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8470339 Antigens for paratuberculosis diagnosis and vaccination  
The present invention discloses new antigens of Mycobacterium avium subsp. paratuberculosis, antigenic compositions comprising at least two of said antigens, as well as epitopes, antibodies or...
8470341 Escherichia coli immunogens with improved solubility  
Variants of the pathogenic E. coli ‘AcfD precursor’ have been identified with increased solubility as compared to the native AcfD protein that raise a substantially similar immune response in a...
8470332 Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR  
The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins...
8470313 Ras mutation and compositions and methods related thereto  
Disclosed are newly discovered Ras mutations and combinations of mutations, proteins and peptides and fusion proteins containing these mutations, nucleic acid molecules encoding such proteins,...
8470333 Chimeric peptides comprising HER-2 B-cell epitopes and T-helper epitopes  
Compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the HER-2 protein are provided. Such...
8465743 Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer  
The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of a KDR-1121 or DC101 antibody, an extracellular hinge domain, a T cell receptor transmembrane...
8466104 Therapeutically active alpha MSH analogues  
The invention describes peptide analogues of a-melanocyte-stimulating hormone (a-MSH), which posses an increased efficacy compared to the native α-MSH peptide. The α-MSH analogues exhibit...
8465746 Compositions and methods for treatment, research and therapeutic applications for malaria  
The present invention provides anti-Plasmodium immunogenic compositions comprising EVP1 (PFD0495c) or an antigenic portion thereof, as well as methods of immunizing against malaria employing these...
8466268 Lactobacillus sp. JNU2116 with antimutagenic activity  
Lactobacillus sp. strain with antimutagenic activity and, more particularly, Lactobacillus sp. JNU2116 having a specific amino acid sequence at an N-terminal. Such strain has various advantages in...
8460672 Mosaic protein and nucleic acid vaccines against hepatitis C virus  
The invention relates to immunogenic compositions useful as HCV vaccines. Provided are HCV mosaic polypeptide and nucleic acid compositions which provide higher levels of T-cell epitope coverage...
8460890 Detection and measurement of blood-feeding activity  
This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive...
8460673 Fusion protein inhibiting osteoclast formation, preparation method and medicine compositions thereof  
The present invention provides a coding gene having the nucleic acid sequence shown as SEQ ID NO:1 and the fusion protein RIG (SEQ ID NO:2) that inhibits osteoclast formation. The present...
8461323 Characterization of granulocytic ehrlichia and methods of use  
The present invention relates, in general, to polypeptides having antigenic epitopes from granulocytic ehrlichia (GE) proteins and methods of use thereof.
8460675 Viral chemokine-antigen fusion proteins  
The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral...
8455441 Antidotes for factor Xa inhibitors and methods of using the same  
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially...
8454967 Compositions and methods for modulating the immune system  
A novel class of embryo derived peptides are described (Preimplantation factor) that were generated synthetically and were tested on peripheral blood immune cells and shown to block activated but...
8454968 Method for inducing immunity with a peptide fragment from human CAPRIN-1  
The invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity that is selected from among polypeptides (a),...
8454977 Non-toxic biofilm inhibitor  
The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the...
8454960 Multispecific antibody targeting and multivalency through modular recognition domains  
Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular...
8454963 Tissue targeted complement modulators  
Systemic suppression of the complement system has been shown to be effective to treat inflammatory disease, yet at the potential cost of compromising host defense and immune homeostasis. Herein...
8450462 Compound  
A compound including a polymer is represented by general formula (1): L-Y-A (1) wherein, A is a single-chain antibody moiety, which is a polypeptide including an antigen-binding site, L is a...
8450273 Fusion proteins of collagen-binding domain and parathyroid hormone  
Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented....
8449891 Recombinant flagellin protein and preparation and use thereof  
The present invention provides an optimized recombinant flagellin protein and preparation and use thereof. The protein is with a deletion in the hypervariable region, said hypervariable region is...
8449894 Aspergillus vaccine preparation and methods of making and using thereof  
The present invention relates to compositions and methods in preventing and/or treating diseases caused by Aspergillus. In particular, the present invention is directed to Aspergillus vaccine...
8444995 Peptide sequences and compositions  
Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-6, or comprises two or more...
8445230 Immunosuppressive polypeptides and nucleic acids  
The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding...
8444994 Multivalent antihelminthic vaccine  
A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage...
8440200 Non-anaphylactic forms of grass pollen Ph1 p 6 allergen and their use  
Methods for desensitization of a mammal suffering from IgE mediated allergy comprise the steps of: administering to said mammal a therapeutically effective amount of an immunogenic and...
8440206 Methods for producing an immune response to tuberculosis  
Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional...
8440204 Subtype of Closteridium botulinum neurotoxin type A and uses thereof  
A novel subtype of type A botulinum neurotoxin (BoNT/A) is disclosed in the application. Methods to purify the neurotoxin as well as uses thereof are also disclosed.
8440208 Chlamydial antigens as reagents for diagnosis and treatment of chlamydial infection and disease  
The present invention provides Chlamydia proteins and methods of use in diagnostic and detection assays as well as in treatment and immunization protocols.
8440205 Streptococcal C5A peptidase vaccine  
Novel vaccines for use against β-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of streptococcal C5a peptidase (SCP). Also...
8440201 Stabilized bioactive peptides and methods of identification, synthesis, and use  
An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system,...
8435530 Methods for suppressing activity of activated interferon-producing cells  
The present invention provides agents for regulating the activity of interferon-producing cells (IPCs), which comprise as active ingredients antibodies that bind to BST2 and/or to its homologues,...
8435532 Use of modified extracellular matrix proteins in diagnosis and treatment of atherosclerosis  
The present invention relates to the use of fibronectin, tenascin, collagens type I, III, VI and/or VIII modified by aldehyde or by glycosylation in ELISA for detection of antibodies in plasma and...
8435538 Anti-atheroma vaccine  
The invention relates to a recombinant protein comprising: a carrier portion; a first epitope capable of eliciting an anti-atheroma response; and a second epitope capable of eliciting an...
8435535 Fusion proteins of HIV regulatory/accessory proteins  
The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of...
8435534 Cancer immunotherapy  
A method for stimulating a immune response against IL-13Rα2 in a subject having or at risk for developing a disease having cells expressing IL-13Rα2 includes the steps of formulating the...
8435494 Mesothelin antibody protein fusions and methods of use  
The invention relates to fusion proteins comprising a stress protein fused with an engineered antibody or fragment that binds to mesothelin, or a stress protein fused with a biotin-binding protein...
8431530 Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles  
Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also...
8425914 Methods for enhanced somatostatin immunogenicity in the treatment of obesity  
Compositions and methods are provided for treatment growth hormone and/or insulin-like growth factor 1 deficiency in a patient in need of such treatment. Compositions and methods include novel...
8420096 Cell-penetrating SOCS polypeptides that inhibit cytokine-induced signaling  
Disclosed are compositions and methods related to cell-penetrating suppressor of cytokine signaling (SOCS) proteins that inhibit cytokine-induced signaling.
8420098 Fibronectin based scaffold domain proteins that bind to PCSK9  
The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat...
8420095 Antigen-containing microspheres for the treatment of allergies  
Microspheres containing antigens for allergy therapy, the microspheres having a binding constant of 1×104 M−1 toward a specific carbohydrate residue of intestinal and/or nasal epithelial cells.
8420097 DNA sequence, and recombinant preparation of the grass pollen allergen Lol p 4  
The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and...
8414899 Vaccines comprising multimeric HSP60 peptide carriers  
The present invention provides improved vaccine compositions having enhanced immunogenicity and methods of using same. The compositions and methods include immunogenic conjugates containing...
8409584 Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins  
The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated...
8409582 Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods  
Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like...
8409580 Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers  
The invention relates to an immunogenic composition which comprises, firstly, a carrier and, secondly, as antigenic structure, conjugates comprising all or part of the amino acid sequences of at...
8409581 Compounds for treating amyloidoses  
The present invention relates to the use of mimotopes in the treatment of β-Amyloidoses including but not limited to Alzheimer's disease, whereby said mimotopes are able to induce the in vivo...