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7115569 |
Exendins, exendin agonists, and methods for their use
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist,...
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7115272 |
Compositions and methods for WT1 specific immunotherapy
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise a WT1 polypeptide comprising an immunogenic portion of WT1,...
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7115268 |
Peptides useful for reducing symptoms of toxic shock syndrome and septic shock
This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates...
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7112329 |
T cell epitope peptide
The T-cell epitope site on a Japanese cypress (hinoki) pollen allergen molecule has been identified by stimulating a T-cell line established from a patient suffering from Japanese cypress pollen...
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7112333 |
T cell epitopes of ryegrass pollen allergen
The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne . Therapeutic peptides within the scope of the invention comprise at least one T...
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7112653 |
Composition and method for preserving progenitor cells
The invention relates to a protein material which is effective to preserve progenitor cells, such as hematopoietic progenitor cells. The protein has an amino acid sequence comprising AQSLSFSFTKFD...
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7112568 |
Anti-allergic complex molecules
The present invention discloses novel anti-allergic complex molecules, and in particular, peptidic or peptidomimetic molecules, comprising a first part which is competent for cell penetration and a...
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7112566 |
Systemic administration of Hypocretin-1
The invention provides compositions and methods for treatment of sleep disorders. Such methods entail administering to the patient a therapeutically effective dosage regime of an agonist of a...
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7112655 |
JTT-1 protein and methods of inhibiting lymphocyte activation
A cell surface molecule that is expressed specifically in thymocytes, lymphocytes activated by ConA-stimulation, and peripheral blood lymphocytes. This molecule is involved in signal transmission...
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7109006 |
Virulence of Streptococci
The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention discloses a method for...
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7108855 |
Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E2 and/or E1/E2,...
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7109295 |
Zinc finger-based drug-dependent gene regulation system
The invention is related to a fusion polypeptide involving transcription regulation of a target gene. Said fusion polypeptide consists of (i) a zinc finger domain that recognizes and binds to the...
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7108853 |
Surface protein of Leptospira
The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
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7108856 |
CD4+ T-lymphocyte-specific Hepatitis C virus-epitopes
The invention relates to Hepatitis C virus epitopes which are specific in relation to CD4+ T lymphocytes, in addition to vaccinations which contain said epitopes.
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7108854 |
Surface proteins of Leptospira
The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
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7105162 |
Pharmaceutical composition for immunomodulation based on peptides and adjuvants
Pharmaceutical composition containing at least one peptide or protein (fragment) with an immunomodulatory activity together with an adjuvant. The peptide is derived from a pathogenic agent or a...
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7107092 |
Methods for diagnosing a neurodegenerative condition
A method of diagnosing, prognosing, staging, and/or monitoring a mammalian amyloidogenic disorder or a predisposition thereto by detecting a protein or polypeptide aggregate in the cortical and/or...
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7105163 |
Mite protein
The present invention relates to a novel major mite antigen, which according to the invention has been isolated and sequenced for the first time. More specifically, said antigen is a protein...
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7105170 |
Latent human tuberculosis model, diagnostic antigens, and methods of use
Provided herein is an in vitro granuloma model and methods of its use. Methods of detecting and/or diagnosing latent tuberculosis in a subject are also provided, as are latency-specific antigens...
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7101556 |
Preparation and usage of plasmodium fusion antigen
The invention provides a fusion protein comprising the Plasmodium merozoite surface protein-1 (MSP1) and the Plasmodium apical membrane antigen 1 (AMA-1), the encoding DNA sequence, the vector...
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7101555 |
Mycobacterial proteins, microorganisms producing them and their use for vaccines and the detection of tuberculosis
Mycobacterium tuberculosis protein having a molecular weight of 28 779 Da, and hybrid proteins containing at least portions of its sequence. These proteins may in particular be used in vaccines...
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7101557 |
Combined tissue factor methods for coagulation and tumor treatment
The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic...
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7098303 |
Conserved motif of hepatitis C virus E2/NS1 region
Immunogenic polypeptides comprising hepatitis C virus (HCV) immunogens are described. The HCV immunogen comprises the amino acid sequence...
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7098306 |
Method and compositions for treating hepatocellular cancer
A method for preventing or for treating cancer in a mammal, where the cancer cells express at least a part of an alpha fetoprotein molecule at the cell surface. The method comprises creating an...
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7097841 |
Ferritin fusion proteins for use in vaccines and other applications
An isolated ferritin fusion protein is provided in which ferritin is fused with a protein or peptide capable of being fused to ferritin without interfering with the polymeric self-assembly of the...
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7094396 |
Method for making cytokine specific antibodies and uses thereof
The methods of this invention relate to immunizing animals with conjugates of cytokines and a carrier to induce a prolonged high titre antibody response specific for the cytokine. This invention...
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7094409 |
Antigen arrays for treatment of allergic eosinophilic diseases
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7094410 |
DNA vaccine against proliferating endothelial cells and methods of use thereof
A DNA vaccine effective for inhibiting endothelial cell proliferation comprises a DNA construct operably encoding a vascular endothelial growth factor (VEGF) receptor protein. This invention...
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7094411 |
Avirulent, immunogenic flavivirus chimeras
Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric...
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7094874 |
Soluble CTLA4 mutant molecules
The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4...
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7091181 |
Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution...
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7087235 |
Fusion protein of streptococcal pyrogenic exotoxins
The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an...
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7087717 |
Sp110, a polypeptide component of the nuclear body
Cloning and characterization of a full length cDNA encoding Sp110 (speckled 110), a novel 110 kDa polypeptide, is disclosed. It is disclosed that Sp110 is a component of the nuclear body, is...
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7083796 |
Fusion proteins of mycobacterium tuberculosis
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The...
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7083797 |
32-kDa protein derived from Mycobacterium tuberculosis and related peptides
The invention relates to recombinant polypeptides and peptides and particularly to the polypeptide containing in its polypeptidic chain the following amino acid sequence: the one extending from the...
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7084239 |
Cancer peptides of NY-ESO-1/CAG-3
The present invention discloses the identification, isolation and cloning of a gene encoding a novel cancer antigen NY ESO-1CAG-3 and peptides thereof derived from various open reading frames from...
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7083789 |
Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer
The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as ovarian carcinoma. The invention discloses peptides,...
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7083959 |
Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry
The present invention relates to a method of specifically suppressing an undesired immune response in a mammal suffering from such a response. The method comprises:
i) preparing a construct...
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7083792 |
Immunologically active proteins from Borrelia burgdorferi
Various immunologically active proteins from Borrelia burgdorferi have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a B....
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7083791 |
Methods for enhancing immune responses by fibroblast growth factor receptor 5 polypeptides
Isolated fibroblast growth factor receptor (FGFR5) polypeptides and polynucleotides encoding such polypeptides are provided. Also provided are modulators of FGFR5 gene expression and binding...
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7084247 |
Identification of self and non-self antigens implicated in autoimmune diseases
The present invention provides isolated peptides relating to the autoimmune disease pemphigus vulgaris. The peptides relating to pemphigus vulgaris are self epitopes derived from human pathogens...
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7083788 |
Modulators of the function of receptors of the TNF/NGF receptor family and other proteins
Proteins which are capable of modulating/mediating the function of RIP, their preparation and uses are provided.
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7078043 |
Malaria vaccine
A non-naturally occurring variant of a C-terminal fragment of a Plasmodium merozoite surface protein-1 (MSP-1) wherein said variant has (i) a reduced affinity, compared with a naturally occurring...
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7074408 |
Use of integrin antagonists to inhibit angiogenesis
The present invention provides methods and compositions for inhibiting the biological activity of integrins, for inhibiting endothelial cell migration. and for inhibiting angiogenesis. In...
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7074620 |
Controlling protein levels in eucaryotic organisms
Method for reducing the level and/or activity of a target protein in a eukaryotic cell via activation of ubiquitination of the target protein wherein the cell is contacted with the compound having...
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7074889 |
Identification of a new cytotoxic activity from the ink of Aplysia punctata
The present invention relates to novel proteins having cytotoxic activity derived from the sea hare Aplysia.
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7074896 |
Recombinant soluble Fc receptors
Recombinant soluble Fc receptors according to the present invention are characterized by the absence of transmembrane domains, signal peptides and glycosylation. Such Fc receptors can easily be...
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7074410 |
Modified HCV peptide vaccines
Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139, an isolated...
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7074900 |
Alleviation of the allergenic potential of airborne and contact allergens by thioredoxin
Thioredoxin, a small dithiol protein, is a specific reductant for allergenic proteins and particularly allergenic proteins present in pollen and animal and plant sources. All targeted proteins...
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7070779 |
POLYPEPTIDES CONTAINING POLYMORPHISMS OF THE REPEATED REGIONS OF PERTACTIN IN BORDETELLA PERTUSSIS, BORDETELLA PARAPERTUSSIS, AND BORDETELLA BRONCHISEPTICA, THEIR USE IN DIAGNOSTICS, AND IN IMMUNOGENIC COMPOSITIONS
Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella ...
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