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8034776 |
Materials and methods for the treatment of celiac disease
The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject...
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8034353 |
Peptide vaccine for inducing the production of anti-amyloid β-peptide antibody
An object of the present invention is to provide a peptide vaccine for preventing and/or treating diseases caused by amyloid β-peptide, such as Alzheimer's disease. The present invention solves ...
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8034358 |
Surface antigen
The invention provides a novel surface polypeptide from Neisseria meningitidis as well as nucleic acid and nucleic acid sequence homologues encoding this protein. Pharmaceutical compositions...
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8034349 |
Peptides that mimic non-human cross-reactive protective epitopes of the group B meningococcal capsular polysaccharide
Peptides that mimic the antigenic features of non human-cross-reactive protective epitopes of the MenB CP and nucleic acids encoding the peptide mimetics are disclosed. Antibodies elicited by these...
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8030450 |
Canine RANKL and methods for preparing and using the same
The present invention provides isolated nucleic acid molecules that encode a substantial part of canine RANKL polypeptide, including the extracellular domains of that polypeptide, the polypeptide...
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8029796 |
Therapeutic anti-cytomegalovirus compounds
The present invention provides synthetic compounds, antibodies that recognize and bind to these compounds, polynucleotides that encode these compounds, and immune effector cells raised in response...
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8029806 |
Method for diagnosing of Mycobacterium tuberculosis
The present invention relates to a method and a kit for detecting Mycobacterium tuberculosis (MTB) or Nontuberculous mycobacteria (NTM) of patients. The present invention also relates to primers...
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8029804 |
Recombinant chimeric antigens for diagnosis and prevention of scrub typhus
Recombinant chimeric antigens comprising unmodified and modified reactive polypeptide fragments of expressed product of the recombinant 56 kDa proteins of multiple strain of scrub typhus, such as...
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8029805 |
Recombinant B. pseudomallei adhesin protein and methods and uses thereof
Isolated and/or recombinant adhesin polypeptides from B. pseudomallei are provided, which are used as vaccines. Genetic constructs comprising nucleic acid sequences encoding such polypeptides are...
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8025884 |
Lawsonia intracellularis subunit vaccines
The present invention relates i.a. to nucleic acids encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant...
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8025890 |
Nucleic acids and proteins from streptococcus groups A and B
The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding...
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8021666 |
Method and compositions for stimulation of an immune response to CD20 using a xenogeneic CD20 antigen
Tolerance of the immune system for endogenous CD20 can be overcome and an immune response stimulated by administration of xenogeneic or xenoexpressed CD20 antigen. For example, mouse CD20, or...
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8021667 |
Compositions for immunotherapy and uses thereof
The present invention relates to an immunogenic composition comprising a conjugate between an antigen and an oxidized mannan comprising mannose units and aldehyde groups, and a pharmaceutically...
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8021668 |
Integrin alpha L I domain mutants with increased binding affinity
The present invention provides an isolated polypeptide capable of binding to aCAM-1, comprising the integrin (XL I domain or biologically active portion thereof, wherein one or more residues is...
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8021832 |
Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M....
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8017749 |
Compositions and methods to treat cancer with cupredoxins and CpG rich DNA
The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The present invention includes specific CpG...
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8017124 |
Use of DMBT1 for capturing sulphate and phosphate group exposing agents
Disclosed is the use of DMBT1, or of the nucleic acid encoding it, for the manufacture of a medicament for the treatment of a patient suffering from a disease caused by an agent, which possesses at...
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8017125 |
Copolymers for suppression of autoimmune diseases, and methods of use
Random three- and four-amino acid copolymers having lengths of 14-, 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99- or proteolipid protein...
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8017132 |
Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell
The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell...
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8017753 |
Mycobacterial antigens expressed under low oxygen tension
A method is provided for identifying mycobacterial genes that are induced or up-regulated under continuous culture conditions defined by a dissolved oxygen tension of up to 10% air saturation...
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8017590 |
Method of inducing and/or enhancing an immune response to tumor antigens
An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or...
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8017127 |
Influenza immunogen and vaccine
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An...
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8012493 |
Malaria vaccines
The invention provides isolated placental P. falciparum polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-4 and 6-24, and immunogenic derivatives...
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8012487 |
Synthetic peptides and DNA sequences for treatment of multiple sclerosis
Synthetic unaltered and altered peptides comprising sequences of at least one immunogenic epitope cluster (IEC) of at least one human autoantigen related to multiple sclerosis (MS) and at least one...
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8012469 |
Universal GM-CSF expressing bystander human K562 cell line
The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell...
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8012932 |
Contraceptives based on SP22 and SP22 antibodies
Oral, topical and injectable contraceptives, which are based on sperm protein 22 kDa (SP22) polypeptides and antibodies and infertility diagnostics are provided.
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8008257 |
ANF fusion proteins
A fusion protein comprising an arterial natriuretic factor (ANF) amino acid sequence linked to an albumin amino acid sequence by one or more peptide bonds is provided. The ANF amino acid sequence...
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8007808 |
Composition and method for facilitating the internalization of a therapeutic agent into a cell
The present invention is a composition and method for facilitating the internalization of a therapeutic agent into a cell. Specifically, the invention relates to the use of the extracellular domain...
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8007810 |
HLA-A2 tumor associated antigen peptides and compositions
A peptide or composition comprising at least one HLA-A2 epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
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8007770 |
Purified linear polypeptide epitopes from walnuts and associated methods
A purified Ig-E binding immunogenic polypeptide the amino acid sequence of which consists of SEQ ID NO:1 is disclosed. The purified amino acid sequence is a major allergen of the walnut Juglans...
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8007809 |
Activin-actrii antagonists and uses for increasing red blood cell levels
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly...
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8003776 |
Mycobacterial antigens expressed during latency
A method is provided for identifying mycobacterial genes that are induced or up-regulated under culture conditions that are nutrient-starving and which maintain mycobacterial latency, said...
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8003114 |
AbfB-2 gene from Penicillium funiculosum
The invention relates to the abfB-2 gene of Penicillium funiculosum that codes for a type B α-L-arabinofuranosidase and has a cellulose binding domain. This enzyme α-L-arabinofuranosidase can be i...
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8003110 |
Metalloproteinase oligopeptides and their therapeutic use
The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides and peptidomimetics. The oligopeptides are used for making antibodies. The antibodies are used...
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8003109 |
Pharmaceutical compositions containing the long pentraxin PTX3
Pharmaceutical compositions are described containing a long pentraxin PTX3, particularly human PTX3, for the therapy of infectious and inflammatory or tumor diseases; expression vectors containing...
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8003108 |
Sclerostin epitopes
Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
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8003106 |
Human monoclonal antibodies to influenza M2 protein and methods of making and using same
Human, humanized and chimeric monoclonal antibodies that bind to influenza M2 protein. The antibodies are useful for, among other things, treatment, diagnostics, purifying and isolating M2 or...
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7998490 |
Genes of an otitis media isolate of nontypeable Haemophilus influenzae
The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also...
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7998483 |
Lage-1 tumor associated nucleic acids
The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such...
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7993657 |
Antibody profiles characteristic of tuberculosis state
Serum antibody assays capable of distinguishing cases of inactive TB from cases of active TB include a combination of at least three M. tuberculosis protein antigens, at least one for which a...
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7993650 |
Polypeptides having binding affinity for HER2
A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the...
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7993658 |
Targeting of triacylclycerol synthase gene for tuberculosis treatment
Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or...
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7994279 |
Altered peptide ligands of GAD65
Modified GAD65 compositions antagonize the activities of islet-specific T cells that contribute to the progression of one or more autoimmune disorders. The compositions are also antagonistic in...
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7988973 |
Activin-ActRII antagonists and uses for increasing red blood cell levels
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly...
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7989605 |
Compounds and methods for immunotherapy and diagnosis of tuberculosis
Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more...
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7989162 |
Viral variants with altered susceptibility to nucleoside analogs and uses thereof
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the...
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7982025 |
Fusion proteins of Mycobacterium tuberculosis
The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more...
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7982014 |
FGFR3-IIIc fusion proteins
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
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7981425 |
Thrombopoietic compounds
The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase...
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7981626 |
Method of detecting endometriosis in human subjects using SEQ ID No. 9 or an epitope thereof
A method for diagnosing endometriosis in a human subject comprising the steps of detecting a test amount of an antibody that specifically binds to SEQ ID NO:9 polypeptide or a truncated peptide...
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