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8043623 Immunogenic peptides for the treatment of prostate and breast cancer  
Immunogenic T-cell receptor gamma Alternate Reading Frame Protein (TARP) polypeptides are disclosed herein. These immunogenic TARP polypeptides include nine consecutive amino acids of the amino...
8039008 Identification of residues critical for the function of the vibrio cholerae virulence regulator ToxT by scanning alanine mutagenesis  
Disclosed are Vibrio cholerae comprising a mutated transcriptional regulatory protein (ToxT) amino acid sequence, wherein the mutation results in a reduction in the expression of cholera toxin by...
8034349 Peptides that mimic non-human cross-reactive protective epitopes of the group B meningococcal capsular polysaccharide  
Peptides that mimic the antigenic features of non human-cross-reactive protective epitopes of the MenB CP and nucleic acids encoding the peptide mimetics are disclosed. Antibodies elicited by...
8034776 Materials and methods for the treatment of celiac disease  
The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject...
8034348 Prevention and treatment of amyloidogenic disease  
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Such methods entail administering agents that induce...
8034784 Method of suppressing or reducing IL-TIF-induced inflammation, or treating associated conditions thereof, using Zcytor16  
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16” and uses thereof.
8034358 Surface antigen  
The invention provides a novel surface polypeptide from Neisseria meningitidis as well as nucleic acid and nucleic acid sequence homologues encoding this protein. Pharmaceutical compositions...
8034353 Peptide vaccine for inducing the production of anti-amyloid β-peptide antibody  
An object of the present invention is to provide a peptide vaccine for preventing and/or treating diseases caused by amyloid β-peptide, such as Alzheimer's disease. The present invention solves...
8034351 Mucin fusion polypeptide vaccines, compositions and methods of use thereof  
The present invention provides compositions and methods for augmenting vaccine immunogenicity using mucin-immunoglobulin fusion proteins.
8029796 Therapeutic anti-cytomegalovirus compounds  
The present invention provides synthetic compounds, antibodies that recognize and bind to these compounds, polynucleotides that encode these compounds, and immune effector cells raised in response...
8029805 Recombinant B. pseudomallei adhesin protein and methods and uses thereof  
Isolated and/or recombinant adhesin polypeptides from B. pseudomallei are provided, which are used as vaccines. Genetic constructs comprising nucleic acid sequences encoding such polypeptides are...
8029804 Recombinant chimeric antigens for diagnosis and prevention of scrub typhus  
Recombinant chimeric antigens comprising unmodified and modified reactive polypeptide fragments of expressed product of the recombinant 56 kDa proteins of multiple strain of scrub typhus, such as...
8029806 Method for diagnosing of Mycobacterium tuberculosis  
The present invention relates to a method and a kit for detecting Mycobacterium tuberculosis (MTB) or Nontuberculous mycobacteria (NTM) of patients. The present invention also relates to primers...
8030450 Canine RANKL and methods for preparing and using the same  
The present invention provides isolated nucleic acid molecules that encode a substantial part of canine RANKL polypeptide, including the extracellular domains of that polypeptide, the polypeptide...
8025890 Nucleic acids and proteins from streptococcus groups A and B  
The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding...
8025884 Lawsonia intracellularis subunit vaccines  
The present invention relates i.a. to nucleic acids encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant...
8021666 Method and compositions for stimulation of an immune response to CD20 using a xenogeneic CD20 antigen  
Tolerance of the immune system for endogenous CD20 can be overcome and an immune response stimulated by administration of xenogeneic or xenoexpressed CD20 antigen. For example, mouse CD20, or...
8021832 Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines  
The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M....
8021667 Compositions for immunotherapy and uses thereof  
The present invention relates to an immunogenic composition comprising a conjugate between an antigen and an oxidized mannan comprising mannose units and aldehyde groups, and a pharmaceutically...
8021668 Integrin alpha L I domain mutants with increased binding affinity  
The present invention provides an isolated polypeptide capable of binding to aCAM-1, comprising the integrin (XL I domain or biologically active portion thereof, wherein one or more residues is...
8017124 Use of DMBT1 for capturing sulphate and phosphate group exposing agents  
Disclosed is the use of DMBT1, or of the nucleic acid encoding it, for the manufacture of a medicament for the treatment of a patient suffering from a disease caused by an agent, which possesses...
8017127 Influenza immunogen and vaccine  
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein....
8017753 Mycobacterial antigens expressed under low oxygen tension  
A method is provided for identifying mycobacterial genes that are induced or up-regulated under continuous culture conditions defined by a dissolved oxygen tension of up to 10% air saturation...
8017590 Method of inducing and/or enhancing an immune response to tumor antigens  
An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors...
8017125 Copolymers for suppression of autoimmune diseases, and methods of use  
Random three- and four-amino acid copolymers having lengths of 14-, 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99- or proteolipid protein...
8017132 Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell  
The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell...
8017749 Compositions and methods to treat cancer with cupredoxins and CpG rich DNA  
The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The present invention includes specific CpG...
8012932 Contraceptives based on SP22 and SP22 antibodies  
Oral, topical and injectable contraceptives, which are based on sperm protein 22 kDa (SP22) polypeptides and antibodies and infertility diagnostics are provided.
8012493 Malaria vaccines  
The invention provides isolated placental P. falciparum polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-4 and 6-24, and immunogenic derivatives...
8012487 Synthetic peptides and DNA sequences for treatment of multiple sclerosis  
Synthetic unaltered and altered peptides comprising sequences of at least one immunogenic epitope cluster (IEC) of at least one human autoantigen related to multiple sclerosis (MS) and at least...
8012469 Universal GM-CSF expressing bystander human K562 cell line  
The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell...
8007770 Purified linear polypeptide epitopes from walnuts and associated methods  
A purified Ig-E binding immunogenic polypeptide the amino acid sequence of which consists of SEQ ID NO:1 is disclosed. The purified amino acid sequence is a major allergen of the walnut Juglans...
8007809 Activin-actrii antagonists and uses for increasing red blood cell levels  
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly...
8007810 HLA-A2 tumor associated antigen peptides and compositions  
A peptide or composition comprising at least one HLA-A2 epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
8008257 ANF fusion proteins  
A fusion protein comprising an arterial natriuretic factor (ANF) amino acid sequence linked to an albumin amino acid sequence by one or more peptide bonds is provided. The ANF amino acid sequence...
8007808 Composition and method for facilitating the internalization of a therapeutic agent into a cell  
The present invention is a composition and method for facilitating the internalization of a therapeutic agent into a cell. Specifically, the invention relates to the use of the extracellular...
8003106 Human monoclonal antibodies to influenza M2 protein and methods of making and using same  
Human, humanized and chimeric monoclonal antibodies that bind to influenza M2 protein. The antibodies are useful for, among other things, treatment, diagnostics, purifying and isolating M2 or...
8003109 Pharmaceutical compositions containing the long pentraxin PTX3  
Pharmaceutical compositions are described containing a long pentraxin PTX3, particularly human PTX3, for the therapy of infectious and inflammatory or tumor diseases; expression vectors containing...
8003776 Mycobacterial antigens expressed during latency  
A method is provided for identifying mycobacterial genes that are induced or up-regulated under culture conditions that are nutrient-starving and which maintain mycobacterial latency, said...
8003108 Sclerostin epitopes  
Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
8003110 Metalloproteinase oligopeptides and their therapeutic use  
The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides and peptidomimetics. The oligopeptides are used for making antibodies. The antibodies are used...
8003114 AbfB-2 gene from Penicillium funiculosum  
The invention relates to the abfB-2 gene of Penicillium funiculosum that codes for a type B α-L-arabinofuranosidase and has a cellulose binding domain. This enzyme α-L-arabinofuranosidase can be...
7998490 Genes of an otitis media isolate of nontypeable Haemophilus influenzae  
The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also...
7998483 Lage-1 tumor associated nucleic acids  
The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such...
7994279 Altered peptide ligands of GAD65  
Modified GAD65 compositions antagonize the activities of islet-specific T cells that contribute to the progression of one or more autoimmune disorders. The compositions are also antagonistic in...
7993658 Targeting of triacylclycerol synthase gene for tuberculosis treatment  
Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or...
7993657 Antibody profiles characteristic of tuberculosis state  
Serum antibody assays capable of distinguishing cases of inactive TB from cases of active TB include a combination of at least three M. tuberculosis protein antigens, at least one for which a...
7993650 Polypeptides having binding affinity for HER2  
A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the...
7989162 Viral variants with altered susceptibility to nucleoside analogs and uses thereof  
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the...
7988973 Activin-ActRII antagonists and uses for increasing red blood cell levels  
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly...