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6572860 |
Immunogenic conjugated polypeptide for treatment of herpes simplex virus
Peptide constructs chemically synthesized to contain a Herpes Simplex Virus specific antigenic peptide, such as, the 322-332 peptide (H1) from the ICP27 protein of Herpes Simplex Virus (HSV-1) and...
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6573003 |
Identification of neutralizing epitopes of toxin A and toxin B for the treatment of C. difficile disease
The present invention includes methods for generating neutralizing antitoxin directed against clostridial toxins. In particular, the antitoxin directed against these toxins is produced in avian...
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6558671 |
Cysteine-depleted peptides recognized by A3-restricted cytotoxic lymphocytes, and uses therefor
Cysteine-depleted CTL epitopes can elicit a stronger or more specific CTL response than the native, cysteine-containing CTL epitope of a disease associated antigen.
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6548067 |
Antigenic constructs of major histocompatibility complex class I antigens with specific carrier molecules, the preparation and use thereof
Antigenic constructs which result from linkage of major histocompatibility complex (MHC) class I antigens with specific carrier molecules are described. The linkage is effected N- or C-terminally...
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6548064 |
Isolated peptides consisting of amino acid sequences found in SSX or NY-ESO-1 molecules, which bind to HLA molecules
The invention relates to members of the SSX family of genes, as well as their uses. Also a part of the invention are peptides derived from SSX molecules and the NY-ESO-1 molecule, which form...
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6548066 |
Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a peptide from the CCK-B/gastrin-receptor conjugated to...
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6541459 |
Soluble herpesvirus glycoprotein complex vaccine
The invention is directed to a herpes simplex virus vaccine comprising a herpes simplex virus glycoprotein H-glycoprotein L complex. The invention is also directed to a vaccine comprising a DNA...
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6541007 |
Vaccine for Pseudomonas aeruginosa
A C-terminal pilin peptide vaccine for immunizing or treating a patient for infection by a Pseudomonas aeruginosa (PA) infection is disclosed. The peptide comprises the peptide identified as SEQ...
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6541004 |
Cocaethylene immunogens and antibodies
The ethyl ester of derivatives of benzoyl ecgonine are provided having a linking group at the para position of the benzoyl group. The derivatives are used to bond to immunogenic polypeptides for...
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6540999 |
Immunomodulatory methods using Lewisx oligosacchardies
Methods for modulating immune responses are provided. The methods involve contacting an immune cell with an agent that modulates interaction of a compound comprising a Lewis antigen with the immune...
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6538104 |
Stabilization of cardiac troponin I subunits and complexes
The present invention provides methods for preparing, and compositions comprising, stabilized protein-polymer conjugates. More particularly, the present invention relates to the stabilization of...
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6534062 |
Methods for increasing a cytotoxic T lymphocyte response in vivo
The invention provides methods for T helper-independent activation of an antigen-specific cytotoxic T lymphocyte response in an individual. The methods generally involve administering to an...
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6531133 |
Pseudomonas exotoxin-myelin basic protein chimeric proteins
A chimeric protein comprising a Pseudomonas aeruginosa exotoxin (PE) moiety linked to a myelin basic protein (MBP) moiety is disclosed. The MBP moiety is selected from the group comprising: (a)...
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6531131 |
Conjugate vaccine for Neisseria meningitidis
A conjugate vaccine for Neisseria meningitidis comprising lipooligosaccharide which does not contain a lacto-N-tetraose antigen from which at least one primary O-linked fatty acid has been...
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6528481 |
NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods
The present invention provides angiogenic vasculature homing molecules that bind to NG2/HM proteoglycan, including, for example, a peptide comprising the amino acid sequence TAASGVRSMH (SEQ ID...
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6521234 |
NL3 TIE ligand homologue
The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL2, NL3 and FLS139, the proteins encoded by such nucleic acid molecules, as well as methods and means...
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6517839 |
Methods for inducing interleukin-12 and a type1/Th1 T-cell response
Methods for inducing interleukin-12 production and inducing a type 1/Th1 T cell response in a subject, thereby stimulating cell-mediated immunity for prevention or treatment of pathogen infections...
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6511666 |
Diagnostics and treatments of periodontal disease
This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis in particular a multimeric cell associated protein complex comprising the PrtR and PrtK proteins. There is...
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6512095 |
Molecules designated B7L-1
The invention is directed to B7L-1 as a purified and isolated protein, the DNA encoding the B7L-1, host cells transfected with cDNAs encoding B7L-1 and processes for preparing B7L-1 polypeptides.
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6506362 |
Labeled compounds that bind to a thrombopoietin receptor
Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and...
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6506389 |
ADHERENCE FACTORS OF NON PATHOGENIC MICROORGANISMS AND APPLICATIONS THEREOF FOR SCREENING MICROORGANISMS FOR SPECIFIC PROBIOTIC PROPERTIES; NOVEL PHARMACEUTICAL COMPOSITIONS AND FOOD ADDITIVES COMPRISING SUCH MICROORGANISMS AND ADHERENCE FACTORS
A protein obtainable from a non pathgenic microorgansim, said protein having mucosa binding promoting activity and a molecular weight of 20-40 kD is disclosed. Application of such a protein or a...
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6500933 |
Methods of preparing carbohydrate crosslinked glycoprotein crystals
The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental...
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6500434 |
Chaperone and adhesin proteins; vaccines, diagnostics and method for treating infections
The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of...
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6500435 |
Recombinant vaccine for prevention and/or treatment of pleuropneumonia infections
The invention provides a vaccine for the prevention and/or the treatment of infection by Actinobacillus pleuropneumoniae , the causative agent of porcine pleuropneumonia, which vaccine contains at...
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6491923 |
Stabilized conjugates of uncomplexed subunits of multimeric proteins
The present invention provides methods for preparing, and compositions comprising, stabilized protein-polymer conjugates. More particularly, the present invention relates to the stabilization of...
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6491922 |
Methods and compounds for treating autoimmune and vascular disease
The present invention relates to methods of treating inflammatory diseases, inhibiting production of adhesion molecules on endothelial cells, inhibiting production of nitric oxide synthase by...
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6491919 |
Aqueous immunologic adjuvant compostions of monophosphoryl lipid A
An aqueous adjuvant composition comprising an attenuated lipid A derivative and a non-immunostimulatory surfactant or surfactants enhances the immunological response in a warm blooded animal to a...
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6488926 |
Vaccine compositions
The invention provides a DNA construct comprising a DNA sequence encoding a fusion protein of the formula: TetC-(Z) a -Het, wherein: TetC is the C fragment of tetanus toxin, or a protein comprising...
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6488932 |
Method for treating cancer by administering MAGE-derived peptides
The invention involves the reception of particular nonapeptides by HLA molecules. The nonapeptides are derived from expression products of the MAGE gene family. The resulting complexes are...
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6482927 |
Chimeric proteins comprising the extracellular domain of murine Ob receptor
The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight...
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6479637 |
Hemoglobin-haptoglobin complexes
Construct-complexes of a hemoglobin, a hepatocyte modifying substance bound to the hemoglobin, and a haptoglobin bound to the hemoglobin, are provided, for administration to mammalian patients. The...
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6475490 |
Compositions and methods for promoting tissue repair using heat shock proteins
The invention relates to methods and compositions for the promotion of tissue repair. Specifically, compositions comprising heat shock proteins, including gp96, hsp90, and hsp70, uncomplexed or...
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6471963 |
Purified antigenic material and its use in the diagnosis and treatment of diabetes
Islet cell membrane antigen has been purified and, since it displaces islet cell surface antibodies, is of utility in the prevention or treatment of diabetes.
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6468540 |
Immunotherapeutic stress protein-peptide complexes against cancer
Disclosed is a method for inhibiting the proliferation of a tumor in a mammal. The method involves the steps of (a) isolating a stress protein-peptide complex from tumor cells previously removed...
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6461615 |
Therapeutic and prophylactic methods using heat shock proteins
The present invention relates to immunogenic complexes of heat shock proteins (hsp) noncovalently bound to exogenous antigenic molecules which when administered to an individual elicit specific...
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6458358 |
Compounds encoding the protective M-like protein of Streptococcus equi and assays therefor
The present invention relates generally to molecular compounds which encode the protective M-like protein of Streptococcus equi (SeM), the amino acid compound which is thereby encoded, and...
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6458369 |
Composition comprising tumor cells and extracts and method of using thereof
The present invention is directed to compositions containing hapten-modified tumor cells and extracts and methods of treating cancer by administering a therapeutically effective amount of a...
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6458367 |
Method for detecting the presence of a mycobacterium species and a kit and antibodies for use therein
The invention relates to a diagnostic test for the detection and identification of Mycobacterium species in biological specimens of human and animal origin. The test is based on the immunological...
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6455048 |
Prevention of primary and metastatic neoplastic diseases with hsp70-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6455493 |
Methods for using heat shock proteins
The present invention provides a heat shock protein immunotoxin comprising: at least a fragment of a heat shock protein, the fragment being capable of being bound by an immune cell; and a toxin...
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6455503 |
Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens
Disclosed is a family of vaccines that contain stress protein-peptide complexes which when administered to a mammal are operative to initiate in the mammal a cytotoxic T cell response against cells...
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6451316 |
Methods for generating antigen-reactive T cells in vitro
The present invention provides methods for generating antigen-reactive T cells in vitro comprising priming immune cells and incubating the primed immune cells in vitro with a non-covalent complex...
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6451314 |
MHC conjugates useful in ameliorating autoimmunity
The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These...
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6451320 |
Combined hepatitis and herpesvirus antigen compositions
Novel combined vaccine compositions preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in...
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6447778 |
Peptide compositions for the treatment of HIV infection
The present invention provides for peptide conjugate compositions, methods of using the peptide conjugate compositions, and pharmaceutical compositions comprising the peptide conjugate...
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6448230 |
Testis expressed polypeptide
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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6440408 |
Method of treatment
A method of producing active immunity against a bacterial or protozoal disease in a subject comprises administering to the subject a vaccine conjugate comprising a live bacteria or protozoa and a...
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6436403 |
Pharmaceutical composition of the intercellular adhesion molecule ICAM-1 for use in anti-viral prophylactic therapy
The invention concerns the use of functional derivatives of ICAM-1 to treat viral infection. The invention also provides a vaccine to prevent such infection, and a diagnostic assay to determine the...
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6436652 |
Method of detecting a pathogen using a virus
A bacteriophage linked to an enzyme can replace an antibody in a system for detecting the presence of a bacteria in a sample. Specifically Brucella abortus (a pathogen which causes brucellosis in...
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6429286 |
Immunoregulatory molecules for costimulatory signal transduction
An immunoregulatory molecule that regulates costimulatory signal transduction through interaction with the molecules involved in costimulatory signal transduction present on antigen presenting...
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