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8183338 |
Sterically hindered poly(ethylene glycol) alkanoic acids and derivatives thereof
The invention provides a sterically hindered polymers and conjugates formed therefrom that comprise a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded...
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8173601 |
Activin-ActRIIa antagonists and uses for treating multiple myeloma
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.
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8168195 |
Vaccines against Escherichia coli O157 infection
This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of using of these conjugates and/or...
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8153140 |
Chimeric MSP-based malaria vaccine
The invention provides an immunogenic composition comprising MSP-8 linked to an antigen. Methods of using the composition to induce an immune response in an animal are also provided.
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8153114 |
Hyperglycosylated mammalian IL-7 IgG conjugate composition
The present invention relates to new and improved interleukin-7 polypeptides, as well as compositions comprising the same, their preparation and uses. The invention more particularly relates to...
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8128942 |
Anti-sepsis conjugate vaccine
The present invention provides an immunogenic conjugate comprising biologically deacylated gram-negative bacterial moieties linked to D. discoideum proteinase 1, as well as novel subunits thereof,...
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8124590 |
Biodegradable immunomodulatory formulations and methods for use thereof
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC)...
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8105608 |
Method of treatment using ligand-immunogen conjugates
A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic...
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8093046 |
CVN-12p1: a recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions
The invention provides a recombinant multi-functional chimera of CVN and 12p1. Chimeras of CVN and 12p1 present a model for targeting gp120 at two discrete sites, by two different modes of...
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8092805 |
Dual inhibitors of HIV-1 gp-120 interactions
Compounds, which inhibit the binding of gp120 to CD4 as well as 17b and methods for their use in inhibiting the HIV fusion process, are provided.
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8088884 |
Multi-armed forms of activated polyoxazoline and methods of synthesis thereof
The present disclosure provides novel POZ-2 derivatives, methods for synthesizing POZ-2 derivatives and intermediates useful in such methods. In one embodiment, the POZ-2 derivative comprises two...
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8080254 |
OB fusion protein compositions and methods
The present invention relates to Fc-OB fusion protein compositions, methods of preparation of such compositions and uses thereof. In particular, the present invention relates to a genetic or...
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8067011 |
Compositions and methods for treating B-cell malignancies
The present invention provides a targeted multi-layered drug delivery system for the delivery of cytotoxic agents to B-cells.
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8062641 |
Immunogens for meningitidis-A vaccines
An oligosaccharide useful for a Meningitidis A vaccine contains a first mannose unit having a spacer in the alpha configuration at C-1, which spacer is capable of conjugating to a protein, and...
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8039005 |
Mutant forms of streptolysin O
Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against S. pyogenes are useful in vaccine compositions to induce protection against S....
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8026209 |
Methods and compositions for targeting agents into and across the blood-barrier and other endothelial cell microvascular barriers
The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced...
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8012488 |
Polyoxyalkylene derivative
A novel polyoxyalkylene derivative represented by the following formula (1), wherein each symbol is as defined in the specification, which has a functional group capable of reacting with various...
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7988969 |
Treatment for central nervous system disorders
Compositions that include an Aβ polypeptide linked to a non-Aβ polypeptide are described, as well as methods of using such compositions.
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7972601 |
Method of promoting delivery of an antioxidant agent to a cell expression neuroligin
Provided are methods and compositions for treating autism spectrum disorders by administering an antioxidant or agent that stabilize or enhance expression of altered neuroligins. An aspect of the...
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7964196 |
Self-assembling nanoparticle drug delivery system
A self-assembling nanoparticle drug delivery system for the delivery of drugs including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle...
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7960502 |
Sterically hindered poly(ethylene glycol) alkanoic acids and derivatives thereof
The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic...
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7951379 |
Hollow nanoparticle of NBsAg large protein for drug delivery
The invention provides a therapeutic drug that uses hollow protein nanoparticles displaying an antibody against a specific cell or specific tissue. The effectiveness of the drug has been proved by...
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7951376 |
Multimeric complexes of antigens and an adjuvant
The invention relates to a product which comprises a C4bp domain of a non-mammalian origin, particularly SEQ ID NO:1, SEQ ID NO:23 or SEQ ID NO:37, or a variant thereof, and an antigen. The product...
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7947279 |
Peptide having hydrolase activity
The invention is directed to methods for increasing learning and memory in a subject with a neuropathological condition, specifically a condition related to elevated beta-amyloid deposition, the...
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7947277 |
Wnt antagonists and their use in the diagnosis and treatment of Wnt-mediated disorders
The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc...
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7943141 |
Activated polyoxazolines and compositions comprising the same
The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a...
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7935355 |
Composition and method for controlling intestinal pathogenic organisms
An antigen composition for stimulating an immune response in an inoculated avian species to at least one intestinal pathogenic organism includes naturally-occurring wild Salmonella enterica...
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7931908 |
Chimeric MSP-based malaria vaccine
The invention provides an immunogenic composition comprising MSPk-8 linked to an antigen. Methods of using the composition to induce an immune response in an animal are also provided.
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7910110 |
Bacteriophage-mediated immunisation against hepatitis
The present invention relates to vaccines comprising a bacteriophage which has been engineered to express an immunogenic protein/peptide and wherein the surface of the bacteriophage has not been...
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7897647 |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
Activated polymeric bicine derivatives such as as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
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7887811 |
Method for preparing a stable immunogenic product comprising antigenic heterocomplexes of TNFα and a carrier protein
The present invention concerns a novel method for preparing a stable immunogenic product comprising antigenic heterocomplexes of TNFα and a carrier protein, the method steps of which are disclosed ...
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7867499 |
Methods of treating dementia by administering virus-like particles coupled to Aβ
The present invention relates to novel uses of a construct consisting of virus-like particle (VLP) structure chemically coupled to a fragment of the Aβ-1-42 peptide and its pharmaceutically ...
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7858101 |
Modified streptococcal polysaccharides and uses thereof
Modified streptococcal polysaccharides and methods of using the modified polysaccharides are provided herein.
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7850971 |
PSMA antibodies and protein multimers
The invention includes antibodies or antigen-binding fragments thereof which bind specifically to conformational epitopes on the extracellular domain of PSMA, compositions containing one or a...
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7838014 |
Vaccine compositions comprising L2 and/or L3 immunotype lipooligosaccharides from LGTB- Neisseria meningitidis
The present invention relates to the field of neisserial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to processes of making...
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7824910 |
Method of transducing a protein into cells
The invention relates to a method for transducing a pharmaceutical protein or polypeptide that may be fluorescently labeled into a cell by forming a conjugate with a cationic polymer having cation...
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7820158 |
Ligand-coupled initiator polymers and methods of use
Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the...
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7811573 |
Compositions of antigens bound to HIV-1 Tat, fragments or derivatives thereof
The present invention concerns a method for prophylactic and/or therapeutic vaccination and/or treatment and/or diagnosis of HIV/AIDS, other infectious diseases, inflammatory and angiogenic...
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7807180 |
Poxvirus methods and compositions
Methods and compositions for inducing immune responses against poxviruses are disclosed. The compositions include nucleic acids that encode modified vaccinia and variola antigens. Compositions that...
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7807134 |
Multidrug multiligand conjugates for targeted drug delivery
Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite...
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7807175 |
Therapeutic vaccine
The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or...
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7767212 |
CAT allergen conjugates and uses thereof
The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus...
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7731978 |
Mutant forms of streptolysin O
Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against S. pyogenes are useful in vaccine compositions to induce protection against S....
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7691396 |
Chimeric peptides comprising HER-2 B-cell epitopes and measles virus fusion protein T-cell epitopes
Compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the HER-2 protein are provided. Such...
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7678378 |
Compounds for intracellular delivery of therapeutic moieties to nerve cells
A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve...
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7674879 |
Sterically hindered poly(ethylene glycol) alkanoic acids and derivatives thereof
The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic...
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7625736 |
Methods for preparing immunogenic conjugates
Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a...
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7618635 |
Super-antigen fusion proteins and the use thereof
The present invention relates to a super-antigen fusion protein, comprising: a peptide fragment whose sequence corresponds to a partial SARS E2 spike protein; and a translocating peptide fragment...
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7563446 |
Methods and compositions for inducing autoimmunity in the treatment of cancers
Disclosed are methods and compositions for the prevention and treatment of cancers using lipid-carrier protein conjugate compositions for generating lipid-specific immune responses in an animal....
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7550146 |
Glycopeptide conjugates and uses thereof
The present invention provides novel glycoconjugates such as glycopeptides, as well as convergent methods for the synthesis thereof. An exemplary preparative approach is exemplified by the...
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