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7378234 |
Method for isolating hepatitis C virus peptides
Described is a method for isolating Hepatitis C Virus peptides (HPs) which have a binding capacity to a MHC/HLA molecule or a complex comprising said HCV-peptide and said MHC/HLA molecule...
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7374766 |
Compositions containing virus-like particles as immunopotentiators administered through the mucosa
The present invention is related to the branch of medicine, particularly to the new formulations of vaccine antigens. The technical objective pursued with the present invention is, precisely, the...
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7368118 |
Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus
Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV envelope, and are...
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7361352 |
Influenza immunogen and vaccine
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An...
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7351570 |
HDV nucleic acid molecules and applications thereof
The invention concerns nucleic acid molecules derived from novel hepatitis D virus strains or isolates constituting genotypes different from known I, II and III genotypes, their fragments,...
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7351413 |
Stabilized HBc chimer particles as immunogens for chronic hepatitis
A method of treating chronic hepatitis B is disclosed that comprises administering a T cell-stimulating amount of a vaccine to a patient. The vaccine comprises an immunogenic amount of chimeric,...
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7348011 |
Hepatitis C virus vaccine
The present invention relates to isolation of a novel Hepatitis C virus, more particularly, the present invention relates to a viral class Hepatitis C, polypeptides, polynucleotide, vaccine and...
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7341726 |
Modified HCV peptide immunogens
Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139, an isolated...
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7341723 |
Nucleic acid construct encoding a processing component derived from the N-terminal region of the hepatitis virus ORF2, and an antigenic polypeptide
A method for enhancing an immune response to a nucleic acid vaccine comprising administering to an animal a nucleic acid construct encoding a fusion protein comprising a processing component and an...
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7320795 |
Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof
The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core...
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7319144 |
Polynucleotides encoding a multiple epitope fusion antigen for use in an HCV antigen/antibody combination assay
The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen...
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7314925 |
Constructs and methods for expression of recombinant HCV envelope proteins
The current invention relates to vectors and methods for efficient expression of HCV envelope proteins in eukaryotic cells. More particularly said vectors comprise the coding sequence for an avian...
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7313357 |
Method for typing and detecting HBV
The present invention relates to a method for detection and/or genetic analysis of HBV in a biological sample, comprising hybridizing the polynucleic acids of the sample with a combination of at...
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7291723 |
GB virus C and methods of treating viral infections
The present application provides GB virus C sequences (GBV-C or hepatitis G virus) and methods of using the sequences.
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7285539 |
Activation of HCV-specific T cells
The invention provides a method of activating hepatitis C virus (HCV)-specific T cells, including CD4 + and CD8 + T cells. HCV-specific T cells are activated using fusion proteins comprising HCV...
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7270820 |
CD4+ T-lymphocyte-specific hepatitis C virus epitopes
The invention relates to hepatitis C virus epitopes which are CD4 + T-lymphocyte specific, and to vaccines containing these epitopes.
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7264811 |
Purified active HCV NS2/3 protease
A method for producing a refolded, inactive form of recombinantly produced NS2/3 protease which comprises the steps of: a) purifying the protease from inclusion bodies in the presence of a...
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7255864 |
Diagnostic reagent for hepatitis C virus infection
A diagnostic reagent for hepatitis C virus infection obtained by sensitizing a solid phase with HCV antigen and a conjugated antigen prepared by chemical bonding of HCV antigen and a carrier...
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7241440 |
Vaccines containing ribavirin and methods of use thereof
Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising...
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7238356 |
Core-glycosylated HCV envelope proteins
The current invention relates to HCV envelope proteins or parts thereof which are the product of expression in eukaryotic cells. More particularly said HCV envelope proteins are characterized in...
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7201911 |
Cloned genomes of infectious hepatitis C viruses and uses thereof
The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the...
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7201904 |
Epitopes of hepatitis C virus
The invention provides compositions containing HCV epitopes, which are recognized by cytotoxic T lymphocytes. Such polypeptides are used in prophylactic vaccines, immunotherapies, and assays to...
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7189810 |
Polypeptides, use thereof and process for producing the same
An isolated polypeptide comprises the amino acid sequence of SEQ ID NO: 11, wherein the expression of said polypeptide is significant lower specifically in human livers with hepatitis compared with...
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7166426 |
HCV assay
An HCV antigen/antibody/antigen assay is provided. The assay employs an isolated first antigen from a region of the HCV polyprotein, and an HCV multiple epitope fusion antigen that includes an...
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7166287 |
Viral agent
The invention relates to post-transfusional non-A non-B hepatitis viral polypeptide, DNA sequences encoding such viral polypeptide, expression vectors containing such DNA sequences, and hosts...
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7144712 |
Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof
The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core...
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7141242 |
Hepatitis B virus surface antigen mutant and methods of detection thereof
The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a...
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7135185 |
Conserved motif of hepatitis C virus E2/NS1 region
Immunogenic compositions comprising an immunogenic polypeptide and a pharmaceutically acceptable vehicle are described. The immunogenic polypeptide comprises the amino acid sequence...
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7118874 |
Immunogenic formulation and process for preparation thereof
A process is disclosed for preparation of a immunogenic peptide mixture in a single synthesis. The peptide mixture collectively represents the in vivo variability seen in immunogenic epitopes from...
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7108856 |
CD4+ T-lymphocyte-specific Hepatitis C virus-epitopes
The invention relates to Hepatitis C virus epitopes which are specific in relation to CD4+ T lymphocytes, in addition to vaccinations which contain said epitopes.
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7105165 |
Mutant human hepatitis B viral strain and uses thereof
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-‘S’-133 Oon Strain (Methionine to Threonine) which constituent viral genome is...
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7098303 |
Conserved motif of hepatitis C virus E2/NS1 region
Immunogenic polypeptides comprising hepatitis C virus (HCV) immunogens are described. The HCV immunogen comprises the amino acid sequence...
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7094406 |
Enterically transmitted non-A/non-B hepatitis viral agent and characteristic epitopes thereof
Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in...
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7084266 |
Cloned genome of infectious hepatitus C virus of genotype 2A and uses thereof
The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6 CH , gentotype 2a, and the use of the sequence, and polypeptides encoded by all or...
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7074410 |
Modified HCV peptide vaccines
Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139, an isolated...
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7070790 |
Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
The nucleotide and deduced amino acid sequences of cDNAs encoding the envelope 1 genes and core genes of isolates of hepatitis C virus (HCV) are disclosed. The invention relates to the...
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7067247 |
Hepatitis B virus surface protein
We isolated and characterized a new surface mutant of the hepatitis B virus surface antigen (HBsAg). The mutant was isolated from a symptomatic patient with Down's syndrome who was found to be...
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7052830 |
Hepatitis C virus peptides and uses thereof
Novel hepatitis C virus (HCV) polypetides are provided which are not encoded by the standard HCV open reading frame. These alternate reading frame polypeptides are useful, inter alia, in vaccine...
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7052696 |
Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
Antigenic epitopes of hepatitis C virus (HCV) and mosaic HCV polypeptides useful as reagents in assays for the diagnosis or monitoring of HCV in a biological sample. The antigenic epitopes and...
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7048930 |
Expression of core-glycosylated HCV envelope proteins in yeast
The present invention relates to the general field of recombinant protein expression, purification of recombinant proteins, diagnosis of HCV infection, prophylactic treatment against HCV infection...
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7038035 |
Vaccine-induced hepatitis B viral strain and uses thereof
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-'Ś-145 Singapore Strain (Glycine to Arginine) which constituent viral genome is...
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7029680 |
Delivery of immunogenic molecules vis HBsAg particles
Compositions of HBsAg particles having biologically active molecules contained in the particles, and methods of their use, e.g. in stimulating enhanced immune responses, are described. Antigenic...
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7022830 |
Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed...
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6986892 |
Immunogenic Hepatitis C virus non-structural polypeptides
Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally...
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6964852 |
Antigenic structural peptide, antigenic and immunogenic compounds, and uses for detecting, preventing and treating an HCV infection
The invention concerns a structural peptide, identified by antibodies directed against a polypeptide, comprising the 2-45 amino acid sequence of the N-terminal end of the Core or nucleocapsid (p21)...
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6964769 |
Molecular antigen array
The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the...
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6932972 |
Combined vaccine compositions
Novel combined vaccine composition preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in...
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6930095 |
Hepatitis C virus constructs characterized by high efficiency replication
The present invention relates to recombinant hepatitis C virus (HCV)-derived nucleic acids and to stable rapidly growing cell clones derived from human hepatoma Huh-7 cell line and supporting high...
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6921534 |
Hepatitis B virus treatment
The invention relates to HBV antigen-containing compositions that are useful in treating or preventing HBV infection. The content of the compositions can vary, as described herein, but the...
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6919318 |
Enhancing immune responses to genetic immunization by using a chemokine
The immune response to a DNA immunogen in a mammal can be enhanced by administration of a chemokine or a polynucleotide encoding the chemokine. This method can be used, for example, to immunize or...
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