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7074410 |
Modified HCV peptide vaccines
Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139, an isolated...
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7074900 |
Alleviation of the allergenic potential of airborne and contact allergens by thioredoxin
Thioredoxin, a small dithiol protein, is a specific reductant for allergenic proteins and particularly allergenic proteins present in pollen and animal and plant sources. All targeted proteins...
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7070779 |
POLYPEPTIDES CONTAINING POLYMORPHISMS OF THE REPEATED REGIONS OF PERTACTIN IN BORDETELLA PERTUSSIS, BORDETELLA PARAPERTUSSIS, AND BORDETELLA BRONCHISEPTICA, THEIR USE IN DIAGNOSTICS, AND IN IMMUNOGENIC COMPOSITIONS
Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella ...
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7070780 |
Treatment of demyelinating autoimmune disease with ordered peptides
Compositions and methods are provided for the treatment of demyelinating autoimmune disease. Therapeutic doses are administered of an ordered peptide comprising a repeated motif {SEQ ID NO: 1} [ 1...
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7070782 |
Prostate-specific membrane antigen
The invention provides a purified prostate-specific membrane antigen.
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7071322 |
HIV envelope polynucleotides and immunogenic composition
Oligonucleotide sequences encoding gp120 polypeptides from breakthrough isolates of vaccine trials using MN-rgp120 and the encoded gp120 polypeptides are provided. Use of the gp120 polypeptides...
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7071303 |
Androgen regulated prostate specific nucleic acids
The present invention provides novel androgen regulated nucleic acid molecules. Related polypeptides and diagnostic methods also are provided.
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7070774 |
Antibodies that bind testis-specific insulin homolog polypeptides
The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The...
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7070784 |
Method for down-regulating GDF-8 activity using immunogenic GDF-8 analogues
Disclosed are novel methods for increasing muscle mass by means of immunization against Growth Differentiation Factor 8 (GDF-8, myostatin). Immunization is preferably effected by administration of...
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7070793 |
Antigen protein and nucleic acid coding for said protein
To provide a novel antigenic protein and a nucleic acid encoding the antigenic protein, which are useful for prophylaxis, treatment and diagnosis of diseases caused by fungi including Candida...
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7070783 |
Small molecular weight TNF receptor multimeric molecule
The present invention relates to a receptor molecule which binds to TNF comprising all or a functional portion of the extracellular domain (ECD) of two or more TNF-Rs linked via one or more...
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7070785 |
Heat shock proteins for use in enhancing cellular factor production
The present invention relates to the use of heat shock proteins to enhance production of one or more chemokines by a cell. The present invention also relates to the use of a heat shock protein in...
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7067133 |
Methods and compositions for diseases associated with amyloidosis
The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of...
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7067247 |
Hepatitis B virus surface protein
We isolated and characterized a new surface mutant of the hepatitis B virus surface antigen (HBsAg). The mutant was isolated from a symptomatic patient with Down's syndrome who was found to be...
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7067138 |
Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis
A Candida albicans bloodstream infections cause significant morbidity and mortality in hospitalized patients. Filament formation and adherence to host cells are critical virulence factors of C....
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7067135 |
Methods and compositions for the treatment and prevention of Staphylococcus aureus infections
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, Staphylococcus spp., particularly S. aureus.
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7067136 |
Method of screening anti-mycobacterial molecules
This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic...
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7063853 |
DNA immunization against Chlamydia infection
Nucleic acid, including DNA, for immunization to generate a protective immune response in a host, including humans, to a major outer membrane protein of a strain of Chlamydia , preferably contains...
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7063846 |
Outer membrane protein of Ehrlichia canis and Ehrlichia chaffeensis
Diagnostic tools for for serodiagnosing ehrlichiosis in mammals, particularly in members of the Canidae family and in humans are provided. The diagnostic tools are a group of outer membrane...
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7063854 |
Composition and methods for WTI specific immunotherapy
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
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7063841 |
Mammalian cell surface antigens; related reagents
Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided....
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7060281 |
Groups of barrelia burgdorferi and borrelia afzelii that cause lyme disease in humans
The present invention is drawn to an immunogenic composition comprising OspC polypeptides from Lyme Disease causing Borrelia . In one embodiment, the immunogenic composition of the present...
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7060277 |
Broad spectrum antagonists and vaccines directed against pyrogenic exotoxins
The invention relates to peptides comprising an amino acid sequence homologous to the amino sequence of a fragment of a pyrogenic exotoxin, and functional derivatives of said peptides, capable of...
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7060279 |
Compositions and methods for dendritic cell-based immunotherapy
Disclosed are immunostimulatory fusion proteins and methods for generating protective DC-induced, T cell-mediated immune responses in vitro and in vivo. The immunostimulatory fusion proteins...
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7060284 |
Polypeptides and polynucleotides for enhancing immune reactivity to HER-2 protein
Compositions for stimulating the immune system and for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include immunogenic epitopes of the...
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7060800 |
Antibodies binding the TNF related protein, TNF-X
Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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7056512 |
Method for down-regulating GDF-8 activity
Disclosed are novel methods for increasing muscle mass by means of immunization against Growth Differentiation Factor 8 (GDF-8, myostatin). Immunization is preferably effected by administration of...
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7056517 |
Glucosyltransferase immunogens
Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a...
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7056516 |
I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis
The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided...
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7056513 |
Telomerase
The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various...
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7056514 |
Partial peptide mimetics and methods
Partial peptide mimetics and methods of making and using, wherein the partial peptide mimetics have a first amino acid sequence comprising ANIKLSVQMKL (SEQ ID NO:8), a homolog thereof, or a segment...
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7056515 |
Antigens for immunocontraception
The present invention provides immunocontraceptive vaccines comprising a zona pellucida (ZP) polypeptide, and/or a variant thereof, from a carnivorous mammal such as cat, dog, ferret or mink. Such...
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7053041 |
Methods and compositions useful for inhibition of αvβ5mediated angiogenesis
The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin α v β 5 antagonists. The α v β 5 -mediated angiogenesis is correlated with exposure to...
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7052698 |
Surface proteins of Leptospira
The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
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7052699 |
Immunogenic composition
The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to an HLA-based HIV vaccine.
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7052696 |
Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
Antigenic epitopes of hepatitis C virus (HCV) and mosaic HCV polypeptides useful as reagents in assays for the diagnosis or monitoring of HCV in a biological sample. The antigenic epitopes and...
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7053177 |
Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastrointestinal tissue, and derivatives (e.g.,...
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7052703 |
T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof
This invention provides nucleic acids containing sequences from a TCRγ transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame...
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7048928 |
Anti-allergic pharmaceutical composition containing at least one allergen and at least one antihistamine compound
The present invention relates to an anti-allergic pharmaceutical composition containing at least two active agents chosen from among: (i) one allergen, (ii) one antihistamine compound, and (iii)...
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7048931 |
Compositions and methods for the therapy and diagnosis of prostate cancer
Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions...
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7049094 |
Methods for identifying modulators of N-type ion channel inactivation
Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an α-subunit of a voltage-gated ion channel and an amino-terminal...
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7045596 |
Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
An isolated polynucleotide at least 60% homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids...
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7045302 |
Expressed ligand-vascular intercellular signaling molecule
The present invention provides for a modified TIE-2 ligand 2 which has been altered by addition, deletion or substitution of one or more amino acids, or by way of tagging, with for example, the Fc...
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7045597 |
Mast cell surface antigen, DNA thereof, and antibody against the antigen
A mast cell surface antigen, DNA thereof and an antibody against the antigen are provided. The amino acid sequence of this mast cell surface antigen is the translation of the coding region of its...
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7045133 |
VEGF-D/VEGF-C/VEGF peptidomimetic inhibitor
Monomeric monocyclic peptide inhibitors and dimeric bicyclic peptide inhibitors based on exposed loop fragments of a growth factor protein, such as loop 1, 2 or 3 of VEGF-D, and methods of making...
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7045134 |
Borellia burgdorferi epitope peptides
Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay.
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7045552 |
Pharmaceutical composition for improved administration of HIV gp41-derived peptides, and its use in therapy
Provided is a pharmaceutical composition comprising a solution comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic...
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7041297 |
Tumor antigen peptides originating in cyclophilin B
Tumor antigen peptides derived from cyclophilins or derivatives thereof having the functionally equivalent properties; medicaments, prophylactics, or diagnostics for tumors comprising as an active...
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7041646 |
Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists
The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2...
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7037502 |
Peptide with the amino acid sequence of KVLDGQDP having anti-inflammatory properties
The present invention provides novel anti-inflammatory peptides having the amino acid of the SEQ ID NO:1(KVLDPVKG); SEQ ID NO:2(KVLDGQDP) or SEQ ID No:3(DPVKG) containing inhibitory effects of...
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