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8637039 Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof therapeutic uses thereof  
The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same...
8637234 Molecular scaffolds for HIV-1 epitopes  
Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The...
8632781 Immunogenic compounds comprising peptides of IL1β  
The present invention relates to peptides derived from the proinflammatory cytokines, interleukin-1β (IL1β) and tumor necrosis factor α (TNFα), and their use in human or veterinary therapy, such...
8632780 Human complement C3 derivates with cobra venom factor-like function  
A modified human complement C3 protein (C3) is disclosed comprising a substitution of a portion of a human C3 protein, with a corresponding portion of a Cobra Venom Factor protein (CVF) which...
8628781 Prevention and treatment of cast nephropathy  
Provided herein are polypeptides comprising or consisting essentially of a QSYDNTLSGSYVF (SEQ ID NO:1) or LSADSSGSYLYVF (SEQ ID NO:2) amino acid sequence. Also provided herein are methods of...
8628779 Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof. therapeutic uses thereof  
The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same...
8628780 Lutzomyia longipalpis polypeptides and methods of use  
Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides...
8623348 Interferon-α (IFN-α) fused proteins comprising IFN-α and a cytoplasmic transduction peptide (CTP)  
Disclosed is an interferon-α (IFN-α) fused protein having IFN-α fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to...
8623609 Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents  
The present invention is directed to proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents.
8623374 Method for enhancing immune response with peptide  
An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β...
8623816 Compositions and methods for treating malaria with cupredoxin and cytochrome  
The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by...
8617561 Immune disease medicament comprising a modulator of the binding between a heparin binding domain of thrombospondin-1 and a beta1 integrin  
An article of manufacture comprising packaging material and a pharmaceutical composition is disclosed, the article of manufacture being identified in print in or on the packaging material for...
8617562 FOXM1 peptides and immunogenic compositions containing them  
The present invention provides isolated peptides having the amino acid sequence of SEQ ID NO: 34 or fragments thereof, which bind to HLA antigen and induce cytotoxic T lymphocyte (CTL). The...
8617563 Antichlamydial agents  
An antichlamydial agent comprising an inhibitor of Chlamydial Protease-like Activity Factor (CPAF). The inhibitor of CPAF can comprise a CPAF inhibitory segment and can optionally include one or...
8613931 Compounds for treating beta-amyloidoses  
The present invention relates to the use of mimotopes in the treatment of diseases associated with β-amyloid formation and/or aggregation (β-Amyloidoses) including Alzheimer's disease, whereby...
8613932 GP100-specific T cell receptors and related materials and methods of use  
The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having...
8609605 Immunomodulatory methods for treatment of atherosclerosis via inhibition of CD4+ T cell response to APOB100  
Immunostimulatory methods and systems for treating or preventing atherosclerosis and/or a condition associated thereto in an individual.
8609090 Specific binding agents to hepatocyte growth factor  
Specific binding agents that interact with hepatocyte growth factor (HGF) are described. Methods of treating cancer by administering a pharmaceutically effective amount of a specific binding agent...
8609110 Citrobacter freundii antibacterial agents and their use  
Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter...
8603487 Palmitoylated AB 1-15 in a liposome as a treatment for amyloid associated diseases  
The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or...
8603486 Protein A compositions and methods of use  
Methods and compositions for modulating an immune response in a subject are provided. Methods include administering to the subject a composition comprising an effective amount of a lymphocyte...
8597659 Tetrameric cytokines with improved biological activity  
The present invention concerns methods and compositions for forming cytokine-antibody complexes using dock-and-lock technology. In preferred embodiments, the cytokine-MAb DNL complex comprises an...
8597656 Process for the production of immunogenic compositions  
The present invention relates to a process for producing immunogenic polypeptides, comprising reducing disulfide bonds and blocking the resulting free thiol group with a blocking agent. The...
8591908 Immunogen for preparation of therapeutic vaccines or drugs for treatment of hepatitis B and the producing method and use thereof  
The present invention relates to immunogens for treatment of hepatitis B and their preparation and use, and to vaccines or medicaments comprising said immunogens for treatment of hepatitis B and...
8592556 Phage φmru polynucleotides and polypeptides and uses thereof  
The invention encompasses phage φmru including phage induction, phage particles, and the phage genome. Also encompassed are phage polypeptides, as well as polynucleotides which encode these...
8591914 Influenza hemagglutinin and neuraminidase variants  
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
8591906 Immunoreactive protein orthologs of Ehrlichia canis and E. chaffeensis  
The present invention concerns gp36 immunoreactive compositions for E. canis and gp 47 immunoreactive compositions for E. chaffeensis. In particular, epitopes for E. canis gp36 and E. chaffeensis...
8591907 Hypoallergenic variants of the major allergen from Betula verrucosa pollen  
The invention provides hypoallergenic variants of Bet v 2 major allergen from Betula verrucosa plant pollen and the use thereof for the preventive or therapeutic treatment of allergic diseases.
8591913 Methods of decreasing adipose tissue  
A pharmaceutical composition including, as an active ingredient, one of the following proteins (I) and (II): (I) an apoptosis inhibitor of macrophage; and (II) a protein which consists of an amino...
8586538 Method of treating a patient suffering from a bleeding disorder comprising administering an antibody against the A3-C1 of FVIII  
The present invention concerns the use of peptides derived from and antibodies generated against Factor VIII and the inhibition of Factor VIII interaction with LRP. Furthermore, the present...
8586709 Cell-permeabilising peptides and polypeptides for microbial cells  
Signal peptides and polypeptides from Methanobrevibacter ruminantium, a methanogenic archaea present in ruminants. Methods of using these peptides to permeabilise microbial cells, particularly M....
8580269 Survivin peptides for autoimmune therapies  
Compositions and methods for stimulating an immune response against cells that express survivin are provided. The method is suitable for prophylaxis and/or therapy of autoimmune disorders. The...
8580274 Drug transporter, and adjuvant and vaccine each utilizing same  
An objective of the invention is to provide a drug delivery vehicle capable of allowing a vaccine or adjuvant to reach a target cell or tissue efficiently while being capable of improving the...
8574585 KDR peptides and vaccines comprising the same  
The present invention provides nonapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO:2, 3, 5, 8, 11, or 12; nonapeptides or decapeptides selected from peptides...
8574591 Multi plasmid system for the production of influenza virus  
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid...
8575308 Method for cancer immunotherapy  
A novel compound of the formula (1): wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond or the like; R1 is a hydrogen atom or the like; R2 is a hydroxy group...
8574592 Modified influenza virus for monitoring and improving vaccine efficiency  
The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as...
8574584 EphA2 T cell epitopes and uses therefor  
EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative...
8574586 KDR peptides and vaccines comprising the same  
The present invention provides nonapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO:2, 3, 5, 8, 11, or 12; nonapeptides or decapeptides selected from peptides...
8574577 VEGF antibodies comprising modular recognition domains  
Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular...
8563000 Melanocortin receptor ligands modified with hydantoin  
The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the...
8563508 Method for preventing or reducing acute renal failure by administration of therapeutically active α-MSH analogues  
The invention describes peptide analogues of α-melanocyte-stimulating hormone (α-MSH), which possess an increased efficacy compared to the native α-MSH peptide. The α-MSH analogues exhibit...
8563001 Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (BHS) disease  
A number of β-hemolytic streptococci polynucleotides and polypeptides, particularly Streptococcus pyogenes polypeptides and polynucleotides, are described. Two or more of the polypeptides of the...
8563506 Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles  
Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also...
8563008 Polynucleotides and polypeptides involved in gestational malaria, and biological applications  
The disclosure provides novel antigens involved in gestational malaria, and more particularly to polynucleotide and polypeptide sequences, conjugates, cloning vectors including the sequences for...
8563516 Foxp3 peptide vaccine  
The present invention provides Foxp3 peptides comprising the amino acid sequence of SEQ ID NOs: 3-5, 7-9, 12, 15-19, 22, 24, 27-30, 37, 67 or 74, and Foxp3 peptides comprising the above-mentioned...
8562988 Strategies for improved cancer vaccines  
The present invention concerns methods and compositions for forming anti-cancer vaccine complexes. In preferred embodiments, the anti-cancer vaccine complex comprises an antibody moiety that binds...
8557243 EFGR antibodies comprising modular recognition domains  
Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular...
8557957 Methods of treating disorders by administration of F11 receptor antagonists  
The present invention provides a compound including a peptidomimetic which interacts sterically with the binding site of a F11R molecule, the peptidomimetic including a peptidomimetic having the...
8557955 Peptide vaccines for cancers expressing MPHOSPH1 or DEPDC1 polypeptides  
The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: 7, 8, 9, 10, 11, 12, 192, 195, 197, 209, 225, 226, 228, 230, 240, 241, 243, 244, 249, 253, 254 or...