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7989605 Compounds and methods for immunotherapy and diagnosis of tuberculosis  
Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more...
7982014 FGFR3-IIIc fusion proteins  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
7981434 Surface exposed immunoglobulin D-binding protein from Moraxella catarrhalis  
The present invention relates to a surface exposed protein, which can be detected in Moraxella catarrhalis, having an amino acid sequence as described in SEQ ID NO: 1, an apparent molecular weight...
7981626 Method of detecting endometriosis in human subjects using SEQ ID No. 9 or an epitope thereof  
A method for diagnosing endometriosis in a human subject comprising the steps of detecting a test amount of an antibody that specifically binds to SEQ ID NO:9 polypeptide or a truncated peptide...
7981425 Thrombopoietic compounds  
The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase...
7981429 Influenza hemagglutinin and neuraminidase variants  
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
7981427 Canine respiratory coronavirus (CRCV) spike protein  
A canine respiratory coronavirus (CRCV) that is present in the respiratory tract of dogs with canine infectious respiratory disease and which has a low level of homology to the enteric canine...
7981426 Method for stimulating wound healing  
The present invention relates to a method for stimulating wound healing, and more particularly to a method for stimulating wound healing in a subject in need thereof, comprising administering to a...
7982025 Fusion proteins of Mycobacterium tuberculosis  
The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or...
7976843 Method for screening peptides for use in immunotherapy  
Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule, is new. Identifying subdominant/cryptic epitopes (I) that are presented by a...
7976844 Fusion proteins of Mycobacterium tuberculosis  
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The...
7976851 Non-toxic biofilm inhibitor  
The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal...
7972602 Promiscuous HER-2/Neu CD4 T cell epitopes  
The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to...
7972814 Antimicrobial polypeptides from Pseudoplectania nigrella  
The present invention relates to polypeptides having antimicrobial activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to...
7972604 Recombinant attenuated clostridium organisms and vaccine  
The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the...
7972611 Fungus-induced inflammation and eosinophil degranulation  
This document relates to methods and materials involved in fungus-induced inflammation and eosinophil degranulation. For example, isolated nucleic acids encoding fungal polypeptides, fungal...
7972601 Method of promoting delivery of an antioxidant agent to a cell expression neuroligin  
Provided are methods and compositions for treating autism spectrum disorders by administering an antioxidant or agent that stabilize or enhance expression of altered neuroligins. An aspect of the...
7968097 Identification of Hla-A2-presented T-cell epitopes derived from the oncofoetal antigen-immature laminin receptor protein and uses thereof  
The present invention relates to the immunotherapB of cancer, in particular several tumor entities including hematological malignancies. The present invention relates to tumor-associated T-helper...
7968098 HLA-A24-binding KIF-derived peptide  
An object of the invention is to provide a peptide derived from a glioma-associated antigen being useful for the specific immunotherapy for glioma patients. The invention provides a KIF-derived...
7968099 Nucleic acid and corresponding protein entitled 193P1E1B useful in treatment and detection of cancer  
A novel gene (designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly...
7968106 ABFB-1 gene of penicillium funiculosum  
The invention relates to the abfB-1 gene of Penicillium funiculosum that codes for a type B α-L-arabinofuranosidase. This enzyme α-L-arabinofuranosidase can be incorporated in nutritional...
7968105 Tuberculosis vaccines comprising antigens expressed during the latent infection phase  
The invention is related to an immunogenic composition, vaccine or pharmaceutical composition for preventing, boosting or treating infection caused by a species of the tuberculosis complex (M....
7964341 Human endogenous retrovirus K102 with foamy-virus-like properties and uses thereof  
The invention relates to the discovery of a human endogenous retrovirus (HERV) family, Type I HERV-K (HML-2) which appear to be active in vitro and in vivo, infectious, and which have the have the...
7959929 Materials and methods for respiratory disease control in canines  
The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and...
7960504 Inhibitors of HIV membrane fusion  
Inhibitors of HIV membrane fusion and a method of identifying drugs or agents which inhibit binding of the N-helix coiled-coil and the C helix of HIV gp41 envelope protein.
7960535 Recombinant lipidated PsaA protein, methods of preparation and use  
The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated...
7959924 Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof  
The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like...
7959925 Trimeric OX40-immunoglobulin fusion protein and methods of use  
Compositions including a trimeric OX-40 fusion protein are disclosed. Also disclosed are methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the...
7956034 FSH glycosylation variant D3N  
FSH mutant with increased glycosylation and longer half-life is described. The use of this FSH mutant for inducing folliculogenesis in human patients is also described.
7947280 Apelin and uses thereof  
The invention provides a method of treating or preventing heart failure or a disease or condition associated with heart failure comprising administering an effective dose of an apelin peptide or...
7947805 BCMA polypeptides and uses thereof  
The present invention relates to BCMA polypeptide variants and their uses, particularly for therapeutic or prophylactic treatment in human subjects. The invention also relates to nucleic acids...
7947289 Multimeric protein toxins to target cells having multiple identifying characteristics  
The present invention provides compositions comprising modified bacterial toxins and methods for using the modified bacterial toxins for targeting particular cell populations and for treating...
7947279 Peptide having hydrolase activity  
The invention is directed to methods for increasing learning and memory in a subject with a neuropathological condition, specifically a condition related to elevated beta-amyloid deposition, the...
7947648 Methods for treating asthma in human and non human primates using IL-4 mutant compositions  
The present invention relates generally to methods and compounds for treating pulmonary disorders, and more specifically to the inhalation administration and use of hIL-4 mutant proteins to treat...
7943153 Vaccines for Mycoplasma bovis and methods of use  
The invention of novel, effective vaccines against Mycoplasma. bovis for use in cattle is described. These vaccines demonstrate no undesirable side effects and protect against M. bovis related...
7943138 Survivin peptides as cancer vaccines  
Provided are compositions and methods for treating survivin expressing cancers. The compositions contain peptide survivin peptide mimics with improved MHC-I binding characteristics. The method...
7943143 Chloramphenicol acetyl transferase (CAT)-defective somatostatin fusion protein and uses thereof  
Chimeric somatostatin-based polypeptides, polynucleotides used to encode the polypeptides, the methods for isolating and producing the polypeptides and the uses thereof are provided. In addition,...
7943137 FPRL1 ligands and use thereof  
By using FPRL1 ligand, which comprises the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 17 or SEQ ID NO: 21, and FPRL1, an...
7939492 Factor C for treating gram-negative bacterial infection  
Recombinant fragments of Factor C are disclosed. These proteins and peptides show great potency in recognizing, binding to, neutralizing and removing endotoxin. These molecules can thus be used...
7939080 HER-2 binding antagonists  
There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from...
7939650 Stra6 polypeptides  
The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides....
7939627 Peptides comprising an epitope of the wilms tumor gene product  
A compound of formula (1): wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond; R1 is a hydrogen atom; R2 is a hydroxy group; R3 is a hydrogen atom, alkyl...
7935355 Composition and method for controlling intestinal pathogenic organisms  
An antigen composition for stimulating an immune response in an inoculated avian species to at least one intestinal pathogenic organism includes naturally-occurring wild Salmonella enterica...
7935348 Combination therapy for the treatment of Alzheimer's disease  
The invention relates to a method for treating Alzheimer's disease by inducing sequestration of amyloid β into a plasma with a Aβ-mimotope peptide, and treatment with an apheresis device such that...
7935349 CRMP4b inhibitory peptide  
The present invention relates to the identification of the cytosolic phosphoprotein CRMP4b as a protein that physically and functionally interacts with RhoA to mediate neurite outgrowth...
7935347 DNA sequence, and recombinant preparation of group 4 major allergens from cereals  
The invention relates to the preparation of DNA sequences of group 4 major allergens from cereals. The invention also includes fragments, novel combinations of partial sequences and point...
7935350 Ii-key/Her-2/neu hybrid cancer vaccine  
Provided are methods and compositions for treating cancer in humans, the cancer being characterized by expression of Her-2/neu. The methods involve vaccinating a patient with an Ii-Key/MHC class...
7932351 Activin receptor-like kinase-1 proteins having serine-threonine kinase domains  
A new receptor family has been identified, of activin-like kinases. Novel proteins have activin/TGF-beta-type I receptor functionality, and have consequential diagnostic/therapeutic utility. They...
7932373 Proteins expressed by mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines  
The invention provides polypeptides encoded by open reading frames present in the genome of Mycobacterium tuberculosis but absent from the genome of BCG and diagnostic and prophylactic...
7931905 Cynomolgus gp80 receptor and uses thereof  
Isolated polynucleotides encoding cynomolgus monkey gp80, polypeptides obtainable from expression of these polynucleotides, compositions, recombinant cells, methods of making and using these...