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7541040 |
Chimeric molecule for the treatment of th2-like cytokine mediated disorders
The invention provides uses and methods for alleviating respiratory tract symptoms of allergy, asthma, and of viral, bacterial, fungal and parasitic infections by shifting inappropriate TH2...
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7541334 |
Hybrid peptides modulate the immune response
The present invention provides an MHC class II antigen presentation enhancing hybrid polypeptide. The hybrid has an N-terminus comprising the mammalian Ii key peptide LRMKLPKPPKPVSKMR (SEQ ID NO:...
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7537766 |
Neisseria meningitidis inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof
The present invention is directed to novel Neisseria meningitidis lipo-oligosaccharide inner core molecules, conjugates thereof and immunogenic compositions thereof. In particular embodiments,...
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7534440 |
Fusion molecules and methods for treatment of immune diseases
The invention concerns bifunctional fusion molecules, and novel, safer and more efficacious methods for the treatment of immune disorders resulting from excessive or unwanted immune responses. The...
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7534866 |
Methods and compositions for generating bioactive assemblies of increased complexity and uses
The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In...
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7534427 |
Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
The invention is directed to a method for treating a treating and diagnosing a B cell-related disease, T cell-related disease or an autoimmune disease in a mammal by concurrently or sequentially...
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7531173 |
Ophthalmic composition of a VEGF antagonist
Methods of reducing or treating angiogenesis and/or inflammation associated with eye injury in a subject in need thereof, comprising administering an agent capable of blocking or inhibiting...
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7531178 |
Immunoadhesin comprising a glycoprotein VI domain
The present invention provides a fusion protein comprising (1) the extracellular domain of glycoprotein VI or a variant thereof that is functional for binding to collagen and (b) the Fc domain of...
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7531172 |
Methods of treating diseases with a VEGF antagonist
A method of reducing or preventing hypertension associated with administration of a vascular endothelial growth factor (VEGF) antagonist in a human subjects suffering from a disease or condition...
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7527946 |
Interferon-beta-1a-immunoglobulin fusion proteins and uses
A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety;...
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7527794 |
Hybrid proteins with neuregulin heparin-binding domain for targeting to heparan sulfate proteoglycans
Polypeptides of the neuregulin (NRG) heparin binding domain (N-HBD) and nucleic acids coding therefor are disclosed. In particular, fusion polypeptides are produced that comprise, as a targeting...
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7527796 |
Genetic engineering of streptavidin-binding peptide tagged single-chain variable fragment antibody to Venezuelan equine encephalitis virus
A recombinant gene encoding a single-chain variable fragment (scFv) antibody against Venezuelan equine encephalitis virus (VEE) being cloned into a prokaryotic T7 RNA polymerase-regulated...
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7527787 |
Multivalent immunoglobulin-based bioactive assemblies
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred...
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7524499 |
Modified chimeric polypeptides with improved pharmacokinetic properties
Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their...
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7524674 |
Multimodality imaging of reporter gene expression using a novel fusion vector in living cells and animals
Novel double and triple fusion reporter gene constructs harboring distinct imageable reporter genes are provided, as well as applications for the use of such double and triple fusion constructs in...
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7521057 |
Lamprey GnRH-III polypeptides and methods of making thereof
Lamprey GnRH-III polypeptides for the four species of fish lamprey are disclosed. Also disclosed is a procedure for producing such polypeptides by recombinant techniques. Also disclosed are methods...
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7521059 |
Kennel cough vaccine
Improved, low cost vaccines for administration to living subjects such as mammals and birds are provided, which include killed recombinantly modified microorganisms (whole cell recombinant bacterin...
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7521056 |
Stably tethered structures of defined compositions with multiple functions or binding specificities
The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments...
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7514088 |
Multivalent Clostridial toxin derivatives and methods of their use
The present invention is directed to multivalent Clostridial neurotoxin derivatives having more than one binding domain directed to a cell surface feature of a target cell. Such modified...
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7510718 |
Expression vectors and uses thereof
The present invention relates to novel vectors, to DNA vaccines and gene therapeutics containing the vectors, to methods for the preparation of the vectors and DNA vaccines and gene therapeutics...
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7507412 |
Glycoprotein VI fusion proteins
The present invention relates to Glycoprotein VI (GPVI) fusion proteins (GPVI-fusion proteins) comprising a tag like myc, GST, HA, FLAG, STREP but preferably a Immunoglobulin molecule (Ig), more...
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7504481 |
TRP channel family member, LTRPC3 polypeptides
The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice...
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7504483 |
α-β C4BP-type recombinant heteromultimeric proteins
A recombinant heteromultimeric protein including at least (a) a polypeptide fusion molecule A consisting of a C4BP α-chain C-terminal fragment and a polypeptide fragment heterologous to said α...
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7501234 |
Stress proteins and uses therefor
The present invention relates to stress proteins and methods of modulating an individual's immune response. In particular, it relates to the use of such stress proteins in immune therapy and...
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7501128 |
IHNV G protein for immune stimulation
A vaccine comprises a portion of IHNV G protein and a portion of a second protein from a fish pathogen, or their respective nucleic acid coding sequences. The presence of the IHNV G protein boosts...
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7501125 |
Vivo CTL elicitation by heat shock protein fusion proteins maps to a discrete domain and is CD4+ T cell-independent
The present invention relates to a method of inducing a CD8 + CTL response to a molecule in an individual deficient in CD4 + T cells comprising administering to the individual an hsp or a portion...
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7494656 |
Molecular antigen arrays
The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant...
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7491397 |
Receptor binding polypeptides
Isolated polypeptides containing fragments of SARS CoV S protein and functional equivalents thereof. Also disclosed are isolated nucleic acids encoding the polypeptides, related expression vectors,...
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7491706 |
Artificial cpg single-stranded oligodeoxynucleotide and antiviral use thereof
The present invention provides a series of artificial CpG-containing single-stranded oligodeoxynucleotides (ODNs), each of which is consisted of single-stranded oligodeoxynucleotide DNA molecule...
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7491515 |
Recombinant polypeptides for diagnosing infection with Trypanosoma cruzi
Recombinant polypeptides are disclosed that are useful for diagnosing American trypanosomiasis, or Chagas disease, a disease caused by the infectious agent Trypanosoma cruzi . Preferably, DNA...
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7488804 |
Modified fusion molecules for treatment of allergic disease
The present invention comprises a fusion molecule comprising a Fcε fragment sequence including functionally active CH2, CH3 and CH4 domains of the constant region of an IgE heavy chain...
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7488478 |
Methods and compositions for treatment of inflammatory disease using cadherin-11 modulating agents
A method for treating inflammatory joint diseases by inhibiting cadherin-11 mediated cellular function using a cadherin-11 modulating agent is provided. Also provided are screening assays for...
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7488484 |
Nucleic acid expression cassette encoding an HIV polyprotein comprising the ancillary gene products Vif, Vpu, and Nef
Improved vaccines and methods of using the same are disclosed. Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are...
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7488489 |
Identification of a conserved region of Plasmodium falciparum MSP3 targeted by biologically active antibodies
Antigenic and immunogenic determinants of Merozoite surface protein 3 (MSP3). Antigenicity and functional assays identified a 68-amino acid conserved domain of MSP3 as a target of biologically...
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7485307 |
Human cystathionine β-synthase variants and methods of production thereof
Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the...
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7485313 |
Recombinant Chlamydia trachomatis pgp3 protein suitable for enzyme-linked immunoassay, and used of the protein in eliciting and diagnosing an immune response
Uses of the plasmid-encoded protein pgp3 from C. trachomatis, serotype D, purified by ion exchange column chromatography and shown to be suitable for quantitative immunoassay on clinical samples...
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7485308 |
26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206, and 8843 molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules....
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7482013 |
Albumin fusion proteins
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention,as are vectors...
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7482430 |
Compositions and methods relating to multimeric and oligomeric soluble fragments of the TWEAK receptor
The present invention provides methods and compositions relating to fusion proteins comprising multimeric soluble TWEAK receptor fragments and an oligomerization domain. Such fusion proteins are...
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7482001 |
Method of administering and using VEGF inhibitors for the treatment of non small cell lung cancer
A method of treating a human patient suffering from cancer, comprising administering an effective amount of a vascular endothelial growth factor (VEGF) trap antagonist to the human patient, the...
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7479550 |
Amyloid β gene vaccines
The invention generally concerns compositions and methods for genetic vaccination with amyloid beta (Aβ) protein. Such vaccines may provide effective treatment for neurodegenerative disease such...
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7479547 |
HIV-1 subtype isolate regulatory/accessory genes, and modifications and derivatives thereof
The invention describes HIV-1 subtype isolate regulatory/accessory genes, and modifications and derivatives thereof. The genes which are described are the tat, nef and rev genes. Consensus amino...
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7476387 |
Chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV), process for their production and applications
The chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV) are formed by the assembly of fusion proteins comprising a region A consisting of an IBDV pVP2...
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7470521 |
RAGE protein derivatives
The present invention is drawn to fusion proteins comprising a Receptor for Advanced Glycation Endproducts (RAGE) and an immunoglobulin element. The invention also encompasses methods of treating a...
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7470432 |
Surface explosed immunoglobulin D-binding protein from Moraxella catarrhalis
The present invention relates to a surface exposed protein, which can be detected in Moraxella catarrhalis , having an amino acid sequence as described in SEQ ID NO 1, an apparent molecular weight...
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7462354 |
Method and system for optimizing minigenes and peptides encoded thereby
The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of amino acid...
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7462356 |
Chimeric papillomavirus-like particles
The present invention provides a papillomavirus-like particle, characterized as having conformational epitopes, comprising a papillomavirus L1 product and a papillomavirus L2 fusion product; and...
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7459158 |
Immunogenic polypeptides for inducing anti-self IgE responses
The invention relates to methods and materials involved in the treatment and prevention of various diseases such as infections and IgE-related diseases. Specifically, the invention relates to...
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7455843 |
Adjuvant activities of mutants of LT-IIa and LT-IIb enterotoxin lacking binding to ganglioside
The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is...
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7449191 |
Compositions and methods for detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies
The invention provides methods and compositions for the detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies and antibody fragments.
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