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7635480 |
Peptides for preventing, diagnosing and treating animal and/or human leptospirosis
The present invention provides a compound chosen from: a peptide represented by the sequence SEQ ID No: 1 below:
SEQ ID No: 1...
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7635481 |
Canine vaccine for protection against ehrlichiosis
The present invention provides a safe and effective vaccine composition which comprises: an effective immunizing amount of an inactivated Ehrlichia canis bacterin; a pharmacologically acceptable...
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7635482 |
Streptococcus antigens
Streptococcus proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus ...
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7632513 |
Immunogenic detoxified mutants of cholera toxin
An immunogenic detoxified protein comprising the amino acid sequence of subunit A of a cholera toxin (CT-A) or a fragment thereof or the amino acid sequence of subunit A of an Escherichia coli ...
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7632514 |
Universal carrier for targeting molecules to Gb3 receptor expressing cells
The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys,...
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7632515 |
Streptococcus pneumoniae proteins and nucleic acid molecules
Protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described.
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7632516 |
Moraxella catarrhalis BASB115 polypeptides
The invention provides BASB115 polypeptides and polynucleotides encoding BASB115 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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7628994 |
S. epidermidis antigens
The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments...
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7625571 |
Transformed bacteria producing CS6 antigens as vaccines
Disclosed herein are antigens that stimulate protective antibodies against enterotoxigenic Escherichia coli . Also disclosed herein are proteins encoded by cssA and cssB genes as well as...
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7622121 |
Heat shock proteins from Mycobacterium leprae and uses thereof
The present invention is directed to heat shock proteins from Mycobacterium leprae as well as their encoding polynucleotides and vectors and host cells containing these polynucleotides. These...
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7618636 |
Antigenic meningococcal peptides
WO99/36544 discloses a large number of proteins from Neisseria Meningitidis . The present invention relates to fragments of those proteins which comprise at least one antigenic determinant....
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7611714 |
Methods and compositions for immunizing against Pseudomonas infection
Methods and compositions for inducing an immune response against Pseudomonas aeruginosa are provided herein. In one aspect, the invention provides a chimeric immunogen, comprising a receptor...
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7611720 |
Tuberculosis vaccines including recombinant BCG strains expressing alanine dehydrogenase, serine dehydratase and/or glutamine synthetase
The invention relates to a live recombinant Mycobacterium bovis -BCG strain comprising a nucleic acid capable of expression, the nucleic acid encoding at least one protein or polypeptide that...
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7608276 |
Staphylococcus aureus proteins and nucleic acids
The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic...
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7608277 |
Tuberculosis nucleic acids, polypeptides and immunogenic compositions
The present invention provides transcriptionally active Mtb polynucleotides, recombinant Mtb peptides and polypeptides, and immunogenic Mtb antigens. Immunogenic compositions are also provided that...
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7608266 |
Yersinia species compositions
A method of protecting an animal from infections with pathogens originating from Yersinia comprising administering an isolated or recombinant YscF protein to the animal is disclosed. The isolated...
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7601357 |
Targeting of long chain triacylglycerol hydrolase gene for tuberculosis treatment
Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or...
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7595058 |
Chlamydia antigens and vaccine uses of the protein
The present invention provides vaccines and methods for immunizing a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The...
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7595383 |
Secreted proteins of Mycobacterium tuberculosis and their use as vaccines and diagnostic reagents
The invention provides mycobacterium tuberculosis polypeptides and genes encoding them for use in diagnostic and prophylactic methodologies.
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7595059 |
Methods and compositions for detecting larval Taenia solium with a cloned diagnostic antigen
Compositions and methods for the detection of Taenia solium and the diagnosis of T. solium infection are described. The nucleotide and amino acid sequences of the antigenic T. solium ...
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7592011 |
Genes and proteins, and their use
A protein from Group B Streptococcus is shown to be an outer surface protein and is a useful target for antimicrobial therapy.
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7592135 |
High resolution typing system for pathogenic Mycobacterium tuberculosum
MLVA methods for strain discrimination among Mycobacterium tuberculosum strains are disclosed. Nine VNTR loci have been identified from genomic sequences of Mycobacterium tuberculosum strains...
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7592158 |
BASB019 proteins and genes from Moraxella catarrhalis, antigens, antibodies, and uses
The invention provides BASB019 polypeptides and polynucleotides encoding BASB019 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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7588930 |
Compositions and methods for enhancing the immunogenicity of antigens
The present invention includes compositions, methods and kits for enhancing the immunogenicity of an antigen via fusion to a Listerial protein. The present invention further encompasses Listeria ...
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7588765 |
Polysaccharide and glycoconjugate vaccines
The present invention concerns a conjugation process for coupling a endotoxin (LPS) free polyfunctional polysaccharide with a polyfunctional carrier protein with quantitative yields. The invention...
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7585658 |
Staphylococcus aureus antigenic polypeptides and compositions
The invention relates to a method for the identification of antigenic polypeptides expressed by pathogenic microbes; vaccines comprising such polypeptides; recombinant methods to manufacture such...
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7582304 |
Groups of Borrelia burgdorferi and Borrelia afzelii that cause Lyme Disease in humans
The present invention is drawn to an immunogenic composition comprising OspC polypeptides from Lyme Disease causing Borrelia. In one embodiment, the immunogenic composition of the present...
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7579141 |
Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
The invention provides polypeptides encoded by open reading frames present in the genome of Mycobacterium tuberculosis but absent from the genome of BCG and diagnostic and prophylactic...
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7579012 |
Targeting of triacylglycerol synthase gene for tuberculosis treatment
Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or...
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7576176 |
Neisseria meningitidis antigens and compositions
The invention provides proteins from Neisseria meningitidis , including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for...
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7572457 |
Use of Streptococcus suis 38 kDa polypeptide as an immunogen
Disclosed are methods, compositions, and kits for inducing polyclonal antibodies against one or more pathogens that include Streptococcus suis . The methods may include administering to an animal...
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7569226 |
Alkaline protease from Bacillus sp. (DSM 14392) and washing and cleaning products comprising said alkaline protease
The invention relates to a novel alkaline protease of the subtilisin type from Bacillus sp. (DSM 14392) and various related proteins and derivatives thereof. The invention further relates to...
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7556810 |
Compositions and methods to control angiogenesis with cupredoxins
The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that...
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7556816 |
Ehrlichia chaffeensis 28 kDa outer membrane protein multigene family
The 28-kDa outer membrane proteins (P28) of Ehrlichia chaffeensis are encoded by a multigene family consisting of 21 members located in a 23-kb DNA fragment in the genome of E. chaffeensis ....
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7556807 |
Signal peptides, nucleic acid molecules and methods for treatment of caries
Peptide analogues of S. mutans CSP peptide which inhibit biofilm formation, uses thereof in the preparation of pharmaceutical compositions, antimicrobial compositions and uses thereof in the...
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7553493 |
Chlamydia flagellar protein antigen
The present invention provides purified and isolated polynucleotide molecules that encode Chlamydia polypeptides which can be used in methods to prevent, treat, and diagnose Chlamydia ...
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7541039 |
Immunization with bacterial ghost-based vaccines
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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7537772 |
Chlamydia protein, gene sequence and the uses thereof
The invention discloses the Chlamydia PMPE and PMPI polypeptide, polypeptides derived thereof (PMP-derived polypeptides), nucleotide sequences encoding said polypeptides, antibodies that...
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7534445 |
Chlamydia protein, sequence and uses thereof
A high molecular weight (“HMW”) protein of chlamydia , the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence...
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7534444 |
Molecular mimetics of meningococcal B epitopes which elicit functionally active antibodies
Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed....
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7534857 |
Methods and compositions for the treatment and prevention of staphylococcal infections
A biologically pure RNAIII inhibiting peptide (RIP), that includes five contiguous amino acids of the sequence YX 2 PX 1 TNF, where X 1 is C, W, I or a modified amino acid, and X 2 is K or S is...
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7534437 |
Helminth-derived antigens having capacity of providing protection against parasites
The primary objective of the present invention is the development of new mutant forms of the Sm14 protein, for producing a greater production volume. The recombinant proteins here obtained were...
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7531176 |
Brachyspira pilosicoli 72 kDa outer-membrane protein and diagnostic and therapeutic uses thereof
The invention relates to Brachyspira pilosicoli 72 kDa outer-membrane protein (Bpmp-72) and its amino acid and nucleotide sequence. The invention also relates to the uses of these sequences in...
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7531177 |
Surface protein of leptospira
The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
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7527802 |
Vaccine for transcutaneous immunization
A vaccine delivered by transcutaneous immunization provides an effective treatment against infections by pathogens such as, for example, enterotoxigenic Escherichia coli (ETEC) and/or for...
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7521549 |
Compounds
The invention provides BASB041, 43, 44 and 48 polypeptides and polynucleotides encoding BASB041, 43, 44 and 48 polypeptides and methods for producing such polypeptides by recombinant techniques....
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7517533 |
Pseudomonas aeruginosa antigens
Proteins derived from Pseudomonas aeruginosa are antigenic and are of use in the treatment, prophylaxis and diagnosis of P. aeruginosa infection.
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7517955 |
Streptococcus uberis adhesion molecule
A polypeptide, designated as “ Streptococcus uberis Adhesion Molecule” (SUAM), and fragments of SUAM, prevent internalization and adherence of Streptococcus uberis and other streptococcal...
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7504110 |
Protein-based Streptococcus pneumoniae vaccines
The present invention is primarily directed to a method for preventing infection of a mammalian subject with S. pneumoniae , wherein said method comprises administering to said subject an...
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7501132 |
Multiple antigenic peptides immunogenic against Streptococcus pneumonia
The invention provides a nucleic acid encoding the 37-kDa pneumococcal surface adhesion A protein (PsaA) from Streptococcus pneumoniae . Also provided are isolated nucleic acids comprising a...
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