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8409817 Methods and compositions for detection of Ehrlichia chaffeensis (VLPT)  
The invention provides methods and compositions for the detection of Ehrlichia chaffeensis.
8404244 Papillomavirus L2 N-terminal peptides for the induction of broadly cross-neutralizing antibodies  
The invention comprises a method for inducing broadly cross-neutralizing antibodies against cutaneous and mucosal papillomavirus types or against heterologous papillomavirus types in humans...
8404826 Mycobacterial antigens expressed under low oxygen tension  
A method is provided for identifying mycobacterial genes that are induced or up-regulated under continuous culture conditions defined by a dissolved oxygen tension of up to 10% air saturation...
8404243 Peptide adjuvants  
Adjuvant compositions comprising specific 5mer polypeptides in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for...
8399610 HPV vaccine comprising peptides from host cell proteins  
The present invention relates to an immunogenic composition for a human papillomavirus (HPV) vaccine that comprises BAX peptides from BAX host cell proteins and more particularly, a vaccine...
8398999 Chimeric, hybrid and tandem polypeptides of meningococcal NMB1870  
NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families,...
8399247 Methods and apparatus for selectively processing eggs having identified characteristics  
Methods and apparatus for processing eggs based upon a characteristic such as gender are provided. Material is extracted from each of a plurality of live eggs, the extracted material is assayed to...
8398985 Antigenic polysaccharides and process for their preparation  
A robust and industrial scale process to afford highly pure antigenic polysaccharides is claimed.
8399613 Tumour-associated peptides that bind to MHC molecules  
The invention relates to a tumor-associated peptide containing an amino sequence, which is selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:79 of the enclosed listing. The peptide...
8398984 Removal promoters and inhibitor for apoptosis cells in vivo  
The present invention is to provide a removal promoter for apoptotic cells which is capable of immediately removing apoptotic cells in vivo by macrophages, or a removal inhibitor which inhibits...
8401800 Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity  
The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or...
8398993 Immunogenic formulation  
The present invention describes an immunogenic formulation to be used in mammals against the respiratory syncytial virus (RSV), consisting in the Calmette-Guérin bacillus (BCG) strain or other...
8398972 Methods of treating dementia using a GM-CSF antagonist  
The invention is based on the discovery that GM-CSF antagonists can be used for the treatment of a patient that has Alzheimer's disease or vascular dementia, or is at risk for developing...
8398983 Immunogenic composition  
The present application discloses an immunogenic composition comprising a Hib saccharide conjugate, at least one additional bacterial, for example N. meningitidis, saccharide conjugate(s), and a...
8398997 Compositions and methods for topical application and transdermal delivery of botulinum toxins  
A composition for topical application of a botulinum toxin (including botulinum toxin derivatives) comprises a botulinum toxin and a carrier comprising a polymeric backbone comprising a long-chain...
8398970 Method of preventing early Lawsonia intracellularis infections  
The present invention relates inter alia to the use of a combination of a vaccine against Lawsonia intracellularis and an anti-Lawsonia antibiotic for the prevention or reduction of early,...
8399650 Mycobacterial antigens expressed during latency  
A method is provided for identifying mycobacterial genes that are induced or up-regulated under culture conditions that are nutrient-starving and which maintain mycobacterial latency, said...
8398992 Methods and compositions for polytopic vaccination  
The present invention relates to therapeutic and prophylactic methods for treating or preventing an infectious disease in a subject by stimulating or enhancing an immune response against an...
8399000 Haemophilus influenzae type IV pili  
The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type pili from nontypeable H. influenzae...
8394387 Recombinant modified Bacillus anthracis protective antigen for use in vaccines  
The invention relates to improved methods of producing and recovering sporulation-deficient B. anthracis mutant stains, and for producing and recovering recombinant B. anthracis protective antigen...
8394758 Tumor-targeting peptides and uses thereof  
Tumor targeting peptides and uses thereof in tumor diagnosis and treatment.
8394388 Mycobacterial mutants affecting host apoptosis  
Provided are recombinant mycobacteria having a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium....
8394390 Neisserial antigenic peptides  
This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such...
8394929 Nogo receptor-mediated blockade of axonal growth  
Disclosed are NgR proteins and biologically active Nogo (ligand) protein fragments. Also disclosed are compositions and methods for modulating the expression or activity of the Nogo and NgR...
8394384 Recombinant avian influenza vaccine and uses thereof  
The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be...
8388946 Bacteriophage-containing therapeutic agents  
The present invention relates in its broadest aspect to combined phage/antibiotic therapy. More particularly, it relates to use of (i) one or more bacteriophages and (ii) one or more antibiotics...
8388933 Multimeric protein toxins to target cells having multiple identifying characteristics  
The present invention provides compositions comprising modified bacterial toxins and methods for using the modified bacterial toxins for targeting particular cell populations and for treating...
8388976 Polypeptide specifically binding to vascular endothelial growth factor, fusion protein including polypeptide, and methods therefor  
A polypeptide inhibiting binding between a vascular endothelial growth factor and a vascular endothelial growth factor receptor, a fusion protein including the same, and a method of preparing the...
8389694 Biologically active antibodies recognizing a cell surface molecule selectively expressed on living mouse natural type one (I) interferon producing cells  
An isolated and characterized monoclonal antibody (“440c”) prepared by immunizing Wistar/CRL rats subcutaneously with purified rat bone marrow IPC, fusing popliteal lymph nodes of the rats with...
8383125 Antimicrobial protein  
The present invention provides improved antimicrobial compositions comprising peptide fragments of tammar wallaby milk proteins and analogs and derivatives thereof exemplified by the amino acid...
8383084 Destruction of spores through glycoconjugate enhanced phagocytosis  
Methods for enhancing destruction and killing of bacterial spores via phagocytosis, where phagocytosis of bacterial spores is enhanced by using a glycoconjugate. In one embodiment, the method...
8383124 Mobilization of hematopoietic stem cells  
Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and/or cancer stem cells from bone marrow into peripheral blood,...
8383107 Single domain brain-targeting antibody fragments derived from llama antibodies  
A phage-displayed library of llama single heavy domain antibodies (sdAbs) was enriched for species that selectively bind to and are internalized by human cerebromicrovascular endothelial cells...
8383767 Immunogenic protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain  
A protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain. Also described herein is an immunoconjugate containing the protein carrier with an antigen...
8378084 Fusion molecule based on novel TAA variant  
This invention provides novel carbonic anhydrase (CAIX) nucleic acid and peptide sequences, as well as related methods and compositions, including anti-cancer immunogenic agent(s) (e.g. vaccines...
8372963 RSV F-protein and its use  
The present invention relates to a nucleic acid molecule, which codes for the F-protein of the respiratory syncytial virus (RSV) or a fragment thereof, for the expression in a human cell...
8372406 Antitumoral and antiviral peptides  
The invention relates to novel compositions of general formula (1) consisting of X1 Trp Gly Gln X2 or the pharmaceutically acceptable salts or esters or amides thereof, wherein X1 is absent or...
8372412 Bioassay and peptides for use therein  
The invention provides a bioassay for detection of Mycobacterium tuberculosis infection comprising artificially modified peptide subsequences of the T-cell epitope from M. tuberculosis Ag85B....
8372393 Method of inducing a CTL response  
Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system....
8367070 Modified surface antigen  
Novel proteins that constitute modified forms of a Neisseria meningitidis surface antigen and encoding nucleic acids are provided. The modified surface proteins are characterized by having...
8367068 Use of triplex structure DNA in transferring nucleotide sequences  
A method to induce an immune response in a host in need thereof, comprises administering to the host, recombinant lentiviral vector particles comprising: a) a GAG polypeptide or a functional...
8367067 Immunogenic lipopeptides comprising T-helper and B-cell epitopes  
The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary...
8367069 Cytotoxic T cell defined EGFR peptide and an optimized derivative peptide  
The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic...
8367076 Glyceroglycolipid antigen of Mycoplasma pneumoniae  
The present invention provides a novel glyceroglycolipid produced by Mycoplasma pneumoniae. The glyceroglycolipid can be used as a diagnostic marker for a disease caused by Mycoplasma pneumoniae.
8361749 Process for preparing variant of Erysipelothrix rhusiopathiae surface protective antigen in E. coli  
A variant of Erysipelothrix rhusiopathiae surface protective antigen SpaA protein or of a shortened form of SpaA (ΔSpaA) in which a portion of SpaA protein is deleted for protection from...
8361471 Immunostimulatory regimen comprising administering type 1 interferon and agonistic anti-CD40 antibody  
A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or...
8361441 Detection and therapy of bacterial infection caused by Enterobacteriaceae  
The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood...
8361483 Epinecidin-1 as a vaccine adjuvant for enhancing immune responses  
A method of enhancing a mammalian immune response to a virus is disclosed. The method comprises administering a composition comprising an effective amount of epinecidin (Epi)-1 and the virus to a...
8362202 Methods for inhibiting immune complex formation in a subject  
Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, and methods for using such polypeptides and compounds to inhibit Fc-mediated immune...
8361986 Synthetic agonists of TLR9  
The invention relates to synthetic chemical compositions that are useful for modulation of Toll-Like Receptor (TLR)-mediated immune responses. In particular, the invention relates to agonists of...