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7247305 |
Amino acid sequences, DNA encoding the amino acid sequences, antibodies directed against such sequences and the different uses thereof
The invention is directed to a peptide comprising the amino acid sequence substantially as denoted by SEQ ID NO:1 and biologically functional homologues and derivatives thereof.
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7247441 |
Nucleic acid sequence and protein in addition to polypeptides coding for mannitol dehydrogenases or parts thereof and the production and use thereof in diagnosis and therapy
The invention relates to polypeptides made of mannitol-dehydrogenase of Cladosporium herbarum and Alternaria alternata nucleic acids coding therefor and the use thereof in diagnosis and therapy.
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7247308 |
Streptococcus pyogenes antigens
The present invention relates to antigens, more particularly an antigen of Streptococcus pygenes (also called group A Streptococcus (GAS)) bacterial pathogen which is useful as vaccine...
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7247306 |
Bacteria strain and bacteriocin produced therefrom
The present invention concerns an isolated bacteriocin, Divergicin M35, derived form Carnobacterium divergens M35. It also concerns a composition comprising an effective amount of Divergicin M35...
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7244827 |
Nucleic acid and corresponding protein entitled 24P4C12 useful in treatment and detection of cancer
A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is...
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7244431 |
Allergy vaccines and their preparation
The present invention relates to a pharmaceutical composition containing a peptide and a pharmaceutically acceptable carrier or diluent wherein the peptide has a length of 8 to 50 amino acids, at...
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7241440 |
Vaccines containing ribavirin and methods of use thereof
Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising...
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7241446 |
Methods for modulating angiogenesis via VEGF
Recombinant plasminogen activator inhibitor-1 (PAI-1) isoforms which lack the reactive center loop and contain the complete heparin-binding domain or lack at least a portion of the heparin-binding...
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7241735 |
Pharmacologically active polypeptide glycoconjugates
The invention relates to glycopeptidic glycoconjugates, in which the polysaccharide is obtained from Candida utilis cells and the peptides are obtained from Ricinus communis seeds. The...
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7238356 |
Core-glycosylated HCV envelope proteins
The current invention relates to HCV envelope proteins or parts thereof which are the product of expression in eukaryotic cells. More particularly said HCV envelope proteins are characterized in...
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7238359 |
Antigen ORF Rv2430c and a method thereof
The present invention relates to a PPE family antigenic protein Rv2430c of SEQ ID No. 1; a set of three high antigenic index peptides of SEQ ID Nos. 2 to 4; an antigenic ORF Rv2430c of SEQ ID No. 5...
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7238358 |
Compounds and methods for immunotherapy and diagnosis of tuberculosis
Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more ...
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7235240 |
Antagonists of interleukin-15
Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are...
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7235242 |
IgA1 protease fragment as carrier peptides
The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO:1,...
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7235241 |
Monomer protein with bone morphogenetic activity and medicinal agent containing the same for preventing and treating diseases of cartilage and bone
This invention provides for a protein of the TGF-β superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as...
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7235232 |
Interferon alpha hybrids
Hybrid human interferon-α polypeptides, and the corresponding nucleic acid molecules, are disclosed. Pharmaceutical compositions comprising these peptides, and the use of these polypeptides to...
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7235529 |
Brain-associated inhibitor of tissue-type plasminogen activator
The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are...
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7232682 |
Expression vectors encoding epitopes of target-associated antigens and methods for their design
The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing...
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7232563 |
Hybrid interferon/interferon tau proteins, compositions and methods of use
The present invention relates to hybrid interferon fusion proteins formed of an interferon-α protein where the C-terminal region of the interferon-α protein is replaced by a C-terminal region of...
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7232562 |
E38N interferon gamma polypeptide variants
A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence...
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7230081 |
Interferon gamma conjugates
A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence...
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7229624 |
Ordered molecular presentation of antigens, method of preparation and use
The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the...
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7226996 |
Equine Fc epsilon receptor alpha protein
The present invention relates to equine Fc epsilon receptor alpha chain nucleic acid molecules, proteins encoded by such nucleic acid molecules, antibodies raised against such proteins, and...
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7223398 |
Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
The invention provides classes of immunomodulatory compositions which comprise an average of one or more immunostimulatory sequence (ISS) containing polynucleotide conjugated, or attached, to...
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7220421 |
Moraxella bovis cytotoxin, cytotoxin gene, antibodies and vaccines for prevention and treatment of Moraxella bovis infections
Moraxella bovis cytotoxin and a gene encoding Moraxella bovis cytotoxin. Identification, isolation, cloning and identification of nucleotide sequence of the Moraxella bovis genes mbxA, mbxB,...
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7220826 |
Expressing gp140 fragment of primary HIV-1 isolate
A vector for eliciting an immune response to a host comprising a gene encoding the gp140 protein of the primary isolate of HIV-1, BX08, under the control of a promotor for expression of the protein...
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7217791 |
Compositions and methods for treating or preventing pneumococcal infection
The invention provides polypeptides, polysaccharide-polypeptide conjugates, and expression vectors for treating or preventing pneumococcal infection. The compositions induce an anti-pneumococcal...
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7214788 |
Insect inhibitory Bacillus thuringiensis proteins, fusions, and methods of use therefor
Novel insect inhibitory proteins are disclosed comprising two different components, both of which are required for biological activity. Various methods of linking both components together, so that...
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7211644 |
Diagnostic markers of human female infertility
Methods and reagents for the diagnosis of female infertility, prognostic indicators for female infertility, compounds for the treatment of female infertility, compounds and methods for...
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7211258 |
Protein A compositions and methods of use
The invention provides methods for modulating an immune response in a subject including, for example, administering to the subject a composition comprising an effective amount of a lymphocyte...
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7211259 |
4-1BB polypeptides and DNA encoding 4-1BB polypeptides
Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences,...
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7208574 |
Host receptor for pathogenic bacteria
A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli ....
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7208156 |
Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule
Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when...
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7208475 |
Peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders
A pharmaceutical composition comprising peptide HA3G76 Tyr-Leu-Ser-Lys-Gly-Arg-Leu-Val-Phe-Ala-Leu-Gly (SEQ ID NO:8).
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7204982 |
Compositions and methods for treatment and detection of multiple cancers
The invention provides a method for inhibiting proliferation of cancer cells, as well as methods for detecting and treating various cancers, including cancer of the brain, lung, breast, prostate...
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7204980 |
Methods for inhibiting viral replication in vivo
The present invention is directed to methods of modulating viral replication in vivo comprising administering to an individual a therapeutically or prophylactically effective amount of a...
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7201905 |
Bi-functional cancer treatment agents
A novel fusion protein, comprising a receptor-antagonizing domain and a positive immunomodulator domain, characterized, for example, by its ability to block apoptosis and/or inhibit endocrine...
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7202334 |
Compositions and methods for the therapy and diagnosis of ovarian cancer
Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions...
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7199218 |
ICBP90 polypeptide and its fragments and polynucleotides coding for said polypeptides and applications for diagnosing and treating cancer
The invention concerns a novel ICBP90 (Inverted CCAAT box binding protein 90) and its fragments, polynucleotides coding for said polypeptides and specific antibodies directed against said...
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7198791 |
Compositions and methods for the generation of protective immune responses against malaria
The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory...
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7195768 |
Polyvalent immunogen
The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for...
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7195767 |
Method to detect IgE
The present invention includes a method to detect IgE using a human Fc epsilon receptor (Fc ε R) to detect IgE antibodies in a biological sample from a cat, a dog, or a horse. The present...
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7192715 |
Diagnostics and therapy of epstein-barr virus in autoimmune disorders
Data consistent with autoimmune disease being caused by Epstein-Barr virus are shown. Based on this evidence, an effective vaccine would prevent the autoimmune disease in those vaccinated, modified...
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7192589 |
Treatment of inflammatory disorders with STIgMA immunoadhesins
The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
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7189398 |
Broad spectrum pyrogenic exotoxins antagonists and vaccines
The invention relates to peptides having an amino acid sequence substantially homologous to an amino sequence of a domain of a pyrogenic exotoxin, which domain forms a central turn in the exotoxin...
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7189809 |
Scavenger receptors
Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the...
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7189699 |
Peptides for the treatment of Alzheimer's disease and other β-amyloid protein fibrillogenesis disorders
A pharmaceutical composition comprising peptide
A5G81 Ala-Gly-Gln-Trp-His-Arg-Val-Ser- (SEQ ID NO: 15) Val-Arg-Trp-Gly.
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7189400 |
Methods of treatment with antagonists of MU-1
Provided is a method of suppressing an immune response in a subject by administering an antagonist of a MU-1 hematopoietin receptor superfamily chain protein.
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7186800 |
Tumor necrosis factor 6α and 6β
The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α &...
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7186408 |
Viral CD30 polypeptide
The present invention relates to the identification and characterisation of a viral homologue (vCD30) of mammalian CD30. The vCD30 polypeptide is shown to have immunomodulatory activity and has...
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