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7449551 |
PRO211 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7449188 |
Recombinant oligometric protein complexes with enhanced immunogenic potential
The present invention relates to a chimeric protein comprising an antigen and an oligomerisation domain. The present invention relates further to recombinant oligomeric protein complexes comprising...
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7442376 |
Glycoprotein hormone compositions containing two β subunits
Forms of differentially acting glycoprotein hormones are disclosed. These compositions are of the formula
β 1 -(linker 1 ) m -α-(linker...
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7438917 |
Peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or...
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7438914 |
Composition and method for enhancing immune response
A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to...
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7435410 |
Methods of treatment with interferson and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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7435792 |
Hybrid proteins that migrate retrogradely and transynaptically into the CNS
The non-toxic proteolytic C fragment of tetanus toxin (TTC peptide) has the same ability to bind nerve cells and be retrogradely transported through a synapse as the native toxin. A hybrid protein...
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7432077 |
High-affinity choline transporter
The present invention provides a protein having high-affinity choline transporter activity which is important physiologically, a gene encoding the protein, and a method of screening a material...
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7429653 |
Stabilized soluble glycoprotein trimers
The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin...
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7429384 |
Chimeric antagonist anth1
A recombinant chimeric antagonist formed by a 60 amino acid fragment of the N-terminal region of human interleukin 2 (IL-2) fused to the N-terminal of the extracellular region of the alpha subunit...
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7422746 |
Chemically programmable immunity
Methods and compositions for immediately immunizing an individual against any molecule or compound. The present invention comprises an immunity linker with at least two sites; (1) at least one...
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7422849 |
Method for determining expression of a PI3 kinase gene
This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways...
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7422741 |
VEGFR-3 fusion proteins
The present invention provides materials and methods for antagonizing the function of vascular endothelial growth factor receptors, platelet derived growth factor receptors and other receptors....
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7419671 |
P. gingivalis antigenic composition
The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive...
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7419674 |
Alpha virus-based cytomegalovirus vaccines
The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising alphavirus replicon RNAs, wherein a first replicon RNA comprises nucleic...
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7413741 |
HCV E1 comprising specific disulfide bridges
The invention relates to recombinantly or synthetically produced HCV E1 envelope proteins or parts thereof comprising disulfides between specific cysteine residues. The invention further relates to...
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7410954 |
Adenovirus serotype 30 (Ad30)
The present invention provides an adenovirus serotype 30 (Ad30) fiber amino acid sequence. The present invention also provides polynucleotides and expression vectors encoding an Ad30 fiber and...
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7408044 |
Carrier protein having an adjuvant effect
The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40...
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7402315 |
Hepatitis-C virus type 4, 5 and 6
The present invention relates to a polynucleic acid composition comprising or consisting of at least one polynucleic acid containing 8 or more contiguous nucleotides corresponding to a nucleotide...
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7402316 |
Group A streptococcal vaccines
The present invention provides methods for eliciting an immune response against Group A streptococci , comprising use of recombinant fusion polypeptides, and compositions thereof, that include a...
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7399612 |
VEGF-binding fusion proteins and nucleic acids encoding the same
Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating...
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7399473 |
Virus coat protein/receptor chimeras and method of use
The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor....
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7396533 |
Polypeptides and nucleic acids encoding same
DNAs are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid...
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7393942 |
Nucleic acids encoding mutant forms of Fas ligand
The invention provides for DNA encoding Fas ligand muteins and chimeras and the proteins encoded thereby. The invention further includes the use of DNA and vectors to produce transformed cells...
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7393536 |
Group B Streptococcus antigens and corresponding DNA fragments
The present invention relates to antigens, more particularly antigens of Group B Streptococcus (GBS) ( S. agalactiae ) which may be useful to prevent, diagnose and/or treat streptococcal infections.
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7390485 |
Design and therapeutic use of adpase enhanced apyrases
The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and...
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7387777 |
Methods of treating hemophilia or von willebrand disease with p-selectin
The present invention identifies P-selectin as a modulator of hemostasis. Accordingly, the present invention relates to methods for the identification and use of modulators of P-selectin activity...
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7384638 |
Compounds and methods for treatment and diagnosis of Chlamydial infection
Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia ...
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7378096 |
Stress protein compositions and methods for prevention and treatment of cancer and infectious disease
Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or...
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7378095 |
Methods of treating type I diabetes by blocking VEGF-mediated activity
Methods of treating diabetes in mammals, particularly humans, by blocking or inhibiting VEGF-mediated activity. A preferred inhibitor of VEGF-mediated activity is a VEGF antagonist such as the VEGF...
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7374763 |
Protein sequences containing antigenized antibodies for foot-and-mouth disease
Protein sequences encoding antigenized antibodies for treatment of foot-and-mouth disease (FMD) or foot-and-mouth disease virus (FMDV) of swine is provided. The antigenized antibodies are created...
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7371387 |
Vaccine compositions and methods of modulating immune responses
The invention provides compositions and methods for modulating immune responses in subjects. The invention is based, at least in part, on the discovery that an in-frame translation fusion of an...
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7371388 |
Treatment of Sjogren's syndrome by administration of TR18 polypeptides
The present invention relates to TR18 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR18 protein. TR18 polypeptides are also provided as are vectors, host...
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7371391 |
Papilloma virus capsomere vaccine formulations and methods of use
Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.
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7368114 |
Fusion protein including of CD4
Novel recombinant polypeptides are disclosed herein that include a CD4 polypeptide ligated at its C-terminus with a portion of an immunoglobulin comprising a hinge region and a constant domain of a...
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7364743 |
Nucleotide sequence encoding PTD and CEA fusion protein, TAT-CEA fusion protein, anti-tumor vaccine and pharmaceutical composition for treating tumor comprising the fusion protein
A nucleotide sequence encoding a fusion protein of PTD and CEA. The nucleotide sequence includes a CEA-encoding nucleotide sequence into which a PTD-encoding nucleotide sequence is inserted.
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7364740 |
Molecular differences between species of the M. tuberculosis complex
Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared...
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7365156 |
PRO1316 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7361356 |
Self-assembling recombinant papillomavirus capsid proteins
Recombinant papillomavirus capsid proteins that are capable of self assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer...
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7361350 |
Use of an IL-1 antagonist for treating arthritis
Methods of treating, inhibiting, or ameliorating arthritis, including rheumatoid arthritis, osteoarthritis, psoriatic arthritis, ankylosing spondylitis, or juvenile rheumatoid arthritis, in a human...
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7361352 |
Influenza immunogen and vaccine
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An...
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7358087 |
Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand linked to an immunogen. In particular, these molecular adjuvants are employed in compositions designed to...
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7354579 |
Method of treating cancer with a VEGF antagonist and an anti-proliferative agent
Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth...
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7354581 |
Therapeutic combination of a VEGF antagonist and anti-hypertensive agent
Disclosed are compositions and methods for treating a disease or condition related to angiogenesis with a vascular endothelial growth factor (VEGF) inhibitor and one or more anti-hypertensive...
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7354582 |
Use of VEGF antagonists for the treatment of malignant gliomas
Methods for treating a human patient suffering from a brain tumor, including glioblastoma, by administering an effective amount of a vascular endothelial growth factor (VEGF) inhibitor to the human...
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7354735 |
Nucleic acid encoding fluorescent protein constructs and methods for detecting apoptosis
Isolated nucleic acids encoding a fluorescent protein construct that detect apoptosis are disclosed. The isolated nucleic acids contain a donor-acceptor pair of green fluorescent proteins and a...
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7354578 |
Method of tumor regression with VEGF inhibitors
Methods of regressing or inhibiting a tumor in a subject by administering an agent capable of blocking, inhibiting, or ameliorating vascular endothelial growth factor (VEGF)-mediated activity to a...
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7351411 |
Methods of treating anemia by inhibition of vascular endothelial growth factor (VEGF)
Methods of treating anemic disorders in human subjects comprising administering a VEGF antagonist comprising a fusion polypeptide having an immunoglobulin-like (Ig) domain 2 of the VEGF receptor...
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7351794 |
PRO1754 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7351413 |
Stabilized HBc chimer particles as immunogens for chronic hepatitis
A method of treating chronic hepatitis B is disclosed that comprises administering a T cell-stimulating amount of a vaccine to a patient. The vaccine comprises an immunogenic amount of chimeric,...
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