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5879673 |
Administration of thrombopoietin on a single day only
The present invention is directed to the surprising and unexpected finding that biologically active thrombopoietin materials can be administered with substantial therapeutic effect at dosage rates...
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5876718 |
Methods of inducing T cell non-responsiveness to transplanted tissues and of treating graft-versus-host-disease with anti-gp39 antibodies
Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred...
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5874083 |
Immunopotentiating complexes comprising TraT proteins
Class of carrier molecules which when covalently linked to an immunogen enhances the host's immune response to that immunogen regardless of whether the complex of carrier and immunogen is...
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5874085 |
Vaccine for enhanced production of IgA antibodies
The invention describes compositions and methods for optimizing IgA class switching in B cells. The compositions comprise a multivalent antigen receptor crosslinker, CD40 ligand or...
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5871747 |
Antigen-carrying microparticles and their use in the indication of humoral or cellular responses
The invention concerns the use, in the induction of an immune response, of a synthetic microparticle polymer carrying on the surface one or more covalently bonded proteins capable of carrying one...
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5869348 |
Methods for the preparation of antibodies directed against dithiocarbamates and the use thereof for detection of nitric oxide in body fluids
In accordance with the present invention, ELISA methods for the measurement of NO levels in mammalian body fluids utilizing monoclonal antibodies directed against dithiocarbamates and related iron...
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5858367 |
Methods for screening for antimicrobials utilizing AarC and compositions thereof
The present invention provides an oligonucleotide (aarC) which encodes a novel bacterial polypeptide (AarC) that is essential for the viability of bacteria. The invention provides recombinant...
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5858363 |
Target specific antibody-superantigen conjugates and their preparation
A soluble antibody conjugate comprising an antibody linked to a structure which is recognizable by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the...
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5856084 |
Hepatitis B vaccine
A variant or so-called "escape mutant" HBsAg protein or fragment thereof displaying the antigenicity of hepatitis B virus surface antigen is disclosed, in which the mutant protein or fragment...
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5849301 |
Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents
The invention relates to a process for producing an immunogenic construct comprising activating at least one first carbohydrate-containing moiety with CDAP, CTEA or pNPC, and covalently joining the...
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5846545 |
Targeted delivery of cyclopropylbenzindole-containing cytotoxic drugs
Gytotoxic agents containing a cell binding agent chemically linked to one or more analogue or derivative of CC-1065 are described. The therapeutic use of the cytotoxic agents is also described....
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5846826 |
Isolated cytolytic T cell line specific to complexes of HLA-B44 molecules and specific nonapeptides
The invention involves cytolytic T cell lines which are specific for complexes of HLA-B44 molecules and nonamers which bind to these.
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5843454 |
HIV immunogenic complexes
A vaccine and a method of raising neutralizing antibodies against HIV infection. The vaccine comprises a complex of gp120 covalently bonded to CD4 or to succinyl concanvalin A. Also disclosed are...
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5843461 |
Group B streptococcus type II polysaccharide-tetanus toxoid conjugate vaccines
This invention relates to antigenic conjugate molecules comprising the capsular polysaccharide of Group B streptococcus type II which are covalently linked to protein. This invention also relates...
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5843688 |
Isolated tyrosinase derived peptides and uses thereof
The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic...
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5843453 |
Growth hormone potentiating molecules
Antigenic molecules cause antibodies to be raised against at least some of the 91 to 102 region of a natural growth hormone when parenterally administered in vivo. The molecules can include...
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5840305 |
Treatment of HIV-Infection by interfering with host cell cyclophilin receptor activity
The present invention relates to therapeutic modalities and pharmaceutical compositions for the treatment of HIV-infection using cyclophilin A and its corresponding human cellular binding partner...
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5837250 |
Adjuvant compositions
Adjuvant compositions for modulating an immune response to an antigen administered to a host comprise a mineral salt adjuvant and at least one other adjuvant. The compositions provide an...
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5837825 |
Campylobacter jejuni flagellin/Escherichia coli LT-B fusion protein
A fusion protein which comprises the B subunit of the labile toxin (LT-B) of E. coli and part of the flagellin (flaA) protein of C. jejuni is antigenic and is useful for decreasing colonization in...
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5824315 |
Binding affinity of antigenic peptides for MHC molecules
This invention provides methods of improving the binding affinity of a peptide epitope for MHC Class II molecules by attaching to the N-terminus of the peptide epitope a hydrophobic amino acid or a...
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5824310 |
Lipopplysaccharide conjugate vaccines
The present invention relates to lipopolysaccharides from Brucella abortus and their use as carriers in vaccines for humans and animals. In particular, the present invention relates to conjugate...
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5820866 |
Product and process for T cell regulation
The present invention relates to a product and process for regulating the activity of T cells using major histocompatibility complexes (MHC) stably linked to antigenic peptides. Disclosed is an...
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5817315 |
Recombinant vaccine
A method for an induction of immune response against polypeptide employing antigenic presentation of said polypeptide in the form of either fusion protein with MHC product amino acid sequence or...
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5814459 |
Phosphospecific transcription factor antibodies
Phospho-specific antibodies which recognize the phosphorylated forms of cAMP-responsive transcription factors are provided.
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5811100 |
Compounds for the prevention and treatment of helmith infections
A compound for protecting a vertebrate against infection by helminths comprising hyaluronidase covalently coupled to an immunostimulating carrier, in preferred form, the immunostimulating carrier...
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5811106 |
Plasmodium falciparum thrombospondin-related anonymous proteins (TRAP), fragments and functional derivatives
Proteins, fragments and functional derivatives of a Plasmodium falciparum merozoite-stage thrombospondin-related anonymous protein (TRAP) and pharmaceutical compositions comprising said products.
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5807553 |
Immonogenic oligosaccharide compositions
The invention provides immunogenic oligosaccharide compositions and methods of making and using them. In particular, the compositions comprise oligosaccharides covalently coupled to carrier...
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5807832 |
Oral delivery of biologically active substances bound to vitamin B.sub.12
Complex of a drug, hormone, bio-active peptide, or immunogen with the carrier molecule vitamin B12 and a method for delivering the complex to the intestine of a host vertebrate in order to deliver...
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5804191 |
Sperm as immunogen carriers
Vaccine compositions, contraceptives, and gene therapy delivery vectors are disclosed in which sperm cells or components thereof are used to deliver immunogens or selected gene sequences to target...
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5785973 |
Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines
The present invention relates to novel T-cell epitopes of bacterial products. The epitopes of the invention may be employed in the preparation of conjugates between the epitopes and medically...
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5776459 |
TCR V beta 5 peptides
TCR peptides from the Vβ5 family, particularly those encompassing at least a part of the second complementarity determining region, are useful, e.g., in the diagnosis and treatment of multiple...
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5770577 |
BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
Derivatives of the neurotrophic factors BDNF and NT-3 have been prepared by attachment of these polypeptides to a water soluble polymer, for instance, polyethylene glycol.
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5767072 |
Therapeutic compositions comprising a CD4 peptide and methods of treatment of HIV infections
Disclosed are methods and compositions for the treatment of HIV infections through the specific elimination of cells which express HIV env determinants such as gp120. The compositions of the...
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5763284 |
Methods for peptide synthesis and purification
The present invention provides novel methods for the synthesis and isolation and purification of a peptide of interest (target peptide). In particular, the invention relates to peptide synthesis,...
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5760177 |
Lipopolysaccharide binding protein and process for producing the same
The invention provides a lipopolysaccharide (LPS) binding protein isolated from horseshoe crab. The LPS binding protein is isolated by (i) extracting the hemocyte membrane fraction of horseshoe...
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5756104 |
Liposome-containing intranasal vaccine formulation
The present invention relates to a vaccine formulation for intranasal or inhalation administration, and to the preparation thereof, which formulation contains antigenic material freely mixed with...
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5753203 |
CD30 ligand conjugates
There is disclosed a polypeptide (CD30-L) and DNA sequences, vectors and transformed host cells useful in providing CD30-L polypeptides. The CD30-L polypeptide binds to the receptor known as CD30,...
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5747048 |
Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with animal and human mucin and with synthetic carbohydrate-carrier conjugates
A method of producing monoclonal antibodies that bind to human cancer-associated mucin-type glycoprotein antigens comprising: (1) immunizing a host with a core structure of a mucin-type...
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5744316 |
Isolated, tyrosinase derived peptides and uses thereof
The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic...
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5744354 |
Calcineurin inhibitory compounds and anchoring protein to induce IL-2 gene expression
The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are...
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5736146 |
Conjugates of poorly immunogenic antigens and synthetic peptide carriers and vaccines comprising them
The invention relates to conjugates of poorly immunogenic antigens, e.g. peptides, proteins and polysaccharides, with a synthetic peptide carrier constituting a T cell epitope derived from the...
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5734023 |
MHC class II β chain/peptide complexes useful in ameliorating deleterious immune responses
The present invention is directed to complexes comprising an isolated MHC subunit component, an antigenic peptide and, in some cases, an effector component. The antigenic peptide is associated with...
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5728519 |
Assay for virulent revertants of attenuated live vaccines and kits therefor
The present invention provides a method of classifying an unclassified live poliovirus vaccine as having an acceptable or unacceptable level of neurovirulence, comprising, prior to vaccine...
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5725858 |
Methods of enhancing production performance of birds comprising administration of heterologous protein comprising avian alpha-subunit inhibin protein
The present invention relates, in general, to a method of enhancing the production performance of avians, by administering to a bird a heterologous protein comprised of inhibin protein, or a...
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5716848 |
Cultured cells of quillaja sp
The present invention relates to cultured cells of Quillaja sp. For the preparation of active substances from Quillaja sp., such as saponins. The cells may either originate from a callus tissue...
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5714166 |
Bioactive and/or targeted dendrimer conjugates
Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response...
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5707844 |
Immunoassay reagents and methods for detecting brequinar and analogs
The present invention is directed to immunoassay reagents including specific antibodies to quinoline carboxylic acids, such as brequinar; novel quinoline carboxylic acid haptens useful as standards...
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5705606 |
Peptides derived from GPIIIa
The present invention provides oligopeptides corresponding to regions of the GPIIIa protein, which are capable of specifically binding aggregation mediators, such as fibrinogen. The oligopeptides...
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5698424 |
Capsid forming and cystein modified chimaeric MS2-coat protein
A chimaeric protein is provided, capable of forming part of a capsid assembly and comprising the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof,...
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5695756 |
Methods for treating hypertension
Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are...
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