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8097257 MAGE3 polypeptides  
The present invention relates to novel MAGE3 polypeptides, including a fragment of MAGE3 fused to an immunological fusion partner, and compositions thereof.
8097256 Cancer vaccines and vaccination methods  
Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
8097252 Methods and compositions for administering therapeutic and diagnostic agents  
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
8097587 IGF-I protein variants for treating IGFBP-1-related disorders  
IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder...
8092805 Dual inhibitors of HIV-1 gp-120 interactions  
Compounds, which inhibit the binding of gp120 to CD4 as well as 17b and methods for their use in inhibiting the HIV fusion process, are provided.
8093008 Characterization of granulocytic ehrlichia and methods of use  
The present invention relates, in general, to granulocytic ehrlichia (GE) proteins. In particular, the present invention relates to nucleic acid molecules coding for GE S2, S7, S22, S23, C6.1,...
8092807 Modified leukocyte Ig-like receptor family members (LIRs) with increased affinity for class 1 MHC and their uses in modulating T-cell activation  
The present invention provides polypeptides having the property of binding to a given Class I pMHC CHARACTERISED IN THAT said polypeptide has a KD for the said given Class I pMHC of less than or...
8092806 Chimeric proteins, their preparation and pharmaceutical compositions containing them  
The present invention relates to a chimeric protein comprising a cell-targeting agent and a Yersinia outer protein, connected by a translocating polypeptide. The invention further relates to the...
8093046 CVN-12p1: a recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions  
The invention provides a recombinant multi-functional chimera of CVN and 12p1. Chimeras of CVN and 12p1 present a model for targeting gp120 at two discrete sites, by two different modes of...
8088390 Methods for the early diagnosis of ovarian cancer  
The present invention discloses the protease stratum corneum chymotryptic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce...
8088388 Stabilized synthetic immunogen delivery system  
The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG...
8088389 Synthetic human genes and polypeptides and their use in the treatment of autoimmune diseases  
Synthetic human target autoantigen genes comprising sequences coding for at least two immunogenic epitopic clusters (hereinafter IEC) of autoantigen(s) related to a specific autoimmune disease,...
8084015 Stabilized synthetic immunogen delivery system  
The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG...
8084578 Monoclonal antibody against human scavenger receptor SRCL-P1  
Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the...
8084035 CD38 modulated chemotaxis  
The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia,...
8084041 Use of mycrobacterial vaccines in CD4+ or CD8+ lymphocyte-deficient mammals  
Methods of treating a mammal that is deficient in CD4+ and/or CD8+ lymphocytes are provided. The methods comprise inoculating the mammal with an attenuated mycobacterium in the M. tuberculosis...
8084042 Compounds and methods for immunotherapy and diagnosis of tuberculosis  
Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more...
8080251 Antigenic peptides  
The present invention relates to peptide antigens of SEQ ID Nos. 1 to 10; repeat motif Gly-X-Gly-Asn-X-Gly of SEQ ID No. 11; and a method of developing drug against tuberculosis, said method...
8080252 Compounds and methods of modulating angiogenesis  
A method of modulating angiogenesis in a tissue comprises administering to the tissue a therapeutically effective amount of an agent that modulates complex formation of αvβ3 integrin and VEGFR2.
8080525 Peptide compositions and their use against the hepatitis C virus  
Novel peptide compositions are described. In particular, peptide compositions are described which include at least two peptides which are selected from among the following peptides: a peptide A...
8080254 OB fusion protein compositions and methods  
The present invention relates to Fc-OB fusion protein compositions, methods of preparation of such compositions and uses thereof. In particular, the present invention relates to a genetic or...
8080253 Chimeric VEGF peptides  
Compositions for and methods of treating patients with malignancies associated with overexpression of VEGF, particularly ovarian cancer are provided herein. The compositions include but are not...
8075891 Antibodies that bind ALS specific epitopes and methods of making  
The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion...
8075900 Melanoma associated peptide analogues and vaccines against melanoma  
The present invention is concerned with cancer treatment and diagnosis, especially with melanoma associated peptide analogues with improved immunogenicity, epitopes thereof; vaccines against...
8075899 Peptides of the A-chain of proinsulin or insulin  
The present invention relates generally to the field of immunotherapy and immunodiagnosis of autoimmune conditions. More particularly, the present invention provides peptides of the A-chain of...
8075893 Pharmaceutical composition of F(ab′)2 antibody fragments and a process for the preparation thereof  
The present invention is directed to a pharmaceutical composition comprising F(ab′)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of...
8076470 VMP-like sequences of pathogenic Borrelia species and strains  
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino...
8075898 Mite allergen  
A safe and efficient recombinant mite allergen is provided as a therapeutic agent or a diagnostic agent for mite allergic diseases, which contains no anaphylaxis-inducing impurities. The following...
8075897 Allergen peptide fragments and use thereof  
The present invention relates generally to in vivo methods and compositions designed for allergen specific immunotherapy. The compositions include contiguous overlapping peptide fragments which...
8075894 Use of soluble CD164 in inflammatory and/or autoimmune disorders  
The present invention relates to novel therapeutic uses of soluble proteins comprising the extracellular region of human CD164, in particular for treating inflammatory and/or autoimmune disorders.
8071747 Fusion proteins of mycobacterium tuberculosis  
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The...
8071095 Immunosuppressive polypeptides and nucleic acids  
The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding...
8071112 Compositions and methods of use of ORF-1358 from beta-hemolytic streptococcal strains  
The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions...
8071111 Virulence of Streptococci  
The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention discloses a method for...
8071552 Peptides and peptidomimetics binding to CD23  
The present invention describes compounds comprising new and useful peptides and peptidomimetics that can bind to CD23. They are capable of reducing inflammatory responses associated with...
8071109 VMP-like sequences of pathogenic Borrelia  
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded...
8067538 Gene related to growth promoting function of acetic acid bacterium, acetic acid bacterium bred using the gene and method for producing vinegar using the acetic acid bacterium  
The present invention is to obtain a novel gene that encodes a protein having a function of promoting acetic acid bacterial growth in the presence of a high concentration of acetic acid; to...
8067009 Metalloproteinase oligopeptides and their therapeutic use  
The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides and peptidomimetics. The oligopeptides are used for making antibodies. The antibodies are used...
8067016 Fusion proteins of Mycobacterium tuberculosis  
The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or...
8067008 Peptide inhibitors for mediating stress responses  
The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions and methods for the treatment of...
8067004 Surface antigen  
The invention provides a novel surface polypeptide from Neisseria meningitidis as well as nucleic acid and nucleic acid sequence homologues encoding this protein. Pharmaceutical compositions...
8062644 Immunogens from uropathogenic Escherichia coli  
Disclosed herein are various genes that can be included in immunogenic compositions specific for pathogenic E. coli strains. The genes are from uropathogenic strains but are absent from...
8057806 Viruses comprising mutant ion channel protein  
A method to prepare viruses lacking ion channel activity is provided.
8057801 Tick galectin  
A novel galectin, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the galectin, and a screening method for screening a substance...
8057800 Immunointeractive molecules and uses thereof  
The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with T lymphocytes in subjects having peanut allergy, or allergy to...
8052975 Compounds and methods for treatment and diagnosis of chlamydial infection  
Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia...
8053556 Glypican-3 (GPC3)-derived tumor rejection antigenic peptides useful for HLA-A2-positive patients and pharmaceutical comprising the same  
It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an...
8048424 Insect poison allergens with reduced IgE reactivity and method for producing the same  
The invention relates to recombinant insect poison allergens and to a specific method for producing them. Said allergens can be varied according to whether they are produced using folds...
8048428 DNA composition encoding an immunogenic VEGF receptor peptide and methods of use thereof  
A DNA composition effective for inhibiting endothelial cell proliferation comprises a DNA construct operably encoding a vascular endothelial growth factor (VEGF) receptor polypeptide, which can be...
8048434 Vaccine adjuvants  
The invention relates to a novel adjuvant Mycobacterium w and or its constituents and adjuvant containing composition, which contains antigen (s) with pharmaceutical acceptable carrier and its...