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7378096 |
Stress protein compositions and methods for prevention and treatment of cancer and infectious disease
Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or...
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7374765 |
Methods and compositions for diagnosis and treatment of iron misregulation diseases
Methods and compositions are provided for the diagnosis and treatment of iron misregulation diseases, including HFE polypeptides, agonists, and antagonists, and transferrin receptor agonists and...
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7374762 |
Drug conjugate composition
The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid....
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7364740 |
Molecular differences between species of the M. tuberculosis complex
Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared...
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7361346 |
Therapeutic compositions that produce an immune response
The invention provides a method for stimulating the production of antibodies to a cryptic epitope on a soluble antigen by administering to a patient having such a cryptic epitope a binding agent...
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7358087 |
Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand linked to an immunogen. In particular, these molecular adjuvants are employed in compositions designed to...
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7357914 |
Use of metal chelates in human or animal feeding
The present invention relates to the use in human and animal nutrition (monogastric and polygastric animals) of known chelates of bivalent metal Mg, Ca, Mn, Co, Cu, Zn and Fe with methionine...
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7354589 |
Multiple antigenic agents and methods for using the same
The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections. The multiple antigenic agents of the invention contain at least one...
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7351797 |
Labeled peptides, and processes and intermediates useful for their preparation
The invention provides intermediates and methods that allow for site-specific modification of peptides after synthesis. Accordingly, functional molecules can be selectively linked to a peptide to...
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7348010 |
Vaccine against cancer diseases that are associated with the her-2/neu oncogene
The present invention relates to peptides of the extracellular domain of a HER-2/neu protein, conjugates comprising said peptides linked to an immunogenic carrier, compositions thereof, nucleic...
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7342091 |
Soluble cyclic analogues of β amyloid peptide
The invention concerns a peptide having the biological activity of an inhibitor of amyloid formation and its diagnostic and medical use.
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7341730 |
Inhibitors of angiogenesis and tumor growth
This invention provides for polypeptides that have surprising anti-angiogenic activity. These peptides are derived from Saposin B, a previously known protein involved in the hydrolysis of...
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7341710 |
Method of identifying molecules that home to a selected organ in vivo
The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
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7335640 |
Administration of hypocretin-1 for treatment of narcolepsy
The invention provides compositions and methods for treatment of sleep disorders. Such methods entail administering to the patient a therapeutically effective dosage regime of an agonist of a...
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7335368 |
BVH-A2 and BVH-A3 antigens of group B Streptococcus
Group B streptococcus polypeptides and polynucleotides encoding them are disclosed. Said polypeptides may be useful for the prophylaxis, diagnostic and/or therapy of streptococcal infection in...
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7332164 |
Heterobifunctional polymeric bioconjugates
Heterobifunctional polymeric prodrug platforms for delivering biologically active compounds, including proteins, monoclonal antibodies and the like are disclosed. One preferred compound is
...
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7329500 |
Moraxella (Branhamella) catarrhalis polypeptides and corresponding DNA fragments
The present invention relates to polypeptides of Moraxella ( Branhamela ) catarrhalis which may be used for prophy-laxis, diagnostic and/or therapy purposes.
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7326535 |
Immunoreactive peptides from Epstein-Barr virus
Epstein-Barr virus (EBV) specific polypeptides are disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment...
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7323175 |
Immunogenicity of glucan binding protein
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7320793 |
Molecular antigen array
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7318926 |
Glycosylated specificity exchangers
The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and...
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7314632 |
Pseudomonas exotoxin A-like chimeric immunogens
This invention provides Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin. Methods of eliciting an immune response using...
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7314627 |
Cationic lipid-mediated enhancement of nucleic acid immunization of cats
The present invention relates to a method to introduce a nucleic acid molecule into a felid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of...
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7314626 |
Use of peptide vectors to improve the immune response to antigens
The invention relates to conjugates of an antigen coupled to a linear derivative of a β-stranded antibiotic peptide, which are useful for immunogenic agents to enhance a CTL response. Two groups...
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7312188 |
Peptide derivatives having β-secretase inhibitory activity
Provided are excellent β-secretase inhibitors, that is, compounds represented by the general formula (1) or prodrugs thereof:
wherein A is amino or protected amino; B 1 and B 2 are each a...
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7311915 |
Method of producing an HIV-1 immune response
The present invention comprises novel and modified peptides capable of inducing an HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
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7311892 |
Multidrug multiligand conjugates for targeted drug delivery
Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite...
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7291722 |
Polypeptide from haemophilus influenza
The invention provides BASB203 polypeptides and polynucleotides encoding BASB203 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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7291339 |
Homogeneity and secretion of a recombinant follicle stimulating hormone (FSH) in mammalian systems
A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-β and...
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7282207 |
Reagents and methods useful for detecting diseases of the reproductive tissues
This invention relates generally to a multimeric polypeptide complex/antigen which may be utilized in detecting or diagnosing diseases of the uterus such as uterine cancer. Furthermore, the...
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7279165 |
Amyloid β1-6 antigen arrays
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7264819 |
Lyase treatment for P. carinii
Infection by P. carinii can be treated by administering methioninase optionally in combination with additional therapeutic agents, such as antibiotics.
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7255867 |
Vaccine
Effective stimulation of immune responses is achieved through the use of a group A streptococcal antigen combined with proteosome adjuvant. The compositions are provided in particular for...
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7255864 |
Diagnostic reagent for hepatitis C virus infection
A diagnostic reagent for hepatitis C virus infection obtained by sensitizing a solid phase with HCV antigen and a conjugated antigen prepared by chemical bonding of HCV antigen and a carrier...
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7255851 |
Non-invasive localization of a light-emitting conjugate in a mammal
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for...
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7241735 |
Pharmacologically active polypeptide glycoconjugates
The invention relates to glycopeptidic glycoconjugates, in which the polysaccharide is obtained from Candida utilis cells and the peptides are obtained from Ricinus communis seeds. The...
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7241447 |
Adeno-associated virus vectors and uses thereof
The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated...
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7238356 |
Core-glycosylated HCV envelope proteins
The current invention relates to HCV envelope proteins or parts thereof which are the product of expression in eukaryotic cells. More particularly said HCV envelope proteins are characterized in...
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7235243 |
Immunological combination compositions and methods
Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself...
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7235242 |
IgA1 protease fragment as carrier peptides
The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO:1,...
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7226601 |
Conjugate between a modified superantigen and a target-seeking compound and the use of the conjugate
A method for the treatment of a disease in a mammal by administering a therapeutically effective amount of a conjugate comprising a biospecific affinity counterpart and a peptide, wherein the...
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7223398 |
Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
The invention provides classes of immunomodulatory compositions which comprise an average of one or more immunostimulatory sequence (ISS) containing polynucleotide conjugated, or attached, to...
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7220552 |
Bifunctional molecules and their use in the disruption of protein-protein interactions
Bifunctional inhibitor molecules and methods for their use in the inhibition of protein—protein interactions are provided. The subject bifunctional inhibitor molecules are conjugates of a target...
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7217791 |
Compositions and methods for treating or preventing pneumococcal infection
The invention provides polypeptides, polysaccharide-polypeptide conjugates, and expression vectors for treating or preventing pneumococcal infection. The compositions induce an anti-pneumococcal...
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7211445 |
Conjugation of biomolecules using diels-alder cycloaddition
A method is provided for covalently linking carbohydrates, proteins, nucleic acids, and other biomolecules under neutral conditions, using a Diels-Alder cycloaddition reaction. In an example,...
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7208157 |
Proteolysis targeting chimeric pharmaceutical
The present invention is based on the discovery of a composition that provides targeted ubiquitination. Specifically the composition contains a ubiquitin pathway protein binding moiety which...
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7208156 |
Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule
Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when...
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7198791 |
Compositions and methods for the generation of protective immune responses against malaria
The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory...
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7195767 |
Method to detect IgE
The present invention includes a method to detect IgE using a human Fc epsilon receptor (Fc ε R) to detect IgE antibodies in a biological sample from a cat, a dog, or a horse. The present...
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7193031 |
Polyalkylene glycol acid additives
A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small...
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