Match Document Document Title
8642048 Multiple antigenic peptides immunogenic against Streptococcus pneumonia  
The invention provides a nucleic acid encoding the 37-kDa pneumococcal surface adhesion A protein (PsaA) from Streptococcus pneumoniae. The invention also provides purified polypeptides encoded by...
8642565 Increase of immune response and targeting by antigens and/or drug linkage  
The present invention relates to compounds consisting of glycolipids covalently bound to an antigen or a drug via a linker. The said compounds are able to induce a stronger immune response than a...
8642047 Non-protein stabilized Clostridial toxin pharmaceutical compositions  
A Clostridial toxin pharmaceutical composition comprising a Clostridial toxin, such as a botulinum toxin, wherein the Clostridial toxin present in the pharmaceutical composition is stabilized by a...
8642258 Immunogenical complex formed by vaccinal antigens encapsulated by nanostructured mesoporous silica  
The present invention relates to a product named “immunogenical complex”, which comprises an adjuvant characterized by solid particles of highly ordinated nanostructured mesoporous silica,...
8637013 Treatment of drug-related side effect and tissue damage by targeting the CD24-HMGB1-Siglec10 axis  
The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24...
8637051 Compositions and methods for treatment of mucosal infections  
The present invention is concerned with novel compositions and vaccines useful for prophylactic an/or therapeutic treatment of mucosal infections, and in particular it is concerned with oral...
8636979 TLR 4 and 9 receptors agonists for preventing septic complications of post-traumatic immunodepression in patients hospitalized for severe traumatic injuries  
The present invention concerns a pharmaceutical composition comprising at least one agonist of at least one Toll Like receptor (TLR) chosen from TLR 4 and 9, for use in the prophylactic treatment...
8637037 Allergens and allergoids from bee venom  
The present invention concerns the preparation of purified allergens and allergoids, both derived from whole bee venom, for the desensitization (immunotherapy) of subjects affected by a specific...
8637644 H5 subtype-specific binding proteins useful for H5 avian influenza diagnosis and surveillance  
The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus (“AIV”). The monoclonal...
8637050 Peptide vaccines against group A streptococci  
This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of...
8637048 Immunizing compositions and methods of use  
The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccharide at a concentration of no greater...
8637234 Molecular scaffolds for HIV-1 epitopes  
Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The...
8637047 Erysipelothrix rhusiopathiae-haemophilus parasuis vaccine and methods of using the same  
The present invention provides a composition and an improved single dose vaccine against E. rhusiopathiae and an improved single dose vaccine against E. rhusiopathiae and H. parasuis which...
8637038 Methods for inhibiting allograft rejection  
Disclosed herein are methods for treating or inhibiting allograft rejection in a transplant recipient. In some embodiments, the methods include administering to the transplant recipient a first...
8632784 Nucleic acids and proteins from Streptococcus pneumoniae  
Novel proteins from Streptococcus pneumoniae are described, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described.
8632777 Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen as diagnostic and therapeutic tools for prostate cancer  
Isolated monoclonal antibodies or an antigen binding portion thereof which bind to prostate specific membrane antigen in its native form occurring on the surface of tumor cells characterized in...
8628937 Vaccines with enhanced immune response and methods for their preparation  
The present invention is concerned with vaccines and their preparation. An effective long-term immune response, especially in mammals, can be produced using a vaccine comprising an antigen...
8629100 Method of inhibiting clostridium difficile by administration of oritavancin  
Glycopeptide antibiotics, such as oritavancin, demonstrate significant activity against both a vegetative form of C. difficile and C. difficile spores. Methods for the treatment, prophylaxis and...
8628766 Vaccine for protection against Streptococcus suis bacteria of various serotypes  
The present invention pertains to the use of Streptococcus suis antigens corresponding to Streptococcus suis bacteria of a predetermined serotype in the manufacture of a vaccine for administration...
8623397 Delivery device and method for forming the same  
A delivery device includes a hollow container, and a plurality of biodegradable and/or erodible polymeric layers established in the container. A layer including a predetermined substance is...
8623347 Antiviral drugs for treatment of arenavirus infection  
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the...
8623380 Acellular pertussis vaccine with diphthriae- and tetanus-toxoids  
The invention provides a diphtheria, tetanus and pertussis vaccine comprising a low dose of each of diphtheria toxoid (D), tetanus toxoid (T), pertussis toxin (PT), filamentous haemagglutinin...
8623349 Systems, methods and microrganisms for antibody production with type III secretion system  
Exemplary embodiments disclosed herein include a microorganism that produces, secretes and injects recombinant antibodies into eukaryote cells said the described microorganisms can be used to...
8623383 Recombinant antigens for diagnosis and prevention of spotted fever rickettsiae  
The invention relates to the construction of recombinant, immunodominant polypeptides against spotted fever group Rickettsia. The invention also relates to a method for the use of the recombinant...
8623416 Formulations comprising aminosterols  
This invention relates to stable aminosterol phosphate compositions. The aminosterol phosphate compositions permit administration without associated tissue damage and achieve a sustained release...
8617561 Immune disease medicament comprising a modulator of the binding between a heparin binding domain of thrombospondin-1 and a beta1 integrin  
An article of manufacture comprising packaging material and a pharmaceutical composition is disclosed, the article of manufacture being identified in print in or on the packaging material for...
8617573 Botulinum neurotoxin B receptors and use thereof  
It is disclosed here that synaptotagmin I (syt I) and synaptotagmin II (syt II) are the cellular receptors for botulinum neurotoxin B (BoNT/B) that mediate the cellular entry and toxicity of...
8617520 Cancer therapy  
The present invention relates to a method of preventing, treating or inhibiting the development of tumors or metastases in a subject and to an immunomodulator for use in such therapy, in...
8617560 Peptides for vaccination against human CMV  
The present invention relates to peptides or pretide derivatives of the 65kD lower matrix phosphoprotein of human cytomegalovirus. The peptides disclosed are useful for determining whether...
8617621 Composition for enhancing immunity containing plant stem cell line derived from cambium of Panax ginseng including wild ginseng or ginseng as an active ingredient  
The present invention relates to a composition for enhancing immunity, comprising one or more of the following: a homogenous cell line, and a lysate, an extract and a culture medium thereof as an...
8617575 Methods for conferring immunity against protozoans in an animal  
Immunity against protozoan is conferred on an animal by a method comprising orally administering to an animal a transformed plant cell comprising a polynucleotide encoding a protective antigen...
8617571 Suture line administration technique using botulinum toxin  
The present invention utilizes patient-specific landmarks in order to treat headache pain. In one aspect, the present invention relates to the administration of Clostridial toxins, such as a...
8613922 Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP)  
A method of inhibiting cellular activation by insulin-like growth factor-1 (IGF-1) in a subject in need thereof (e.g., a subject afflicted with cancer, atherosclerosis, diabetic retinopathy or...
8609108 Gamma-glutamyl transpeptidase attenuated Francisella  
The present invention relates to a mutated Francisella bacterium, wherein the ggt gene is silenced or deleted; pharmaceutical compositions comprising the same, in particular, vaccine compositions,...
8609110 Citrobacter freundii antibacterial agents and their use  
Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter...
8609111 Antibodies against clostridium difficile toxins and uses thereof  
Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
8603491 cDNA construct of salmonidae alphavirus  
The invention concerns recombinant DNA's comprising cDNA of genomic RNA of a Salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant DNA's...
8603486 Protein A compositions and methods of use  
Methods and compositions for modulating an immune response in a subject are provided. Methods include administering to the subject a composition comprising an effective amount of a lymphocyte...
8603484 Multivalent pneumococcal polysaccharide-protein conjugate composition  
An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared...
8603485 Bystander immune suppression as a predictor for response to a vaccine  
The present invention relates to antigen-specific immune regulatory response. Methods for detecting an antigen-specific immune regulatory response, methods for selecting candidate vaccine...
8597663 Polysaccharide immunogens from Clostridium difficile  
The application relates to Clostridium difficile cell surface polysaccharides, compositions comprising Clostridium difficile cell surface polysaccharides, and includes kits, methods and uses thereof.
8597665 Chimeric immunomodulatory compounds and methods of using the same-IV  
The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
8597664 Endogenous adjuvant molecules and uses thereof  
Methods of modulating the immune response using pharmaceutical compositions containing crystalline adjuvants are described. In various embodiments the crystalline adjuvants are selected from the...
8597661 Neuraminidase-deficient live influenza vaccines  
Attenuated, neuraminidase deficient influenza virus, and compositions and methods to prepare that virus, are provided.
8597662 Vaccine for protection against Lawsonia intracellularis  
The present invention pertains to the use of a non-live carbohydrate containing composition, the carbohydrate being also found in live Lawsonia intracellularis cells in association with the outer...
8598112 HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells  
The present invention provides a conjugate which contains a therapeutic moiety linked to a homing molecule that selectively homes to tumor blood vessels and tumor cells and that specifically binds...
8597653 Asymmetrically branched polymer conjugates and microarray assays  
A conjugate of a modified randomly branched asymmetric polymer without a core and a member of a binding pair is described. The modified randomly branched asymmetric polymer can contain chain...
8591890 Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality  
The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a...
8591906 Immunoreactive protein orthologs of Ehrlichia canis and E. chaffeensis  
The present invention concerns gp36 immunoreactive compositions for E. canis and gp 47 immunoreactive compositions for E. chaffeensis. In particular, epitopes for E. canis gp36 and E. chaffeensis...
8592196 Modified influenza virus  
The present invention provides an influenza B virus M gene with a modification of at least one nucleotide proximate to the N-terminus of the M gene, more specifically at any one of nucleotide...