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6706271 |
Cloning of BASB023 antigen from Moraxella catarrhalis
The invention provides BASB023 polypeptides encoding BASB023 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and...
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6706494 |
BASB028 polypeptides and polynucleotides encoding therefor from moraxella catarrhalis
The invention provides BASB028 polypeptides and polynucleotides encoding BASB028 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6706269 |
Moraxella catarrhalis PILQ proteins
The invention provides BASB031 polypeptides and polynucleotides encoding BASB031 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6703360 |
Compositions and methods related to canine IgG and canine IL-13 receptors
The invention relates to canine immunoglobulin G (IgG) and canine interleukin-13 receptors (IL-13R) as well as fusion proteins containing canine IgG and/or canine IL-13R. In particular, the present...
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6689365 |
Single-chain fertility hormones with fsh and LH activity
Glycosylated or nonglycosylated proteins of the formula FSHβ-(linker 1 ) n 1 -LHβ(1-X)-(linker 2 ) n 2 -α wherein FSHβ is a vertebrate follicle stimulating hormone β subunit or a variant...
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6689368 |
Immunodominant human T-cell epitopes of hepatitis C virus
The present invention relates to a polypeptide of about 8 to about 100 amino acids comprising or consisting of at least 8 contiguous amino acids selected from the core, and/or the NS3 regions of...
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6685941 |
Methods of treating autoimmune disease via CTLA-4Ig
The method of immunotherapy of the present invention involves the regulation of the T cell immune response through the activation or suppression/inactivation of the CD28 pathway. Induction of...
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6682739 |
Methods of inhibiting osteoclastogenesis
Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. The present invention...
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6682741 |
β2 microglobulin fusion proteins and high affinity variants
β 2 -microglobulin fusion proteins and modified forms of β 2 -microglobulin are disclosed. The fusion proteins are shown to incorporate onto the surface of MHC I expressing mammalian cells and to...
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6680058 |
Compositions and methods for contraception in or sterilization of mammals
Amphipathic lytic peptides are ideally suited to use in a ligand/cytotoxin combination to induce sterility or long-term contraception in mammals. The peptides act directly on cell membranes, and...
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6680057 |
Methods of treating autoimmune disease by administering interleukin-17 receptor
Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
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6676945 |
Mycobacterial proteins, microorganisms producing them and their use for vaccines and for the detection of tuberculosis
Mycobacterium tuberculosis protein having a molecular weight of 28.779 Da, and hybrid proteins containing at least portions of its sequence. These proteins may in particular be used in vaccines...
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6673574 |
Oral delivery of peptides using enzyme-cleavable membrane translocators
Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine in addition to having the...
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6673572 |
Methods for rescue of RNA viruses
This invention relates to improved methods for producing nonsegmented, negative-sense, single-stranded RNA viruses of the Order designated Mononegavirales virus, including embodiments relating to...
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6669939 |
(Poly)peptides which represent the epitopes of the human herpes virus type 8
The present invention relates to (poly)peptides, which are recognized by anti-HHV8 antibodies of HHV-8 infected patients, whereby these (poly)peptides are not naturally occurring HHV-8 proteins....
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6669941 |
Soluble lymphotoxin-β receptor as a therapeutic agent for treating TH-1 cell-associated autoimmune disease
This invention relates to compositions and methods comprising “lymphotoxin-β receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents...
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6663867 |
Hybrid heterodimeric protein hormone comprising a TNF binding protein and a glycoprotein hormone subunit and method of using same
A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-β and...
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6660274 |
Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease
A novel isolated Borrielia burgdorferi sensu lato surface antigen is characterized by a relative molecular mass of 39.5 kDa. This antigen is expressed in vitro by spirochetes of a B. burgdorferi...
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6660271 |
Ubiquitin fusion-based vaccine system
Disclosed are epitope-containing heat shock fusion proteins, DNA constructs encoding such fusion proteins, and methods of use. More specifically, disclosed are ubiquitin fusion proteins comprising...
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6653444 |
Polypeptides comprising a B7 extracellular domain
Isolated nucleic acid molecules encoding a B cell activation antigen, B7, are provided. In one embodiment, the nucleic acid molecules are DNA sequences. The DNA sequences of the invention can be...
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6652858 |
Use of OX-2 to suppress an immune response
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of an OX-2 protein or a nucleic acid encoding an OX-2 protein. The...
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6653086 |
Endogenous constitutively activated G protein-coupled orphan receptors
Disclosed herein are techniques for directly identifying candidate compounds as agonists, partial agonists and/or, most preferably, inverse agonists, to endogenous, constitutively activated orphan...
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6652863 |
Method of reducing the immunogenicity of compounds
Reduced-immunogenic fusion compounds are disclosed. The fusion compounds of the invention comprise immunogenic compounds linked to auto-antigenic sequences which render the compound less...
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6649374 |
Recombinant Chlamydia trachomatis PGP3 antigen
A new recombinant form of the plasmid-encoded protein pgp3 from C. trachomatis , serotype D, to be used in immunogenic compositions and in the preparation of immunogenic compositions was purified...
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6649166 |
Peptides and proteins for desensitizing subjects allergic to bee venom and compositions containing same
The invention concerns peptides and proteins for desensitizing specifically the vast majority of subjects allergic to bee venom and compositions containing said peptides or proteins. The peptides...
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6649164 |
Method for enhancing the functional capacity of dendritic cells
Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to enhance the functional capacity of dendritic cells.
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6649171 |
Moraxella catarrahalis polynucleotides and polypeptides
The invention provides BASB021 polypeptides and polynucleotides encoding BASB021 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6645500 |
Method for down-regulating osteoprotegerin ligand activity
The invention provides a novel method for down-regulating the biological activity of osteoprotegerin ligand (OPGL, TRANCE) thereby rendering possible the treatment/amelioration of diseases...
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6645501 |
Anti-pathogen system and methods of use thereof
The present invention provides an anti-pathogen system comprising one or more fusion proteins that includes a transduction domain and a cytotoxic domain. The cytotoxic domain is specifically...
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6641809 |
Method of regulating cellular processes mediated by B7 and CD28
The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins...
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6638511 |
Mycobacterium polypeptides and nucleic acids encoding them for diagnosis and control of tuberculosis
The invention relates to nucleic acids which contain particularly a nucleotide sequence extending from the extremity constituted by the nucleotide at position (1) to the extremity constituted by...
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6638518 |
Method for inhibiting inflammatory responses
The present invention provides methods for treating at least one symptom of an inflammatory response in a mammal by administering a polypeptide to the mammal. The polypeptide can be a microbial...
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6635472 |
Retrovirus and viral vectors
This invention relates to the fields of genetic engineering, virus replication and gene transfer. More specifically, this invention relates to polynucleotide construct, recombinant virus,...
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6635256 |
Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
Forms of differentially acting glycoprotein hormones are disclosed. These compositions are of the formula β 1 -(linker 1 ) m -α-(linker 2 ) n -β 2 (1); β 1 -(linker 1 ) m -β 2 -(linker 2 )...
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6632436 |
Vaccine compositions and method of modulating immune responses
The invention provides compositions and methods for modulating immune responses in subjects. The invention is based, at least in part, on the discovery that an in-frame translation fusion of an...
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6630348 |
Single-chain insulin analog and a polynucleotide sequence encoding the analog
The subject matter of the invention is directed to a single-chain insulin analog that is used to treat diabetes by gene therapy methods.
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6613331 |
Vaccine against Lyme disease
The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of ...
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6613327 |
Methods of preventing immune-mediated abortion by inhibiting a CD28-mediated costimulatory signal
Methods of inhibiting and diagnosing spontaneous abortion in a subject are provided. The subject methods are based, inter alia, on the administration of an agent that inhibits a CD28-C mediated...
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6610306 |
OMP85 protein of neisseria meningitidis, compositions containing the same and methods of use thereof
Nucleic acid and amino acid sequences of the Omp85 proteins of N. gonorrhoeae and N. meningitidis , and fragments thereof are useful in vaccine compositions, therapeutic compositions and...
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6610473 |
Peptides for inhibiting HPV E6-proteins
The present invention relates to peptides suited for inhibiting HPV-E6 proteins, DNAs encoding them and the use of both, particularly for eliminating HPV tumor cells.
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6607724 |
Compositions and methods for inhibiting angiogenesis
The invention provides for methods of reducing or inhibiting angiogenesis, tumor growth and endothelial cell proliferation by the administration of compositions containing fragments, conformations,...
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6605699 |
Galectin-11 polypeptides
The present invention relates to galectin 11 proteins which are members of the galectin superfamily. In particular, the present invention relates to full-length polypeptides, fragments, and...
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6605286 |
Delivery of biologically active polypeptides
Biologically active polypeptides and/or antigens are delivered by administering to a subject a non-invasive or non-pathogenic bacterium which expresses one or more antigens or polypeptides. The...
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6602510 |
HLA class I A2 tumor associated antigen peptides and vaccine compositions
A composition or vaccine composition comprising eight isolated epitopes consisting of YLSGANLNV (SEQ. ID. NO: 1), IMIGVLVGV (SEQ. ID. NO: 2), KLBPVQLWV (SEQ. ID. NO: 3), SMPPPGTRV (SEQ. ID. NO: 4),...
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6602504 |
Canine coronavirus S gene and uses therefor
The present invention provides the amino acid and nucleotide sequences of a CCV spike gene, and compositions containing one or more fragments of the spike gene and encoded polypeptide for...
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6600018 |
Secreted frizzled related protein, sFRP, fragments and methods of use thereof
The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of...
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6596278 |
Immunological response potentiation process
An immunological response potentiation process is disclosed for synthetic or genetically engineered antigens having low immunogenicity. The antigen is embedded into biodegradable microparticles,...
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6592872 |
Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein
The present invention provides a vaccine for inducing an immune response in mammal to a specific antigen, where the vaccine comprises a unit dose of a binary, cytotoxic T lymphocyte vaccine...
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6592871 |
HCV peptide antigens and methods for the determination of HCV
Novel HCV peptide antigens are described representing partial sequences of the C-100-3 and env/core with C-regions. These peptide antigens are suitable for the determination of HCV antibodies as...
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6586392 |
Conjugates of antiviral proteins or peptides and virus or viral envelope glycoproteins
The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention...
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