Match Document Document Title
8491911 Pharmaceutical product for up-dosing of allergy vaccine  
This invention relates to the use of a pharmaceutical product comprising allergen and optionally an adjuvant for fast up-dosing in connection with allergy vaccination wherein a reduced number of...
8491910 Vaccine comprising AMB A 1 peptides for use in the treatment of ragweed allergy  
The present invention relates to compositions for preventing or treating allergy to ragweed by tolerization. The compositions are based on combinations of peptide fragments derived from the major...
8491894 Method for inhibiting the growth of Mycobacterium tuberculosis by using CD13 receptor  
The present invention discloses a method for inhibiting the growth of Mycobacterium tuberculosis, comprising: administering at least one selective binding agent such as an anti-CD13 antibody or a...
8491912 Methods of treating ocular and other diseases with Syn-134R polypeptide  
Disclosed herein TPV1 is a method of treating ocular and systemic conditions by administering IL-10 and TPV134R polypeptides.
8492103 Diagnosis and treatment of ehrlichiosis  
The present invention provides an isolated Ehrlichia peptide and therapeutic and diagnostic uses therefor.
8486886 Botulinum toxin treatments  
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
8486412 Immunity to folate receptors  
This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FRα immunity in a mammal are provided. This...
8486410 RLIP76 liposomes for protection against irradiation  
Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and...
8486908 Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response  
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated...
8486421 Antigen-norovirus P-domain monomers and dimers, antigen-norovirus P-particle molecules, and methods for their making and use  
A substituted Norovirus capsid protein monomer, having only the P-domain and called an antigen-Norovirus P-domain monomer, includes a foreign antigen inserted into one or more of three surface...
8481024 Vaccines against tularemia  
The disclosure relates generally to an antigenic composition useful for immunization against tularemia. The disclosure is a method for producing a vaccine for preventing tularemia in humans and...
8481044 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These...
8481056 Pro-apoptotic bacterial vaccines to enhance cellular immune responses  
Whole-cell vaccines and methods for their use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria. The present invention involves a method of...
8481043 Nasal immunization  
Compositions and methods for intranasal delivery of antigens for immunization of a mammal are disclosed. Antigens include peptides, proteins, peptidomimetics, DNA, RNA, carbohydrates and...
8481022 Method of treating autoimmune disease with mesenchymal stem cells  
Methods and compositions for treating an autoimmune disease, such as new onset type 1 diabetes (T1D) in a subject using autologous or allogeneic mesenchymal stem cells administered to the subject...
8481045 Immunogenic protein constructs  
Bacterial immunity proteins are utilized to increase immune response to an antigen of interest.
8481051 Cytotoxic T-cell epitope peptides that specifically attack epstein-barr virus-infected cells and uses thereof  
The present inventors introduced mRNAs for the Epstein-Barr virus proteins LMP1 and EBNA1 into antigen-presenting cells, and as a result, demonstrated that the cells induced Epstein-Barr...
8476237 Compositions and methods for treating cancer by inhibiting the secretion of microparticles  
Novel peptides that inhibit the release of microparticles from cells are disclosed. Also disclosed are polynucleotides encoding the peptides, expression vectors carrying the polynucleotides and...
8476024 Botulinum neurotoxin a protein receptor and uses thereof  
The invention relates to an isolated polypeptide of the luminal domain of synaptic vesicle glycoprotein 2C of Homo sapiens wherein at least 70 percent of the amino acid sequence is identical to...
8475787 Beneficial effects of bacteriophage treatments  
The invention relates to use of one or more bacteriophages in vivo in a human or animal in order to induce sensitivity to chemical antibiotics in bacterial cells, where such susceptibility is...
8476416 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes  
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing...
8475809 Composition comprising sortase anchored surface proteins of Streptococcus uberis  
The present invention provides an immunogenic composition comprising one or more Streptococcus uberis sortase-anchored surface proteins, or an immunogenic part thereof, wherein the composition is...
8470343 Immunogenic compositions and uses thereof  
The present invention relates generally to a method of eliciting or otherwise inducing an effective immune response to a micro-organism and compositions for use therein. More particularly, the...
8470585 Process for adenovirus purification from high cell density cultures  
The invention provides methods for large-scale adenovirus purification from high cell density suspensions, using host cell DNA fragmentation and/or precipitation followed by a clarification step...
8470340 Peptides presenting an epitope of a domain of factor H binding protein and methods of use  
Polypeptides that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis, and methods of use, are provided.
8470339 Antigens for paratuberculosis diagnosis and vaccination  
The present invention discloses new antigens of Mycobacterium avium subsp. paratuberculosis, antigenic compositions comprising at least two of said antigens, as well as epitopes, antibodies or...
8470331 Composition of antigen and glycolipid adjuvant for sublingual administration  
A method of producing a mucosal and systemic immune response in a mammal comprising administering sublingually an effective amount of a composition comprising at least one antigen and a glycolipid...
8470598 Modified Vaccinia Ankara virus variant and cultivation method  
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell...
8470342 Methods of altering an immune response induced by CpG oligodeoxynucleotides  
It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune...
8466116 Use of CpG oligodeoxynucleotides to induce epithelial cell growth  
This disclosure provides a method of inducing epithelial cell growth. The method includes administering an effective amount of a K-type CpG oligonucleotide, thereby inducing epithelial cell...
8465746 Compositions and methods for treatment, research and therapeutic applications for malaria  
The present invention provides anti-Plasmodium immunogenic compositions comprising EVP1 (PFD0495c) or an antigenic portion thereof, as well as methods of immunizing against malaria employing these...
8466259 Adjuvants  
Disclosed are lipopeptides or lipoproteins, related compositions, and related methods.
8460648 Probiotic recolonisation therapy  
The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in...
8460920 Method for the purification of adenovirus particles  
The invention provides methods for large-scale adenovirus purification from high cell density suspensions, using host cell DNA precipitation followed by a clarification step.
8460669 Compositions and methods for identifying response targets and treating flavivirus infection responses  
Cellular receptors are identified that induce plasma leakage and other negative effects when infected with flaviviruses, such as dengue virus or Japanese encephamyelitis virus. Using fusion...
8460682 Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells  
The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain;...
8460914 Decreasing potential iatrogenic risks associated with vaccines and vaccine antigens  
Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero,...
8461323 Characterization of granulocytic ehrlichia and methods of use  
The present invention relates, in general, to polypeptides having antigenic epitopes from granulocytic ehrlichia (GE) proteins and methods of use thereof.
8460675 Viral chemokine-antigen fusion proteins  
The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral...
8455210 Biochip, and method for the selective identification of Chlamydia trachomatis infections  
The present invention relates to a method for the selective identification of Chlamydia trachomatis infections wherein the antigens CT017, CT098, CT318-L1 P, CT431-TARP, CT603-TSAP, and CT664 are...
8454966 Nanoparticles for protein drug delivery  
The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability...
8454977 Non-toxic biofilm inhibitor  
The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the...
8455615 Methods and compositions for prostate cancer immunotherapy  
The present invention features methods and compositions (e.g., immune response stimulating peptides (e.g., ERG or SIM2 peptides), activated immune cells, antigen-presenting cells, and antibodies...
8454965 Method for the treatment of multiple sclerosis  
A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple sclerosis that includes administering to...
8454964 Microparticles comprising carbohydrate beads covalently linked with allergen  
Microparticles are disclosed which comprise a bead essentially consisting of a cross-linked carbohydrate and an antigen covalently linked thereto. The microparticle can be used for the treatment...
8454975 Method for enhancing skin appearance  
A method for treating skin by administration of a neurotoxin such as a botulinum toxin by means of a dry needle. The method can be used to accomplish what has generally been described as skin...
8449894 Aspergillus vaccine preparation and methods of making and using thereof  
The present invention relates to compositions and methods in preventing and/or treating diseases caused by Aspergillus. In particular, the present invention is directed to Aspergillus vaccine...
8449891 Recombinant flagellin protein and preparation and use thereof  
The present invention provides an optimized recombinant flagellin protein and preparation and use thereof. The protein is with a deletion in the hypervariable region, said hypervariable region is...
8449893 Compositions and dosage regimes comprising a clostridial vaccine and levamisole  
A composition and dosage regime including a vaccine and levamisole for the treatment of clostridial diseases and helminthiasis. New methods of administration relating to particular dosage regimes...
8450055 Malaria antigen screening method  
The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors,...