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8414899 Vaccines comprising multimeric HSP60 peptide carriers  
The present invention provides improved vaccine compositions having enhanced immunogenicity and methods of using same. The compositions and methods include immunogenic conjugates containing peptide...
8409584 Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins  
The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated...
8409582 Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods  
Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like...
8409580 Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers  
The invention relates to an immunogenic composition which comprises, firstly, a carrier and, secondly, as antigenic structure, conjugates comprising all or part of the amino acid sequences of at...
8409581 Compounds for treating amyloidoses  
The present invention relates to the use of mimotopes in the treatment of β-Amyloidoses including but not limited to Alzheimer's disease, whereby said mimotopes are able to induce the in vivo ...
8404243 Peptide adjuvants  
Adjuvant compositions comprising specific 5mer polypeptides in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for...
8404826 Mycobacterial antigens expressed under low oxygen tension  
A method is provided for identifying mycobacterial genes that are induced or up-regulated under continuous culture conditions defined by a dissolved oxygen tension of up to 10% air saturation...
8404638 Dimer VEGF antagonist formulations  
Formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided including a pre-lyophilized formulation, a reconstituted lyophilized formulation, and a...
8398992 Methods and compositions for polytopic vaccination  
The present invention relates to therapeutic and prophylactic methods for treating or preventing an infectious disease in a subject by stimulating or enhancing an immune response against an...
8399650 Mycobacterial antigens expressed during latency  
A method is provided for identifying mycobacterial genes that are induced or up-regulated under culture conditions that are nutrient-starving and which maintain mycobacterial latency, said...
8398988 Adjuvanting meningococcal factor H binding protein  
Factor H binding protein (fHBP) has been proposed for use in immunising against serogroup B meningococcus (‘MenB’). This antigen can be efficiently adsorbed to an aluminum hydroxyphosphate adj...
8398987 Use of platelet glycopeptide IIIa epitopes in the treatment of immune thrombocytopenic purpura  
The present invention relates to a composition for treating diseases associated with autoantibodies specific for platelet proteins, in particular autoimmune thrombocytopenic purpura. The...
8398986 ADP-ribosylating toxin from listeria monocytogenes  
An ADP-ribosylating toxin from Listeria monocytogenes is disclosed, together with mutant toxins and uses therefor. There is only a low level of sequence identity between this toxin and known toxins...
8394383 Allergens from Aspergillus versicolor, and method of detecting a mold allergy caused by interior rooms  
The invention relates to seven allergens of Aspergillus versicolor which are suitable for specific diagnostics of this mold which predominantly pollutes the interior. The invention is also directed...
8394384 Recombinant avian influenza vaccine and uses thereof  
The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be...
8394387 Recombinant modified Bacillus anthracis protective antigen for use in vaccines  
The invention relates to improved methods of producing and recovering sporulation-deficient B. anthracis mutant stains, and for producing and recovering recombinant B. anthracis protective antigen...
8388976 Polypeptide specifically binding to vascular endothelial growth factor, fusion protein including polypeptide, and methods therefor  
A polypeptide inhibiting binding between a vascular endothelial growth factor and a vascular endothelial growth factor receptor, a fusion protein including the same, and a method of preparing the...
8388966 Combination treatment of pancreatic cancer  
A combination for use in the treatment of pancreatic cancer comprising: (i) an anti-gastrin effective immunogenic composition; and,(ii) one or more chemotherapeutic agents suitable for inhibiting...
8389469 Bacteriophage lysins for Bacillus anthracis  
The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and B. cereus bacteria and spores, and related conditions. The...
8389472 Exendin-4 to treat nonalcoholic steatohepatitis and nonalcoholic fatty liver disease  
The present invention relates generally to the novel use of incretin compounds (ICs) and amylinomimetic compounds to treat, prevent, or ameliorate a variety of metabolic conditions or diseases.
8388933 Multimeric protein toxins to target cells having multiple identifying characteristics  
The present invention provides compositions comprising modified bacterial toxins and methods for using the modified bacterial toxins for targeting particular cell populations and for treating...
8388975 Cancer antigen peptides derived from WT1  
The present invention relates to HLA-A26-binding cancer antigen peptides derived from WT1, polynucleotides encoding said peptide, CTL-inducers, and cancer vaccine comprising said peptide or...
8383768 CD133 epitopes  
An immunogen includes an isolated peptide that includes the amino sequence of any one of SEQ ID NOs:1-21 with four or fewer amino acid substitutions.
8383125 Antimicrobial protein  
The present invention provides improved antimicrobial compositions comprising peptide fragments of tammar wallaby milk proteins and analogs and derivatives thereof exemplified by the amino acid...
8383119 Biological substance nesfatin and its related substances and uses thereof  
The present invention relates to a novel method of obtaining a factor involved in appetite control and/or body weight control, as well as genes obtained by said method, polypeptides encoded by said...
8377448 CD47 related compositions and methods for treating immunological diseases and disorders  
Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an...
8377447 Monomeric recombinant MHC molecules useful for manipulation of antigen-specific T cells  
The present invention provides, in particular embodiments, for modified recombinant T cell receptor (TCR) ligands (RTLs) comprising a MHC class I or MHC class II component. The modified RTLs have...
RE44024 Isolation and characterization of ECA1, a gene overexpressed in endometroid carcinomas of ovary and endometrium  
This invention provides an isolated polynucleotide encoding an ECA1 polypeptide. Also provided is the isolated ECA1 polypeptide Further provided is an antibody that specifically recognizes and...
8372406 Antitumoral and antiviral peptides  
The invention relates to novel compositions of general formula (1) consisting of X1 Trp Gly Gln X2 or the pharmaceutically acceptable salts or esters or amides thereof, wherein X1 is absent or...
8372398 Single domain VHH antibodies against Von Willebrand Factor  
The present invention relates to improved Nanobodies™ against von Willebrand Factor (vWF), as well as to polypeptides comprising or essentially consisting of one or more of such Nanobodies. The i...
8372412 Bioassay and peptides for use therein  
The invention provides a bioassay for detection of Mycobacterium tuberculosis infection comprising artificially modified peptide subsequences of the T-cell epitope from M. tuberculosis Ag85B....
8367069 Cytotoxic T cell defined EGFR peptide and an optimized derivative peptide  
The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid,...
8367073 Chloramphenicol acetyl transferase (CAT)-defective somatostatin fusion protein and uses thereof  
Chimeric somatostatin-based polypeptides, polynucleotides used to encode the polypeptides, the methods for isolating and producing the polypeptides and the uses thereof are provided. In addition,...
8367071 Verotoxin B subunit for immunization  
Methods for stimulating an immune response in a mammal by administering a toxin-antigen conjugate are provided. Pharmaceutical compositions and methods for treating an antigen-related state are...
8367067 Immunogenic lipopeptides comprising T-helper and B-cell epitopes  
The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary...
8361479 Promiscuous PAP CD4 T cell epitopes  
The present invention relates to the discovery of novel T cell epitopes of the human prostatic acid phosphatase (PAP) protein that is promiscuous for at least 15 different HLA-DR alleles. The...
8361749 Process for preparing variant of Erysipelothrix rhusiopathiae surface protective antigen in E. coli  
A variant of Erysipelothrix rhusiopathiae surface protective antigen SpaA protein or of a shortened form of SpaA (ΔSpaA) in which a portion of SpaA protein is deleted for protection from ...
8361482 Recombinant BCG tuberculosis vaccine designed to elicit immune responses to mycobacterium tuberculosis in all physiological stages of infection and disease  
A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or...
8354240 VMP-like sequences of pathogenic Borrelia  
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino...
8354111 Stable cell binding chimeric peptides  
The present invention relates to novel family of homologous cell attachment chimeric peptides. In particular, the present invention relates to chimeric peptides, each comprising synthetic peptides...
8349333 Allergy inhibitor compositions and kits and methods of using the same  
Compositions and kits for inhibiting an allergic response against an allergenic protein are disclosed. The compositions comprise a eukaryotic cell expression vector containing nucleotide sequences...
8349334 Molecule  
We describe an Fve polypeptide being a fragment, homologue, variant or derivative of Fve protein, which comprises at least one biological activity of Fve protein. uses of such a polypeptide, etc,...
8343500 Peptide composition  
There is provided a method for selecting a tolerogenic peptide by selecting a peptide which is capable of binding to an MHC class I or II molecule without further processing. There is also provided...
8343503 Contiguous overlapping peptides for treatment of birch pollen allergy  
Contiguous overlapping peptides (COPs) for the treatment of allergic patients by Specific Immunotherapy (SIT) are provided from the sequence of the major allergen of birch pollen Bet v 1. Such...
8343504 Methods of administering IGBPMA to treat type 1 hypersensitivity  
The present invention relates generally to methods and materials for treating conditions associated with IgE activation in humans and animals, and to agents capable of modulating the activation....
8343502 Yeast-based vaccines as immunotherapy  
Compositions and methods for treating and/or preventing a variety of diseases and conditions that are amenable to immunotherapy and, in one particular embodiment, compositions and methods for...
8343501 Bispecific EGFR/IGFIR binding molecules  
The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The...
8337857 Chimeric poly peptides and the therapeutic use thereof against a Flaviviridae infection  
The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral...
8333953 Methods of delivery of exogenous proteins to the cytosol and uses thereof  
The present invention is directed to a method for delivering exogenous proteins to the cytosol, by binding a target antigen (such as a protein) to a transport factor that contains a fragment of a...
8333972 Unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions  
The invention provides a novel antigen, MPD6, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the...