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8557242 ERBB2 antibodies comprising modular recognition domains  
Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular...
8551943 Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles  
Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also...
8551493 Peptide with reduced dimer formation  
The present invention relates to peptides which are formulated or engineered to prevent or reduce the formation of dimers.
8551500 Composition comprising the N-terminal region of histone H2B of leishmania—use thereof for inducing an immune response  
The invention concerns an immunogenic composition comprising: i) an antigenic polypeptide consisting of a fragment of the protein histone H2B of Leishmania, said fragment including the N-terminal...
8551492 Vaccine peptide combinations against cat allergy  
The present invention relates to compositions comprising peptides for preventing or treating allergy to cats, and in particular to optimal combinations of peptides.
8551480 Compositions and methods of use of immunotoxins comprising ranpirnase (Rap) show potent cytotoxic activity  
The present invention concerns methods and compositions for forming immunotoxin complexes having a high efficacy and low systemic toxicity. In preferred embodiments, the toxin moiety is a...
8545812 Transport agents for crossing the blood-brain barrier and into brain cancer cells and methods of use thereof  
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished...
8541230 Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof  
The present invention relates to polynucleotides encoding immunogenic HIV type C Gag- and/or Env-containing polypeptides. Uses of the polynucleotides in applications including DNA immunization,...
8541179 Immunodetection assay for Mycobacterium tuberculosis complex  
The present invention provides a method for specifically detecting a Mycobacterium tuberculosis complex-specific secretory protein MPT64 antigen in a biological sample, whereby diagnosis of...
8541649 Brassinosteroid regulated kinases (BRKs) that mediate brassinosteroid signal transduction and uses thereof  
The present invention identifies a novel family of kinases regulated by brassinosteroids, referred to as BRKs (brassinosteroid regulated kinases) or BSKs (brassinosteroid signaling kinases). The...
8540999 Allergenic proteins and peptides from Japanese cedar pollen  
The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The...
8541006 Methods and devices for the detection of biofilm  
The present invention provides methods and kits for biofilm detection.
8541551 Immunogen and antivenom against violin spider venom  
The invention relates to the isolation, characterization and expression of DNA fragments encoding sphingomyelinases D from three species of Loxosceles genus spiders, namely L. boneti., L. reclusa...
8541008 Pharmaceutical compositions and methods to vaccinate against candidiasis  
A Candida albicans bloodstream infections cause significant morbidity and mortality in hospitalized patients. Filament formation and adherence to host cells are critical virulence factors of C....
8541000 Variant of mite allergen and uses thereof  
The present invention relates to a new variant of the group 2 allergen from the house dust mite Dermatophagoides pteronyssinus, named Der p 2 variant, and uses thereof. The new variant exhibits...
8535680 Anti-LPS factor from Parietaria judaica and methods of use thereof  
The present invention falls within the field of molecular biology, and in particular it refers to peptides, polypeptides, protein molecules, uses, methods, processes, systems and compositions for...
8535942 Glypican-3 (GPC3)-derived tumor rejection antigenic peptides useful for HLA-A2-positive patients and pharmaceutical comprising the same  
It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an...
8535690 Tumor specific animal proteins  
CASB7439 polypeptides and polynucleotides, immunogenic compositions comprising them and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods...
8535681 Sustained drug delivery system  
A drug composition comprising a charged moiety coupled to a therapeutic compound is disclosed. The charged moiety is configured to interact with at least one type of component of opposite charge...
8530189 Sustained drug delivery system  
A drug composition comprising a charged moiety coupled to a therapeutic compound is disclosed. The charged moiety is configured to interact with at least one type of component of opposite charge...
8530635 Cupredoxin derived transport agents and methods of use thereof  
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains...
8530430 TTK peptides and vaccines including the same  
Peptide vaccines against cancer are described herein. In particular, epitope peptides derived from the TTK gene that elicit CTLs are provided. Antigen-presenting cells and isolated CTLs that...
8529905 Soluble inhibitors of vascular endothelial growth factor and use thereof  
The present invention relates to cDNA encoding a soluble neuropilin protein (sNP) which is isolated from neuropilin (NP) producing cells or is recombinantly engineered from NP-encoding DNA. NP-1...
8529912 Group B Streptococcus polypeptides, nucleic acids and therapeutic compositions and vaccines thereof  
This invention provides an isolated nucleic acid encoding a polypeptide comprising amino acid sequences of a streptococcal matrix adhesion E (EmaE) polypeptide. Antibodies to the EmaE polypeptide...
8529904 Immunotherapeutic methods using epitopes of WT-1 and GATA-1  
A peptide comprising the amino acid sequence RMFPNAPYL or a portion or variant thereof provided that the peptide is not intact human WT-1 polypeptide or a peptide comprising the amino acid...
8524244 Targeted therapeutics based on engineered proteins that bind EGFR  
The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research...
8518415 Engineered type IV pilin of Clostridium difficile  
The present invention relates to engineered Clostridium difficile type IV pilin (tfp) genes, type IV pilin proteins which can serve as a diagnostic marker for identification of patients infected...
8512709 Modified amyloid β peptide  
An object of the invention is to provide a peptide based on a sequence of an amyloid β peptide that may allow for induction of enhanced immune response and is safe and efficacious for prophylaxis...
8512708 GP96 derived peptides  
Provided is a gp96-derived peptides or homologs or derivatives thereof, pharmaceutical composition including them, a use thereof for therapy and for the manufacture of a medicament, a method of...
8512706 Compositions of F(ab′)2 antibody fragments  
The present invention is directed to a pharmaceutical composition comprising F(ab′)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of...
8507249 Bacterial virulence factors and uses thereof  
The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for...
8501189 Synthetic human genes and polypeptides and their use in the treatment of autoimmune diseases  
Synthetic human target autoantigen genes comprising sequences coding for at least two immunogenic epitopic clusters (hereinafter IEC) of autoantigen(s) related to a specific autoimmune disease,...
8501167 Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer  
Provided herein are compositions and methods for targeted ablation of mutational escape in the face of cancer therapeutic agents. Compositions comprising the yeast-based vehicles are used in...
8501912 Filipil compositions and methods for treating cancer  
A purified DOC1 polypeptide comprising a fragment of SEQ ID NO: 1 is provided, wherein the DOC1 polypeptide is not the full-length DOC1 polypeptide sequence. A method of inhibiting angiogenesis in...
8497072 Amyloid-beta globulomer antibodies  
The subject invention relates to monoclonal antibodies (e.g., 8F5 and 8C5) that may be used, for example, in the prevention, treatment and diagnosis of Alzheimer's Disease or other...
8491909 Methods and compositions for dosing of allergens  
The present invention comprises methods and compositions for immunotherapy. An aspect of the invention comprises administration of one or more allergens in compositions via oral and sublingual...
8491914 Dock-and-lock (DNL) complexes for delivery of interference RNA  
Described herein are compositions and methods of use of targeted delivery complexes for delivery of siRNA to a disease-associated cell, tissue or pathogen. The targeted delivery complex comprises...
8492516 Zona pellucida binding peptides for species specific immunocontraception of animals  
Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals. The disclosed compositions...
8491910 Vaccine comprising AMB A 1 peptides for use in the treatment of ragweed allergy  
The present invention relates to compositions for preventing or treating allergy to ragweed by tolerization. The compositions are based on combinations of peptide fragments derived from the major...
8491890 Methods and compositions for inhibiting diseases of the central nervous system  
Methods and compositions for treating central nervous system diseases and disorders are disclosed.
8486411 Methods for identifying an epitope of a polypeptide, chlamydial antigenic polypeptides identified thereby, and methods of use thereof  
The present invention provides a method of classifying an epitope displayed by a polypeptide; a method of determining the presence of an epitope on a polypeptide encoded by a test nucleotide...
8486412 Immunity to folate receptors  
This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FRα immunity in a mammal are provided. This...
8486413 Immunological compositions as cancer therapeutics  
The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto....
8481056 Pro-apoptotic bacterial vaccines to enhance cellular immune responses  
Whole-cell vaccines and methods for their use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria. The present invention involves a method of...
8475802 Peptide sequences and compositions  
Provided is a polypeptide having no more than 100 amino acids, which polypeptide has one or more sequences having at least 60% homology with any of SEQ ID 1-6, or has two or more epitopes having 7...
8476024 Botulinum neurotoxin a protein receptor and uses thereof  
The invention relates to an isolated polypeptide of the luminal domain of synaptic vesicle glycoprotein 2C of Homo sapiens wherein at least 70 percent of the amino acid sequence is identical to...
8475800 Phosphorylated derivatives of a U1-70K peptide and their use in the treatment of autoimmune pathologies  
Derivatives of the peptide corresponding to the sequence RIHMVYSKRSGKPRGYAFIEY (SEQ ID NO: 1), pharmaceutical compositions, and methods of use thereof are provided.
8475809 Composition comprising sortase anchored surface proteins of Streptococcus uberis  
The present invention provides an immunogenic composition comprising one or more Streptococcus uberis sortase-anchored surface proteins, or an immunogenic part thereof, wherein the composition is...
8475801 IgE CH3 peptide vaccine  
The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of...
8470332 Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR  
The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins...