Sign up


Match Document Document Title
8278412 Polypeptide, nucleic acid molecule encoding it and their uses  
A polypeptide containing epitope of the amino acid sequence shown in SEQ ID NO:3 is provided, which is selected from the amino acid sequence of SEQ ID NO:3 and amino acids at 16-32 positions, amino...
8277814 Avian Astrovirus  
The present invention relates to the fields of veterinary virology and immunology. In particular the invention relates to a novel avian Astrovirus; to antibodies or fragments thereof against the...
8277817 PEGylation by the dock and lock (DNL) technique  
The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using...
8277820 Process for preparing variant of Erysipelothrix rhusiopathiae surface protective antigen in E. coli  
A variant of Erysipelothrix rhusiopathiae surface protective antigen SpaA protein or of a shortened form of SpaA (ΔSpaA) in which a portion of SpaA protein is deleted for protection from ...
8277813 Identification and molecular characterisation of proteins, expressed in the Ixodes ricinus salivary glands  
The invention relates to a new polynucleotide which encodes a polypeptide expressed in the salivary glands of ticks, more particularly the Ixodes ricinus arthropod tick, during the slow-feeding...
8277778 Vaccine adjuvants  
The invention relates to a novel adjuvant Mycobacterium w and or its constituents and adjuvant containing composition, which contains antigen(s) with pharmaceutical acceptable carrier and its uses....
8277816 Bacillus anthracis antigens, vaccine compositions, and related methods  
The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by Bacillus...
8273865 Multivalent clostridial toxins  
The present invention is directed to multivalent Clostridial toxin comprising more than one binding domain directed to a cell surface molecule of a target cell. Such modified toxins are useful as...
8268322 Polypeptide specifically binding to vascular endothelial growth factor, fusion protein including polypeptide, and methods therefor  
A polypeptide inhibiting binding between a vascular endothelial growth factor and a vascular endothelial growth factor receptor, a fusion protein including the same, and a method of preparing the...
8268783 Antidotes for factor Xa inhibitors and methods of using the same  
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the factor Xa inhibitors thereby...
8268321 Antigen-drug vehicle enabling transmucosal and transdermal administration, and method of inducing mucosal immunity and mucosal vaccine and DDS using the same  
Disclosed are an antigen-drug vehicle (AD vehicle) exerting a function of inducing the preferential and selective production of an antigen-specific secretory IgA antibody, local immunity or mucosal...
8268587 Immunosuppressive polypeptides and nucleic acids  
The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding...
8263088 Clostridial toxin NetB  
The present invention relates to a polypeptide based toxin that originates from Clostridium perfringens. The invention further relates to immunogenic compositions comprising the toxin and methods...
8263089 Compounds and methods for treatment and diagnosis of chlamydial infection  
Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia...
8263081 Antibody-light fusion products for cancer therapeutics  
Antibody-LIGHT fusion products or conjugates stimulate immunity against tumors and eradicate metastases. Tumor-specific antibodies coupled with LIGHT effectively target metastatic tumors and...
8258257 Claudin-4 binding peptides, compositions and methods of use  
The disclosure provides methods and compositions useful for treating claudin-4 associated disorders including cell proliferative disorders. The disclosure also provide claudin-family binding...
8257714 Compositions and methods for immunotherapy of cancer and infectious diseases  
The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in...
8257713 Vaccine  
The present invention is concerned with the development of a vaccine against Aeromonas hydrophila for use especially in fish. The invention provides an immunogenic S-layer protein of approximately...
8257711 Epitope peptides derived from vascular endothelial growth factor receptor 1 and vaccines containing these peptides  
The present invention provides immunogenic peptides comprising the amino acid sequence of SEQ ID NO: 1, 2, 13, 32, and peptides comprising the above-mentioned amino acid sequences in which 1, 2, or...
8252545 Peptides of a melanoma antigen and their use in diagnostic, prophylactic, and therapeutic methods  
Immunogenic peptides of a melanoma antigen recognized by T cells, designated gp100, bioassays using the peptides to diagnose, assess or prognose a mammal afflicted with cancer, more specifically...
8252293 Binding domain of Plasmodium reticulocyte binding proteins  
The present invention provides isolated polynucleotides, polypeptides, antibodies and/or vaccines for the prevention and/or treatment of malaria caused by Plasmodium falciparum and/or Plasmodium...
8246960 Methods and compositions for generating bioactive assemblies of increased complexity and uses  
The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In...
8241608 Treating allergy with detoxified E. coli heat-labile enterotoxin  
A method for treating allergy with a pharmaceutical composition containing a detoxified E. coli heat-labile enterotoxin, and, optionally, an allergen.
RE43581 Peptide epitopes of apolipoprotein B  
The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including...
8241637 DNA composition encoding an immunogenic VEGF receptor peptide and methods of use thereof  
A method of inhibiting endothelial cell proliferation in a mammal is provided. The method comprises the step of administering to the mammal an effective immunological response eliciting amount of a...
8241639 Extracellular domains of Epstein Barr Virus (EBV) tumor-associated latent membrane proteins  
Described are a method for the identification of extracellular epitopes of Epstein Barr virus (EBV) encoded membrane proteins, expressed on the cuter cell surface of EBV-transformed mammalian...
8232373 Immunogenic peptide composition for the prevention and treatment of alzheimer's disease  
The present invention relates to a composition comprising a peptide immunogen useful for the prevention and treatment of Alzheimer's Disease. More particularly, the peptide immunogen comprises a...
8226958 Modified SEB and prophylactics/remedies for immunopathy containing the same  
A novel prophylactic/remedy for immunopathy is provided which is not neutralized by a neutralizing antibody to Staphylococcal enterotoxin B (SEB), known as one of superantigens, and may effectively...
8222370 Nucleophosmin protein (NPM) mutants, corresponding gene sequences and uses thereof  
The invention relates to new nucleophosmin protein (NPM) mutants, corresponding gene sequences and relative uses thereof for diagnosis, monitoring of minimal residual disease; prognostic evaluation...
8221764 Secreted campylobacter flagella coregulated proteins as immunogens  
The invention relates to an immunogenic composition composed of secreted polypeptides derived from Campylobacter jejuni non-flagellar proteins that are coordinately expressed with the flagellar...
8221762 Naturally processed measles virus peptides from class II HLA molecules  
A preparation of peptides eluted from class II HLA molecules is disclosed. Methods of decreasing measles infections comprising inoculating human patients with a vaccine comprising one or more of...
8211438 Human hookworm vaccine  
A vaccine for human hookworm is provided. The vaccine comprises at least one L3 larval stage antigen (e.g. Na-ASP-2 or Na-SAA-2) and at least one adult stage human hookworm antigen (e.g. Na-APR-1,...
8211633 Viral variants with altered susceptibility to nucleoside analogs and uses thereof  
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the...
8211445 PSM peptides as vaccine targets against methicillin-resistant Staphylococcus  
This disclosure concerns compositions and methods for the treatment and inhibition of infectious disease, particularly methicillin-resistant Staphylococcus. In certain embodiments, the disclosure...
8212000 Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules  
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
8212004 Neutrokine-alpha fusion proteins  
The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha...
8211999 Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules  
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
8207113 Methods for characterizing glycoproteins and generating antibodies for same  
The invention provides methods for preparing a peptide useful in generating an antibody specific for the glycosylated form of a glycopolypeptide wherein the glycosylated portion is isolated and a...
8206718 Expression and export of angiogenesis inhibitors as immunofusins  
A homodimeric protein of the invention has angiogenesis inhibiting activity. The homodimeric protein consists of two identical fusion proteins bound together as a homodimer. Each fusion protein...
8206719 KDR peptides and vaccines comprising the same  
The present invention provides nonapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO:2, 3, 5, 8, 11, or 12; nonapeptides or decapeptides selected from peptides...
8206685 Cupredoxin derived transport agents and methods of use thereof  
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains...
RE43472 Tropomyosin isoforms, and diagnostic and therapeutic uses therefor  
A novel isoform of tropomyosin is disclosed. The isoform is closely related to epithelial human tropomyosin (hTM) and more particularly to hTM5 except the last coding exon. The novel isoform, is...
8198235 Use of GILZ protein expressed in dendritic cells to modulate an antigen-specific immune response  
The invention concerns the use of at least one: a) a GILZ protein, a functional fragment of at least 5 consecutive amino acids of said protein, a GILZ modulator, or a recombinant vector expressing...
8197818 EML4-ALK fusion gene  
The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding...
8193326 Nucleic acids encoding novel TERT polypeptides  
The present invention relates to polypeptides, and nucleic acids DNA encoding these polypeptides, capable of eliciting an immune reaction against cancer, methods for generating T lymphocytes...
8192744 Drug for treating states related to the inhibition of angiogenesis and/or endothelial cell proliferation  
Soluble recombinant CD44 hyaluronic acid binding domain (CD44HABD) inhibits angiogenesis in vivo in chick and mouse and thereby inhibits human tumor growth of various origins. The anti-angiogenic...
8187605 Means for the inhibition of anti-β1-adrenergic receptor antibodies  
Embodiments of the present invention provide for novel peptides of use for detection and/or inhibition of anti-β1-adrenergic receptor antibodies. Certain embodiments concern uses of cyclic and/or ...
8188251 Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof  
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished...
8188214 Brachyury polypeptides and methods for use  
It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and...
8182819 Composition and method for facilitating the internalization of a therapeutic agent into a cell  
The present invention is a composition and method for facilitating the internalization of a therapeutic agent into a cell. Specifically, the invention relates to the use of the extracellular domain...