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8591905 Nicotine immunonanotherapeutics  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
8591881 Chimeric Newcastle disease viruses and uses thereof  
Described herein are chimeric Newcastle disease viruses engineered to express a heterologous interferon antagonist and compositions comprising such viruses. The chimeric Newcastle disease viruses...
8592558 H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use  
The present invention relates to novel hemagglutinin H5 proteins, nucleic acids and vectors encoding for those as well as vaccines comprising any of such H5 proteins, nucleic acids or vectors...
8586051 Glycolipids and analogues thereof as antigens for NKT cells  
This invention relates to immunogenic compounds which serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.
8586052 Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells  
The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached...
8586525 Biologically active peptides and their new uses  
Novel peptides are disclosed with their use as a pharmaceutical composition. A method is also disclosed for making pharmaceutical compositions and treatment of an individual.
8586538 Method of treating a patient suffering from a bleeding disorder comprising administering an antibody against the A3-C1 of FVIII  
The present invention concerns the use of peptides derived from and antibodies generated against Factor VIII and the inhibition of Factor VIII interaction with LRP. Furthermore, the present...
8586528 Biologically active peptides and their new uses  
Novel peptides are disclosed with their use as a pharmaceutical composition. A method is also disclosed for making pharmaceutical compositions and treatment of an individual.
8586057 Enterohemorrhagic Escherichia coli vaccine  
Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.
8580730 Methods of treating lesional vestibular disorders by administering serotonin 5-HT3 receptor antagonists  
The invention relates to serotonin 5-HT3 receptor antagonists or inhibitors of serotonin 5-HT3 receptor gene expression for use in the treatment of a lesional vestibular disorder.
8580268 CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity  
The invention relates to oligonucleotides including at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical...
8580274 Drug transporter, and adjuvant and vaccine each utilizing same  
An objective of the invention is to provide a drug delivery vehicle capable of allowing a vaccine or adjuvant to reach a target cell or tissue efficiently while being capable of improving the...
8574315 Electrospun structures and methods for forming and using same  
The present invention relates to structures that contain one or more fiber and/or nanofiber structures where such structures can be formed on a wide variety of structures or surfaces (e.g.,...
8575308 Method for cancer immunotherapy  
A novel compound of the formula (1): wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond or the like; R1 is a hydrogen atom or the like; R2 is a hydroxy group...
8575110 Peptidic nanoparticles as drug delivery and antigen display systems  
Described is a new type of nanoparticle using the concept of self-organization of a single continuous chain to form peptidic nanoparticles. In particular, nanoparticles of the invention consist of...
8574593 Influenza hemagglutinin and neuraminidase variants  
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
8575340 Purine derivatives and their pharmaceutical uses  
The present invention relates to compounds of formula (I): wherein; R1 represents hydrogen or C1-3alkyl;n is an integer having a value of 1 to 5;X represents O or NH;Y represents C or N; or a...
8574599 Methods and products for inducing mucosal immunity  
The invention relates methods and products for inducing mucosal immunity. In particular, the invention relates to the use of immunostimulatory oligonucleotides containing a CpG motif for inducing...
8574595 Virus purification using ultrafiltration  
Described are methods for purification of recombinant adenovirus from cell culture using a step of ultrafiltration wherein the retentate contains the virus. By applying back pressure on the...
8574597 Immunogenic compositions for the prevention and treatment of meningococcal disease  
The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic...
8568742 Methods and compositions involving immunostimulatory oligodeoxynucleotides  
Described is an immunostimulatory oligodeoxynucleic acid molecule (ODN) having the structure according to formula (I) whereinany NMP is a 2′ deoxynucleoside monophosphate or monothiophosphate,...
8568731 Staphylococcus aureus antigenic polypeptides and compositions  
The invention relates to a method for the identification of antigenic polypeptides expressed by pathogenic microbes; vaccines comprising the polypeptides; recombinant methods to manufacture the...
8568730 Compositions for use in the treatment of chronic obstructive pulmonary diseases and asthma  
The present invention provides compounds and methods for treating or preventing pulmonary diseases include COPD and asthma. In particular, the present invention provides for compounds comprising...
8563006 Immunogenic compositions for the prevention and treatment of meningococcal disease  
The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic...
8563001 Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (BHS) disease  
A number of β-hemolytic streptococci polynucleotides and polypeptides, particularly Streptococcus pyogenes polypeptides and polynucleotides, are described. Two or more of the polypeptides of the...
8563684 Tumor antigen protein SART-3 and tumor antigen peptides thereof  
A novel tumor antigen protein and gene therefor, tumor antigen peptides derived from said tumor antigen protein or derivatives thereof as well as medicaments, prophylactics, or diagnostics for...
8563003 Method for the treatment of malignant and infectious chronic diseases  
The present invention relates to methods of treatment useful in chronic diseases, by means of the rupture of tolerance to self-antigens and increasing autoimmune response against these antigens....
8563007 Immunogenic compositions for the prevention and treatment of meningococcal disease  
The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic...
8562999 Formulations which stabilize and inhibit precipitation of immunogenic compositions  
The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention...
8563511 Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway  
An improved non-human animal model of severe pulmonary arterial hypertension (PAH) and its use for testing of therapeutic agents that can treat symptoms of PAH are disclosed. In addition, the...
8563506 Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles  
Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also...
8563008 Polynucleotides and polypeptides involved in gestational malaria, and biological applications  
The disclosure provides novel antigens involved in gestational malaria, and more particularly to polynucleotide and polypeptide sequences, conjugates, cloning vectors including the sequences for...
8562988 Strategies for improved cancer vaccines  
The present invention concerns methods and compositions for forming anti-cancer vaccine complexes. In preferred embodiments, the anti-cancer vaccine complex comprises an antibody moiety that binds...
8562998 Targeting of antigen presenting cells with immunonanotherapeutics  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
8557258 Vaccines comprising TB10.4  
Vaccination with the combination of Ag85B-TB10.4 and IC31® adjuvant generated a high amount of polyfunctional CD4+T cells expressing high levels of IFN-γ, TNF-α, and IL-2. This in turn led to...
8557246 Fusion protein that directs vaccine antigens to antigen-presenting cells, and applications thereof  
Fusion protein with directioning of vaccinal antigens toward antigen-presenting cells and the applications thereof. This invention relates to a gene construct that comprises, operatively bound, at...
8557254 Lawsonia intracellularis bacterium of a novel serotype, vaccine based on that bacterium, antibodies suitable for diagnosing the novel Lawsonia intracellularis serotype and hybridomas for producing the said antibodies  
This invention pertains to Lawsonia intracellularis bacterium of a serotype which is reactive with monoclonal antibody INT-LIC-02-02 as produced by hybridoma INT-LIC-02-02 deposited with the...
8557250 Methods for preparing complex multivalent immunogenic conjugates  
Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the...
8557247 Lyophilised antigen composition  
The present invention provides lyophilised compositions comprising an antigen and a Toll-like receptor (TLR) 9 agonist. Such compositions may be reconstituted into immunogenic compositions for use...
8551451 Combination vaccine with acellular pertussis  
The present invention relates to a combination vaccine comprising a mixture of antigens for protection against diseases such as diphtheria, tetanus, acellular pertussis, and infections caused by...
8552145 Vaccine for modulating between T1 and T2 immune responses  
The present invention provides liposomal vaccines containing immunogenic lipopeptides that are capable of modulating the humoral and cellular immune responses in vivo.
8551481 Anti-cancer vaccine composition comprising an anti-CD223 antibody and kit comprising an anti-cancer vaccine and an anti-CD223 antibody  
Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic...
8551943 Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles  
Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also...
8551491 Processes for the preparation of a batch of an active pharmaceutical ingredient, a container comprising cryogranules of an allergen product, and a cryogranule of an allergen product  
The present invention relates to processes for the preparation of a batch of an active pharmaceutical ingredient, e.g. an allergen product. The invention also relates to a container comprising...
8551500 Composition comprising the N-terminal region of histone H2B of leishmania—use thereof for inducing an immune response  
The invention concerns an immunogenic composition comprising: i) an antigenic polypeptide consisting of a fragment of the protein histone H2B of Leishmania, said fragment including the N-terminal...
8551498 Solid composition containing Bacillus-type non-pathogenic bacterial spores  
The invention relates to a composition of spores of nonpathogenic bacteria of the Bacillus genus, adsorbed onto a matrix made up of at least one water-insoluble adsorbent compound and a cellulose...
8551757 Bacillus thuringiensis isolate  
A novel bacterial strain of Bacillus thuringiensis, VBTS 2528, is described. This strain comprises genes encoding Cry1Ac, Cry 1Ca, and Cry2Aa endotoxin proteins. The invention further relates to...
8551959 Glycolipid and use thereof  
The invention provides a glycolipid effective for cancer treatment and the like and a synthetic intermediate therefor, as well as a medicament containing the glycolipid and the like. The...
8545838 Compositions and methods for cancer immunotherapy  
Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a liver-expressed chemokine (LEC). In one embodiment, the cancer targeting molecule is an antibody that...
8545812 Transport agents for crossing the blood-brain barrier and into brain cancer cells and methods of use thereof  
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished...