant derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of...
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6800296 |
Modification of surfaces using biological recognition events
The present invention provides a novel surface engineering strategy that uses biomolecular interactions to immobilize surface modifying ligands on biomaterial architectures. The surface modified...
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6800735 |
Interferon-beta fusion proteins and uses
A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety;...
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6790446 |
Campylobacter vaccine
The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonization in animals. The invention also...
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6780420 |
Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine
The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40...
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6764686 |
Modified immunogenic pneumolysin compositions as vaccines
This invention relates to modified pneumolysin polypeptides that retain the immunogenic nature of pneumolysin but have reduced or undetectable hemolytic activity compared to native pneumolysin. The...
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6756037 |
Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups
The present invention is directed to polymer conjugates of biologically active agents and methods of preparing the same. In preferred aspects of the invention, the conjugates are of the formula ...
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6756041 |
Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process
A process for preparing a protein-polysaccharide conjugate includes reacting a protein with a polysaccharide to produce a mixture including a protein-polysaccharide conjugate and free protein. At...
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6719976 |
Peptide-based immunotherapeutic agent for treating allergic diseases
The present invention provides a monomolecular multi-epitope peptide prepared by binding T cell epitope regions derived from different allergen molecules with each other. A peptide-based...
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6719975 |
Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught.
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6676946 |
Multiple antigen glycopeptide carbohydrate vaccine comprising the same and use thereof
A carbohydrate peptide conjugate containing: (i) a carrier containing a dendrimeric poly-lysine enabling multiple epitopes to be covalently attached thereto, (ii) at least one peptide containing...
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6663869 |
Polyoxime compounds and their preparation
A homogeneous polyoxime composition is provided, in which the polyoxime molecules present comprise a first organic baseplate molecule, which is a polypeptide, wherein the baseplate molecule is...
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6663861 |
Method of producing antibodies by immunization with conjugates of molecules coupled to charge-modified proteins
A method for raising antibodies against molecules, particularly molecules with low immunogenicity, by coupling the molecule to a carrier containing a balanced charge mixture of proteins is...
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6652864 |
Compounds for intracellular delivery of therapeutic moieties to nerve cells
A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B—L—TM where: B is a binding agent capable of selectively binding to a...
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6645503 |
Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria
Antigenic conjugates are provided which comprise a carrier protein covalently bonded to the conserved portion of a lipopolysaccharide of a gram negative bacteria, wherein the conserved portion of...
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6632437 |
Immunogenic polysaccharide-protein conjugates containing poly α(2→8), α(2→9) NeuNAc capsular polysaccharides
The present invention relates to a polysaccharide-protein conjugate. The invention also relates to a method of using the conjugate to prevent systemic infections. The invention further relates to a...
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6602508 |
Method of immunization using a Group B Streptococcus type II and type III polysaccharide conjugate vaccine
The process for depolymerizing Group B Types II and III streptococcal polysaccharide is disclosed which results in polysaccharide fragments having a reducing end suitable for conjugating to...
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6602507 |
Synthetic peptides from streptococcal M protein and vaccines prepared therefrom
Synthetic polypeptides from the conserved exposed region of streptococcal M protein are useful to prepare vaccines for oral or intranasal administration which will protect against streptococcal...
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6586392 |
Conjugates of antiviral proteins or peptides and virus or viral envelope glycoproteins
The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention...
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6585973 |
Method for preparing solid phase conjugated vaccine
A method of preparing conjugate vaccines by adsorbing a protein to a solid phase adjuvant, and covalently linking a carbohydrate to the adsorbed protein. Alternatively, the carbohydrate is first...
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6582700 |
Linear antigen supporting units
The present invention concerns a synthetic construct comprising a linear core chain having two or more side chains pending directly from different points on the linear core chain. Each of the side...
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6583272 |
Erythropoietin conjugates
Conjugates of erythropoietin with poly(ethylene glycol) comprise an erythropoietin glycoprotein having at least one free amino group and having the in vivo biological activity of causing bone...
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6576746 |
Site-specific labeling of disulfide-containing targeting vectors
A method of producing a diagnostic or therapeutic conjugate of a protein, polypeptide or peptide containing at least one disulfide bond which is necessary to maintain its biological activity, and...
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6573245 |
Modified polysaccharide adjuvant-protein antigen conjugates, the preparation thereof and the use thereof
The present invention is directed to chemical conjugates (herein referred to as polysaccharide adjuvant-antigen conjugates) that have a polysaccharide backbone capable of binding to the cell...
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6572867 |
Inhibition of xenoreactive antibodies
One aspect of the present invention relates to methods and compositions for attenuating xenograft rejection by administering, to an animal receiving the xenograft, an amount of a...
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6572860 |
Immunogenic conjugated polypeptide for treatment of herpes simplex virus
Peptide constructs chemically synthesized to contain a Herpes Simplex Virus specific antigenic peptide, such as, the 322-332 peptide (H1) from the ICP27 protein of Herpes Simplex Virus (HSV-1) and...
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6541004 |
Cocaethylene immunogens and antibodies
The ethyl ester of derivatives of benzoyl ecgonine are provided having a linking group at the para position of the benzoyl group. The derivatives are used to bond to immunogenic polypeptides for...
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