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8449890 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof....
8449888 Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells  
The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached...
8444974 Use of antibodies for the vaccination against cancer  
Described is the use of antibodies which are directed against human cellular membrane antigens for the vaccination against cancer diseases.
8444993 Multi-phase emulsions based on amphiphilic block copolymers  
A method for enhancing a body's response to an immunogen is disclosed. The method comprises immunizing a subject in need thereof a vaccine composition in a water-in-oil (W/O/W) emulsion that...
8445642 Methods to differentiate protein conformers  
The invention is directed to methods to distinguish among different protein conformers of the same protein such as proteins which form amyloid deposits. Using the methods of the invention, one or...
8444994 Multivalent antihelminthic vaccine  
A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage...
8444991 Method of preparing an immunologically-active adjuvant-bound dried vaccine composition  
The disclosure provides a method of preparing an immunologically-active adjuvant-bound freeze dried vaccine composition. A specific embodiment provides a stable vaccine composition comprising an...
8444992 Multiple vaccination including serogroup C meningococcus  
Various improvements to vaccines that include a serogroup C meningococcal conjugate antigen, including: (a) co-administration with acellular B. pertussis antigen; (b) co-administration with an...
8444989 One dose vaccination against mycoplasma infections of pigs  
The present invention provides a one phase, aqueous vaccine composition for immunizing an animal against infection by Mycoplasma hyopneumoniae, comprising: an immunizing amount of a Mycoplasma...
8440207 Live bacterial vaccines for viral infection prophylaxis or treatment  
A live bacterium, having a DNA construct stabilized against transduction of other bacteria, having a promoter sequence and encoding a fusion peptide, comprising a bacterial secretion peptide...
8440203 Methods of immunizing pregnant heifers at three months of gestation  
The present invention discloses methods for protecting newborn calves against neonatal diarrhea by vaccinating pregnant cows and/or pregnant heifers, while minimizing the number of separate...
8440206 Methods for producing an immune response to tuberculosis  
Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional...
8440412 Compositions, methods and animal models for screening therapeutics for TH2-type disease  
The present invention provides a complex of an antigen and IgE binding to the antigen, a composition including an antigen and IgE binding to the antigen, and a method of using the complex or the...
8440198 Compositions and methods for wound healing  
The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osetoarthritic diseases, or diabetes). In...
8440205 Streptococcal C5A peptidase vaccine  
Novel vaccines for use against β-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of streptococcal C5a peptidase (SCP). Also...
8440199 Methods for mobilizing mesenchymal stem cells in a patient  
The current invention provides a method for mobilizing endothelial progenitor cells (EPC) and/or mesenchymal stem cells (MSC) in a patient, wherein the method comprises the steps of (i)...
8435532 Use of modified extracellular matrix proteins in diagnosis and treatment of atherosclerosis  
The present invention relates to the use of fibronectin, tenascin, collagens type I, III, VI and/or VIII modified by aldehyde or by glycosylation in ELISA for detection of antibodies in plasma and...
8435565 Bioresorbable polymer matrices and methods of making and using the same  
A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a...
8435531 Method of treating cancer cells to create a modified cancer cell that provokes an immunogenic response  
The present invention relates to a delipidation method employing a solvent system useful for extracting lipids from cancer cells, thereby creating a modified cancer cell particle. Upon...
8435534 Cancer immunotherapy  
A method for stimulating a immune response against IL-13Rα2 in a subject having or at risk for developing a disease having cells expressing IL-13Rα2 includes the steps of formulating the...
8436139 Peptide-based immunization therapy for treatment of atherosclerosis  
The present invention relates to a fragment of apolipoprotein B, for immunization for prophylactic or therapeutic treatment of mammals, including humans, against ischemic cardiovascular diseases,...
8435494 Mesothelin antibody protein fusions and methods of use  
The invention relates to fusion proteins comprising a stress protein fused with an engineered antibody or fragment that binds to mesothelin, or a stress protein fused with a biotin-binding protein...
8435525 FGF modulation of in vivo antibody production and humoral immunity  
The invention provides methods for increasing or decreasing antibody production in vivo by inhibiting or promoting the activity of fibroblast growth factor-2 (FGF2) respectively.
8435530 Methods for suppressing activity of activated interferon-producing cells  
The present invention provides agents for regulating the activity of interferon-producing cells (IPCs), which comprise as active ingredients antibodies that bind to BST2 and/or to its homologues,...
8435533 Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of Chlamydia  
The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of...
8435495 Characterization of granulocytic Ehrlichia and methods of use  
The present invention relates, in general, to methods of screening a sample obtained from a subject for antibodies relating to granulocytic ehrlichia (GE) infection.
8431139 Nucleic acids and proteins from Streptococcus groups A and B  
The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding...
8431221 Therapeutic calcium phosphate particles and methods of manufacture and use  
Novel calcium phosphate core particles, methods of making them, and methods of using them as vaccine adjuvants, as cores, as carriers of biologically active material, and as controlled release...
8431160 Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions  
Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide...
8431530 Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles  
Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also...
8431133 Augmentation of titer for vaccination in animals  
The disclosure relates to a composition added to animal feed used in combination with a vaccine to enhance the effectiveness of the vaccine. Amongst other effects, the composition raises the titer...
8425915 Nanoparticles for providing immune responses against infectious agents  
Nanoparticles for providing immune responses for the treatment or prophylaxis of infection by infectious agents such as viruses, parasites, bacteria, prions and fungi are described which comprises...
8425913 Immunogenic agents against Burkholderia pseudomallei and/or Burkholderia mallei, comprising lipopolysaccharide, capsular polysaccharide and/or proteins from Burkholderia pseudomallei  
An immunogenic agent which comprises a killed strain of Burkholderia pseudomallei, or a combination of components thereof which combination produces a protective immune response in an animal to...
8425916 Immunizing compositions and methods of use  
The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater...
8420330 Diagnosis and treatment of cardiac troponin 1 (cTn1) autoantibody-mediated heart disease  
Provided herein are, inter alia, methods of diagnosing and treating autoimmune cardiomyopathy in subjects, based upon the detection of IgG4 autoantibodies to cardiac troponin I (cTnI).
8420072 Vaccination of sex reversed hybrid tilapia (Oreochromis niloticus x O. aureus) with an inactivated Vibrio vulnificus vaccine  
Vibrio vulnificus can cause infections in aquaculture-raised fish and is considered an opportunistic human pathogen. We isolated V. vulnificus from diseased hybrid tilapia (Oreochromis niloticus X...
8420097 DNA sequence, and recombinant preparation of the grass pollen allergen Lol p 4  
The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and...
8420095 Antigen-containing microspheres for the treatment of allergies  
Microspheres containing antigens for allergy therapy, the microspheres having a binding constant of 1×104 M−1 toward a specific carbohydrate residue of intestinal and/or nasal epithelial cells.
8420096 Cell-penetrating SOCS polypeptides that inhibit cytokine-induced signaling  
Disclosed are compositions and methods related to cell-penetrating suppressor of cytokine signaling (SOCS) proteins that inhibit cytokine-induced signaling.
8420107 Peptide vaccines against group A streptococci  
This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of...
8420607 Anthrax carbohydrates, synthesis and uses thereof  
The present invention presents the isolation, characterization and synthesis of oligosaccharides of Bacillus anthracis. Also presented are antibodies that bind to such saccharide moieties and...
8414899 Vaccines comprising multimeric HSP60 peptide carriers  
The present invention provides improved vaccine compositions having enhanced immunogenicity and methods of using same. The compositions and methods include immunogenic conjugates containing...
8415095 Use of nucleoside derivatives comprising a citrate group for the production of antibodies having an affinity for triphosphorylated nucleosides  
Nucleoside analogues comprising a citrate group can be used to obtain immunogens designed to produce antibodies having an affinity for triphosphorylated nucleosides. Such antibodies are useful for...
8414884 Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response  
Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I...
8415317 Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines  
The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of...
8414886 Method of treating disease  
This invention relates to compositions comprising a bacterium of the genus Dietzia that is useful for treating paratuberculosis in ruminants and to a method for culturing the bacterium. The...
8414901 Canine Lyme disease vaccine  
The present invention provides a vaccine for canine Lyme disease and methods of making and using the vaccine alone, or in combinations with other protective agents.
8414947 Pharmaceutical preparation that can be administered orally for treating fish, production method for said preparation and use of the latter  
The present invention is directed to a pharmaceutical preparation for oral application for treatment of fish, in particular for vaccination of fish of the salmon family and other fish having a...
8409589 Mutant forms of streptolysin O  
Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against S. pyogenes are useful in vaccine compositions to induce protection against S....
8409562 Chimeric vaccine antigens against classical swine fever virus  
The current invention describes chimeric vaccine antigens against the virus that causes the Classic Swine Fever (CSFV). Such vaccine antigens are based on viral subunits coupled to proteins able...