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6146635 |
System for the expression of heterologous antigens as fusion proteins
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6146634 |
Proteins with urease activity
The invention relates more particularly to any nucleotide sequence corresponding, according to the universal genetic code, to at least one part of the following amino acid sequence (VIII) of 61 kDa...
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6143872 |
Borrelia burdorferi Osp A and B proteins and immunogenic peptides
Disclosed and claimed are isolated polypeptides consisting of amino acid sequences derived form ospA and/or ospB of various B. burgdorferi or portions thereof and methods of making and using the same.
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6136323 |
Bacterial plasmin receptors as fibrinolytic agents
The subject invention concerns novel methods and compositions for thrombolytic therapy. More specifically, a receptor with high affinity for plasmin has been characterized, purified, cloned, and...
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6130059 |
Helicobacter pylori proteins useful for vaccines and diagnostics
Helicobacter pylori is known to cause or be a cofactor in type B gastritis, peptic ulcers, and gastric tumors. In both developed and developing countries, a high percentage of people are infected...
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6129917 |
Immunogenic compositions comprising porphyromonas gingivalis proteins and/or peptides and methods
Provided herein are methods and immunogenic compositions useful for protecting mammals from infection and pathology of P. gingivalis. Specifically, arginine-specific proteases of Porphyromonas...
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6123942 |
Bacterial hemoglobin receptor gene
The present invention relates to a novel bacterial hemoglobin receptor protein and genes that encode such a protein. The invention is directed toward the isolation, characterization, diagnostic and...
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6117421 |
Method for promoting cell growth and immunosuppression using chaperonin
A process for the detection of cpn10 in serum or other biological fluids including the steps of (i) raising antibody to cpn10; (ii) reacting said antibody with a sample of biological fluid...
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6110464 |
Broad-spectrum δ-endotoxins
Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed...
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6096321 |
ClpG subunit of CS31A protein capsule containing heterologous peptides
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6086895 |
Fibronectin binding protein
The present invention relates to new recombinant DNA-molecules comprising nucleotide sequences of S. dygalactiae encoding for at least one protein or polypeptide having fibronectin binding property.
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6072032 |
FtsY polypeptides from Streptococcus pneumoniae
The invention provides ftsY polypeptides and polynucleotides encoding ftsY polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6060059 |
Haemophilus adhesion proteins
The invention relates to novel Haemophilus adhesion proteins, nucleic acids, and antibodies.
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6051239 |
Compositions and methods for systemic delivery of oral vaccines and therapeutic agents
Compositions and methods of oral delivery of an antigen or therapeutic agent to the general circulation using a modified botulinum toxin which is capable of translocating from the gut to the...
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6045798 |
Membrane-associated immunogens of mycobacteria
Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive...
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6018019 |
Synthetic Haemophilus influenzae conjugate vaccine
The present invention provides immunogenic synthetic peptides which are useful alone or in PRP-conjugates in vaccines against Hemophilus influenza infection. Modifications are possible within the...
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6001372 |
Antigenic peptides of Chlamydia trachomatis
Disclosed herein are short antigenic peptides of MOMP protein from Chlamydia trachomatis. They can be used to stimulate antigenic responses and to diagnose the presence of the bacteria.
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6001361 |
Mycobacterium vaccae antigens
The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae soluble protein and DNA molecules encoding such polypeptides, together with methods for their use in the...
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5989547 |
Leptospiral outer membrane proteins
This invention presents antigenic preparations of Leptospira species outer membrane proteins and their immunogenic fragments which are useful for inducing immune response in animals, e.g., for use...
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5989553 |
Expression library immunization
A general method for vaccinating against any pathogen is presented. The method utilizes expression library immunization, where an animal is inoculated with an expression library constructed from...
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5989884 |
HisS polypeptides from Chlamydia trachomatis
The invention provides hisS polypeptides and DNA (RNA) encoding hisS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing hisS...
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5985288 |
Outer membrane protein P1 and peptides of Haemophilus influenzae type B
The gene for outer membrane protein P1 of Haemophilus influenzae b is expressed in E. coli. Methods for expression and demonstration of the immunogenicity of recombinant P1 and portions thereof are...
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5976543 |
12-kDa protein derived from M. Tuberculosis useful for treatment of autoimmune diseases
Disclosed is a 12-kDa PPD protein isolated and purified from the purified protein derivative, the major fraction of Mycobacterium tuberculosis that protects mice against the induction of...
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5976542 |
Compositions and methods for treatment of streptococcus pneumoniae infection
The invention relates to an isolated nucleic acid encoding Streptococcus pneumoniae IgA protease and an isolated polypeptide comprising Streptococcus pneumoniae IgA protease and methods of use...
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5976544 |
Polypeptides and vaccines for Bordetellapertussis and method of use
A polypeptide for use in a vaccine against Bordetella pertussis, B. parapertussis or B. bronchiseptica contains an epitope selected from (a) the amino acid sequence coded for by nucleotides 1885 to...
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5962636 |
Peptides capable of modulating inflammatory heart disease
Disclosed are novel peptides that modulate inflammatory heart disease. Also disclosed are DNA molecules encoding the peptides, and methods of making the peptides.
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5958416 |
Heat shock protein peptides and methods for modulating autoimmune central nervous system disease
The invention provides for peptides and methods of using peptides to block or inhibit a pathogenic autoimmune response to central nervous system components. One class of peptides are antigens...
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5955077 |
Tuberculosis vaccine
The invention relates to novel secreted antigens from mycobacteria capable of evoking early (within 4 days) immunological responses from T-helper cells in the form of gamma-interferon release in...
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5955078 |
Fibronectin binding protein polypeptides
A monoclonal antibody (Mab), or a fragment thereof, that binds to one or more epitopes of a matrix binding protein and an isolated D1-D4 polypeptide (SEQ ID NO. 6, 7, and 8) from a Staphylococcus...
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5955596 |
NucA protein of Haemophilus influenzae and the gene encoding that protein
A protein from H. influenzae designated NucA is isolated and purified. The NucA protein has the amino acid sequence of amino acids 26-603 of SEQ ID NO:2 or a biologically equivalent amino acid...
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5955090 |
Immunogenic hybrid protein OprF-OprI derived from Pseudomonas aeruginosa membrane proteins
The present invention relates to a hybrid protein comprising the Pseudomonas aeruginosa outer membrane protein I (OprI) which is fused with its amino terminal end to the carboxy-terminal end of a...
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5951980 |
Identification, production and use of new staphylokinase derivatives with reduced immunogenicity
Methods for the identification, production and use of derivatives of the invention obtained by preparing a DNA fragment comprising at least the part of the coding sequence of staphylokinase that...
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5935580 |
Recombinant mutants for inducing specific immune responses
This invention relates to a recombinant plasmid comprising the cyaC and the cyaA genes of Bordetella which directs the expression of Bordetella adenylate cyclase in a transformed host cell. This...
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5932217 |
Peptides which inhibit adhesion between leukocytes and endothelial cells
Peptides which will inhibit the reaction between the RGD tripeptide of FHA and the integrin receptors of endothelial cells and their utility as therapeutic agents are described.
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5932483 |
Synthetic peptide and its uses
The invention provides a fragment of C1q which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric...
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5932705 |
Methods and compositions for the treatment and diagnosis of shipping fever
Novel compositions are disclosed for use in the treatment or diagnosis of bovine pasteurellosis, commonly referred to as Shipping Fever. Cell-free Pasteurella haemolytica supernatants are employed...
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5932220 |
Diagnostic tests for a new spirochete, Borrelia lonestari sp. nov.
Bites from Amblyomma americanum, a hard tick, have been associated with a Lyme disease-like illness in the southeastern and south-central United States. Present in 2% of ticks collected in four...
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5928644 |
T-cell epitopes
T-cell epitopes of or derived from the TraT protein of E. coli have been identified and used in the preparation of complexes with immunogens to enhance or provide immune responses to the...
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5922323 |
Transferrin receptor genes and immunogenic compositions derived therefrom
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
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5916562 |
Membrane proteins and peptides of haemophilus influenzae type B
The nucleotide sequence of the P2 gene and the derived amino acid sequence of the P2 protein of Haemophilus influenzae type b are disclosed and the methods used to determine the same. Also...
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5911996 |
43 Kd protein vaccine and method for the production thereof
A protein derivable from Actinobacillus pleuropneumoniae (APP) having a molecular size ranging between 43 Kd on SDS PAGE is described. The protein is soluble on sodium lauryl sarcosinate (SLS) and...
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5889172 |
DNA sequences for immunologically active peptides of pertussis toxin
Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating...
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5876725 |
Actinobacillus pleuropneumoniae transferrin binding protein vaccines and uses thereof
Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one A. pleuropneumoniae transferrin binding protein and/or one A. pleuropneumoniae...
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5871742 |
Recombinant Avipox virus encoding polypeptide of mycoplasma gallisepticum, and utilized a live vaccine
A polypeptide exhibiting the antigenicity of Mycoplasma gallisepticum, a fused polypeptide comprising the above polypeptide and, connected to the N-terminus thereof, a signal membrane anchor of a...
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5869058 |
Peptides used as carriers in immunogenic constructs suitable for development of synthetic vaccines
The invention relates to conjugates of poorly immunogenic antigens, e.g., peptides, proteins and polysaccharides, with a synthetic peptide carrier constituting a T cell epitope derived from the...
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5861157 |
Diagnosis and treatment of infections due to Streptococci and Enterococci
The present invention provides a purified bacterial protein expressed during infection due to streptococci or enterococci and isolated from human sera, together with immunogenic fragments, analogs,...
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5858965 |
Pharmaceutical compositions for the treatment of autoimmune diseases comprising the B-oligomer of pertussis toxin or its subunits
The invention provides the use of a protein selected from the B-oligomer of pertussis toxin, an individual subunit S2, S3, S4 or S5 thereof, or a combination of the subunits, for the preparation of...
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5859207 |
Superantigen agonist and antagonist peptides
The subject invention concerns novel peptide agonists and antagonists of staphylococcal enterotoxin A. Specifically exemplified are peptide agonists which stimulate T cell proliferation.
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5858367 |
Methods for screening for antimicrobials utilizing AarC and compositions thereof
The present invention provides an oligonucleotide (aarC) which encodes a novel bacterial polypeptide (AarC) that is essential for the viability of bacteria. The invention provides recombinant...
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5849295 |
Nucleotide sequences coding for a protein with urease activity
The invention relates to a sequence of nucleotides, characterized in that it comprises at least a part of a sequence coding for a protein with urease activity such as that expressed by C. pylori....
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