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7186407 |
Methods and compositions for the treatment of peripheral artery disease
Compositions and methods for treating peripheral artery disease in a patient are provided. Compositions comprise recombinant fibroblast growth factor-2. Fibroblast growth factor, such as FGF-2, is...
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7183386 |
Feline immunoglobulin E proteins and compositions thereof
The invention relates to: nucleic acid molecules encoding the light chain and heavy chain of feline immunoglobulin E (IgE), including species-specific regions of feline IgE; proteins encoded by the...
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7179467 |
DCMP2 polypeptide
Nucleic acids encoding various lymphocyte cell proteins from mammalian, including primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of...
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7175848 |
Ricin A chain mutants lacking enzymatic activity as vaccines to protect against aerosolized ricin
The present invention provides methods to produce toxoid vaccines, such as ricin A chain vaccines, with reduced ability to promote vascular leak syndrome (VLS) and catalytic toxicity associated...
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7175849 |
Nectin polypeptides
This invention relates to nectin polypeptides and polynucleotides, to methods of making such polypeptides and polynucleotides, and to methods of using such polypeptides and polynucleotides to...
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7173002 |
150 KDA TGF-B1 accessory receptor acts a negative modulator of TGF-B signaling
The present invention relates to a TGF-β1 binding protein called r150. This protein has a GPI-anchor contained in r150 itself and not on a tightly associated protein and that it binds TGF-β1 with...
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7166291 |
Allergenic proteins and peptides from dog dander and uses therefor
Isolated nucleic acids encoding allergens of Canis familiaris , Can fI or Can fII. are disclosed. A cDNA encoding a peptide having a Can fI activity and a predicted molecular weight of about...
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7166289 |
Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia , specifically C....
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7166694 |
Vaccine against cancerous diseases which is based on mimotopes of antigens expressed on tumor cells
The present invention provides a method for producing a vaccine against cancerous disease, and the vaccine itself. This method involves first using one or more antibodies that are specifically...
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7163682 |
Glucan binding protein and glucosyltransferase immunogens
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7163810 |
Method for producing target substance
In a method for producing a target substance by using a microorganism comprising culturing a microorganism having an ability to produce the target substance in a medium to produce and accumulate...
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7160546 |
Human G-protein chemokine receptor (CCR5) HDGNR10
Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are...
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7160544 |
Method of vaccinating vertebrates
The invention provides a vaccine composition and a method of preparation including the steps of: forming a water-in-oil emulsion including an alginate in water, an oil, an antigen, and either (a) a...
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7160548 |
Mycobacterium strains with modified erp gene and vaccine composition containing same
Mycobacterium strains in which the erp gene is modified, and vaccine compositions comprising such Mycobacterium strains are provided. The modification of the erp gene may decrease the virulence...
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7160547 |
Streptococcal streptolysin S vaccines
Provided are streptolysin S (SLS) polypeptides, peptides, and variants thereof, antibodies directed thereto, and isolated nucleic acids encoding such proteins. In one embodiment, a method is...
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7160856 |
α-O-linked glycoconjugates, methods of preparation and uses thereof
The present invention provides novel α-O-linked glycoconjugates such as α-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified...
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7157091 |
MAGE-A1 peptides presented by HLA class II molecules
The invention provides isolated HLA DRB1*15-binding peptides consisting of the amino acid sequence set forth as SEQ ID NO:7 with 0–10 amino acids added to either or both ends of the amino acid...
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7157089 |
Immune responses using compositions containing stress proteins
The present invention relates to a vaccine for inducing an immune response to an antigen in a vertebrate (e.g., mammal) comprising an antigen and all or a portion of a stress protein or all or a...
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7147858 |
Methods to improve immunogenicity of antigens and specificity of antibodies
A method of improving specific immune responses to small immunogens, haptens, has been developed by changing the linkage between the hapten and carrier being used for immunization. High affinity...
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7148037 |
Platelet-derived growth factor D, DNA coding therefor, and uses thereof
PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing...
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7148061 |
Identification of a novel domain in the tumor necrosis factor receptor family that mediates pre-ligand receptor assembly and function
The present invention provides a polypeptide comprising the isolated amino acid sequence of a pre-ligand assembly domain (PLAD) of a TNF-like receptor. Also provided by this invention is a...
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7144581 |
Compositions and methods for WT1 specific immunotherapy
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
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7144569 |
Diagnosis of coeliac disease using a gliadin epitope
A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope...
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7141244 |
Helicobacter pylori proteins useful for vaccines and diagnostics
This invention provides polypeptides of Helicobacter pylori cytotoxin associated immunodominant (CAI) antigen. The invention also provides prophylactic and therapeutic vaccines comprising...
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7138274 |
Advanced oral poliovirus vaccine (Adv-OPV) deprived of the possibility of vaccine associated paralytic poliomyelities (VAPP)
The present invention relates to a novel recombinant Sabin type 1 poliovirus vector for the immunogenicity of neutralizing antibody against polioviral infection, which comprises: (a) a genomic...
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7135181 |
Method for down-regulation of amyloid
A method for in vivo down-regulation of amyloid protein in an animal, including a human being, the method comprising effecting presentation to the animal's immune system of an immunogenically...
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7135549 |
Nucleic acid and corresponding protein entitled 184P1E2 useful in treatment and detection of cancer
A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
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7135457 |
Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g.,...
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7135182 |
Inhibition of transglutaminase-mediated microbial interaction with a mammalian host
The infection of a mammalian host by a microorganism can be prevented or treated through the administration of substrates for transglutaminases or antibodies against such substrates that inhibit...
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7135176 |
VMP-like sequences of pathogenic Borrelia
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia , the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded...
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7132107 |
Streptococcus pneumoniae proteins and vaccines
The present invention relates to novel immunogenic polypeptides, and fragments thereof, and vaccines for the prevention and treatment of pneumococcal infection, especially by Streptococcus...
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7132104 |
Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression,...
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7132099 |
Methods of modulating T lymphocyte costimulation with an antibody to an 8F4 polypeptide
A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the...
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7128920 |
metRS2
The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred...
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7128919 |
Group B streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof
This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids...
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7128918 |
Streptococcus antigens
Streptococcus proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus ...
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7128911 |
Antigen arrays for treatment of bone disease
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7129328 |
Liver tumor marker sequences
Polypeptides whose expression is upregulated in liver tumor cells and cells from liver preneoplastic foci relative to expression in normal liver cells are disclosed as are polynucleotides that...
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7128912 |
Fibronectin binding protein compositions and methods of use
Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB...
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7125837 |
Elastin-based compositions
The present invention provides screening methods that use organisms or cells that lack function in one or both elastin genes. These methods are useful in identifying drugs for the prevention and...
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7122197 |
Compounds from Moraxella catarrhalis
The invention provides BASB020 polypeptides and polynucleotides encoding BASB020 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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7122196 |
Compounds and methods for diagnosis of tuberculosis
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins,...
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7122621 |
Anti-cellular proliferative disorder polypeptide
Disclosed is a cell lytic polypeptide that has a region capable of forming an amphipathic alpha helix and a net charge of +12 or more, or that contains 3 regions, each capable of forming an...
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7118758 |
Transformed bacteria producing CS6 antigens as vaccines
Disclosed herein are antigens that stimulate protective antibodies against enterotoxigenic Escherichia coli . Also disclosed herein are proteins encoded by cssA and cssB genes as well as...
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7118749 |
Transferrin receptor genes
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
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7118753 |
Enhancing cell-based immunotherapy
An immunogenic composition containing antigen-presenting cells and a heat shock protein or a heat shock fusion protein. Also disclosed is a method of using such a composition for enhancing...
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7118747 |
AT4 receptor ligands as angiogenic, anti-angiogenic, and anti-tumor agents
AT 4 receptor agonists are potent activators of angiogenesis and can be used to treat diseases that are characterized by vascular insufficiency. AT 4 receptor antagonists, which are potent...
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7118888 |
Gene expression vaccine
An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to...
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7118748 |
Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
The present invention provides methods, improved cell culture medium and kits for promoting hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth...
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7115267 |
Stimulator of stem cell division
Disclosed and claimed are methods for the isolation and use of stem cell modulating factors for regulating stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery....
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