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7632513 |
Immunogenic detoxified mutants of cholera toxin
An immunogenic detoxified protein comprising the amino acid sequence of subunit A of a cholera toxin (CT-A) or a fragment thereof or the amino acid sequence of subunit A of an Escherichia coli ...
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7632507 |
Synovial cell protein
The present invention discloses a novel protein called Synoviolin and a gene that encodes it. This protein is expressed specifically by synovial tissue and also accompanies the presence of an...
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7632514 |
Universal carrier for targeting molecules to Gb3 receptor expressing cells
The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys,...
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7632816 |
Treatment of Alzheimer amyloid deposition
The present invention is directed to a method of preventing or treating Alzheimer's Disease or of inhibiting accumulation of amyloid-β deposits in a subject by administering to the subject an...
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7632505 |
Treatment of macrophage mediated disease
The invention relates to a method of treating or monitoring/diagnosing a disease state mediated by activated macrophages. The method comprises the step of administering to a patient suffering from...
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7629309 |
Targeted therapeutic proteins
Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds...
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7628990 |
Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
The invention provides classes of immunomodulatory compositions which comprise an average of one or more immunostimulatory sequence (ISS) containing polynucleotide conjugated, or attached, to...
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7625571 |
Transformed bacteria producing CS6 antigens as vaccines
Disclosed herein are antigens that stimulate protective antibodies against enterotoxigenic Escherichia coli . Also disclosed herein are proteins encoded by cssA and cssB genes as well as...
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7622119 |
Cancer antigen peptides derived from WT1
The present invention relates to HLA-A26-binding cancer antigen peptides derived from WT1, polynucleotides encoding such a peptide, CTL-inducers, and cancer vaccines comprising such a peptide or...
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7622120 |
Peptide originating from vaccinia virus
A vaccine for preventing or treating Orthopoxvirus infection that induces a protective or therapeutic immune response, wherein the vaccine comprises (1) an amino acid sequence of 20 amino acid or...
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7622105 |
Modified cytokines for use in cancer therapy
Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
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7622122 |
Methods of using novel tissue factor targeted thrombomodulin fusion proteins as anticoagulants
This invention relates to novel fusion proteins which are comprised of a targeting protein that binds tissue factor (TF), which is operably linked to the thrombomodulin (TM) EGF456 domain alone or...
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7618635 |
Super-antigen fusion proteins and the use thereof
The present invention relates to a super-antigen fusion protein, comprising: a peptide fragment whose sequence corresponds to a partial SARS E2 spike protein; and a translocating peptide fragment...
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7618634 |
Neurotoxic oligomers
This invention relates to methods and compositions for the treatment or alleviation of Alzheimer's disease and of other conditions related to abnormal protein aggregation. In particular, the...
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7618936 |
Methods for treating and diagnosing cancer with WNT inhibitory Factor-1 (WIF-1)
This invention provides compositions, methods and kits for the diagnosis and treatment of cancers wherein Wnt Inhibitory Factor-1 (WIF-1) is underexpressed.
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7618636 |
Antigenic meningococcal peptides
WO99/36544 discloses a large number of proteins from Neisseria Meningitidis . The present invention relates to fragments of those proteins which comprise at least one antigenic determinant....
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7615229 |
Mutants of the P4 protein of nontypable Haemophilus influenzae with reduced enzymatic activity
A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful...
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7612174 |
Scavenger receptor
Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the...
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7611711 |
VEGFR-3 inhibitor materials and methods
The present invention relates to the diagnosis, evaluation, and therapeutic intervention of disorders mediated by the activity of cell surface receptor VEGFR-3, which activity often is stimulated...
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7611719 |
Enterovirus, vaccines, medicaments and diagnostic kits
The invention provides a new enteroviral species call EV79, and functional parts, derivatives and analogues of said virus. Proteinaceous molecules capable of specifically binding EV79, such as...
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7612168 |
Modified HIV peptides, antigens, compositions, immunoassay kit and a method of detecting antibodies induced by HIV
The present invention comprises novel and modified peptides capable of inducing a HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
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7611720 |
Tuberculosis vaccines including recombinant BCG strains expressing alanine dehydrogenase, serine dehydratase and/or glutamine synthetase
The invention relates to a live recombinant Mycobacterium bovis -BCG strain comprising a nucleic acid capable of expression, the nucleic acid encoding at least one protein or polypeptide that...
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7612175 |
Scavenger receptor
Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the...
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7612038 |
Biglycan and related therapeutics and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with...
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7608269 |
Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
An alternative HER-2/neu product, herstatin, consists of subdomains I and II from the ectodomain of p185HER-2 and a unique 79 amino acid C-terminus encoded by intron 8. Recombinant herstatin added...
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7608277 |
Tuberculosis nucleic acids, polypeptides and immunogenic compositions
The present invention provides transcriptionally active Mtb polynucleotides, recombinant Mtb peptides and polypeptides, and immunogenic Mtb antigens. Immunogenic compositions are also provided that...
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7608683 |
Stress proteins and peptides and methods of use thereof
Provided are HLA pan DR-binding peptides and methods of using such peptides to modulate, block, or inhibit immune responses to effect treatment of immune-mediated diseases and conditions, such as...
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7608256 |
Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response
Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I...
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7608266 |
Yersinia species compositions
A method of protecting an animal from infections with pathogens originating from Yersinia comprising administering an isolated or recombinant YscF protein to the animal is disclosed. The isolated...
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7608268 |
Ferritin fusion proteins for use in vaccines and other applications
An isolated ferritin fusion protein is provided in which ferritin is fused with a protein or peptide capable of being fused to ferritin without interfering with the polymeric self-assembly of the...
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7601814 |
Reducing the immunogenicity of fusion proteins
Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces...
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7601357 |
Targeting of long chain triacylglycerol hydrolase gene for tuberculosis treatment
Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or...
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7601358 |
Mycobacterium tuberculosis protein composition
Mycobacterium tuberculosis proteins and protein compositions that are components of a desaturase complex are provided. The Mycobacterium tuberculosis desaturase complex may include a desaturase...
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7597894 |
Compositions and methods employing alternative reading frame polypeptides for the treatment of cancer and infectious disease
Provided are alternative reading frame (ARF) polypeptides as well as antigen presenting cell (APC) and dendritic cell (DC) based compositions and methods that employ alternative reading frame...
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7597896 |
Composition comprising a protein encoded by a modified ERP gene of Mycobacterium
The invention concerns Mycobacterium strains whereof the erp gene is modified and a vaccine composition containing same. The modification of the erp gene decreases the virulence and the...
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7598223 |
Methods for producing target cell reactive lymphocytes
Methods and compositions for producing target cell reactive lymphocytes, e.g., cytolytic T-lymphocytes, in a subject are provided. In practicing the subject methods, a lymphocyte population is...
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7595057 |
Streptococcus pyogenes antigens and corresponding DNA fragments
The present invention relates to antigens, more particularly antigens of Streptococcus pyogenes (also called group A Streptococcus (GAS)) bacterial pathogen which are useful as vaccine...
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7595058 |
Chlamydia antigens and vaccine uses of the protein
The present invention provides vaccines and methods for immunizing a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The...
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7595383 |
Secreted proteins of Mycobacterium tuberculosis and their use as vaccines and diagnostic reagents
The invention provides mycobacterium tuberculosis polypeptides and genes encoding them for use in diagnostic and prophylactic methodologies.
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7595052 |
Composition and method for the prevention and/or the treatment of allergy
The present invention is related to a method for modulating the immune system of a mammal patient towards an allergen, which comprises the step of inducing a pre-sensitisation of the immune system...
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7591997 |
Method for determining the susceptibility of a subject to infection
A method for determining the susceptibility of a subject to infection, which method comprises: (i) providing a sample from said subject; (ii) detecting any LL-37 present in said sample; (iii)...
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7592010 |
Albumin fusion proteins
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors...
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7592009 |
Polypeptide ligands for targeting cartilage and methods of use thereof
Ligands that specifically bind to articular cartilage tissues are disclosed, including uses for targeting therapeutics towards articular cartilage tissue and new materials for articular cartilage....
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7592008 |
Membrane scaffold proteins
The membrane scaffold proteins (MSP) of the present invention assemble with hydrophobic or partially hydrophobic proteins to form soluble nanoscale particles which preserve native structure and...
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7592421 |
HLA class II peptide mimics
The present invention provides peptide mimics for HLA class II antigens. The peptide mimics were identified by panning phage display peptide libraries with anti-HLA class II monoclonal antibodies....
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7592425 |
Cytokine zalpha11 ligand fusion proteins
Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino...
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7592310 |
Induction of antibiotic proteins and peptides by LAIT/sCD14-protein
A method of ameliorating the symptoms of sepsis comprising directly exposing epithelial cells of a mammal in need thereof to soluble CD14, or active variants thereof. A method of obtaining CD14...
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7588930 |
Compositions and methods for enhancing the immunogenicity of antigens
The present invention includes compositions, methods and kits for enhancing the immunogenicity of an antigen via fusion to a Listerial protein. The present invention further encompasses Listeria ...
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7588763 |
Methods for the prevention against or treatment of diabetes with ETXB and/or insulin
This application relates to methods for modulating an immune response in a mammalian subject in need of prevention against or treatment of diabetes comprising the administration of EtxB and/or...
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7589177 |
Nucleic acid molecules encoding cyclotide polypeptides and methods of use
The present invention relates to isolated nucleic acids encoding plant cyclotides. The invention also relates to the construction of a chimeric gene encoding all or a portion of the plant...
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