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7390485 |
Design and therapeutic use of adpase enhanced apyrases
The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and...
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7387777 |
Methods of treating hemophilia or von willebrand disease with p-selectin
The present invention identifies P-selectin as a modulator of hemostasis. Accordingly, the present invention relates to methods for the identification and use of modulators of P-selectin activity...
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7384638 |
Compounds and methods for treatment and diagnosis of Chlamydial infection
Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia ...
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7378096 |
Stress protein compositions and methods for prevention and treatment of cancer and infectious disease
Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or...
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7378095 |
Methods of treating type I diabetes by blocking VEGF-mediated activity
Methods of treating diabetes in mammals, particularly humans, by blocking or inhibiting VEGF-mediated activity. A preferred inhibitor of VEGF-mediated activity is a VEGF antagonist such as the VEGF...
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7374763 |
Protein sequences containing antigenized antibodies for foot-and-mouth disease
Protein sequences encoding antigenized antibodies for treatment of foot-and-mouth disease (FMD) or foot-and-mouth disease virus (FMDV) of swine is provided. The antigenized antibodies are created...
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7371391 |
Papilloma virus capsomere vaccine formulations and methods of use
Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.
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7371388 |
Treatment of Sjogren's syndrome by administration of TR18 polypeptides
The present invention relates to TR18 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR18 protein. TR18 polypeptides are also provided as are vectors, host...
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7371387 |
Vaccine compositions and methods of modulating immune responses
The invention provides compositions and methods for modulating immune responses in subjects. The invention is based, at least in part, on the discovery that an in-frame translation fusion of an...
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7368114 |
Fusion protein including of CD4
Novel recombinant polypeptides are disclosed herein that include a CD4 polypeptide ligated at its C-terminus with a portion of an immunoglobulin comprising a hinge region and a constant domain of a...
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7365156 |
PRO1316 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7364743 |
Nucleotide sequence encoding PTD and CEA fusion protein, TAT-CEA fusion protein, anti-tumor vaccine and pharmaceutical composition for treating tumor comprising the fusion protein
A nucleotide sequence encoding a fusion protein of PTD and CEA. The nucleotide sequence includes a CEA-encoding nucleotide sequence into which a PTD-encoding nucleotide sequence is inserted.
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7364740 |
Molecular differences between species of the M. tuberculosis complex
Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared...
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7361356 |
Self-assembling recombinant papillomavirus capsid proteins
Recombinant papillomavirus capsid proteins that are capable of self assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer...
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7361352 |
Influenza immunogen and vaccine
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An...
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7361350 |
Use of an IL-1 antagonist for treating arthritis
Methods of treating, inhibiting, or ameliorating arthritis, including rheumatoid arthritis, osteoarthritis, psoriatic arthritis, ankylosing spondylitis, or juvenile rheumatoid arthritis, in a human...
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7358087 |
Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand linked to an immunogen. In particular, these molecular adjuvants are employed in compositions designed to...
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7354735 |
Nucleic acid encoding fluorescent protein constructs and methods for detecting apoptosis
Isolated nucleic acids encoding a fluorescent protein construct that detect apoptosis are disclosed. The isolated nucleic acids contain a donor-acceptor pair of green fluorescent proteins and a...
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7354582 |
Use of VEGF antagonists for the treatment of malignant gliomas
Methods for treating a human patient suffering from a brain tumor, including glioblastoma, by administering an effective amount of a vascular endothelial growth factor (VEGF) inhibitor to the human...
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7354581 |
Therapeutic combination of a VEGF antagonist and anti-hypertensive agent
Disclosed are compositions and methods for treating a disease or condition related to angiogenesis with a vascular endothelial growth factor (VEGF) inhibitor and one or more anti-hypertensive...
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7354579 |
Method of treating cancer with a VEGF antagonist and an anti-proliferative agent
Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth...
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7354578 |
Method of tumor regression with VEGF inhibitors
Methods of regressing or inhibiting a tumor in a subject by administering an agent capable of blocking, inhibiting, or ameliorating vascular endothelial growth factor (VEGF)-mediated activity to a...
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7351794 |
PRO1754 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7351413 |
Stabilized HBc chimer particles as immunogens for chronic hepatitis
A method of treating chronic hepatitis B is disclosed that comprises administering a T cell-stimulating amount of a vaccine to a patient. The vaccine comprises an immunogenic amount of chimeric,...
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7351411 |
Methods of treating anemia by inhibition of vascular endothelial growth factor (VEGF)
Methods of treating anemic disorders in human subjects comprising administering a VEGF antagonist comprising a fusion polypeptide having an immunoglobulin-like (Ig) domain 2 of the VEGF receptor...
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7348422 |
Fused protein, gene therefor, recombinant vector, recombinant virus, and its use
A DNA coding for a fusion protein comprising a polypeptide having the antigenicity of Mycoplasma gallisepticum and a polypeptide derived from Herpesvirus outer membrane protein, in which the...
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7348405 |
PRO10274 polypeptides
The present invention is directed to PRO10013 polypeptides.
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7348008 |
Ricin-like toxins for treatment of cancer
The present invention provides a protein having chain of a ricin-like toxin, a B chain of a ricin-like toxin and a novel heterologous linker amino acid sequence, linking the A and B chains. The...
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7343721 |
PRO4406 polypeptide
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7342096 |
PRO1879 polypeptide
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7341730 |
Inhibitors of angiogenesis and tumor growth
This invention provides for polypeptides that have surprising anti-angiogenic activity. These peptides are derived from Saposin B, a previously known protein involved in the hydrolysis of...
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7341729 |
Recombinant parainfluenza virus expression systems and vaccines
The present invention relates to recombinant bovine para influenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue...
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7341728 |
Internalisation of virus into cells
A chimeric transmembrane protein which promotes viral entry into cells comprises: (i) an extracellular domain capable of binding a virus; and (ii) an intracellular internalisation signal.
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7341710 |
Method of identifying molecules that home to a selected organ in vivo
The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
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7339024 |
PRO1772 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7335728 |
PRO1310 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7335637 |
Biglycan and related therapeutics and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with...
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7335370 |
Chlamydia antigens and corresponding DNA fragments and uses thereof
The present invention provides a method of immunizing a host against disease caused by infection by a strain of Chlamydia , specifically C. pneumoniae . The method involves nucleic acid...
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7335369 |
Fusion proteins of mycobacterium tuberculosis antigens and their uses
The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M....
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7335368 |
BVH-A2 and BVH-A3 antigens of group B Streptococcus
Group B streptococcus polypeptides and polynucleotides encoding them are disclosed. Said polypeptides may be useful for the prophylaxis, diagnostic and/or therapy of streptococcal infection in...
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7335361 |
Fusion antigen used as vaccine
The present invention mainly provides a fusion antigen specific for a target cell comprising a ligand moiety which is capable of reacting, recognizing or binding to the receptors on the target...
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7332595 |
DNA sequences encoding peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
The invention discloses isolated DNA sequences encoded by polypeptides characterized by the presence in their structure of one or more sequences bearing all or part of one or more T epitopes, and...
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7332168 |
Composition for the elimination of autoreactive B-cells
The present invention relates to a composition for the selective elimination of autoreactive B-cells comprising at least one (poly)peptide construct consisting of at least two domains wherein one...
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7329500 |
Moraxella (Branhamella) catarrhalis polypeptides and corresponding DNA fragments
The present invention relates to polypeptides of Moraxella ( Branhamela ) catarrhalis which may be used for prophy-laxis, diagnostic and/or therapy purposes.
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7323545 |
PRO1885 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7323544 |
PRO1434 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7323171 |
Methods of treating skin conditions using inhibitors of the CD2/LFA-3 interaction
Methods of using inhibitors of the CD2/LFA-3 interaction in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in...
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7320796 |
Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family
Novel TNF receptor polypeptides are disclosed, along with polynucleotides encoding the polypeptides and uses thereof.
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7320795 |
Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof
The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core...
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7320793 |
Molecular antigen array
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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