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7329500 |
Moraxella (Branhamella) catarrhalis polypeptides and corresponding DNA fragments
The present invention relates to polypeptides of Moraxella ( Branhamela ) catarrhalis which may be used for prophy-laxis, diagnostic and/or therapy purposes.
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7323179 |
Methods and compositions for the treatment and prevention of Staphylococcus and other bacterial infections
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, certain species of bacteria, including in particular bacteria in...
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7323175 |
Immunogenicity of glucan binding protein
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7320794 |
Transporter protein
A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912,...
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7314632 |
Pseudomonas exotoxin A-like chimeric immunogens
This invention provides Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin. Methods of eliciting an immune response using...
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7314625 |
Chimeric protein comprising non-toxic Pseudomonas exotoxin A and Type IV pilin sequences
The invention provides chimeric proteins comprising a non-toxic Pseudomonas exotoxin A sequence and a Type IV pilin loop sequence, wherein the Type IV loop sequence is inserted within the...
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7311917 |
Moraxella catarrhalis protein, gene sequence and uses thereof
The invention discloses the Moraxella catarrhalis outer membrane protein polypeptide and polypeptides derived therefrom (collectively “OMP21”), nucleotide sequences encoding said OMP21, and...
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7306805 |
Nontypeable Haemophilus influenzae virulence factors
The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes...
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7306808 |
Orientia tsutsugamushi truncated recombinant outer membrane protein (r47) and (r57) vaccines diagnostics and therapeutics for scrub typhus
A scrub typhus vaccine comprising truncated r47 protein and truncated r56 protein is disclosed. Vaccines composed of r56 protein variants are also disclosed. Methods of reducing HIV viral loads...
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7304139 |
Polynucleotides and polypeptides of Anaplasma phagocytophilum and methods of using the same
We have successfully sequenced and cloned the gene expressing the Major Surface Protein 5 (MSP5) of A. phagocytophilum . The recombinant MSP5 (rMSP5) protein has been tested using sera from humans...
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7297340 |
Vaccine and method for preventing biofilm formation
The present invention is directed to compounds and methods for immunizing a patient against a biofilm-producing bacterial infection and a vaccine related thereto.
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7291722 |
Polypeptide from haemophilus influenza
The invention provides BASB203 polypeptides and polynucleotides encoding BASB203 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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7288261 |
Mid-life vaccine and methods for boosting anti-mycobacterial immunity
Vaccine compositions for boosting immunity to mycobacteria when administered in mid-life in a subject who has been vaccinated neonatally or in early childhood with BCG and in whom protective...
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7279170 |
32-kDa protein derived from Mycobacterium tuberculosis and related peptides
The invention relates to recombinant polypeptides and peptides and particularly to the polypeptide containing in its polypeptidic chain the following amino acid sequence: the one extending from the...
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7273611 |
Proteinase K resistant surface protein of neisseria meningitidis
The identification of a highly conserved, immunologically accessible antigen on the surface of Neisseria facilitates treatment, prophylaxis, and diagnosis of Neisseria diseases. This antigen is...
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7273605 |
Vaccine
The present invention relates to a fowlpox virus genome which has modifications in one or more wild-type FPV genes. The present invention also relates to a viral particle comprising such a genome...
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7270827 |
Multivalent streptococcal vaccine compositions and methods for use
Compositions and methods for making and using therapeutic formulations of multivalent hybrid polypeptides comprising immunogenic peptides of M proteins from various different serotypes of group A...
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7261897 |
Fusion proteins of mycobacterium tuberculosis
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The...
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7261900 |
Recombinant modified Bacillus anthracis protective antigen for use in vaccines
The invention relates to improved methods of producing and recovering sporulation-deficient B. anthracis mutant stains, and for producing and recovering recombinant B. anthracis protective...
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7256265 |
Streptococcal C5a peptidase vaccine
Novel vaccines for use against β-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of streptococcal C5 a peptidase (SCP)....
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7250172 |
Vaccine and compositions for the prevention and treatment of neisserial infections
The present invention is directed to novel polypeptides, polynucleotides and vaccines for use against Neisseria gonorrhoeae colonization or infection. The vaccines contain an immunogenic amount...
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7247308 |
Streptococcus pyogenes antigens
The present invention relates to antigens, more particularly an antigen of Streptococcus pygenes (also called group A Streptococcus (GAS)) bacterial pathogen which is useful as vaccine...
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7247306 |
Bacteria strain and bacteriocin produced therefrom
The present invention concerns an isolated bacteriocin, Divergicin M35, derived form Carnobacterium divergens M35. It also concerns a composition comprising an effective amount of Divergicin M35...
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7241449 |
Transferrin receptor genes of moraxella
Purified and isolated nucleic acid molecules are provided which encode Tbp2 proteins of M. catarrhalis strains M35, 3 and LES1. The nucleic acid sequence may be used to produce recombinant Tbp2...
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7238359 |
Antigen ORF Rv2430c and a method thereof
The present invention relates to a PPE family antigenic protein Rv2430c of SEQ ID No. 1; a set of three high antigenic index peptides of SEQ ID Nos. 2 to 4; an antigenic ORF Rv2430c of SEQ ID No. 5...
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7235242 |
IgA1 protease fragment as carrier peptides
The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO:1,...
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7229622 |
Synthetic chimeric fimbrin peptides
The present invention provides synthetic chimeric fimbrin peptides which induce an immunogenic response in animals to non-typable Haemophilus influenzae and that do not require tedious...
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7226597 |
Mutants of Clostridium difficile toxin B and methods of use
An active or passive vaccine utilizing purified non-toxic mutant TcdB toxins from Clostridium difficile for humans and animals against infections caused by C. difficile and/or C. sordellii. ...
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7223836 |
Peptides for chlamydophila pneumoniae vaccine and diagnosis
Peptides are disclosed that include SEQ ID NO:1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6, or a conservative variant or mimic thereof, wherein the conservative variant...
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7223412 |
Staphylococcal enterotoxin SEC-SER, expression vector and host cell, production method thereof, and manufacturing method of vaccine
The present invention relates to a method of producing recombinant modified Staphylococcal toxin having improved stability, comprising the steps of preparing a modified toxin in which a specific...
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7220415 |
Vaccine composition
A polypeptide is described herein which comprises (a) the sequence of SEQ ID No. 2, (b) a variant of (a) which is capable of generating a protective immune response to S. pyogenes , or (c) a...
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7217791 |
Compositions and methods for treating or preventing pneumococcal infection
The invention provides polypeptides, polysaccharide-polypeptide conjugates, and expression vectors for treating or preventing pneumococcal infection. The compositions induce an anti-pneumococcal...
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7217415 |
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase for therapeutic use
According to the present invention, a series of genes are identified in Group B Streptococcus , the products of which may be located on the outer surface of the organism. The genes, or functional...
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7208574 |
Host receptor for pathogenic bacteria
A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli ....
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7204980 |
Methods for inhibiting viral replication in vivo
The present invention is directed to methods of modulating viral replication in vivo comprising administering to an individual a therapeutically or prophylactically effective amount of a...
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7204991 |
Porphyromonas gingivalis recombinant proteins and truncations
The present invention relates to soluble P. gingivalis polypeptides derived from PG32 and PG33 and to polynucleotides encoding these polypeptides. The P. gingivalis polypeptides and nucleotides...
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7201912 |
Recombinant immunogenic compositions and methods for protecting against lethal infections from Bacillus anthracis
Recombinant immunogenic compositions and methods for protecting against lethal infections from Bacillus anthracis having a variant of recombinant Bacillus anthracis protective antigen (rPA) and...
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7192590 |
Compounds for treatment of infectious and immune system disorders and methods for their use
The present invention provides polypeptides comprising an immunogenic epitope of a M. vaccae protein, polynucleotides encoding such polypeptides, and fusion proteins comprising at least one such...
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7189405 |
Peptide mimics of conserved gonococcal epitopes and methods and compositions using them
The present invention relates to peptide mimics of a conserved gonococcal epitope of Neisseria gonorrhoeae , which epitope is not found on human blood group antigens. This invention also relates...
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7183100 |
Aconitase
A bacterial protein which converts 2-methyl citrate to 2-methyl isocitrate is a previously unknown target for antibacterial agents. The protein of this activity is associated with mucoid bacteria...
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7166289 |
Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia , specifically C....
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7163682 |
Glucan binding protein and glucosyltransferase immunogens
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7163810 |
Method for producing target substance
In a method for producing a target substance by using a microorganism comprising culturing a microorganism having an ability to produce the target substance in a medium to produce and accumulate...
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7153515 |
Method of preventing T cell-mediated responses by the use of the major histocompatibility complex class II analog protein (map protein) from Staphylococcus aureus
A method of immunomodulating the T cell response in Staphylococcal bacteria is provided wherein an effective amount of the Map protein from Staphylococcus aureus is administered to a host to...
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7144580 |
M. haemolytica outer membrane protein P1pE as a vaccine or vaccine component against shipping fever
Vaccines and methods against M. haemolytica infections in cattle. The vaccine compositions include a recombinant outer membrane protein of M. haemolytica designated PlpE and/or subunits...
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7144576 |
Modified pertussis toxin
The development of subunits and subunit analogs of the Bordetella exotoxin by recombinant DNA techniques provides vaccine products that retain their biological activity, are highly immunogenic,...
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7141244 |
Helicobacter pylori proteins useful for vaccines and diagnostics
This invention provides polypeptides of Helicobacter pylori cytotoxin associated immunodominant (CAI) antigen. The invention also provides prophylactic and therapeutic vaccines comprising...
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7135176 |
VMP-like sequences of pathogenic Borrelia
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia , the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded...
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7135188 |
Methods and compositions for immunotherapy of cancer
Methods and vaccines for suppressing formation of or inhibiting growth of tumors in a host are provided, via administration of a vaccine containing either a fusion protein of the tumor associated...
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7132102 |
Bacteriocins and novel bacterial strains
Novel bacteriocins and/or the novel lactic acid-producing strains are used for at least reducing the levels of colonization by at least one target bacteria in animals, especially poultry.
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