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9040055 Conjugation of streptococcal capsular saccharides  
Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive animation of oxidized sialic acid residue side chains is used, but the...
9040057 Method of diagnosing and preventing pneumococcal diseases using pneumococcal neuraminidases  
A method of providing protection against pneumococcal infection in a subject is disclosed. The method includes steps of administering to the subject a composition that includes combination of...
9040058 Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use  
The present invention relates to a fermentation medium for cultivating Corynebacterium diphtheriae. The present invention also relates to the use of the fermentation medium in processes for...
9040059 Recombinant bacterium capable of eliciting a protective immune response against C. perfringens  
The present invention encompasses recombinant bacteria and immunogenic compositions comprising the bacteria. The immunogenic composition may be used to induce an immune response against C....
9040053 Her2 DNA vaccine as adjunct treatment for cancers in companion animals  
The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as...
9034339 Nucleic acid and amino acid sequences, and vaccine for the control of ectoparasite infestations in fish  
The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a...
9034345 GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis  
The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis...
9034336 Immunomodulators and immunomodulator conjugates  
The invention provides compounds of formula I: wherein R1-R3, Ra, and Rb have any of the values defined herein, and salts thereof. The compounds have immunomodulatory properties.
9034338 Nucleic acid and amino acid sequences, and vaccine for the control of ectoparasite infestations in fish  
The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a...
9034335 Adult stem cell derived conditioned medium and/or adult stem cells for use in the therapeutic treatment of a tumor disease  
The invention is in the field of therapeutic treatment of tumors. It has been found that the conditioned medium resulting from culturing an adult stem cell capable of differentiating into a...
9034343 Attenuated human parainfluenza virus, methods and uses thereof  
The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the...
9034313 Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same  
Nucleic acid molecules comprising a nucleotide sequence encoding RANTES and fragments and variants thereof are disclosed. Additionally, nucleic acid molecules and compositions comprising the...
9028834 Pneumovirus compositions and methods for using the same  
Provided are newly identified pneumoviruses that can infect mammals, including dogs cats and potentially humans. Isolated polynucleotides and proteins of the viruses, as well as the isolated...
9028844 Vaccine against Trypanosoma cruzi infection  
The present invention relates to a vaccine against Trypanosoma cruzi infection, useful in the prevention and/or treatment of the Chagas disease. More specifically, the present invention relates to...
9028843 Malaria vaccine  
The present invention provides a vaccine for preventing and/or treating Plasmodium falciparum infections, which comprises a polypeptide set forth in SEQ ID NO: 1 or represented by formula (1), and...
9028809 Compositions, methods and uses for expression of enterobacterium-associated peptides  
Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing enterobacterial-associated peptides. In some embodiments,...
9023367 Compositions comprising chimeric OSPA molecules and methods of use thereof  
The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA...
9017691 Antiviral vaccines with improved cellular immunogenicity  
The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate...
9017689 Peptides for vaccine against birch allergy  
The present invention relates to compositions comprising peptides for preventing or treating allergy to birch, and in particular to optimal combinations of peptides for preventing or treating said...
9017688 Peptide vaccines for cancers expressing MPHOSPH1 or DEPDC1 polypeptides  
The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: 7, 8, 9, 10, 11, 12, 192, 195, 197, 209, 225, 226, 228, 230, 240, 241, 243, 244, 249, 253, 254 or...
9018360 Modified biotin-binding protein  
The present invention provides a modified biotin-binding protein comprising an amino acid sequence represented by SEQ ID NO: 2 or its modified sequence and having a biotin-binding activity and...
9011871 Broad spectrum vaccine against typhoidal and non-typhoidal Salmonella disease  
The present invention is drawn to multivalent Salmonella enterica serovar conjugate vaccines comprising conjugates of S. Typhimurium, S. Enteritidis, S. Choleraesuis, S. Typhi, S. Paratyphi A and...
9011874 Compositions, methods and uses for poxvirus elements in vaccine constructs  
Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza...
9011866 RNA interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by DNA and transfected dendritic cell vaccines  
An immunotherapeutic strategy is disclosed that combines antigen-encoding DNA vaccine compositions combined with siRNA directed to pro-apoptotic genes, primarily Bak and Bax, the products of which...
9005627 Contiguous overlapping peptides for treatment of ragweed pollen allergy  
Contiguous overlapping peptides (COPs) for the treatment of allergic patients by Specific Immunotherapy (SIT) are provided from the sequence of the major allergen of ragweed pollen Amb a 1. Such...
9005628 Biotherapy for pain  
The present invention is directed to analgesic Clostridial neurotoxin derivatives comprising polypeptides having a long-lasting SNARE protein-selective endopeptidase activity. These derivatives...
9005621 Human binding molecules capable of binding to and neutralizing influenza B viruses and uses thereof  
Described are binding molecules, such as human monoclonal antibodies, that bind to hemagglutinin of influenza B viruses, and have a broad neutralizing activity against such influenza viruses....
9005908 Mycobacterial infections  
The present invention relates to Mycobacterial infections and provides a method of diagnosing infections of Mycobacterium avium subsp. paratuberculosis (Map), the causative agent of Johne's...
9005626 Liquid compositions capable of foaming and including active agents, and methods for making or developing same  
A liquid composition suitable for topical use comprising is provided that includes a phospholipid foaming agent and at least one solvent; and a pharmaceutically acceptable active agent; wherein...
9005632 Compositions, methods and uses for poxvirus elements in vaccine constructs against influenza virus subtypes or strains  
Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza...
9005629 Method for treating cancer with an antibody to CD223 protein  
Mammals with cancer are treated with an antibody which specifically binds to CD223 protein and inhibits negative T cell regulatory function of CD223. The mammal may be a human. The antibody may be...
9005631 Membrane proximal region of HIV gp41 anchored to the lipid layer of a virus-like particle vaccine  
Disclosed herein are isolated immunogens including variant hepatitis B surface antigens (HBsAgs). In an example, a variant HBsAg includes a HBsAg with one or more transmembrane domains of the...
9005622 Cell wall components of enterococci and uses thereof  
The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.
9005599 Genetically modified human umbilical cord perivascular cells for prophylaxis against or treatment of biological or chemical agents  
The invention provides methods of preventing or treating diseases or disorders caused by biological agents or chemical agents in a subject (e.g., a mammal, such as a human) by administering...
8999354 Multivalent meningococcal polysaccharide-protein conjugate vaccine  
The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacteria Neisseria meningitidis. The vaccine is comprised of...
8999291 Compositions and methods for the removal of biofilms  
This invention provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an...
8999697 Shortened purification process for the production of capsular Streptococcus pneumoniae polysaccharides  
A shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular Streptococcus pneumoniae lysate broth is described. Ultrafiltering and...
8999345 Compositions and methods for enhancing immune responses to vaccines  
The disclosure provides adjuvants, immunogenic compositions, and methods useful for vaccination and immune response. In particular, the disclosure provides a class of adjuvants comprising cationic...
8999382 Drug delivery system for administration of poorly water soluble pharmaceutically active substances  
This invention relates to a drug delivery system for administration of poorly water soluble pharmaceutically active substance, a pharmaceutical composition comprising such a drug delivery system,...
8999931 Pharmaceutical composition using gonadotropin-releasing hormone (GNRH) combined variants as immunogen  
A pharmaceutical composition using natural gonadotropin-releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule;...
8992933 Methods for activating T cells and modulating an immune response  
The present invention is directed to a method for promoting differentiation, activation and proliferation of human T helper lymphocytes such as those that express IL17 and IL22 (Th-IL17+ and...
8992938 Genes and proteins of Brachyspira hyodysenteriae and uses thereof  
Novel polynucleotide and amino acids of Brachyspira hyodysenteriae are described. These sequences are useful for diagnosis of B. hyodysenteriae disease in animals and as a therapeutic treatment or...
8992940 Agent for treating allergic or hypersensitivity condition  
The use of an agent in the manufacture of a medicament to affect an allergic condition and/or a hypersensitivity condition is described. The agent is capable of modulating a ganglioside associated...
8992942 Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines  
The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M....
8993302 Mutants of Francisella tularensis and uses thereof  
The present invention relates to a mutant Francisella tularensis strain comprising an inactivated clpB gene and compositions comprising such mutant. Methods of producing the mutant are also...
8992935 Means of controlling infection persistence of Helicobacter pylori  
The present invention relates to a means of controlling infection persistence of Helicobacter pylori (H. pylori). In particular, the present invention relates to an isolated, genetically modified...
8986698 Method of using fusion proteins  
The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex...
8986701 Enzyme prodrug cancer therapy selectively targeted to tumor vasculature and methods of production and use thereof  
Methods of treating cancer by targeting tumor vasculature using an enzyme prodrug cancer therapy treatment are provided.
8986703 Peptide sequences and compositions  
Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells...
8986987 Herpesvirus of turkeys vectored vaccine against avian influenza in poultry  
The present application applies to the field of veterinary vaccines, in particular of vaccines for poultry against avian influenza. The vaccine is based on a recombinant viral vector expressing...