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8545851 Composition for improving inflammatory disease using ABH antigens  
The present invention relates to a composition for improving inflammatory disease, and more specifically to a composition for improving inflammatory disease able to improve inflammatory reactions...
8545853 Recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted  
It refers to a recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, comprising a deletion in the stem domain, wherein at least one heterologous sequence is inserted in a region...
8546337 Self-assembling peptide nanoparticles useful as vaccines  
Self-assembling peptide nanoparticles (SAPN) incorporating T-cell epitopes and/or B-cell epitopes are described. The nanoparticles of the invention consist of aggregates of a continuous peptidic...
8545852 Edwardsiella ictaluri E-ict-VL33 strain, vaccines thereof, and a method for protecting fishes using said vaccines  
A novel Edwardsiella ictaluri E-ict-VL33 strain, a vaccine derived from the novel Edwardsiella ictaluri E-ict-VL33 strain, especially in immersion form and oral form, and a method for protecting...
8545858 Porous calcium phosphate bone material  
Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an...
8540994 H5 subtype-specific binding proteins useful for H5 avian influenza diagnosis and surveillance  
The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus (“AIV”). The monoclonal...
8541230 Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof  
The present invention relates to polynucleotides encoding immunogenic HIV type C Gag- and/or Env-containing polypeptides. Uses of the polynucleotides in applications including DNA immunization,...
8541179 Immunodetection assay for Mycobacterium tuberculosis complex  
The present invention provides a method for specifically detecting a Mycobacterium tuberculosis complex-specific secretory protein MPT64 antigen in a biological sample, whereby diagnosis of...
8540999 Allergenic proteins and peptides from Japanese cedar pollen  
The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The...
8541023 Immunogenic compositions containing phospholipid  
Immunogenic compositions containing phospholipid adjuvants, including microparticle and emulsion compositions. According to one aspect of the invention, an immunogenic microparticle composition is...
8541008 Pharmaceutical compositions and methods to vaccinate against candidiasis  
A Candida albicans bloodstream infections cause significant morbidity and mortality in hospitalized patients. Filament formation and adherence to host cells are critical virulence factors of C....
8535688 Vaccine  
The invention relates to a vaccine for the treatment of disease caused by Neisseria, the vaccine including one or more immunogenic components for Neisseria serogroups, as well as antibodies to the...
8535942 Glypican-3 (GPC3)-derived tumor rejection antigenic peptides useful for HLA-A2-positive patients and pharmaceutical comprising the same  
It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an...
8536304 Tumour-associated peptides that bind to MHC molecules  
The invention relates to a tumor-associated peptide containing an amino sequence, which is selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:79 of the enclosed listing. The peptide...
8535665 Process for identification of molecular mimicry and the uses thereof  
The present invention discloses a process for simple and rapid detection and identification of molecular mimicry or mimic antigens or molecules existing in/on humans, animals and plants. The...
8535690 Tumor specific animal proteins  
CASB7439 polypeptides and polynucleotides, immunogenic compositions comprising them and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods...
8530635 Cupredoxin derived transport agents and methods of use thereof  
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains...
8529913 Immunogenic compositions for Streptococcus pyogenes  
The invention includes a GAS antigen, GAS 40, which is particularly suitable for use either alone or in combinations with additional GAS antigens, such as GAS 117, GAS 130, GAS 277, GAS 236, GAS...
8529906 Compositions for inducing immune responses  
The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or...
8529910 Enterococcus antigens  
The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments...
8529905 Soluble inhibitors of vascular endothelial growth factor and use thereof  
The present invention relates to cDNA encoding a soluble neuropilin protein (sNP) which is isolated from neuropilin (NP) producing cells or is recombinantly engineered from NP-encoding DNA. NP-1...
8529904 Immunotherapeutic methods using epitopes of WT-1 and GATA-1  
A peptide comprising the amino acid sequence RMFPNAPYL or a portion or variant thereof provided that the peptide is not intact human WT-1 polypeptide or a peptide comprising the amino acid...
8524246 Treatment of immune disease by mucosal delivery of antigents using genetically modified Lactobacillus  
The present invention relates to the treatment of autoimmune and allergic diseases by mucosal delivery by micro-organism, in particular Lactococcus lactis, of secreted immunodominant antigens.
8524243 Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same  
The present invention relates to avirulent Salmonella Gallinarum variants by inactivating virulence gene clusters of Salmonella Gallinarum (SG), a main pathogen of avian salmonellosis, and various...
8524482 Method and system for sampling and separating submicron-sized particles based on density and or size to detect the presence of a particular agent  
A system for sampling and separating submicron-sized particles to detect the presence of an agent such as viruses in an environmental sample, which includes collecting means for collecting a...
8524248 Methods to diagnose and immunize against the virus causing human Merkel cell carcinoma  
The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a...
8524868 Polypeptide fragments of the hepatitis E virus, the vaccine composition comprising said fragments and the diagnostic kits  
The present invention relates to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of n-polymeric...
8524250 Carrier  
The present invention is directed to providing a carrier which can transport a compound to a gut-associated lymphoid tissue efficiently without being degraded or digested. For that purpose, the...
8524242 Soluble aggregate, immune tolerance inducer and manufacturing method thereof  
A soluble aggregate of allergen proteins, prepared by heating multiple allergen proteins and aggregating the allergen proteins and thus enclosing the antigen structures causing allergic reactions...
8518415 Engineered type IV pilin of Clostridium difficile  
The present invention relates to engineered Clostridium difficile type IV pilin (tfp) genes, type IV pilin proteins which can serve as a diagnostic marker for identification of patients infected...
8518873 Method of inhibiting clostridium difficile by administration of oritavancin  
Glycopeptide antibiotics, such as oritavancin, demonstrate significant activity against both a vegetative form of C. difficile and C. difficile spores. Methods for the treatment, prophylaxis and...
8513008 Mature dendritic cell compositions and methods for culturing same  
This invention provides methods to prepare and use immunostimulatory cells for enhancing an immune response. The invention provides a method for preparing mature dendritic cells (DCs), comprising...
8512712 Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions  
Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with...
8507249 Bacterial virulence factors and uses thereof  
The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for...
8506949 Methods for modulating inflammatory and/or immune responses  
The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells)...
8501187 Stabilized biodegradable neurotoxin implants  
Biodegradable neurotoxin implants and methods of making and using such implants are provided. Biodegradable neurotoxin implants include a neurotoxin, a biodegradable polymer component, and an...
8501221 Methods for preparing and delivering adjuvant compositions  
Methods are provided for preparing and delivering an adjuvant for vaccines including lecithin and a polymer. The polymer is preferably polyacrylic acid-based and the delivery method involves...
8501908 Immunogenic peptides  
The present invention relates to immunogenic peptides and their various applications. In particular the invention relates to immunogenic peptides derived from the PASD1 protein and their use in...
8501178 Use of DR6 and p75 antagonists to promote survival of cells of the nervous system  
The present invention relates to Death Receptor-6 (DR6) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to be important for regulating...
8501183 Immunogenic compositions and diagnostic and therapeutic uses thereof  
The present invention relates to a method of inducing an immune response to a parasite utilizing an immunogenic composition comprising a glycosylphosphatidylinositol (“GPI”) inositolglycan domain...
8501197 Compositions and methods for stimulating immune response against Moraxella catarrhalis  
This invention provides a method for stimulating in an individual an immune response against M. catarrhalis. The method comprises administering to an individual a composition comprising M....
8501188 Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides  
The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for inhibiting or treating inflammatory lung disease by administering a...
8501190 Vaccine against Clostridium perfringens  
There is provided a vaccine for controlling Clostridium perfringens in animals, and particularly necrotic enteritis in poultry. The vaccine may comprise a C. perfringens antigenic polypeptide or...
8501186 Adjuvant composition for vaccine  
The present invention provides a Withania somnifera fraction rich in withanolides and a vaccine comprising a “Withania somnifera fraction” as an adjuvant.
8497072 Amyloid-beta globulomer antibodies  
The subject invention relates to monoclonal antibodies (e.g., 8F5 and 8C5) that may be used, for example, in the prevention, treatment and diagnosis of Alzheimer's Disease or other...
8496939 Injectable water-in-oil emulsions  
Personal care or cosmetic oil in water emulsions include an oil emulsifier and a combination of a Xanthan polysaccharide and a polyglucomannan polysaccharide to provide enhanced stability even at...
RE44399 One dose vaccination with Mycoplasma hyopneumoniae  
The present invention relates to methods for treating or preventing a disease or disorder in an animal caused by infection by Mycoplasma hyopneumoniae (M. hyo) by administering to the animal at...
8491909 Methods and compositions for dosing of allergens  
The present invention comprises methods and compositions for immunotherapy. An aspect of the invention comprises administration of one or more allergens in compositions via oral and sublingual...
8492516 Zona pellucida binding peptides for species specific immunocontraception of animals  
Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals. The disclosed compositions...
8492356 Methods of inhibiting tumor growth using TTK antagonists  
The present invention relates to methods for treating TTK positive breast cancers or soft-tissue sarcomas in a mammalian subject by administering a therapeutically effective amount of a TTK...